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Edward G. Shaw, M.D.Wake Forest School of Medicine

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Edward G. Shaw, M.D.

Professor,

Clinical Interests

General Radiation Oncology, Radiation Therapy for Brain Tumors and Spinal Cord Tumors in Adults and Children, Radiation-Induced Brain Injury, Radiation Oncology, Gamma Knife

Contact Information

Returning Patient Appointments: 336-713-3600
Department: 336-713-3600

Email: eshaw@wakehealth.edu

Insurance Accepted »

Education & Training

  • B.S., University of Iowa, 1979
  • M.D., Rush Medical College, 1983
  • Internship, Mayo Clinic, 1984
  • Residency, Mayo Clinic, 1987

Board Certifications

  • American Board of Radiology, Radiation Oncology

Memberships

  • Am Assn Of Sex Educatrs & Coun
  • Am Coll Of Radiology
  • Am Medical Assn
  • Am Soc Of Hospital Pharmacists
  • Am Veterinary Radiological Soc
  • Int'L Soc For Stereotactic Rad
  • Int'L Soc For Study Of Lung Ca

NPI Number

  • 1538141585
Edward G. Shaw, M.D.

Doctor Rating

No Rating Available
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Edward G. Shaw, M.D.

Professor, Gerontology and Geriatric Medicine

Research Interests

Brain Neoplasms; Glioma; Radiosurgery; Supratentorial Neoplasms; Quality of Life
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Contact Information

Academic: 336-713-3600 | Department: 336-713-3600

Email: eshaw@wakehealth.edu

Recent Publications

A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy. Lawrence JA, Griffin L, Balcueva EP, Groteluschen DL, Samuel TA, Lesser GJ, Naughton MJ, Case LD, Shaw EG, Rapp SR.. J Cancer Surviv. 2016;10(1):176-184.

Radiation plus procarbazine, CCNU, and vincristine in low-grade glioma. Buckner JC, Shaw EG, Pugh SL, Chakravarti A, Gilbert MR, Barger GR, Coons S, Ricci P, Bullard D, Brown PD, Stelzer K, Brachman D, Suh JH, Schultz CJ, Bahary JP, Fisher BJ, Kim H, Murtha AD, Bell EH, Won M, Mehta MP, Curran WJ Jr.. N Engl J Med. 2016;374(14):1344-1355.

A mutation and prognostic biomarker study in grade II and III gliomas utilizing a combined cohort of NRG oncology/RTOG 9802 and 9813 [abstract]. Bell EH, McElroy JP, Fleming J, Timmers C, Chakraborty AR, Salavaggione AL, Chang SM, Shaw EG, Aldape K, Brachman D, Schultz CJ, Shih HA, Curtis M, Hunter GK, Murtha AD, Zhang P, Won M, Mehta MP, Chakravarti A.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):S91.

Phase II double-blind placebo-controlled randomized study of armodafinil for brain radiation-induced fatigue. Page BR, Shaw EG, Lu L, Bryant D, Grisell D, Lesser GJ, Monitto DC, Naughton MJ, Rapp SR, Savona SR, Shah S, Case D, Chan MD.. Neuro Oncol. 2015;17(10):1393-1401.

Effect of ArginMax on sexual functioning and quality of life among female cancer survivors: results of the WFU CCOP Research Base Protocol 97106. Greven KM, Case LD, Nycum LR, Zekan PJ, Hurd DD, Balcueva EP, Mills GM, Zon R, Flynn PJ, Biggs D, Shaw EG, Lesser G, Naughton MJ.. J Community Support Oncol. 2015;13(3):87-94.

Mild cognitive impairment (MCI) in chemotherapy-treated breast cancer survivors [abstract]. Gifford A, Lawrence J, Case D, Rapp S, Baker L, Craft S, Groteluschen DL, Klepin H, Lesser G, Naughton MJ, Sachs B, Samuel TA, Sink K, Williamson, J, Shaw EG.. J Clin Oncol. 2015;33(15 Suppl):9560.

Preliminary efficacy of an enhanced quitline smoking cessation intervention for cancer patients [abstract]. Weaver KE, Urbanic JJ, Case D, Kaplan SG, Lesser GJ, Zbikowski S, Bryant D, Dakhil SR, Wilson C, Shaw EG, Danhauer S.. J Clin Oncol. 2015;33(15 Suppl):e20671.

A prospective evaluation of radiotherapy (RT) related skin reactions in a multi-racial/ethnic population of women with newly diagnosed breast cancer (BC) [abstract]. Urbanic JJ, Case D, Baez-Diaz L, Brown DR, Strasser J, Enevold G, Naughton M, Weaver KE, Baglan K, Bryant D, Langefeld C, Lad TE, Lee L, Rine G, Curtis AE, Koprowski CD, Tomlinson WV, Lesser GJ, Shaw EG, Hu JJ,.. J Clin Oncol. 2015;33(15 Suppl):6593.

Adult patients with supratentorial pilocytic astrocytoma: long-term follow-up of prospective multicenter clinical trial NCCTG-867251 (Alliance). Brown PD, Anderson SK, Carrero XW, O'Neill BP, Giannini C, Galanis E, Shah SA, Abrams RA, Curran WJ Jr, Buckner JC, Shaw EG.. Neurooncol Pract. 2015;2(4):199-204.

Late breast toxicity rates in a prospective evaluation of radiation therapy (RT) in a multiracial/ethnic population of breast cancer (BC) patient [abstract]. Urbanic JJ, Case D, Baez-Diaz L, Brown DR, Strasser J, Enevold G, Naughton M, Weaver KE, Baglan K, Bryant D, Langefeld C, Lad T, Lee L, Rine GP, Curtis AE, Koprowski CD, Tomlinson WV, Lesser GJ, Shaw EG, Hu J.. Int J Radiat Oncol Biol Phys. 2015;93(3 Suppl):E50-E51.

Oxidative DNA damage in radiation therapy related early adverse skin reactions in breast cancer [abstract]. Hu J, Nelson O, Takita C, Case D, Wright JL, Lee E, Baez-Diaz L, Brown DR, Strasser J, Enevold G, Baglan K, Bryant D, Lad T, Lee L, Rine GP, Curtis AE, Koprowski CD, Tomlinson WV, Lesser GJ, Shaw EG, Urbanic JJ.. Int J Radiat Oncol Biol Phys. 2015;93(3 Suppl):S108.

Effect of the addition of chemotherapy to radiotherapy on cognitive function in patients with low-grade glioma: secondary analysis of RTOG 98-02. Prabhu RS, Won M, Shaw EG, Hu C, Brachman DG, Buckner JC, Stelzer KJ, Barger GR, Brown PD, Gilbert MR, Mehta MP.. J Clin Oncol. 2014;32(6):535-541.

Local control and toxicity outcomes in brainstem metastases treated with single fraction radiosurgery: is there a volume threshold for toxicity?. Kilburn JM, Ellis TL [deceased], Lovato JF, Urbanic JJ, Bourland JD, Munley MT, Deguzman AF, McMullen KP, Shaw EG, Tatter SB, Chan MD.. J Neurooncol. 2014;117(1):167-174.

Single-institution retrospective series of gamma knife radiosurgery in the treatment of multiple sclerosis-related trigeminal neuralgia: factors that predict efficacy. Weller M, Marshall K, Lovato JF, Bourland JD, deGuzman AF, Munley MT, Shaw EG, Tatter SB, Chan MD.. Stereotact Funct Neurosurg. 2014;92(1):53-58.

Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH. Cairncross JG, Wang M, Jenkins RB, Shaw EG, Giannini C, Brachman DG, Buckner JC, Fink KL, Souhami L, Laperriere NJ, Huse JT, Mehta MP, Curran WJ Jr.. J Clin Oncol. 2014;32(8):783-790.

Variables associated with high caregiver stress in patients with mild cognitive impairment or Alzheimer's disease: implications for providers in a co-located memory assessment clinic. Hall D, Wilkerson J, Lovato J, Sink K, Chamberlain D, Alli R, Clarke P, Rogers S, Villalba J, Williams J, Shaw EG.. J Ment Health Couns. 2014;36(2):145-159.

Limited margins using modern radiotherapy techniques does not increase marginal failure rate of glioblastoma. Paulsson AK, McMullen KP, Peiffer AM, Hinson WH, Kearns WT, Johnson AJ, Lesser GJ, Ellis TL, Tatter SB, Debinski W, Shaw EG, Chan MD.. Am J Clin Oncol. 2014;37(2):177-181.

A nomogram for predicting distant brain failure in patients treated with gamma knife stereotactic radiosurgery without whole brain radiotherapy. Ayala-Peacock DN, Peiffer AM, Lucas JT, Isom S, Kuremsky JG, Urbanic JJ, Bourland JD, Laxton AW, Tatter SB, Shaw EG, Chan MD.. Neuro Oncol. 2014;16(9):1283-1288.

Predictors of survival, neurologic death, local failure, and distant failure after gamma knife radiosurgery for melanoma brain metastases. Neal MT, Chan MD, Lucas JT Jr, Loganathan A, Dillingham C, Pan E, Stewart JH IV, Bourland JD, Shaw EG, Tatter SB, Ellis TL.. World Neurosurg. 2014;82(6):1250-1255.

Mature survival data from RTOG 9802: a phase III study of radiation therapy (RT) with or without procarbazine, CCNU, and vincristine (PCV) for adult patients with high-risk low-grade glioma (LGG) [abstract]. Mehta MP, Won M, Shaw EG, Buckner J, Gilbert M, Barger G, Coons S, Ricci P, Bullard D, Brown PD, Stelzer K, Brachman DG, Suh JH, Schultz C, Bahary J, Fisher BJ, Kim H, Murtha AD, Curran WJ.. Int J Radiat Oncol Biol Phys. 2014;90(Suppl 1):S37-S38.

Incidence of mild cognitive impairment in irradiated brain tumor survivors [abstract]. Shaw E, McKee N, Case D, Lawrence J, Lesser G, Naughton M, Peiffer A, Loghin M, Giguere J, Stieber V, Rapp S.. Int J Radiat Oncol Biol Phys. 2014;90(Suppl 1):S162-S163.

L-arginine - based nutritional supplement did not improve erectile function or quality of life in prostate cancer survivors previously treated with radiation therapy: results of CCOP research base protocol 98110-A randomized phase 2 dose. Urbanic JJ, Case D, Lesser G, Enevold G, Naughton M, Danhauer S, Rapp S, Vitolins M, Johnson S, McCollough M, Duncan D, Papagikos M, Shaw EG.. Int J Radiat Oncol Biol Phys. 2014;90(Suppl 1):S86-S87.

Phase III study of radiation therapy (RT) with or without procarbazine, CCNU, and vincristine (PCV) in low-grade qlioma: results by histologic type [abstract]. Buckner J, Shaw E, Pugh S, Gilbert M, Barger G, Coons S, Ricci P, Bullard D, Brown P, Stelzer K, Brachman D, Suh J, Schultz C, Bahary JP, Fisher B, Kim H, Murtha A, Won M, Mehta M, Curran W Jr.. Neuro Oncol. 2014;16(Suppl 5):v11.

Induction of robust type-1 CD8(+) T-cell responses in WHO grade II low-grade glioma patients receiving peptide-based vaccines in combination with poly-ICLC [abstract]. Okada H, Butterfield L, Hamilton R, Ahn B, Kohanbash G, Drappatz J, Engh J, Amankulor N, Lively M, Chan M, Salazar A, Shaw E, Potter D, Lieberman F.. Neuro Oncol. 2014;16(Suppl 5):v114.

Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402. Cairncross G, Wang M, Shaw E, Jenkins R, Brachman D, Buckner J, Fink K, Souhami L, Laperriere N, Curran W, Mehta M.. J Clin Oncol. 2013;31(3):337-343.

Neuroanatomical target theory as a predictive model for radiation-induced cognitive decline. Peiffer AM, Leyrer CM, Greene-Schloesser DM, Shing E, Kearns WT, Hinson WH, Tatter SB, Ip EH, Rapp SR, Robbins ME [deceased], Shaw EG, Chan MD.. Neurology. 2013;80(8):747-753.

Melanoma in horses: current perspectives. Moore JS, Shaw C, Shaw E, Buechner-Maxwell B, Scarratt WK, Crisman M, Furr M, Robertson J.. Equine Vet Educ. 2013;25(3):144-151.

A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer. Lesser GJ, Case D, Stark N, Williford S, Giguere J, Garino LA, Naughton MJ, Vitolins MZ, Lively MO, Shaw EG.. J Support Oncol. 2013;11(1):31-42.

Mike Robbins 1954-2013 [obituary]. Hopewell JW, Bourland JD, Shaw EG.. Int J Radiat Biol. 2013;89(6):482-483.

Radiosurgical management of trigeminal neuralgia. Chan MD, Shaw EG, Tatter SB.. Neurosurg Clin N Am. 2013;24(4):613-621.

Mental health symptoms in people with cognitive impairment and memory loss and their caregivers: initial finding and implications for counselors and geriatricians [abstract]. Hall D, Wilkerson J, Lovato J, Sink K, Chamberlain D, Clarke P, Villalba J, Alli R, Williams J, Rogers S, Shaw E.. Alzheimers Dement. 2013;9(4 Suppl):P485-P486.

High neuroticism in caregivers is associated with greater burden independent of degree of cognitive impairment or neuropsychiatric symptoms [abstract]. Sink K, Lovato J, Chamberlain D, Alli R, Clarke P, Hall D, Villalba J, Shaw E.. Alzheimers Dement. 2013;9(4 Suppl):P493.

An interdisciplinary counseling center for individuals, couples and families afftected by MCI and dementia [abstract]. Alli R, Hall D, Clarke P, Hugenschmidt C, Rogers S, Sink K, Villalba J, Williams J, Wilson V, Shaw E.. Alzheimers Dement. 2013;9(4 Suppl):P646.

Caregiver Burden Scale item analysis: implications for mental health counseling approaches [abstract]. Shaw E, Hall D, Lovato J, Alli R, Clarke P, Villalba J, Sink K.. Alzheimers Dement. 2013;9(4 Suppl):P646.

A brain fitness program for people with dementia concurrent with a support group for their caregivers is feasible [abstract]. Neth B, Colmer HG IV, Hugenschmidt C, Fitzsimmons S, Shaw E, Alli R, Sun D, Henningsen D, Mugweru J, Sink K.. Alzheimers Dement. 2013;9(4 Suppl):P647-P648.

Therapeutic interactions to enhance the mental health and wellness of dementia caregivers and patients. Clarke PB, Shaw EG, Villalba JA, Alli R, Sink KM.. J Gerontol Nurs. 2013;39(11):7-10.

Adverse toxicity after stereotactic radiosurgery for treatment of meningiomas [abstract]. Kuhn E, Taksler GB, Dayton O, Loganathan A, Bourland J, Ellis TL [deceased], Laxton AW, Shaw EG, Chan MD, Tatter SB.. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl):S259.

Impact of radiosurgical management of geriatric patients with brain metastases: clinical and quality of life outcomes [abstract]. Randolph D, Peiffer AM, Klepin H, Ayala-Peacock DN, Lester SC, Laxton AW, Tatter SB, Shaw EG, Chan MD.. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl):S609.

Tumor histology predicts patterns of failure and survival in patients with brain metastases from lung cancer treated with gamma knife radiosurgery. Kuremsky JG, Urbanic JJ, Petty WJ, Lovato JF, Bourland JD, Tatter SB, Ellis TL [deceased], McMullen KP, Shaw EG, Chan MD.. Neurosurgery. 2013;73(4):641-647.

Randomized trial to assess the impact of venlafaxine and soy protein on hot flashes and quality of life in men with prostate cancer. Vitolins MZ, Griffin L, Tomlinson WV, Vuky J, Adams PT, Moose D, Frizzell B, Lesser GJ, Naughton M, Radford JE Jr, Shaw EG.. J Clin Oncol. 2013;31(32):4092-4098.

Robust induction of type-1 CD8(+) T-cell responses INWHOgrade II low-grade glioma patients receiving peptide-based vaccines in combination with poly-ICLC [abstract]. Okada H, Butterfield L, Hamilton R, Drappatz J, Engh J, Amankulor N, Lively M, Chan M, Salazar A, Potter D, Shaw E, Lieberman F.. Neuro Oncol. 2013;15(Suppl 3):71.

Normal tissue complication probability (Ntcp) model of radiation-induced mood disruption [abstract]. Peiffer AM, Burke A, Leyer CM, Shing E, Kearns WT, Hinson WH, Case D, Rapp SR, Shaw EG, Chan MD.. Neuro Oncol. 2013;15(Suppl 3):230.

Michael E. Robbins, Ph.D. 1954-2012 [in memoriam]. Hopewell JW, Bourland JD, Shaw EG.. Radiat Res. 2013;179(5):615-616.

Phase II double-blind placebo-controlled study of armodafinil for brain radiation induced fatigue [abstract]. Shaw EG, Case D, Bryant D, Grisell D, Lesser G, Monitto DC, Naughton MJ, Rapp SR, Sovano SR, Shah S, Chan MD.. J Clin Oncol. 2013;31(15 Suppl):9505.

Minority accrual on a prospective study targeting a diverse US breast cancer population: an analysis of Wake Forest CCOP research base protocol 97609 [abstract]. Urbanic JJ, Case D, Naughton MJ, Hu JJ, Enevold G, Beech B, Weaver KE, Danhauer S, Rapp SR, Sheidler V, Vitolins M, Lesser G, Shaw EG.. J Clin Oncol. 2013;31(15 Suppl):6564.

Phase III randomized, double-blind, placebo-controlled trial of donepezil in irradiated brain tumor survivors [abstract]. Rapp SR, Case D, Peiffer A, Naughton MJ, Stieber VW, Bayer GK, Bilodeau PA, Moore DF, Falchuk SC, Needles BM , Piephoff J, Edenfield WJ, Giguere JK, Erickson N, Loghin ME, Shaw EG.. J Clin Oncol. 2013;31(15 Suppl):2006.

Quality of life (QOL) and cognitive status among irradiated brain tumor survivors treated with donepezil or placebo [abstract]. Case D, Naughton MJ, Stieber VW, Bayer GK, Bilodeau PA, Moore DF, Falchuk SC, Needles BM, Piephoff J, Edenfield WJ, Giguere JK, Erickson N, Loghin ME, Shaw EG, Rapp SR.. J Clin Oncol. 2013;31(15 Suppl):2051.

A phase I dose escalation study of hypofractionated IMRT field-in-field boost for newly diagnosed glioblastoma multiforme. Monjazeb AM, Ayala D, Jensen C, Case LD, Bourland JD, Ellis TL, McMullen KP, Chan MD, Tatter SB, Lesser GJ, Shaw EG.. Int J Radiat Oncol Biol Phys. 2012;82(2):743-748.

A phase II trial of thalidomide and procarbazine in adult patients with recurrent or progressive malignant gliomas. Ruiz J, Case D, Enevold G, Rosdhal R, Tatter SB, Ellis TL, McQuellon RP, McMullen KP, Stieber VW, Shaw EG, Lesser GJ.. J Neurooncol. 2012;106(3):611-617.

Predictive variables for the successful treatment of trigeminal neuralgia with gamma knife radiosurgery. Marshall K, Chan MD, McCoy TP, Aubuchon AC, Bourland JD, McMullen KP, deGuzman AF, Munley MT, Shaw EG, Tatter SB, Ellis TL.. Neurosurgery. 2012;70(3):566-573.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Gerontology and Geriatric Medicine

Clinical Interests

General Radiation Oncology, Radiation Therapy for Brain Tumors and Spinal Cord Tumors in Adults and Children, Radiation-Induced Brain Injury, Radiation Oncology, Gamma Knife
Edward G. Shaw, M.D.

Edward G. Shaw, M.D.

Professor, Gerontology and Geriatric Medicine

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