Michael C. Seeds, Ph.D.Wake Forest School of Medicine

Michael C. Seeds, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-716-9811 | Department: 336-716-2011

Education & Training

  • B.S., University of Virginia, 1976
  • M.S., University of Virginia, 1982
  • Ph.D., Wake Forest University, 1987
Michael C. Seeds, Ph.D.

Michael C. Seeds, Ph.D.

Assistant Professor, Molecular Medicine
Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Research Interests

critical/intensive care medici, immunology/allergy/inflammatio, rare diseases

Contact Information

Academic: 336-716-9811 | Department: 336-716-2011

Recent Publications

Miller LR, Jorgensen MJ, Kaplan JR, Seeds MC, Rahbar E, Morgan TM, Welborn A, Chilton SM, Gillis J, Hester A, Rukstalis M, Sergeant S, Chilton FH. Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood. Physiol Behav. 2016;156():71-78.

Cui T, Hester AG, Seeds MC, Rahbar E, Howard TD, Sergeant S, Chilton FH. Impact of genetic and epigenetic variations within the FADS cluster on the composition and metabolism of polyunsaturated fatty acids in prostate cancer. Prostate. 2016;():.

Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med. 2015;7(278):278ra32.

Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, Hawkins GA, Sellers M, Ainsworth HC, Sergeant S, Miller LR, Chilton FH. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. PLoS One. 2014;9(5):e97510.

Chilton FH, Murphy RC, Wilson BA, Sergeant S, Ainsworth H, Seeds MC, Mathias RA. Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. Nutrients. 2014;6(5):1993-2022.

Chilton F, Mathias R, Seeds M, Herrington D, Hixson J, Hawkins G, Sergeant S, Miller L, Howard T. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver [abstract]. FASEB J. 2014;28(1 Suppl):373.8.

Hite RD, Grier BL, Waite BM, Veldhuizen RA, Possmayer F, Yao L-J, Seeds MC. Surfactant protein B inhibits secretory phospholipase A2 hydrolysis of surfactant phospholipids. Am J Physiol Lung Cell Mol Physiol. 2012;302(2):L257-265.

Seeds MC, Grier BL, Suckling BN, Safta AM, Long DL, Waite BM, Morris PE, Hite RD. Secretory phospholipase A2-mediated depletion of phosphatidylglycerol in early acute respiratory distress syndrome. Am J Med Sci. 2012;343(6):446-451.

Updaw RJ, Hite R, Blair R, Ireland L, Grier B, Waite M, Seeds M. Cytokine regulation of secretory phospholipases A2 in a differentiated human monocyte cell model [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A5234.

Hite RD, Seeds MC, Morris PE, Grier BL, Waite BM, Douglas IS, Hudson LD, Goodman RB. Regulation of secretory A2 phospholipase activity in persistent ARDS [abstract]. Am J Respir Crit Care Med. 2010;181():A6474.

Hite RD, Seeds MC, Grier BL, Possmayer F, Veldhuizen RA, Waite BM. Regulation of hydrolysis by secretory phospholipases A2 in surfactant monolayer films [abstract]. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A6278.

Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH. Effect of dietary fatty acids on inflammatory gene expression in healthy humans. J Biol Chem. 2009;284(23):15400-7.

Seeds MC, Peachman KK, Bowton DL, Sivertson KL, Chilton FH. Regulation of arachidonate remodeling enzymes impacts eosinophil survival during allergic asthma. Am J Respir Cell Mol Biol. 2009;41(3):358-366.

Lorenz E, Muhlebach MS, Tessier PA, Alexis NE, Hite RD, Seeds MC, Peden DB, Meredith W. Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseases. Respir Med. 2008;102(4):567-573.

Chilton FH, Rudel LL, Parks JS, Arm JP, Seeds MC. Mechanisms by which botanical lipids affect inflammatory disorders. Am J Clin Nutr. 2008;87(2 Suppl):498S-503S.

Hite RD, Hastie AT, Seeds MC, Grier BL, Peters SP, Moore WC, Bleecker ER. Surfactant alterations in asthmatics from the Wake Forest Severe Asthma Research Program Center [abstract]. Am J Respir Crit Care Med. 2008;177(Abstr Issue):A100.

Blair RA, Hite RD, Seeds MC. Regulation of GP IIA sPLA2 mRNA production in a human monocyte cell model (THP-1) [abstract]. Am J Respir Crit Care Med. 2008;177(Abstr Issue):A750.

Pascual RM, Seeds MC, Panettieri RA, Peters SP, Penn RB. Interleukin-1beta (IL-1beta)-mediated microsomal prostaglandin E2(PGE2) synthase (mPGES) induction regulates cyclooxygenase-2 (COX-2) and PGE2 production in human airway smooth muscle (HASM) [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A663.

Sivertson KL, Seeds MC, Long DL, Peachman KK, Bass DA. The differential effect of dexamethasone on granulocyte apoptosis involves stabilization of Mcl-1L in neutrophils but not in eosinophils. Cell Immunol. 2007;246(1):34-45.

El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR. Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett. 2007;111(1):36-44.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Molecular Medicine

Quick Reference

Request an Appointment
New Patients


Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
USNWR 2015-2016Magnet Hospital RecognitionConsumer Choice2015 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.