Profile

James C. Rose, Ph.D.Wake Forest School of Medicine

James C. Rose, Ph.D.

Director,
Professor,

Contact Information

Academic: 336-716-4614 | Department: 336-716-4039

Email: jimrose@wakehealth.edu

Education & Training

  • B.S., University of Richmond, 1965
  • M.S., Medical College of Virginia, 1970
  • Ph.D., Medical College of Virginia, 1973
  • Fellowship, University of California-San F, 1976

Memberships

  • Am Assn Of Advancement Of Scie
  • Am Physiological Society
  • Chittendon County Medical Soci
  • Endocrine Society
James C. Rose, Ph.D.

James C. Rose, Ph.D.

Director, Obstetrics & Gynecology
Professor, Maternal-Fetal Medicine

Contact Information

Academic: 336-716-4614 | Department: 336-716-4039

Email: jimrose@wakehealth.edu

Recent Publications

Sex-specific changes in renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 gene expression and enzyme activity at birth and over the first year of life. Chen K, Bi J, Su Y, Chappell MC, Rose JC.. Reprod Sci. 2016;23(2):200-210.

Evidence for a mitochondrial angiotensin-(1-7) system in the kidney. Wilson BA, Nautiyal M, Gwathmey TM, Rose JC, Chappell MC.. Am J Physiol Renal Physiol. 2016;310(7):F637-F645.

Sex specific effects of prenatal betamethesone (beta) exposure and unilateral nephrectomy on angiotensin - (1-7) (ang-(1-7))-mas receptor expression and inhibition of sodium uptake by ang(1-7) in ovine proximal tubule cells [abstract]. Su YX, Bi JL, Chappell MC, Rose JC.. Reprod Sci. 2016;23(Suppl 1):307A.

A novel G-protein biased kappa opioid that displays analgesic but not dysphoric actions in the rat [abstract]. Martin T, Kim S, Rose J, Jones S, Aube J, Bohn L.. J Pain. 2016;17(4 Suppl 1):S65.

Early pregnancy maternal lipid profiles and the risk of gestational diabetes mellitus stratified for body mass index. Li G, Kong L, Zhang L, Fan L, Su Y, Rose JC, Zhang W.. Reprod Sci. 2015;22(6):712-717.

An angiotensin-(1-7) peptidase in the kidney cortex, proximal tubules, and human HK-2 epithelial cells that is distinct from insulin degrading enzyme. Wilson BA, Cruz-Diaz N, Marshall AC, Pirro NT, Su Y, Gwathmey TM, Rose JC, Chappell MC.. Am J Physiol Renal Physiol. 2015;308(6):F594-F601.

Antenatal glucocorticoid treatment alters sodium uptake in renal proximal tubule cells from adult offspring in a sex specific manner. Su Y, Bi J, Pulgar VM, Figueroa JP, Chappell MC, Rose JC.. Am J Physiol Renal Physiol. 2015;308(11):F1268-1275.

Sex differences in effects of nitric oxide donor (SNAP) on sodium uptake in ovine renal proximal tubule cells (RPTC) from prenatal betamethesone (beta) exposed young adult sheep [abstract]. Su YX, Tang LJ, Figueroa JP, Rose JC.. Reprod Sci. 2015;22(Suppl 1):357A.

Intracerebroventricular infusion of angiotensin-(1-7) improves baroreflex sensitivity in antenatal betamethasone exposed sheep [abstract]. Lawson MJ, Figueroa JP, Rose JC, Chappell MC, Diz DI, Shaltout HA.. FASEB J. 2015;29(1 Suppl):811.30.

Effect of antenatal betamethasone on ovine renal function in obese offspring [abstract]. Bi JL, Figueroa J, Chappell M, Rose J.. FASEB J. 2015;29(Suppl 1):LB762.

Enhanced activity of an angiotensin-(1-7) neuropeptidase in glucocorticoid-induced fetal programming. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC.. Peptides. 2014;52():74-81.

Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep. Marshall AC, Pirro NT, Rose JC, Diz DI, Chappell MC.. J Neurochem. 2014;130(2):313-323.

Evidence for an angiotensin-(1-7) neuropeptidase in the brain medulla of sheep [abstract]. Marshall A, Pirro N, Rose J, Diz D, Chappell M.. FASEB J. 2014;28(1 Suppl):1140.6.

Expression of an angiotensin-(1-7) endopeptidase in proximal tubules of the sheep and human kidney [abstract]. Wilson B, Marshall A, Pirro N, Su Y, Rose J, Chappell M.. FASEB J. 2014;28(1 Suppl):1088.10.

Functional neprilysin-angiotensin-(1-7) system within mitochondria of the sheep kidney [abstract]. Wilson B, Rose J, Chappell M.. FASEB J. 2014;28(1 Suppl):1088.9.

Sex differences in the effects of prenatal betamethesone (Beta) exposure on sodium uptake in ovine renal proximal tubule cells (RPTC) from young adult sheep [abstract]. Su YX, Jorge FP, Rose JC.. Reprod Sci. 2014;21(3 Suppl):367A.

Sex-specific effect of antenatal betamethasone exposure on renal oxidative stress induced by angiotensins in adult sheep. Bi J, Contag SA, Chen K, Su Y, Figueroa JP, Chappell MC, Rose JC.. Am J Physiol Renal Physiol. 2014;307(9):F1013-1022.

Sex specific effect of antenatal glucocorticoids on nitric oxide production stimulated by angiotensin peptides in renal proximal tubule cells [abstract]. Bil JL, Chen K, Su YX, Chappell M, Rose J.. FASEB J. 2014;28(1 Suppl):1085.6.

Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep. Marshall AC, Shaltout HA, Nautiyal M, Rose JC, Chappell MC, Diz DI.. Peptides. 2013;44(C):25-31.

Antenatal betamethasone has a sex-dependent effect on the in vivo response to endothelin in adult sheep. Lee JH, Zhang J, Flores L, Rose JC, Massmann GA, Figueroa JP.. Am J Physiol Regul Integr Comp Physiol. 2013;304(8):R581-R587.

Differential expression of renin-angiotensin system components in the choroid plexus of betamethasone exposed and control sheep [abstract]. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC.. FASEB J. 2013;27(Meeting Abstracts):1107.12.

Gender affects responses of renal ACE and ACE2 activity to unilateral nephrectomy [abstract]. Chen K, Bi J, Su Y, Figueroa J, Chappell M, Rose J.. Reprod Sci. 2013;20(3 Suppl 1A):335A.

Gender differences in effects of prenatal betamethasone exposure on sheep renal ACE and ACE2 activity: a possible mechanism in fetal programmed hypertension in males [abstract]. Chen K, Bi J, Figueroa J, Chappell M, Rose J.. Reprod Sci. 2013;20(3 Suppl 1A):275A.

Gender differences in the effect of antenatal betamethasone (Beta) exposure on NHE3 and Na/K-ATPase expression in adult sheep kidney [abstract]. Su Y, Bi J, Figueroa JP, Rose JC.. Reprod Sci. 2013;20(3 Suppl):141A-142A.

Sex differences in oxidative stress following uniphrectomy in antenatal glucocorticoid exposed sheep [abstract]. Bi JL, Contag S, Su YX, Chen K, Figueroa J, Chappell M, Rose JC.. FASEB J. 2013;27():733.2.

Renal mitochondria predominantly express [des-Ang I]- angiotensinogen and renin [abstract]. Guan MJ, Nautiyal M, Hakuda D, de Lima R, Rose J, Pirro NT, Chappell MC.. FASEB J. 2013;27():909.5.

Antenatal betamethasone exposure alters renal responses to angiotensin-(1-7) in uninephrectomized adult male sheep. Bi J, Contag SA, Carey LC, Tang L, Valego NK, Chappell MC, Rose JC.. J Renin Angiotensin Aldosterone Syst. 2013;14(4):290-298.

Antenatal glucocorticoid exposure enhances the inhibition of adrenal steroidogenesis by leptin in a sex-specific fashion. Su Y, Carey LC, Rose JC, Pulgar VM.. Am J Physiol Endocrinol Metab. 2013;304(12):E1404-1411.

Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC.. Am J Physiol Regul Integr Comp Physiol. 2013;305(7):R679-R688.

Antenatal betamethasone exposure reduces Ang-(1-7) but enhances angiotensin-converting enzyme and a thiol peptidase to metabolize Ang-(1-7) in the cerebrospinal fluid [abstract]. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC.. Hypertension. 2013;62(3 Suppl):177.

Angiotensin-(1-7) deficiency and baroreflex impairment precede the antenatal betamethasone exposure-induced elevation in blood pressure. Shaltout HA, Rose JC, Chappell MC, Diz DI.. Hypertension. 2012;59(2):453-458.

Gender differences in the effect of antenatal betamethasone (Beta) exposure on sodium uptake in ovine renal proximal tubule cells (RPTC) [abstract]. Su Y, Tang L, Bi J, Figueroa JP, Rose JC.. Reprod Sci. 2012;19(3 Suppl):345A.

Effects of prenatal betamethasone (Beta) exposure and unilateral nephrectomy on sodium uptake in ovine renal proximal tubule cells from young adult male sheep [abstract]. Su Y, Bi J, Tang L, Figueroa JP, Rose JC.. FASEB J. 2012;26(Meeting Abstracts):1102.3.

Impact of antenatal betamethasone (B) on p47 phox in kidney and 8-isoprostane responses to angiotensin II in proximal tubule cells in male sheep after uninephrectomy [abstract]. Bi J, Su Y, Figueroa J, Chappell MC, Rose JC.. FASEB J. 2012;26(Meeting Abstracts):1101.10.

Gender difference in renal ACE and ACE2 activity development in sheep [abstract]. Chen K, Bi J, Rose JC.. Reprod Sci. 2012;19(3 Suppl):155A.

Leptin alters adrenal responsiveness by decreasing expression of ACTH-R, StAR, and P450c21 in hypoxemic fetal sheep. Su Y, Carey LC, Rose JC, Pulgar VM.. Reprod Sci. 2012;19(10):1075-1084.

Renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 gender differences in fetal programmed hypertension [abstract]. Stone R, Su YX, Rose JC.. Am J Obstet Gynecol. 2011;204(Suppl 1):S207-S208.

The midgestational maternal blood pressure decline is absent in mice lacking expression of the angiotensin II AT2 receptor. Carey LC, Rose JC.. J Renin Angiotensin Aldosterone Syst. 2011;12(1):29-35.

Glucocorticoid-induced fetal programming alters the functional complement of angiotensin receptor subtypes within the kidney. Gwathmey TM, Shaltout HA, Rose JC, Diz DI, Chappell MC.. Hypertension. 2011;57(3):620-626.

The effect of antenatal steroid exposure on sodium uptake in ovine renal proximal tubule cells (RPTC) [abstract]. Tang L, Bi J, Chappell M, Figueroa J, Rose JC.. FASEB J. 2011;25(Meeting Abstracts):1029.12.

Antenatal betamethasone (B) and gender affect 8-isoprostane responses to unilateral nephrectomy [abstract]. Bi J, Tang L, Figueroa J, Chappell MC, Rose JC.. FASEB J. 2011;25(Meeting Abstracts):1029.11.

Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure. Shaltout HA, Chappell MC, Rose JC, Diz DI.. Am J Physiol Endocrinol Metab. 2011;300(6):E979-985.

Effect of prenatal betamethasone exposure on renal functional reserve in the young adult female sheep [abstract]. Bi J, Figueroa JP, Chappell MC, Rose JC.. Reprod Sci. 2011;18(4 Suppl):90A.

Antenatal glucocorticoid exposure alters in vivo endothelin responsiveness and signaling in adult sheep [abstract]. Figueroa JP, Zhang J, Rose JC, Massmann AG.. Reprod Sci. 2011;18(4 Suppl):209A.

Gender related effects of prenatal steroid exposure on renal angiotensin-converting enzyme 2 in fetal programmed hypertension [abstract]. Stone RA, Su Y, Rose JC.. Reprod Sci. 2011;18(4 Suppl):368A.

Effect of early glucocorticoid treatment on GR and MR expression in adult sheep kidney [abstract]. Su Y, Shaltout HA, Figueroa JP, Chappell M, Rose JC.. Reprod Sci. 2011;18(4 Suppl):220A.

Role of the AT2 receptor in modulating the angiotensin II contractile response of the uterine artery at mid-gestation. Pulgar VM, Yamashiro H, Rose JC, Moore LG.. J Renin Angiotensin Aldosterone Syst. 2011;12(3):176-183.

Ang-(1-7) deficiency and impairment of baroreflex for control of heart rate precede the antenatal betamethasone exposure-induced elevation in blood pressure [abstract]. Shaltout HA, Rose JC, Chappell MC, Diz DI.. Hypertension. 2011;58(5):e76.

Gender-specific effects of prenatal betamethesone (Beta) exposure and unilateral nephrectomy on the intrarenal renin-angiotension system (RAS) in adult sheep [abstract]. Su Y, Bi J, Figueroa JP, Rose JC.. Endocr Rev. 2011;32(3 Meeting Abstracts):.

Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Gwathmey TM, Pendergrass KD, Reid SD, Rose JC, Diz DI, Chappell MC.. Hypertension. 2010;55(1):166-171.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

James C. Rose, Ph.D.

James C. Rose, Ph.D.

Director, Obstetrics & Gynecology
Professor, Maternal-Fetal Medicine

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