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Susan Sergeant, Ph.D.Wake Forest School of Medicine

Susan Sergeant, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-716-7388 | Department: 336-713-1287


Education & Training

  • B.S., Washington College, 1981
  • Ph.D., University of Missouri-Columbia, 1987
  • Fellowship, WFU School of Medicine, 1998


  • Soc for Leukocyte Biology
Susan Sergeant, Ph.D.

Susan Sergeant, Ph.D.

Assistant Professor, Biochemistry

Research Interests

Fatty Acid Desaturases; Neutrophils; Phospholipids; Eicosanoids; Multigene Family
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Contact Information

Academic: 336-716-7388 | Department: 336-713-1287


Recent Publications

Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes. Rahbar E, Waits CMK, Kirby EH Jr, Miller LR, Ainsworth HC, Cui T, Sergeant S, Howard TD, Langefeld CD, Chilton FH.. Clin Epigenetics. 2018;10():46.

Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster. Rahbar E, Ainsworth HC, Howard TD, Hawkins GA, Ruczinski I, Mathias R, Seeds MC, Sergeant S, Hixson JE, Herrington DM, Langefeld CD, Chilton FH.. PLoS One. 2017;12(9):e0180903.

Precision nutrition and omega-3 polyunsaturated fatty acids: a case for personalized supplementation approaches for the prevention and management of human diseases. Chilton FH, Dutta R, Reynolds LM, Sergeant S, Mathias RA, Seeds MC.. Nutrients. 2017;9(11):1165.

Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood. Miller LR, Jorgensen MJ, Kaplan JR, Seeds MC, Rahbar E, Morgan TM, Welborn A, Chilton SM, Gillis J, Hester A, Rukstalis M, Sergeant S, Chilton FH.. Physiol Behav. 2016;156():71-78.

Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans. Sergeant S, Ruczinski I, Ivester P, Lee TC, Morgan TM, Nicklas BJ, Mathias RA, Chilton FH.. Br J Nutr. 2016;115(2):251-261.

Gamma-linolenic acid, dihommo-gamma linolenic, eicosanoids and inflammatory processes. Sergeant S, Rahbar E, Chilton FH.. Eur J Pharmacol. 2016;785():77-86.

Impact of genetic and epigenetic variations within the FADS cluster on the composition and metabolism of polyunsaturated fatty acids in prostate cancer. Cui T, Hester AG, Seeds MC, Rahbar E, Howard TD, Sergeant S, Chilton FH.. Prostate. 2016;76(13):1182-1191.

Measurement of phospholipid metabolism in intact neutrophils. Sergeant S, McPhail LC.. Methods Mol Biol. 2014;1124():89-105.

DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, Hawkins GA, Sellers M, Ainsworth HC, Sergeant S, Miller LR, Chilton FH.. PLoS One. 2014;9(5):e97510.

Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. Chilton FH, Murphy RC, Wilson BA, Sergeant S, Ainsworth H, Seeds MC, Mathias RA.. Nutrients. 2014;6(5):1993-2022.

Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans. Hester AG, Murphy RC, Uhlson CJ, Ivester P, Lee TC, Sergeant S, Miller LR, Howard TD, Mathias RA, Chilton FH.. J Biol Chem. 2014;289(32):22482-89.

LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma. Kazani S, Arm JP, Boyce J, Chhay H, Dutile S, Wechsler ME, Govindarajulu U, Ivester P, Ainsworth HC, Sergeant S, Chilton FH, Israel E.. Springerplus. 2014;3():661.

The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population. Lee TC, Ivester P, Hester AG, Sergeant S, Case LD, Morgan T, Kouba EO, Chilton FH.. Lipids Health Dis. 2014;13(1):196.

DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver [abstract]. Chilton F, Mathias R, Seeds M, Herrington D, Hixson J, Hawkins G, Sergeant S, Miller L, Howard T.. FASEB J. 2014;28(1 Suppl):373.8.

Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. Arm JP, Boyce JA, Wang L, Chhay H, Zahid M, Patil V, Govindarajulu U, Ivester P, Weaver KL, Sergeant S, Israel E, Chilton FH.. Lipids Health Dis. 2013;12():141.

Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH.. Br J Nutr. 2012;107(4):547-555.

Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization. Mishra M, Byrd MS, Sergeant S, Azad AK, Parsek MR, McPhail L, Schlesinger LS, Wozniak DJ.. Cell Microbiol. 2012;14(1):95-106.

Adaptive evolution of the FADS gene cluster within Africa. Mathias RA, Fu W, Akey JM, Ainsworth HC, Torgerson DG, Ruczinski I, Sergeant S, Barnes KC, Chilton FH.. PLoS One. 2012;7(9):e44926.

Botanical oil supplementation alters insulin levels in diabetic/metabolic syndrome subjects in a genotypic-specific manner [abstract]. Sergeant S, Lee TC, Ivester P, Ainsworth HC, Case LD, Chilton FH.. FASEB J. 2012;26(Meeting Abstracts Suppl):647.11.

Racial differences in plasma omega-3 long chain fatty acid levels in a cohort of African Americans and European Americans with diabetes and metabolic syndrome [abstract]. Wilson BA, Sergeant S, Ainsworth H, Mathias R, Chilton FH III.. FASEB J. 2012;26(Meeting Abstracts Suppl):266.4.

Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats. Sergeant S, McQuail JA, Riddle DR, Chilton FH, Ortmeier SB, Jessup JA, Groban L, Nicolle MM.. J Gerontol A Biol Sci Med Sci. 2011;66(5):521-533.

The impact of FADS genetic variants on omega-6 polyunsaturated fatty acid metabolism in African Americans. Mathias RA, Sergeant S, Hugenschmidt CE, Ziegler JT, Ivester P, Case D, Freedman BI, Rudock ME, Langefeld CD, Bowden DW, Chilton FH, et al.. BMC Genet. 2011;12():article 50.

Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet. Chilton FH, Lee TC, Willard SL, Ivester P, Sergeant S, Register TC, Shively CA.. Physiol Behav. 2011;104(2):222-227.

Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding. Lewis EM, Sergeant S, Ledford B, Stull N, Dinauer MC, McPhail LC.. J Biol Chem. 2010;285(5):2959-2967.

FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population. Mathias RA, Vergara C, Gao L, Rafaels N, Hand T, Campbell M, Bickel C, Ivester P, Sergeant, Chilton FH, et al.. J Lipid Res. 2010;51(9):2766-2774.

Effect of a multifaceted, church-based wellness program on metabolic syndrome in 41 overweight or obese congregants. Ivester P, Sergeant S, Danhauer SC, Case LD, Lamb A, Chilton BG, Delar B, Hollingshead ML, Weaver KL, Chilton FH.. Prev Chronic Dis. 2010;7(4):A81.

Novel translocation responses of cytosolic phospholipase A2alpha fluorescent proteins. Wooten RE, Willingham MC, Daniel LW, Leslie CC, Rogers LC, Sergeant S, O'Flaherty JT.. Biochim Biophys Acta. 2008;1783(8):1544-1550.

X-linked chronic granulomatous disease secondary to skewed X chromosome inactivation in a female with a novel CYBB mutation and late presentation. Lewis EM, Singla M, Sergeant S, Koty PP, McPhail LC.. Clin Immunol. 2008;129(2):372-380.

Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation. Shen K, Sergeant S, Hantgan RR, McPhail LC, Horita DA.. Biochemistry. 2008;47(34):8855-8865.

Measurement of phospholipid metabolism in intact neutrophils. Sergeant S, McPhail LC.. Methods Mol Biol. 2007;412():69-83.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Biochemistry

Susan Sergeant, Ph.D.

Susan Sergeant, Ph.D.

Assistant Professor, Biochemistry

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