Profile

James C. Rose, Ph.D.Wake Forest School of Medicine

James C. Rose, Ph.D.

Director,
Professor,

Contact Information

Academic: 336-716-4614 | Department: 336-716-4039

Email: jimrose@wakehealth.edu

Education & Training

  • B.S., University of Richmond, 1965
  • M.S., Medical College of Virginia, 1970
  • Ph.D., Medical College of Virginia, 1973
  • Fellowship, University of California-San F, 1976

Memberships

  • Am Assn Of Advancement Of Scie
  • Am Physiological Society
  • Chittendon County Medical Soci
  • Endocrine Society
James C. Rose, Ph.D.

James C. Rose, Ph.D.

Director, Obstetrics & Gynecology
Professor, Maternal-Fetal Medicine
Office of Women in Medicine and Science

Research Interests

growth & development, hormones/cytokines/signalling, hypertension, maternal & child health, women's health issues

Contact Information

Academic: 336-716-4614 | Department: 336-716-4039

Email: jimrose@wakehealth.edu

Recent Publications

Li G, Kong L, Zhang L, Fan L, Su Y, Rose JC, Zhang W. Early pregnancy maternal lipid profiles and the risk of gestational diabetes mellitus stratified for body mass index. Reprod Sci. 2015;22(6):712-717.

Wilson BA, Cruz-Diaz N, Marshall AC, Pirro NT, Su Y, Gwathmey TM, Rose JC, Chappell MC. An angiotensin-(1-7) peptidase in the kidney cortex, proximal tubules, and human HK-2 epithelial cells that is distinct from insulin degrading enzyme. Am J Physiol Renal Physiol. 2015;308(6):F594-F601.

Su Y, Bi J, Pulgar VM, Figueroa JP, Chappell MC, Rose JC. Antenatal glucocorticoid treatment alters sodium uptake in renal proximal tubule cells from adult offspring in a sex specific manner. Am J Physiol Renal Physiol. 2015;308(11):F1268-1275.

Su YX, Tang LJ, Figueroa JP, Rose JC. Sex differences in effects of nitric oxide donor (SNAP) on sodium uptake in ovine renal proximal tubule cells (RPTC) from prenatal betamethesone (beta) exposed young adult sheep [abstract]. Reprod Sci. 2015;22(Suppl 1):357A.

Lawson MJ, Figueroa JP, Rose JC, Chappell MC, Diz DI, Shaltout HA. Intracerebroventricular infusion of angiotensin-(1-7) improves baroreflex sensitivity in antenatal betamethasone exposed sheep [abstract]. FASEB J. 2015;29(1 Suppl):811.30.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Enhanced activity of an angiotensin-(1-7) neuropeptidase in glucocorticoid-induced fetal programming. Peptides. 2014;52():74-81.

Marshall AC, Pirro NT, Rose JC, Diz DI, Chappell MC. Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep. J Neurochem. 2014;130(2):313-323.

Marshall A, Pirro N, Rose J, Diz D, Chappell M. Evidence for an angiotensin-(1-7) neuropeptidase in the brain medulla of sheep [abstract]. FASEB J. 2014;28(1 Suppl):1140.6.

Wilson B, Marshall A, Pirro N, Su Y, Rose J, Chappell M. Expression of an angiotensin-(1-7) endopeptidase in proximal tubules of the sheep and human kidney [abstract]. FASEB J. 2014;28(1 Suppl):1088.10.

Wilson B, Rose J, Chappell M. Functional neprilysin-angiotensin-(1-7) system within mitochondria of the sheep kidney [abstract]. FASEB J. 2014;28(1 Suppl):1088.9.

Su YX, Jorge FP, Rose JC. Sex differences in the effects of prenatal betamethesone (Beta) exposure on sodium uptake in ovine renal proximal tubule cells (RPTC) from young adult sheep [abstract]. Reprod Sci. 2014;21(3 Suppl):367A.

Bi J, Contag SA, Chen K, Su Y, Figueroa JP, Chappell MC, Rose JC. Sex-specific effect of antenatal betamethasone exposure on renal oxidative stress induced by angiotensins in adult sheep. Am J Physiol Renal Physiol. 2014;307(9):F1013-1022.

Bil JL, Chen K, Su YX, Chappell M, Rose J. Sex specific effect of antenatal glucocorticoids on nitric oxide production stimulated by angiotensin peptides in renal proximal tubule cells [abstract]. FASEB J. 2014;28(1 Suppl):1085.6.

Marshall AC, Shaltout HA, Nautiyal M, Rose JC, Chappell MC, Diz DI. Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep. Peptides. 2013;44(C):25-31.

Lee JH, Zhang J, Flores L, Rose JC, Massmann GA, Figueroa JP. Antenatal betamethasone has a sex-dependent effect on the in vivo response to endothelin in adult sheep. Am J Physiol Regul Integr Comp Physiol. 2013;304(8):R581-R587.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Differential expression of renin-angiotensin system components in the choroid plexus of betamethasone exposed and control sheep [abstract]. FASEB J. 2013;27(Meeting Abstracts):1107.12.

Chen K, Bi J, Su Y, Figueroa J, Chappell M, Rose J. Gender affects responses of renal ACE and ACE2 activity to unilateral nephrectomy [abstract]. Reprod Sci. 2013;20(3 Suppl 1A):335A.

Chen K, Bi J, Figueroa J, Chappell M, Rose J. Gender differences in effects of prenatal betamethasone exposure on sheep renal ACE and ACE2 activity: a possible mechanism in fetal programmed hypertension in males [abstract]. Reprod Sci. 2013;20(3 Suppl 1A):275A.

Su Y, Bi J, Figueroa JP, Rose JC. Gender differences in the effect of antenatal betamethasone (Beta) exposure on NHE3 and Na/K-ATPase expression in adult sheep kidney [abstract]. Reprod Sci. 2013;20(3 Suppl):141A-142A.

Bi JL, Contag S, Su YX, Chen K, Figueroa J, Chappell M, Rose JC. Sex differences in oxidative stress following uniphrectomy in antenatal glucocorticoid exposed sheep [abstract]. FASEB J. 2013;27():733.2.

Guan MJ, Nautiyal M, Hakuda D, de Lima R, Rose J, Pirro NT, Chappell MC. Renal mitochondria predominantly express [des-Ang I]- angiotensinogen and renin [abstract]. FASEB J. 2013;27():909.5.

Bi J, Contag SA, Carey LC, Tang L, Valego NK, Chappell MC, Rose JC. Antenatal betamethasone exposure alters renal responses to angiotensin-(1-7) in uninephrectomized adult male sheep. J Renin Angiotensin Aldosterone Syst. 2013;14(4):290-298.

Su Y, Carey LC, Rose JC, Pulgar VM. Antenatal glucocorticoid exposure enhances the inhibition of adrenal steroidogenesis by leptin in a sex-specific fashion. Am J Physiol Endocrinol Metab. 2013;304(12):E1404-1411.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep. Am J Physiol Regul Integr Comp Physiol. 2013;305(7):R679-R688.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Antenatal betamethasone exposure reduces Ang-(1-7) but enhances angiotensin-converting enzyme and a thiol peptidase to metabolize Ang-(1-7) in the cerebrospinal fluid [abstract]. Hypertension. 2013;62(3 Suppl):177.

Shaltout HA, Rose JC, Chappell MC, Diz DI. Angiotensin-(1-7) deficiency and baroreflex impairment precede the antenatal betamethasone exposure-induced elevation in blood pressure. Hypertension. 2012;59(2):453-458.

Su Y, Tang L, Bi J, Figueroa JP, Rose JC. Gender differences in the effect of antenatal betamethasone (Beta) exposure on sodium uptake in ovine renal proximal tubule cells (RPTC) [abstract]. Reprod Sci. 2012;19(3 Suppl):345A.

Su Y, Bi J, Tang L, Figueroa JP, Rose JC. Effects of prenatal betamethasone (Beta) exposure and unilateral nephrectomy on sodium uptake in ovine renal proximal tubule cells from young adult male sheep [abstract]. FASEB J. 2012;26(Meeting Abstracts):1102.3.

Bi J, Su Y, Figueroa J, Chappell MC, Rose JC. Impact of antenatal betamethasone (B) on p47 phox in kidney and 8-isoprostane responses to angiotensin II in proximal tubule cells in male sheep after uninephrectomy [abstract]. FASEB J. 2012;26(Meeting Abstracts):1101.10.

Chen K, Bi J, Rose JC. Gender difference in renal ACE and ACE2 activity development in sheep [abstract]. Reprod Sci. 2012;19(3 Suppl):155A.

Su Y, Carey LC, Rose JC, Pulgar VM. Leptin alters adrenal responsiveness by decreasing expression of ACTH-R, StAR, and P450c21 in hypoxemic fetal sheep. Reprod Sci. 2012;19(10):1075-1084.

Stone R, Su YX, Rose JC. Renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 gender differences in fetal programmed hypertension [abstract]. Am J Obstet Gynecol. 2011;204(Suppl 1):S207-S208.

Carey LC, Rose JC. The midgestational maternal blood pressure decline is absent in mice lacking expression of the angiotensin II AT2 receptor. J Renin Angiotensin Aldosterone Syst. 2011;12(1):29-35.

Gwathmey TM, Shaltout HA, Rose JC, Diz DI, Chappell MC. Glucocorticoid-induced fetal programming alters the functional complement of angiotensin receptor subtypes within the kidney. Hypertension. 2011;57(3):620-626.

Tang L, Bi J, Chappell M, Figueroa J, Rose JC. The effect of antenatal steroid exposure on sodium uptake in ovine renal proximal tubule cells (RPTC) [abstract]. FASEB J. 2011;25(Meeting Abstracts):1029.12.

Bi J, Tang L, Figueroa J, Chappell MC, Rose JC. Antenatal betamethasone (B) and gender affect 8-isoprostane responses to unilateral nephrectomy [abstract]. FASEB J. 2011;25(Meeting Abstracts):1029.11.

Shaltout HA, Chappell MC, Rose JC, Diz DI. Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure. Am J Physiol Endocrinol Metab. 2011;300(6):E979-985.

Bi J, Figueroa JP, Chappell MC, Rose JC. Effect of prenatal betamethasone exposure on renal functional reserve in the young adult female sheep [abstract]. Reprod Sci. 2011;18(4 Suppl):90A.

Figueroa JP, Zhang J, Rose JC, Massmann AG. Antenatal glucocorticoid exposure alters in vivo endothelin responsiveness and signaling in adult sheep [abstract]. Reprod Sci. 2011;18(4 Suppl):209A.

Stone RA, Su Y, Rose JC. Gender related effects of prenatal steroid exposure on renal angiotensin-converting enzyme 2 in fetal programmed hypertension [abstract]. Reprod Sci. 2011;18(4 Suppl):368A.

Su Y, Shaltout HA, Figueroa JP, Chappell M, Rose JC. Effect of early glucocorticoid treatment on GR and MR expression in adult sheep kidney [abstract]. Reprod Sci. 2011;18(4 Suppl):220A.

Pulgar VM, Yamashiro H, Rose JC, Moore LG. Role of the AT2 receptor in modulating the angiotensin II contractile response of the uterine artery at mid-gestation. J Renin Angiotensin Aldosterone Syst. 2011;12(3):176-183.

Shaltout HA, Rose JC, Chappell MC, Diz DI. Ang-(1-7) deficiency and impairment of baroreflex for control of heart rate precede the antenatal betamethasone exposure-induced elevation in blood pressure [abstract]. Hypertension. 2011;58(5):e76.

Su Y, Bi J, Figueroa JP, Rose JC. Gender-specific effects of prenatal betamethesone (Beta) exposure and unilateral nephrectomy on the intrarenal renin-angiotension system (RAS) in adult sheep [abstract]. Endocr Rev. 2011;32(3 Meeting Abstracts):.

Gwathmey TM, Pendergrass KD, Reid SD, Rose JC, Diz DI, Chappell MC. Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension. 2010;55(1):166-171.

Zhang J, Massmann GA, Rose JC, Figueroa JP. Differential effects of clinical doses of antenatal betamethasone on nephron endowment and glomerular filtration rate in adult sheep. Reprod Sci. 2010;17(2):186-195.

Connors N, Valego NK, Carey LC, Figueroa JP, Rose JC. Fetal and postnatal renin secretion in female sheep exposed to prenatal betamethasone. Reprod Sci. 2010;17(3):239-246.

Contag SA, Bi J, Chappell MC, Rose JC. Developmental effect of antenatal exposure to betamethasone on renal angiotensin II activity in the young adult sheep. Am J Physiol Renal Physiol. 2010;298(4):F847-F856.

Valego NK, Rose JC. A specific CRH antagonist attenuates ACTH-stimulated cortisol secretion in ovine adrenocortical cells. Reprod Sci. 2010;17(5):477-486.

Gwathmey TM, Shaltout HA, Nixon PA, Rose JC, Washburn LK, Chappell MC. Antenatal steroid exposure is associated with reduced urinary ACE2 activity in adolescents [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):605.1.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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