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Michael C. Seeds, Ph.D.Wake Forest School of Medicine

Michael C. Seeds, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-716-9811 | Department: 336-713-4259

Education & Training

  • B.S., University of Virginia, 1976
  • M.S., University of Virginia, 1982
  • Ph.D., Wake Forest University, 1987
Michael C. Seeds, Ph.D.

Michael C. Seeds, Ph.D.

Assistant Professor, Molecular Medicine
Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Research Interests

Phospholipases A; Pulmonary Surfactants; Neutrophils; Arachidonic Acid; Phosphatidylglycerols
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Contact Information

Academic: 336-716-9811 | Department: 336-713-4259

Recent Publications

Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression. Reynolds LM, Howard TD, Ruczinski I, Kanchan K, Seeds MC, Mathias RA, Chilton FH.. PLoS One. 2018;13(3):e0194610.

Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster. Rahbar E, Ainsworth HC, Howard TD, Hawkins GA, Ruczinski I, Mathias R, Seeds MC, Sergeant S, Hixson JE, Herrington DM, Langefeld CD, Chilton FH.. PLoS One. 2017;12(9):e0180903.

Precision nutrition and omega-3 polyunsaturated fatty acids: a case for personalized supplementation approaches for the prevention and management of human diseases. Chilton FH, Dutta R, Reynolds LM, Sergeant S, Mathias RA, Seeds MC.. Nutrients. 2017;9(11):1165.

Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood. Miller LR, Jorgensen MJ, Kaplan JR, Seeds MC, Rahbar E, Morgan TM, Welborn A, Chilton SM, Gillis J, Hester A, Rukstalis M, Sergeant S, Chilton FH.. Physiol Behav. 2016;156():71-78.

Impact of genetic and epigenetic variations within the FADS cluster on the composition and metabolism of polyunsaturated fatty acids in prostate cancer. Cui T, Hester AG, Seeds MC, Rahbar E, Howard TD, Sergeant S, Chilton FH.. Prostate. 2016;76(13):1182-1191.

Time course of increased secretory phospholipase group Iia in human ards from pneumonia or aspiration [abstract]. Novotny MV, Chakrabarti A, Seeds MC, Ruppert C, Wagner J, Guenther A, Hite RD.. Am J Respir Crit Care Med. 2016;193():A4415.

Inhibition of phospholipase-mediated phoshatidylglycerol depletion and replacement of surfactant improve surfactant function in a murine ards model [abstract]. Hite RD, Chakrabarti A, Novotny MV, Waite M, Seeds MC.. Am J Respir Crit Care Med. 2016;183():A4420.

Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O.. Sci Transl Med. 2015;7(278):278ra32.

Reduced lung compliance and phospholipase-mediated depletion of phosphatidylglycerol in a murine ards model [abstract]. Hite RD, Chakrabarti A, Novotny MJ, Ireland L, Waite BM, Seeds MC.. Am J Respir Crit Care Med. 2015;191():A2055.

DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, Hawkins GA, Sellers M, Ainsworth HC, Sergeant S, Miller LR, Chilton FH.. PLoS One. 2014;9(5):e97510.

Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. Chilton FH, Murphy RC, Wilson BA, Sergeant S, Ainsworth H, Seeds MC, Mathias RA.. Nutrients. 2014;6(5):1993-2022.

DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver [abstract]. Chilton F, Mathias R, Seeds M, Herrington D, Hixson J, Hawkins G, Sergeant S, Miller L, Howard T.. FASEB J. 2014;28(1 Suppl):373.8.

Surfactant protein B inhibits secretory phospholipase A2 hydrolysis of surfactant phospholipids. Hite RD, Grier BL, Waite BM, Veldhuizen RA, Possmayer F, Yao L-J, Seeds MC.. Am J Physiol Lung Cell Mol Physiol. 2012;302(2):L257-265.

Secretory phospholipase A2-mediated depletion of phosphatidylglycerol in early acute respiratory distress syndrome. Seeds MC, Grier BL, Suckling BN, Safta AM, Long DL, Waite BM, Morris PE, Hite RD.. Am J Med Sci. 2012;343(6):446-451.

Cytokine regulation of secretory phospholipases A2 in a differentiated human monocyte cell model [abstract]. Updaw RJ, Hite R, Blair R, Ireland L, Grier B, Waite M, Seeds M.. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A5234.

Regulation of secretory A2 phospholipase activity in persistent ARDS [abstract]. Hite RD, Seeds MC, Morris PE, Grier BL, Waite BM, Douglas IS, Hudson LD, Goodman RB.. Am J Respir Crit Care Med. 2010;181():A6474.

Regulation of hydrolysis by secretory phospholipases A2 in surfactant monolayer films [abstract]. Hite RD, Seeds MC, Grier BL, Possmayer F, Veldhuizen RA, Waite BM.. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A6278.

Effect of dietary fatty acids on inflammatory gene expression in healthy humans. Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH.. J Biol Chem. 2009;284(23):15400-7.

Regulation of arachidonate remodeling enzymes impacts eosinophil survival during allergic asthma. Seeds MC, Peachman KK, Bowton DL, Sivertson KL, Chilton FH.. Am J Respir Cell Mol Biol. 2009;41(3):358-366.

Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseases. Lorenz E, Muhlebach MS, Tessier PA, Alexis NE, Hite RD, Seeds MC, Peden DB, Meredith W.. Respir Med. 2008;102(4):567-573.

Mechanisms by which botanical lipids affect inflammatory disorders. Chilton FH, Rudel LL, Parks JS, Arm JP, Seeds MC.. Am J Clin Nutr. 2008;87(2 Suppl):498S-503S.

Surfactant alterations in asthmatics from the Wake Forest Severe Asthma Research Program Center [abstract]. Hite RD, Hastie AT, Seeds MC, Grier BL, Peters SP, Moore WC, Bleecker ER.. Am J Respir Crit Care Med. 2008;177(Abstr Issue):A100.

Regulation of GP IIA sPLA2 mRNA production in a human monocyte cell model (THP-1) [abstract]. Blair RA, Hite RD, Seeds MC.. Am J Respir Crit Care Med. 2008;177(Abstr Issue):A750.

Interleukin-1beta (IL-1beta)-mediated microsomal prostaglandin E2(PGE2) synthase (mPGES) induction regulates cyclooxygenase-2 (COX-2) and PGE2 production in human airway smooth muscle (HASM) [abstract]. Pascual RM, Seeds MC, Panettieri RA, Peters SP, Penn RB.. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A663.

The differential effect of dexamethasone on granulocyte apoptosis involves stabilization of Mcl-1L in neutrophils but not in eosinophils. Sivertson KL, Seeds MC, Long DL, Peachman KK, Bass DA.. Cell Immunol. 2007;246(1):34-45.

Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR.. Immunol Lett. 2007;111(1):36-44.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Molecular Medicine

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