Darren F. Seals, Ph.D., Assistant Professor Cancer Biology

Darren F. Seals, Ph.D.

Assistant Professor, Cancer Biology
Comprehensive Cancer Center

Contact Information

Academic: 336-716-0320 | Department: 336-716-0320

Email: dseals@wakehealth.edu

Education & Training

Ph.D., Indiana University-Purdue Univ-Indianapolis , 1998
B.S., Indiana University-Purdue Univ-Indianapolis , 1992
M.S., Indiana University-Purdue Univ-Indianapolis , 1994
Fellowship, Dartmouth Medical School, 2001

Memberships

Am Assn Of Cancer Research

Darren F. Seals, Ph.D.

Assistant Professor, Cancer Biology Comprehensive Cancer Center

Research Interests

atherosclerosis/thrombosis, cancer/oncogenesis, cell growth, differentiation,d, hormones/cytokines/signalling, immunology/allergy/inflammatio, transgenics

Contact Information

Academic: 336-716-0320 | Department: 336-716-0320

Email: dseals@wakehealth.edu

Recent Publications

Scott KEN, Wheeler FB, Davis AL, Thomas MJ, Ntambi JM, Seals DF, Kridel SJ. Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis. PLoS ONE. 2012;7(1):e29761.

Wu M, Shi L, Cimic A, Romero L, Sui G, Lees CJ, Cline JM, Seals DF, Sirintrapun JS, McCoy TP, Liu W, Kim JW, Hawkins GA, Peehl DM, Xu J, Cramer SD. Suppression of Tak1 promotes prostate tumorigenesis. Cancer Res. 2012;72(11):2833-2843.

Debinski W, Gonzales O, Beauchamp A, Gibo DM, Seals DF. Epha2/Ephrina1 system in conjunction with TKS5 regulates invadopodia formation in glioblastoma cells [abstract]. Neuro Oncol. 2012;14(Suppl 6):14.

Seals DF, Burger KL, Gibo DM, Debinski W. The role of proto-oncogenes in tumor-associated macrophage polarization and promotion of GBM tumor progression [abstract]. Neuro Oncol. 2012;14(Suppl 6):3.

Burger KL, Seals DF. The podosome marker protein Tks5 regulates macrophage invasive behavior [abstract]. Clin Exp Metastasis. 2011;28(2):215-216.

Burger KL, Davis AL, Isom S, Mishra N, Seals DF. The podosome marker protein Tks5 regulates macrophage invasive behavior. Cytoskeleton (Hoboken). 2011;68(12):694-711.

Burger KL, Mishra N, Seals D. Tks5 and macrophage podosome formation [abstract]. Clin Exp Metastasis. 2009;26(7):869.

Blouw B, Seals DF, Pass I, Diaz B, Courtneidge SA. A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo. Eur J Cell Biol. 2008;87(8-9):555-567.

Billotet C, Maitre JL, Saltel F, Rottiers P, Reuzean E, Kramer V, Seals D, Courtneidge S, Genot E. Role of the adaptor protein TKS5 in endothelial cell invasiveness [abstract]. Bull Cancer. 2007;94(Special Issue):S288-S289.