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James C. Rose, Ph.D.

James C. Rose, Ph.D.

Professor, Maternal-Fetal Medicine
Women's Health Center of Excellence for Research, Leadership, Education
Obstetrics & Gynecology

Contact Information

Academic: 336-716-4614 | Department: 336-716-4039

Email: jimrose@wakehealth.edu

Education & Training

  • Ph.D., Medical College of Virginia , 1973
  • B.S., University of Richmond , 1965
  • M.S., Medical College of Virginia , 1970
  • Fellowship, University of California-San Francisco, 1976

Memberships

  • Am Assn Of Advancement Of Scie
  • Am Physiological Society
  • Chittendon County Medical Soci
  • Endocrine Society
James C. Rose, Ph.D.

James C. Rose, Ph.D.

Professor, Maternal-Fetal Medicine Women's Health Center of Excellence for Research, Leadership, Education
Obstetrics & Gynecology

Contact Information

Academic: 336-716-4614 | Department: 336-716-4039

Email: jimrose@wakehealth.edu

Recent Publications

Marshall AC, Shaltout HA, Nautiyal M, Rose JC, Chappell MC, Diz DI. Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep. Peptides. 2013;44(C):25-31.


Su Y, Tang L, Bi J, Figueroa JP, Rose JC. Gender differences in the effect of antenatal betamethasone (Beta) exposure on sodium uptake in ovine renal proximal tubule cells (RPTC) [abstract]. Reprod Sci. 2012;19(3 Suppl):345A.

Su Y, Bi J, Tang L, Figueroa JP, Rose JC. Effects of prenatal betamethasone (Beta) exposure and unilateral nephrectomy on sodium uptake in ovine renal proximal tubule cells from young adult male sheep [abstract]. FASEB J. 2012;26(Meeting Abstracts):1102.3.

Bi J, Su Y, Figueroa J, Chappell MC, Rose JC. Impact of antenatal betamethasone (B) on p47 phox in kidney and 8-isoprostane responses to angiotensin II in proximal tubule cells in male sheep after uninephrectomy [abstract]. FASEB J. 2012;26(Meeting Abstracts):1101.10.

Chen K, Bi J, Rose JC. Gender difference in renal ACE and ACE2 activity development in sheep [abstract]. Reprod Sci. 2012;19(3 Suppl):155A.


Stone R, Su YX, Rose JC. Renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 gender differences in fetal programmed hypertension [abstract]. Am J Obstet Gynecol. 2011;204(Suppl 1):S207-S208.


Gwathmey TM, Shaltout HA, Rose JC, Diz DI, Chappell MC. Glucocorticoid-induced fetal programming alters the functional complement of angiotensin receptor subtypes within the kidney. Hypertension. 2011;57(3):620-626.

Tang L, Bi J, Chappell M, Figueroa J, Rose JC. The effect of antenatal steroid exposure on sodium uptake in ovine renal proximal tubule cells (RPTC) [abstract]. FASEB J. 2011;25(Meeting Abstracts):1029.12.

Bi J, Tang L, Figueroa J, Chappell MC, Rose JC. Antenatal betamethasone (B) and gender affect 8-isoprostane responses to unilateral nephrectomy [abstract]. FASEB J. 2011;25(Meeting Abstracts):1029.11.

Shaltout HA, Chappell MC, Rose JC, Diz DI. Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure. Am J Physiol Endocrinol Metab. 2011;300(6):E979-985.

Bi J, Figueroa JP, Chappell MC, Rose JC. Effect of prenatal betamethasone exposure on renal functional reserve in the young adult female sheep [abstract]. Reprod Sci. 2011;18(4 Suppl):90A.

Figueroa JP, Zhang J, Rose JC, Massmann AG. Antenatal glucocorticoid exposure alters in vivo endothelin responsiveness and signaling in adult sheep [abstract]. Reprod Sci. 2011;18(4 Suppl):209A.

Stone RA, Su Y, Rose JC. Gender related effects of prenatal steroid exposure on renal angiotensin-converting enzyme 2 in fetal programmed hypertension [abstract]. Reprod Sci. 2011;18(4 Suppl):368A.

Su Y, Shaltout HA, Figueroa JP, Chappell M, Rose JC. Effect of early glucocorticoid treatment on GR and MR expression in adult sheep kidney [abstract]. Reprod Sci. 2011;18(4 Suppl):220A.

Pulgar VM, Yamashiro H, Rose JC, Moore LG. Role of the AT2 receptor in modulating the angiotensin II contractile response of the uterine artery at mid-gestation. J Renin Angiotensin Aldosterone Syst. 2011;12(3):176-183.

Shaltout HA, Rose JC, Chappell MC, Diz DI. Ang-(1-7) deficiency and impairment of baroreflex for control of heart rate precede the antenatal betamethasone exposure-induced elevation in blood pressure [abstract]. Hypertension. 2011;58(5):e76.

Su Y, Bi J, Figueroa JP, Rose JC. Gender-specific effects of prenatal betamethesone (Beta) exposure and unilateral nephrectomy on the intrarenal renin-angiotension system (RAS) in adult sheep [abstract]. Endocr Rev. 2011;32(3 Meeting Abstracts):.

Gwathmey TM, Pendergrass KD, Reid SD, Rose JC, Diz DI, Chappell MC. Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension. 2010;55(1):166-171.


Connors N, Valego NK, Carey LC, Figueroa JP, Rose JC. Fetal and postnatal renin secretion in female sheep exposed to prenatal betamethasone. Reprod Sci. 2010;17(3):239-246.

Contag SA, Bi J, Chappell MC, Rose JC. Developmental effect of antenatal exposure to betamethasone on renal angiotensin II activity in the young adult sheep. Am J Physiol Renal Physiol. 2010;298(4):F847-F856.


Gwathmey TM, Shaltout HA, Nixon PA, Rose JC, Washburn LK, Chappell MC. Antenatal steroid exposure is associated with reduced urinary ACE2 activity in adolescents [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):605.1.

Westwood B, Gwathmey T, Shaltout H, Diz D, Rose J, Chappell M. Immunocytochemical distribution of the Ang-(1-7)/mas receptor in the sheep kidney [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):605.6.

Tang L, Valego N, Sun X, Bi J, Carey L, Chappell M, Rose JC. Prenatal steroid exposure attenuates the nitric oxide (NO) - cyclic guanosine monophosphate (cGMP) to Ang-(1-7) in mature male sheep [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):1040.4.

Shaltout HA, Rose JC, Chappell MC, Diz DI. Modulation of baroreflex sensitivity by endogenous angiotensins in lamb solitary tract nucleus [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):624.7.

Gwathmey TM, Shaltout HA, Nixon PA, Rose JC, Washburn LK, Chappell MC. Sex and racial background influence angiotensin peptide metabolism in young adults [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):1024.31.

Bi JL, Contag S, Su YX, Valego N, Massman A, Chappell MC, Rose JC. Renal angiotensinogen (AGT) gene and protein expression are icreased in adult male sheep after prenatal betamethasone (B) exposure [abstract]. Reprod Sci. 2010;17(3 Suppl):215A.

Pulgar VM, Yamashiro H, Rose JC, Moore LG. Uterine vascular reactivity in mice: a role for the AT2 receptor in the angiotensin-II response of the uterine artery at mid gestation [abstract]. Reprod Sci. 2010;17(3 Suppl):311A-312A.

Su YX, Carey LC, Rose JC. Effect of leptin on fetal adrenal responsiveness and ACTH-R, StAR mRNA expression in the sheep [abstract]. Reprod Sci. 2010;17(3 Suppl):97A.

Tang LJ, James RC [sic] [Rose JC]. Prenatal betamethasone (beta) exposure attenuates renal response to Ang-(1-7) in young male sheep [abstract]. Reprod Sci. 2010;17(3 Suppl):293A.

Eckman DM, Kerr BA, Fuloria M, Simandle SA, Watt SE, Rose JC, Figueroa JP. Antenatal betamethasone alters vascular reactivity in adult female ovine cerebral arteries. Pediatr Res. 2010;68(4):344-348.

Shaltout HA, Rose JC, Figueroa JP, Chappell MC, Diz DI, Averill DB. Acute AT1-receptor blockade reverses the hemodynamic and baroreflex impairment in adult sheep exposed to antenatal betamethasone. Am J Physiol Heart Circ Physiol. 2010;299(2):H541-H547.

Tang L, Bi J, Valego N, Carey L, Figueroa J, Chappell M, Rose JC. Prenatal betamethasone exposure alters renal function in immature sheep: sex differences in effects. Am J Physiol Regul Integr Comp Physiol. 2010;299(3):R793-R803.

Gwathmey TM, Westwood BM, Pirro NT, Tang L, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin-(1-7) receptor is functionally coupled to the formation of nitric oxide. Am J Physiol Renal Physiol. 2010;299(5):F983-F990.

Shaltout HA, Rose JC, Chappell MC, Diz DI. Antenatal betamethasone exposure attenuates the functional role of angiotensin-(1-7) in the NTS [abstract]. Hypertension. 2010;56(5):e103.

Su YX, Figueroa JP, Rose JC. Antenatal betamethasone (Beta) exposure enhances leptin induced inhibition of steroidogenic acute regulatory protein (StAR) and ACTH-receptor expression in adult ovine adrenocortical cells [abstract]. Endocr Rev. 2010;31(3 Suppl 1):S692.

Bi J, Contag S, Chappel M [sic] [Chappell M], Rose JC. Evidence that prenatal steroid exposure produces oxidative stress in the kidney in male sheep [abstract]. FASEB J. 2010;24(Meeting Abstracts):793.1.


Shaltout HA, Figueroa JP, Rose JC, Diz DI, Chappell MC. Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension. Hypertension. 2009;53(2):404-408.

Tang L, Carey LC, Bi J, Valego N, Sun X, Deibel P, Perrott J, Figueroa JP, Chappell MC, Rose JC. Gender differences in the effects of antenatal betamethasone exposure on renal function in adult sheep. Am J Physiol Regul Integr Comp Physiol. 2009;296(2):R309-317.

Joy SD, Gruver C, Fitzmaurice M, Rose JC. Morbid obesity: early and mid-gestational cardiovascular disease profiles in the morbidly obese versus the lean gravida [abstract]. Reprod Sci. 2009;16(3 Suppl):228A.

Joy SD, Gruver C, Fitzmaurice M, Rose J. Morbid obesity: longitudinal modulation of the cytokine and cardiovascular profile in the morbidly obese gravida during pregnancy [abstract]. Reprod Sci. 2009;16(3 Suppl):228A.

Su YX, Figueroa JP, Rose JC. Effect of leptin on cortisol production in ovine adrenocortical cells [abstract]. Reprod Sci. 2009;16(3 Suppl):121A.

Adair CD, Luper A, Rose JC, Russell G, Veille J-C, Buckalew VM. The hemodynamic effects of intravenous digoxin-binding fab immunoglobulin in severe preeclampsia: a double-blind, randomized, clinical trial. J Perinatol. 2009;29(4):284-289.

Gwathmey TM, Shaltout HA, Pendergrass KD, Pirro NT, Figueroa JP, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin II type 2 (AT2) receptors are functionally linked to nitric oxide production. Am J Physiol Renal Physiol. 2009;296(6):F1484-1493.

Gwathmey TM, Pendergrass KD, Shaltout HA, Reid SD, Rose JC, Diz DI, Chappell MC. Steroid-induced fetal programming differentially alters nuclear angiotensin II receptor expression and function [abstract]. Hypertension. 2009;54(4):e42.

Gwathmey TM, Pendergrass KD, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin-(1-7) receptors mediate the production of nitric oxide [abstract]. Hypertension. 2009;54(4):e74.

Shaltout HA, Diz DI, Figueroa JP, Chappell MC, Rose JC. Sympathetic nervous system mediated responses to behavioral or pharmacologic challenges are exaggerated as a result of antenatal betamethasone exposure [abstract]. Hypertension. 2009;54(4):e101`.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB, Diz DI. Antenatal betamethasone causes alterations in angiotensin receptors in sheep brain in a gender specific manner [abstract]. FASEB J. 2009;23(1 Meeting Abstracts):941.11.

Bi JL, Contag S, Figueroa JP, Tang LJ, Chappell MC, Rose JC. Effect of intrarenal infusion of angiotensin-(1-7) (Ang 1-7) in male sheep with or without prenatal exposure to betamethasone (B) [abstract]. Reprod Sci. 2008;15(2 Suppl):272A.

Carey LC, Figueroa JP, Rose JC. Effect of prenatal betamethasone exposure on responsiveness of pituitary cells isolated from adult sheep [abstract]. Reprod Sci. 2008;15(2 Suppl):272A-273A.

Contag SA, Bi J, Figueroa JP, Tang L, Chappell M, Rose JC. Effect of intrarenal infusion of angiotensin II (Ang II) in male sheep with or without prenatal exposure to antenatal betamethasone (B) [abstract]. Reprod Sci. 2008;15(2 Suppl):275A.

Figueroa JP, Massmann AG, Zhang J, Rose JC. Nephron number and hypertension following antenatal glueocorticoids: is there a causal relationship? [abstract]. Reprod Sci. 2008;15(2 Suppl):271A.

Kantorowicz L, Valego NK, Figueroa JP, Chappell MC, Tang L, Rose JC. Plasma renin concentration in female sheep following antenatal betamethasone exposure [abstract]. Reprod Sci. 2008;15(2 Suppl):275A.

Smith JG, Nakahara S, Westwood B, Figueora [sic] J [Figueroa J], Chappell MC, Rose JC. Prenatal betamethasone exposure alters renin angiotensin system enzyme expression in adult male sheep [abstract]. Reprod Sci. 2008;15(2 Suppl):274A.

Smith JG, Westwood B, Nakara S, Fiqueroa [sic] J, [Figueroa J], Chappell MC, Rose JC. Gender differences in key enzymes of the renin angiotensin system in adult sheep [abstract]. Reprod Sci. 2008;15(2 Suppl):276A.

So YX, Carey LC, Rose JC. Effects of infusion of ACTH on expression of adrenal ACTH-R and StAR mRNA with or without ACTH-R knockdown [abstract]. Reprod Sci. 2008;15(2 Suppl):271A.

Tang LJ, Carrey L, Valego N, Deibel P, Perrott J, Figueroa J, Chappell M, Rose JC. The effect of betamethasone exposure in mid-gestation on renal sodium excretion in male sheep [abstract]. Reprod Sci. 2008;15(2 Suppl):233A.

Valego NK, Rose JC. Antalarmin antagonism of ACTH-induced cortisol secretion by ovine adrenal cells probably not at ACTH receptor [abstract]. Reprod Sci. 2008;15(2 Suppl):275A.


Carey LC, Valego NK, Chen K, Rose JC. Thyroid hormone regulates renocortical COX-2 and PGE2 expression in the late gestation fetal sheep. Reprod Sci. 2008;15(6):598-603.

Gwathmey TM, Pendergrass KD, Reid SD, Rose JC, Chappell MC. Evidence that the ACE2-angiotensin-(1-7) pathway counterbalances angiotensin II-induced formation of reactive oxygen species in renal nuclei [abstract]. Hypertension. 2008;52(4):e124-e125.

Shaltout HA, Figueroa JP, Rose JC, Diz DI, Chappell MC. Reduced renal ACE2 in fetal programmed hypertension [abstract]. Hypertension. 2008;52(4):e52.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB, Diz DI. Evidence of Ang-(1-7) deficiency in antenatal betamethasone-treated young adult sheep [abstract]. Hypertension. 2008;52(4):e107.

Kantorowicz L, Valego NK, Tang L, Figueroa JP, Chappell MC, Carey LC, Rose JC. Plasma and renal renin concentrations in adult sheep after prenatal betamethasone exposure. Reprod Sci. 2008;15(8):831-838.

Joy S, Courtney G [sic] [Gruver C], Rose J. Morbid obesity: longitudinal modulation of the cytokine profile in the morbidly obese gravida during pregnancy [abstract]. Am J Obstet Gynecol. 2008;199(6 Suppl 1):594.

Joy S, Gruver C, Rose J. Morbid obesity: first trimester adipokine and cytokine profiles in the morbidly obese versus the lean gravida [abstract]. Am J Obstet Gynecol. 2008;199(6 Suppl 1):S188.

Shaltout HA, Westwood BM, Averill DB, Ferrario CM, Figueroa JP, Diz DI, Rose JC, Chappell MC. Angiotensin metabolism in renal proximal tubules, urine and serum of sheep: evidence for ACE2-dependent processing of angiotensin II. Am J Physiol Renal Physiol. 2007;292(1):F82-F91.


Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB, Diz DI. Gender differences in the development of insulin resistance in adult sheep as result of antenatal betamethasone [abstract]. FASEB J. 2007;21(5 Pt I):A434.

Tang L, Chen K, Carey L, Valego N, Figueroa J, Deibel P, Perrott J, Rose JC. The effect of betamethasone exposure in mid-gestation on renal function in adult sheep [abstract]. FASEB J. 2007;21(5):A502.

Zhang Q, Collins V, Chakrabarty K, Rose JC, Wu WX. Regulation of the prostaglandin enzymatic system by estradiol and progesterone in nonpregnant sheep cervix. Reproduction. 2007;133(5):1027-1034.

Chen K, Carey LC, Valego NK, Rose JC. Thyroid hormone replacement normalizes renal renin and angiotensin receptor expression in thyroidectomized fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2007;293(2):R701-706.

Gwathmey TM, Diz DI, Pirro NT, Figueroa J, Rose JC, Chappell MC. Nuclear angiotensin II-type 2 receptors are differentially expressed in the sheep kidney [abstract]. Hypertension. 2007;50(4):e97.


Carey LC, Su Y, Valego NK, Rose JC. Infusion of ACTH stimulates expression of adrenal ACTH receptor and steriodogenic acute regulatory protein mRNA in fetal sheep. Am J Physiol Endocrinol Metab. 2006;291(2):E214-E220.

Zhang Q, Collins V, Chakrabarty K, Wolf RF, Unno N, Howe D, Rose JC, Wu WX. Regulation of membrane-associated prostaglandin E(2) synthase 1 in pregnant sheep intrauterine tissues by glucocorticoid and estradiol. Endocrinology. 2006;147(8):3719-3726.

Chen K, Carey LC, Valego NK, Liu J, Rose JC. Combined thyroidectomy and renal denervation suppress renin expression and secretion in fetal sheep. J Soc Gynecol Investig. 2006;13(8):604-609.

Chappell MC, Figueroa J, Rose JC, Westwood BM. Gender difference in serum ACE2-dependent metabolism of angiotensin II [abstract]. J Hypertens. 2006;24(Suppl 6):125.

Shaltout HA, Figueroa JP, Rose JC, Chappell M, Diz DI, Averill DB. Antenatal betamethasone causes angiotensin II-mediated impairment of cardiovascular function [abstract]. Hypertension. 2006;48(4):e32.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Diz DI, Averill DB. Antenatal betamethasone causes angiotensin II-mediated impairment of baroreflex control of heart rate [abstract]. J Hypertens. 2006;24(Suppl 6):159.

Shaltout HA, Figueroa JP, Rose JC, Averill DB, Diz DI, Chappell MC. Increased blood pressure is associated with lower serum ACE2 activity and higher ACE activity following antenatal steroid exposure [abstract]. J Hypertens. 2006;24(Suppl 6):127.

Westwood BM, Figueroa J, Rose JC, Chappell MC. Gender differences in ACE2-dependent metabolism of angiotensin II in the serum of sheep [abstract]. Hypertension. 2006;48(4):e46.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Maternal-Fetal Medicine

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