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Thomas C. Register, Ph.D.Wake Forest School of Medicine

Thomas C. Register, Ph.D.

Professor,




Clinical Interests

Hormone Replacement Therapy and Menopause, Atherosclerosis, Imaging, Endocrine/Menopausal Management, Osteoporosis

Contact Information

Academic: 336-716-1557 | Department: 336-716-1557

Email: register@wakehealth.edu

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Education & Training

  • B.S., Francis Marion University, 1978
  • B.S., Francis Marion University, 1979
  • Ph.D., University of South Carolina-Columbia, 1985
  • Fellowship, WFU School of Medicine, 1988

Memberships

  • N Am Vascular Biology Organiza
  • Am Assn Of Clinical Chemistry
  • Am Heart Association
  • Am Soc Of Bone & Mineral Resea
  • Endocrine Society
Thomas C. Register, Ph.D.

Thomas C. Register, Ph.D.

Professor, Pathology-Comparative Medicine
Hypertension and Vascular Research Center
Center on Diabetes, Obesity, and Metabolism
Orthopaedic Surgery
Radiology

Research Interests

Isoflavones; Macaca fascicularis; Atherosclerosis; Bone Density; Soybean Proteins
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Contact Information

Academic: 336-716-1557 | Department: 336-716-1557

Email: register@wakehealth.edu

Related Links

Recent Publications

Preclinical laboratory assessments of predictors of social rank in female cynomolgus monkeys. Kromrey SA, Czoty PW, Nader SH, Register TC, Nader MA.. Am J Primatol. 2016;78(4):402-417.

Atherosclerosis and vascular biologic responses to estrogens: histologic, immunohistochemical, biochemical, and molecular methods. Register TC, Appt SE, Clarkson TB [deceased].. Methods Mol Biol. 2016;1366():517-532.

Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys. Silverstein-Metzler MG, Shively CA, Clarkson TB [deceased], Appt SE, Carr JJ, Kritchevsky SB, Jones SR, Register TC.. Psychoneuroendocrinology. 2016;68():29-38.

Effects of pubertal exposure to dietary soy on estrogen receptor activity in the breast of cynomolgus macaques. Dewi FN, Wood CE, Willson CJ, Register TC, Lees CJ, Howard TD, Huang Z, Murphy SK, Tooze JA, Chou JW, Miller LD, Cline JM.. Cancer Prev Res (Phila Pa). 2016;9(5):385-395.

Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American-Diabetes Heart Study. Palmer ND, Divers J, Lu L, Register TC, Carr JJ, Hicks PJ, Smith SC, Xu J, Judd SE, Irvin MR, Gutierrez OM, Bowden DW, Wagenknecht LE, Langefeld CD, Freedman BI.. Bone. 2016;87():71-77.

Relationships between measures of adiposity with subclinical atherosclerosis in patients with type 2 diabetes. Yuan M, Hsu FC, Bowden DW, Xu J, Carrie Smith S, Wagenknecht LE, Comeau ME, Divers J, Register TC, Jeffrey Carr J, Langefeld CD, Freedman BI.. Obesity (Silver Spring). 2016;24(8):1810-1818.

Late effects of total-body gamma irradiation on cardiac structure and function in male rhesus macaques. DeBo RJ, Lees CJ, Dugan GO, Caudell DL, Michalson KT, Hanbury DB, Kavanagh K, Cline JM, Register TC.. Radiat Res. 2016;186(1):55-64.

Novel genetic variants associated with increased vertebral volumetric BMD, reduced vertebral fracture risk, and increased expression of SLC1A3 and EPHB2. Nielson CM, Liu CT, Smith AV, Ackert-Bicknell CL, Reppe S, Jakobsdottir J, Wassel C, Register TC, Oei L, Alonso N, Oei EH, Parimi N, Samelson EJ, Nalls MA, Zmuda J, Lang T, Bouxsein M, Latourelle J, Claussnitzer M, Siggeirsdottir K, Srikanth P,.. J Bone Miner Res. 2016;():.

APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes. Freedman BI, Langefeld CD, Lu L, Palmer ND, Carrie Smith S, Bagwell BM, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Jeffrey Carr J, Bowden DW, Divers J.. Kidney Int. 2015;87(1):176-181.

Beneficial effects of soy supplementation on postmenopausal atherosclerosis are dependent on pretreatment stage of plaque progression. Melendez GC, Register TC, Appt SE, Clarkson TB, Franke AA, Kaplan JR.. Menopause. 2015;22(3):289-296.

Non-human primate and rat cardiac fibroblasts show similar extracellular matrix-related and cellular adhesion gene responses to substance P. Melendez GC, Manteufel EJ, Dehlin HM, Register TC, Levick SP.. Heart Lung Circ. 2015;24(4):395-403.

Type 2 diabetes is a delayed late effect of whole-body irradiation in nonhuman primates. Kavanagh K, Dendinger MD, Davis AT, Register TC, DeBo R, Dugan G, Cline JM.. Radiat Res. 2015;183(4):398-406.

Effects of long-term sertraline treatment and depression on coronary artery atherosclerosis in premenopausal female primates. Shively CA, Register TC, Appt SE, Clarkson TB.. Psychosom Med. 2015;77(3):267-278.

Transcriptomic profiles of aging in purified human immune cells. Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Hoeschele I, McCall CE,.. BMC Genomics. 2015;16(1):333.

Age-related structural changes in upper extremity muscle tissue in a nonhuman primate model. Santago AC II, Plate JF, Shively CA, Register TC, Smith TL, Saul KR.. J Shoulder Elbow Surg. 2015;24(10):1660-1668.

Osteoarthritic changes in vervet monkey knees correlate with meniscus degradation and increased matrix metalloproteinase and cytokine secretion. Stone AV, Vanderman KS, Willey JS, Long DL, Register TC, Shively CA, Stehle JR Jr, Loeser RF, Ferguson CM.. Osteoarthritis Cartilage. 2015;23(10):1780-1789.

Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques. DeBo RJ, Register TC, Caudell DL, Sempowski GD, Dugan G, Gray S, Owzar K, Jiang C, Bourland JD, Chao NJ, Cline JM.. Int J Radiat Biol. 2015;91(6):510-518.

Vitamin D associations with renal, bone, and cardiovascular phenotypes: African American-Diabetes Heart Study. Freedman BI, Divers J, Russell GB, Palmer ND, Wagenknecht LE, Smith SC, Xu J, Carr JJ, Bowden DW, Register T.. J Clin Endocrinol Metab. 2015;100(10):3693-3701.

Subclinical atherosclerosis is inversely associated with gray matter volume in African Americans with type 2 diabetes. Freedman BI, Divers J, Whitlow CT, Bowden DW, Palmer ND, Smith SC, Xu J, Register TC, Carr JJ, Wagner BC, Williamson JD, Sink KM, Maldjian JA.. Diabetes Care. 2015;38(11):2158-2165.

Plasma FGF23 and calcified atherosclerotic plaque in African Americans with type 2 diabetes mellitus. Freedman BI, Divers J, Russell GB, Palmer ND, Bowden DW, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Langefeld CD, Hruska KA, Register TC.. Am J Nephrol. 2015;42(6):391-401.

Bone resorption assessed by serum type I collagen C-terminal telopeptide (crosslaps) is inversely associated with bone mineral density and change in BMD but not with change in calcified atherosclerotic plaque in African Americans. Register T, Carr JJ, Lenchik L, Divers J, Russell GB, Palmer ND, Wagenknecht LE, Smith SC, Xu J, Bowden DW, Freedman BI.. J Bone Miner Res. 2015;30(Suppl 1):.

Effects of estradiol on transcriptional profiles in atherosclerotic iliac arteries in ovariectomized cynomolgus macaques. Eyster KM, Appt S, Chalpe A, Mark-Kappeler CJ, Register TC, Clarkson TB.. Menopause. 2014;21(2):143-152.

Effect of depression and sertraline treatment on cardiac function in female nonhuman primates. Groban L, Kitzman DW, Register TC, Shively CA.. Psychosom Med. 2014;76(2):137-146.

Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI.. J Clin Endocrinol Metab. 2014;99(1):315-321.

Sertraline effects on cerebrospinal fluid monoamines and species-typical socioemotional behavior of female cynomolgus monkeys. Shively CA, Register TC, Higley JD, Willard SL.. Psychopharmacology (Berl). 2014;231(7):1409-1416.

Effects of equol on gene expression in female cynomolgus monkey iliac arteries. Eyster K, Appt S, Chalpe A, Register T, Clarkson T.. Nutr Metab Cardiovasc Dis. 2014;24(4):423-427.

Altered expression of glial and synaptic markers in the anterior hippocampus of behaviorally depressed female monkeys. Willard SL, Hemby SE, Register TC, McIntosh S, Shively CA.. Neurosci Lett. 2014;563():1-5.

Adipose tissue density, a novel biomarker predicting mortality risk in older adults. Murphy RA, Register TC, Shively CA, Carr JJ, Ge Y, Heilbrun ME, Cummings SR, Koster A, Nevitt MC, Satterfield S, Tylvasky FA, Strotmeyer ES, Newman AB, Simonsick EM, Scherzinger A, Goodpaster BH, Launer LJ, Eiriksdottir G,.. J Gerontol A Biol Sci Med Sci. 2014;69(1):109-117.

Associations of BMI and adipose tissue area and density with incident mobility limitation and poor performance in older adults. Murphy RA, Reinders I, Register TC, Ayonayon HN, Newman AB, Satterfield S, Goodpaster BH, Simonsick EM, Kritchevsky SB, Harris TB.. Am J Clin Nutr. 2014;99(5):1059-1065.

Ten-year trends in coronary calcification in individuals without clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Bild DE, McClelland R, Kaufman JD, Blumenthal R, Burke GL, Carr JJ, Post WS, Register TC, Shea S, Szklo M.. PLoS One. 2014;9(4):e94916.

Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis). Silverstein MG, Kaplan JR, Appt SE, Register TC, Shively CA.. Menopause. 2014;21(10):1136-1142.

Nontraditional applications in clinical pathology. Jordan HL, Register TC, Tripathi NK, Bolliger AP, Everds N, Zelmanovic D, Poitout F, Bounous DI, Wescott D, Ramaiah SK.. Toxicol Pathol. 2014;42(7):1058-1068.

Apolipoprotein L1 gene associations with atherosclerosis, nephropathy, and mortality in African Americans with type 2 diabetes [abstract]. Freedman BI, Langefeld CD, Lu L, Palmer ND, Smith SC, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Bowden DW, Divers J.. J Am Soc Nephrol. 2014;25(Abstract Suppl):231A.

Dietary modification of physiological stress responses [abstract]. Shively CA, Register TC, Vitolins MZ, Wilson ME, Appt SE.. Am J Primatol. 2014;76(Suppl 1):71.

Effects of selective serotonin reuptake inhibitors and social stress on body composition and carbohydrate metabolism in female cynomolgus macaques (macaca fascicularis) [abstract]. Silverstein MG, Register TC, Appt SE, Shively CA.. Am J Primatol. 2014;76(Suppl 1):70.

Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI.. J Clin Endocrinol Metab. 2013;98(1):E60-E65.

Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni AG,.. Circ Cardiovasc Genet. 2013;6(1):97-105.

Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys.. Choi SJ, Shively CA, Register TC, Feng X, Stehle J, High K, Ip E, Kritchevsky SB, Nicklas B, Delbono O.. J Gerontol A Biol Sci Med Sci. 2013;68(3):258-267.

Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study. Register TC, Divers J, Bowden DW, Carr JJ, Lenchik L, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI.. J Clin Endocrinol Metab. 2013;98(5):1916-1922.

Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause. Sophonsritsuk A, Appt SE, Clarkson TB, Shively CA, Espeland MA, Register TC.. Menopause. 2013;20(5):540-547.

Behavioral stress accelerates prostate cancer development in mice. Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R Jr, Danial N, Datta SR, Kulik G.. J Clin Invest. 2013;123(2):874-886.

A MMP derived versican neo-epitope is elevated in plasma from patients with atherosclerotic heart disease. Barascuk N, Genovese F, Larsen L, Byrjalsen I, Zheng Q, Sun S, Hosbond S, Poulsen TS, Diederichsen A, Jensen JM, Mickley H, Register TC, Rasmussen LM, Leeming DJ, Christiansen C, Karsdal MA.. Int J Clin Exp Med. 2013;6(3):174-184.

Long term sertraline treatment decreases volumes of hippocampus and anterior cingulate cortex in an adult female primate model of depression [abstract]. Willard S, Johnston WD, Clark A, Uberseder B, Neely D, Massey A, Daunais J, Williamson J, Register TC, Bourland JD, Shively C.. Biol Psychiatry. 2013;73(9 Suppl):235S.

Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model. Ethun KF, Wood CE, Cline JM, Register TC, Appt SE, Clarkson TB.. Menopause. 2013;20(7):777-784.

Dietary soy effects on mammary gland development during the pubertal transition in nonhuman primates. Dewi FN, Wood CE, Lees CJ, Willson CJ, Register TC, Tooze JA, Franke AA, Cline JM.. Cancer Prev Res (Phila Pa). 2013;6(8):832-842.

Development of amyloid burden in African Green monkeys. Kalinin S, Willard SL, Shively CA, Kaplan JR, Register TC, Jorgensen MJ, Polak PE, Rubinstein I, Feinstein DL.. Neurobiol Aging. 2013;34(10):2361-2369.

Variants in adiponectin signaling pathway genes show little association with subclinical CVD in the Diabetes Heart Study. Cox AJ, Lambird JE, Sandy An S, Register TC, Langefeld CD, Carr JJ, Freedman BI, Bowden DW.. Obesity (Silver Spring). 2013;21(9):E456-462.

Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates. Plate JF, Bates CM, Mannava S, Smith TL, Jorgensen MJ, Register TC, Stehle JR, High KP, Shively CA, Kaplan JR, Saul KR, Tuohy CJ.. J Shoulder Elbow Surg. 2013;22(8):1019-1029.

Methylomics of gene expression in human monocytes. Liu Y, Ding J, Reynolds LM, Lohman K, Register TC, De La Fuente A, Howard TD, Hawkins GA, Cui W, Morris J, Smith SG, Barr RG, Kaufman JD, Burke GL, Post W, Shea S, McCall CE, Siscovick D, Jacobs DR Jr, Tracy RP,.. Hum Mol Genet. 2013;22(24):5065-5074.

Beyond breast cancer: mammographic features and mortality risk in a population of healthy women. Murphy RA, Schairer C, Gierach GL, Byrne C, Sherman ME, Register TC, Ding J, Kritchevsky SB, Harris TB.. PLoS One. 2013;8(10):e78722.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Pathology-Comparative Medicine

Clinical Interests

Hormone Replacement Therapy and Menopause, Atherosclerosis, Imaging, Endocrine/Menopausal Management, Osteoporosis

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