Thomas C. Register, Ph.D.Wake Forest School of Medicine

Thomas C. Register, Ph.D.


Clinical Interests

Atherosclerosis, Endocrine/Menopausal Management, Hormone Replacement Therapy and Menopause, Imaging, Osteoporosis

Contact Information

Academic: 336-716-1557 | Department: 336-716-1557


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Education & Training

  • B.S., Francis Marion University, 1978
  • B.S., Francis Marion University, 1979
  • Ph.D., University of South Carolina-Columbia, 1985
  • Fellowship, WFU School of Medicine, 1988


  • Am Assn Of Clinical Chemistry
  • Am Heart Association
  • Am Soc Of Bone & Mineral Resea
  • Endocrine Society
  • N Am Vascular Biology Organiza
Thomas C. Register, Ph.D.

Thomas C. Register, Ph.D.

Professor, Pathology-Comparative Medicine
Center for Comparative Medicine Research
Center for Diabetes Research
Hypertension and Vascular Research Center
Sticht Center on Aging
Center on Diabetes, Obesity, and Metabolism

Research Interests

atherosclerosis/thrombosis, biotechnology, cardiac function, cross(mult/tnslat/inter)discip, drugs/therapeutic agents pharm, engineering/bioengineering, genomics and proteomics, growth & development, hormones/cytokines/signalling, medical technology/devices, metabolism, molecular biology/molecular me

Contact Information

Academic: 336-716-1557 | Department: 336-716-1557


Related Links

Recent Publications

Kromrey SA, Czoty PW, Nader SH, Register TC, Nader MA. Preclinical laboratory assessments of predictors of social rank in female cynomolgus monkeys. Am J Primatol. 2016;78(4):402-417.

Register TC, Appt SE, Clarkson TB [deceased]. Atherosclerosis and vascular biologic responses to estrogens: histologic, immunohistochemical, biochemical, and molecular methods. Methods Mol Biol. 2016;1366():517-532.

Silverstein-Metzler MG, Shively CA, Clarkson TB [deceased], Appt SE, Carr JJ, Kritchevsky SB, Jones SR, Register TC. Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys. Psychoneuroendocrinology. 2016;68():29-38.

Dewi FN, Wood CE, Willson CJ, Register TC, Lees CJ, Howard TD, Huang Z, Murphy SK, Tooze JA, Chou JW, Miller LD, Cline JM. Effects of pubertal exposure to dietary soy on estrogen receptor activity in the breast of cynomolgus macaques. Cancer Prev Res (Phila Pa). 2016;():.

Freedman BI, Langefeld CD, Lu L, Palmer ND, Carrie Smith S, Bagwell BM, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Jeffrey Carr J, Bowden DW, Divers J. APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes. Kidney Int. 2015;87(1):176-181.

Melendez GC, Register TC, Appt SE, Clarkson TB, Franke AA, Kaplan JR. Beneficial effects of soy supplementation on postmenopausal atherosclerosis are dependent on pretreatment stage of plaque progression. Menopause. 2015;22(3):289-296.

Melendez GC, Manteufel EJ, Dehlin HM, Register TC, Levick SP. Non-human primate and rat cardiac fibroblasts show similar extracellular matrix-related and cellular adhesion gene responses to substance P. Heart Lung Circ. 2015;24(4):395-403.

Kavanagh K, Dendinger MD, Davis AT, Register TC, DeBo R, Dugan G, Cline JM. Type 2 diabetes is a delayed late effect of whole-body irradiation in nonhuman primates. Radiat Res. 2015;183(4):398-406.

Shively CA, Register TC, Appt SE, Clarkson TB. Effects of long-term sertraline treatment and depression on coronary artery atherosclerosis in premenopausal female primates. Psychosom Med. 2015;77(3):267-278.

Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Hoeschele I, McCall CE,. Transcriptomic profiles of aging in purified human immune cells. BMC Genomics. 2015;16(1):333.

Santago AC II, Plate JF, Shively CA, Register TC, Smith TL, Saul KR. Age-related structural changes in upper extremity muscle tissue in a nonhuman primate model. J Shoulder Elbow Surg. 2015;24(10):1660-1668.

Stone AV, Vanderman KS, Willey JS, Long DL, Register TC, Shively CA, Stehle JR Jr, Loeser RF, Ferguson CM. Osteoarthritic changes in vervet monkey knees correlate with meniscus degradation and increased matrix metalloproteinase and cytokine secretion. Osteoarthritis Cartilage. 2015;23(10):1780-1789.

DeBo RJ, Register TC, Caudell DL, Sempowski GD, Dugan G, Gray S, Owzar K, Jiang C, Bourland JD, Chao NJ, Cline JM. Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques. Int J Radiat Biol. 2015;91(6):510-518.

Freedman BI, Divers J, Russell GB, Palmer ND, Wagenknecht LE, Smith SC, Xu J, Carr JJ, Bowden DW, Register T. Vitamin D associations with renal, bone, and cardiovascular phenotypes: African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2015;100(10):3693-3701.

Freedman BI, Divers J, Whitlow CT, Bowden DW, Palmer ND, Smith SC, Xu J, Register TC, Carr JJ, Wagner BC, Williamson JD, Sink KM, Maldjian JA. Subclinical atherosclerosis is inversely associated with gray matter volume in African Americans with type 2 diabetes. Diabetes Care. 2015;38(11):2158-2165.

Freedman BI, Divers J, Russell GB, Palmer ND, Bowden DW, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Langefeld CD, Hruska KA, Register TC. Plasma FGF23 and calcified atherosclerotic plaque in African Americans with type 2 diabetes mellitus. Am J Nephrol. 2015;42(6):391-401.

Register T, Carr JJ, Lenchik L, Divers J, Russell GB, Palmer ND, Wagenknecht LE, Smith SC, Xu J, Bowden DW, Freedman BI. Bone resorption assessed by serum type I collagen C-terminal telopeptide (crosslaps) is inversely associated with bone mineral density and change in BMD but not with change in calcified atherosclerotic plaque in African Americans. J Bone Miner Res. 2015;30(Suppl 1):.

Eyster KM, Appt S, Chalpe A, Mark-Kappeler CJ, Register TC, Clarkson TB. Effects of estradiol on transcriptional profiles in atherosclerotic iliac arteries in ovariectomized cynomolgus macaques. Menopause. 2014;21(2):143-152.

Groban L, Kitzman DW, Register TC, Shively CA. Effect of depression and sertraline treatment on cardiac function in female nonhuman primates. Psychosom Med. 2014;76(2):137-146.

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2014;99(1):315-321.

Shively CA, Register TC, Higley JD, Willard SL. Sertraline effects on cerebrospinal fluid monoamines and species-typical socioemotional behavior of female cynomolgus monkeys. Psychopharmacology (Berl). 2014;231(7):1409-1416.

Eyster K, Appt S, Chalpe A, Register T, Clarkson T. Effects of equol on gene expression in female cynomolgus monkey iliac arteries. Nutr Metab Cardiovasc Dis. 2014;24(4):423-427.

Willard SL, Hemby SE, Register TC, McIntosh S, Shively CA. Altered expression of glial and synaptic markers in the anterior hippocampus of behaviorally depressed female monkeys. Neurosci Lett. 2014;563():1-5.

Murphy RA, Register TC, Shively CA, Carr JJ, Ge Y, Heilbrun ME, Cummings SR, Koster A, Nevitt MC, Satterfield S, Tylvasky FA, Strotmeyer ES, Newman AB, Simonsick EM, Scherzinger A, Goodpaster BH, Launer LJ, Eiriksdottir G,. Adipose tissue density, a novel biomarker predicting mortality risk in older adults. J Gerontol A Biol Sci Med Sci. 2014;69(1):109-117.

Murphy RA, Reinders I, Register TC, Ayonayon HN, Newman AB, Satterfield S, Goodpaster BH, Simonsick EM, Kritchevsky SB, Harris TB. Associations of BMI and adipose tissue area and density with incident mobility limitation and poor performance in older adults. Am J Clin Nutr. 2014;99(5):1059-1065.

Bild DE, McClelland R, Kaufman JD, Blumenthal R, Burke GL, Carr JJ, Post WS, Register TC, Shea S, Szklo M. Ten-year trends in coronary calcification in individuals without clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. PLoS One. 2014;9(4):e94916.

Silverstein MG, Kaplan JR, Appt SE, Register TC, Shively CA. Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis). Menopause. 2014;21(10):1136-1142.

Jordan HL, Register TC, Tripathi NK, Bolliger AP, Everds N, Zelmanovic D, Poitout F, Bounous DI, Wescott D, Ramaiah SK. Nontraditional applications in clinical pathology. Toxicol Pathol. 2014;42(7):1058-1068.

Freedman BI, Langefeld CD, Lu L, Palmer ND, Smith SC, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Bowden DW, Divers J. Apolipoprotein L1 gene associations with atherosclerosis, nephropathy, and mortality in African Americans with type 2 diabetes [abstract]. J Am Soc Nephrol. 2014;25(Abstract Suppl):231A.

Shively CA, Register TC, Vitolins MZ, Wilson ME, Appt SE. Dietary modification of physiological stress responses [abstract]. Am J Primatol. 2014;76(Suppl 1):71.

Silverstein MG, Register TC, Appt SE, Shively CA. Effects of selective serotonin reuptake inhibitors and social stress on body composition and carbohydrate metabolism in female cynomolgus macaques (macaca fascicularis) [abstract]. Am J Primatol. 2014;76(Suppl 1):70.

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 2013;98(1):E60-E65.

Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni AG,. Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2013;6(1):97-105.

Choi SJ, Shively CA, Register TC, Feng X, Stehle J, High K, Ip E, Kritchevsky SB, Nicklas B, Delbono O. Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys.. J Gerontol A Biol Sci Med Sci. 2013;68(3):258-267.

Register TC, Divers J, Bowden DW, Carr JJ, Lenchik L, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2013;98(5):1916-1922.

Sophonsritsuk A, Appt SE, Clarkson TB, Shively CA, Espeland MA, Register TC. Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause. Menopause. 2013;20(5):540-547.

Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R Jr, Danial N, Datta SR, Kulik G. Behavioral stress accelerates prostate cancer development in mice. J Clin Invest. 2013;123(2):874-886.

Barascuk N, Genovese F, Larsen L, Byrjalsen I, Zheng Q, Sun S, Hosbond S, Poulsen TS, Diederichsen A, Jensen JM, Mickley H, Register TC, Rasmussen LM, Leeming DJ, Christiansen C, Karsdal MA. A MMP derived versican neo-epitope is elevated in plasma from patients with atherosclerotic heart disease. Int J Clin Exp Med. 2013;6(3):174-184.

Willard S, Johnston WD, Clark A, Uberseder B, Neely D, Massey A, Daunais J, Williamson J, Register TC, Bourland JD, Shively C. Long term sertraline treatment decreases volumes of hippocampus and anterior cingulate cortex in an adult female primate model of depression [abstract]. Biol Psychiatry. 2013;73(9 Suppl):235S.

Ethun KF, Wood CE, Cline JM, Register TC, Appt SE, Clarkson TB. Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model. Menopause. 2013;20(7):777-784.

Dewi FN, Wood CE, Lees CJ, Willson CJ, Register TC, Tooze JA, Franke AA, Cline JM. Dietary soy effects on mammary gland development during the pubertal transition in nonhuman primates. Cancer Prev Res (Phila Pa). 2013;6(8):832-842.

Kalinin S, Willard SL, Shively CA, Kaplan JR, Register TC, Jorgensen MJ, Polak PE, Rubinstein I, Feinstein DL. Development of amyloid burden in African Green monkeys. Neurobiol Aging. 2013;34(10):2361-2369.

Cox AJ, Lambird JE, Sandy An S, Register TC, Langefeld CD, Carr JJ, Freedman BI, Bowden DW. Variants in adiponectin signaling pathway genes show little association with subclinical CVD in the Diabetes Heart Study. Obesity (Silver Spring). 2013;21(9):E456-462.

Plate JF, Bates CM, Mannava S, Smith TL, Jorgensen MJ, Register TC, Stehle JR, High KP, Shively CA, Kaplan JR, Saul KR, Tuohy CJ. Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates. J Shoulder Elbow Surg. 2013;22(8):1019-1029.

Liu Y, Ding J, Reynolds LM, Lohman K, Register TC, De La Fuente A, Howard TD, Hawkins GA, Cui W, Morris J, Smith SG, Barr RG, Kaufman JD, Burke GL, Post W, Shea S, McCall CE, Siscovick D, Jacobs DR Jr, Tracy RP,. Methylomics of gene expression in human monocytes. Hum Mol Genet. 2013;22(24):5065-5074.

Murphy RA, Schairer C, Gierach GL, Byrne C, Sherman ME, Register TC, Ding J, Kritchevsky SB, Harris TB. Beyond breast cancer: mammographic features and mortality risk in a population of healthy women. PLoS One. 2013;8(10):e78722.

Sandy An S, Palmer ND, Hanley AJ, Ziegler JT, Mark Brown W, Freedman BI, Register TC, Rotter JI, Guo X, Ida Chen YD, Wagenknecht LE, Langefeld CD, Bowden DW. Genetic analysis of adiponectin variation and its association with type 2 diabetes in African Americans. Obesity (Silver Spring). 2013;21(12):E721-E729.

Shively CA, Kritchevsky SB, Register TC. Aging and physical function in nonhuman primates: a translational model [abstract]. Gerontologist. 2013;53(Suppl 1):249.

Cammarata MW, Howard TD, Register TC, Shea SJ, Hawkins GA, Burke GL, Jacobs DR, Hoeschele I, Liu YM, Herrington DM. Association of DNA methylation and gene expression of the P2Y12 receptor: the Multi-Ethnic Study on Atherosclerosis [abstract]. Circulation. 2013;128(22 Suppl):A13189.

Wood CE, Boue SM, Collins-Burow BM, Rhodes LV, Register TC, Cline JM, Dewi FN, Burow ME. Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein. J Agric Food Chem. 2012;60(1):81-86.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Pathology-Comparative Medicine

Clinical Interests

Atherosclerosis, Endocrine/Menopausal Management, Hormone Replacement Therapy and Menopause, Imaging, Osteoporosis

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