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Edward G. Shaw, M.D.Wake Forest School of Medicine

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Edward G. Shaw, M.D.

Professor,

Clinical Interests

General Radiation Oncology, Radiation Therapy for Brain Tumors and Spinal Cord Tumors in Adults and Children, Radiation-Induced Brain Injury, Radiation Oncology, Gamma Knife

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-713-3600
Department: 336-713-3600

Email: eshaw@wakehealth.edu

Insurance Accepted »

Education & Training

  • B.S., University of Iowa, 1979
  • M.D., Rush Medical College, 1983
  • Internship, Mayo Clinic, 1984
  • Residency, Mayo Clinic, 1987

Board Certifications

  • American Board of Radiology, Radiation Oncology

Memberships

  • Am Assn Of Sex Educatrs & Coun
  • Am Coll Of Radiology
  • Am Medical Assn
  • Am Soc Of Hospital Pharmacists
  • Am Veterinary Radiological Soc
  • Int'L Soc For Stereotactic Rad
  • Int'L Soc For Study Of Lung Ca

NPI Number

  • 1538141585
Edward G. Shaw, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Edward G. Shaw, M.D.

Professor, Gerontology and Geriatric Medicine

Research Interests

cancer/oncogenesis, immunology/allergy/inflammatio, neurosciences/behavior, vaccines

Contact Information

Academic: 336-713-3600 | Department: 336-713-3600

Email: eshaw@wakehealth.edu

Recent Publications

Lawrence JA, Griffin L, Balcueva EP, Groteluschen DL, Samuel TA, Lesser GJ, Naughton MJ, Case LD, Shaw EG, Rapp SR. A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy. J Cancer Surviv. 2016;10(1):176-184.

Buckner JC, Shaw EG, Pugh SL, Chakravarti A, Gilbert MR, Barger GR, Coons S, Ricci P, Bullard D, Brown PD, Stelzer K, Brachman D, Suh JH, Schultz CJ, Bahary JP, Fisher BJ, Kim H, Murtha AD, Bell EH, Won M, Mehta MP, Curran WJ Jr. Radiation plus procarbazine, CCNU, and vincristine in low-grade glioma. N Engl J Med. 2016;374(14):1344-1355.

Page BR, Shaw EG, Lu L, Bryant D, Grisell D, Lesser GJ, Monitto DC, Naughton MJ, Rapp SR, Savona SR, Shah S, Case D, Chan MD. Phase II double-blind placebo-controlled randomized study of armodafinil for brain radiation-induced fatigue. Neuro Oncol. 2015;17(10):1393-1401.

Greven KM, Case LD, Nycum LR, Zekan PJ, Hurd DD, Balcueva EP, Mills GM, Zon R, Flynn PJ, Biggs D, Shaw EG, Lesser G, Naughton MJ. Effect of ArginMax on sexual functioning and quality of life among female cancer survivors: results of the WFU CCOP Research Base Protocol 97106. J Community Support Oncol. 2015;13(3):87-94.

Gifford A, Lawrence J, Case D, Rapp S, Baker L, Craft S, Groteluschen DL, Klepin H, Lesser G, Naughton MJ, Sachs B, Samuel TA, Sink K, Williamson, J, Shaw EG. Mild cognitive impairment (MCI) in chemotherapy-treated breast cancer survivors [abstract]. J Clin Oncol. 2015;33(15 Suppl):9560.

Weaver KE, Urbanic JJ, Case D, Kaplan SG, Lesser GJ, Zbikowski S, Bryant D, Dakhil SR, Wilson C, Shaw EG, Danhauer S. Preliminary efficacy of an enhanced quitline smoking cessation intervention for cancer patients [abstract]. J Clin Oncol. 2015;33(15 Suppl):e20671.

Urbanic JJ, Case D, Baez-Diaz L, Brown DR, Strasser J, Enevold G, Naughton M, Weaver KE, Baglan K, Bryant D, Langefeld C, Lad TE, Lee L, Rine G, Curtis AE, Koprowski CD, Tomlinson WV, Lesser GJ, Shaw EG, Hu JJ,. A prospective evaluation of radiotherapy (RT) related skin reactions in a multi-racial/ethnic population of women with newly diagnosed breast cancer (BC) [abstract]. J Clin Oncol. 2015;33(15 Suppl):6593.

Brown PD, Anderson SK, Carrero XW, O'Neill BP, Giannini C, Galanis E, Shah SA, Abrams RA, Curran WJ Jr, Buckner JC, Shaw EG. Adult patients with supratentorial pilocytic astrocytoma: long-term follow-up of prospective multicenter clinical trial NCCTG-867251 (Alliance). Neurooncol Pract. 2015;2(4):199-204.

Urbanic JJ, Case D, Baez-Diaz L, Brown DR, Strasser J, Enevold G, Naughton M, Weaver KE, Baglan K, Bryant D, Langefeld C, Lad T, Lee L, Rine GP, Curtis AE, Koprowski CD, Tomlinson WV, Lesser GJ, Shaw EG, Hu J. Late breast toxicity rates in a prospective evaluation of radiation therapy (RT) in a multiracial/ethnic population of breast cancer (BC) patient [abstract]. Int J Radiat Oncol Biol Phys. 2015;93(3 Suppl):E50-E51.

Hu J, Nelson O, Takita C, Case D, Wright JL, Lee E, Baez-Diaz L, Brown DR, Strasser J, Enevold G, Baglan K, Bryant D, Lad T, Lee L, Rine GP, Curtis AE, Koprowski CD, Tomlinson WV, Lesser GJ, Shaw EG, Urbanic JJ. Oxidative DNA damage in radiation therapy related early adverse skin reactions in breast cancer [abstract]. Int J Radiat Oncol Biol Phys. 2015;93(3 Suppl):S108.

Prabhu RS, Won M, Shaw EG, Hu C, Brachman DG, Buckner JC, Stelzer KJ, Barger GR, Brown PD, Gilbert MR, Mehta MP. Effect of the addition of chemotherapy to radiotherapy on cognitive function in patients with low-grade glioma: secondary analysis of RTOG 98-02. J Clin Oncol. 2014;32(6):535-541.

Kilburn JM, Ellis TL [deceased], Lovato JF, Urbanic JJ, Bourland JD, Munley MT, Deguzman AF, McMullen KP, Shaw EG, Tatter SB, Chan MD. Local control and toxicity outcomes in brainstem metastases treated with single fraction radiosurgery: is there a volume threshold for toxicity?. J Neurooncol. 2014;117(1):167-174.

Weller M, Marshall K, Lovato JF, Bourland JD, deGuzman AF, Munley MT, Shaw EG, Tatter SB, Chan MD. Single-institution retrospective series of gamma knife radiosurgery in the treatment of multiple sclerosis-related trigeminal neuralgia: factors that predict efficacy. Stereotact Funct Neurosurg. 2014;92(1):53-58.

Cairncross JG, Wang M, Jenkins RB, Shaw EG, Giannini C, Brachman DG, Buckner JC, Fink KL, Souhami L, Laperriere NJ, Huse JT, Mehta MP, Curran WJ Jr. Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH. J Clin Oncol. 2014;32(8):783-790.

Hall D, Wilkerson J, Lovato J, Sink K, Chamberlain D, Alli R, Clarke P, Rogers S, Villalba J, Williams J, Shaw EG. Variables associated with high caregiver stress in patients with mild cognitive impairment or Alzheimer's disease: implications for providers in a co-located memory assessment clinic. J Ment Health Couns. 2014;36(2):145-159.

Paulsson AK, McMullen KP, Peiffer AM, Hinson WH, Kearns WT, Johnson AJ, Lesser GJ, Ellis TL, Tatter SB, Debinski W, Shaw EG, Chan MD. Limited margins using modern radiotherapy techniques does not increase marginal failure rate of glioblastoma. Am J Clin Oncol. 2014;37(2):177-181.

Ayala-Peacock DN, Peiffer AM, Lucas JT, Isom S, Kuremsky JG, Urbanic JJ, Bourland JD, Laxton AW, Tatter SB, Shaw EG, Chan MD. A nomogram for predicting distant brain failure in patients treated with gamma knife stereotactic radiosurgery without whole brain radiotherapy. Neuro Oncol. 2014;16(9):1283-1288.

Neal MT, Chan MD, Lucas JT Jr, Loganathan A, Dillingham C, Pan E, Stewart JH IV, Bourland JD, Shaw EG, Tatter SB, Ellis TL. Predictors of survival, neurologic death, local failure, and distant failure after gamma knife radiosurgery for melanoma brain metastases. World Neurosurg. 2014;82(6):1250-1255.

Mehta MP, Won M, Shaw EG, Buckner J, Gilbert M, Barger G, Coons S, Ricci P, Bullard D, Brown PD, Stelzer K, Brachman DG, Suh JH, Schultz C, Bahary J, Fisher BJ, Kim H, Murtha AD, Curran WJ. Mature survival data from RTOG 9802: a phase III study of radiation therapy (RT) with or without procarbazine, CCNU, and vincristine (PCV) for adult patients with high-risk low-grade glioma (LGG) [abstract]. Int J Radiat Oncol Biol Phys. 2014;90(Suppl 1):S37-S38.

Shaw E, McKee N, Case D, Lawrence J, Lesser G, Naughton M, Peiffer A, Loghin M, Giguere J, Stieber V, Rapp S. Incidence of mild cognitive impairment in irradiated brain tumor survivors [abstract]. Int J Radiat Oncol Biol Phys. 2014;90(Suppl 1):S162-S163.

Urbanic JJ, Case D, Lesser G, Enevold G, Naughton M, Danhauer S, Rapp S, Vitolins M, Johnson S, McCollough M, Duncan D, Papagikos M, Shaw EG. L-arginine - based nutritional supplement did not improve erectile function or quality of life in prostate cancer survivors previously treated with radiation therapy: results of CCOP research base protocol 98110-A randomized phase 2 dose. Int J Radiat Oncol Biol Phys. 2014;90(Suppl 1):S86-S87.

Buckner J, Shaw E, Pugh S, Gilbert M, Barger G, Coons S, Ricci P, Bullard D, Brown P, Stelzer K, Brachman D, Suh J, Schultz C, Bahary JP, Fisher B, Kim H, Murtha A, Won M, Mehta M, Curran W Jr. Phase III study of radiation therapy (RT) with or without procarbazine, CCNU, and vincristine (PCV) in low-grade qlioma: results by histologic type [abstract]. Neuro Oncol. 2014;16(Suppl 5):v11.

Okada H, Butterfield L, Hamilton R, Ahn B, Kohanbash G, Drappatz J, Engh J, Amankulor N, Lively M, Chan M, Salazar A, Shaw E, Potter D, Lieberman F. Induction of robust type-1 CD8(+) T-cell responses in WHO grade II low-grade glioma patients receiving peptide-based vaccines in combination with poly-ICLC [abstract]. Neuro Oncol. 2014;16(Suppl 5):v114.

Cairncross G, Wang M, Shaw E, Jenkins R, Brachman D, Buckner J, Fink K, Souhami L, Laperriere N, Curran W, Mehta M. Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402. J Clin Oncol. 2013;31(3):337-343.

Peiffer AM, Leyrer CM, Greene-Schloesser DM, Shing E, Kearns WT, Hinson WH, Tatter SB, Ip EH, Rapp SR, Robbins ME [deceased], Shaw EG, Chan MD. Neuroanatomical target theory as a predictive model for radiation-induced cognitive decline. Neurology. 2013;80(8):747-753.

Moore JS, Shaw C, Shaw E, Buechner-Maxwell B, Scarratt WK, Crisman M, Furr M, Robertson J. Melanoma in horses: current perspectives. Equine Vet Educ. 2013;25(3):144-151.

Lesser GJ, Case D, Stark N, Williford S, Giguere J, Garino LA, Naughton MJ, Vitolins MZ, Lively MO, Shaw EG. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer. J Support Oncol. 2013;11(1):31-42.

Hopewell JW, Bourland JD, Shaw EG. Mike Robbins 1954-2013 [obituary]. Int J Radiat Biol. 2013;89(6):482-483.

Chan MD, Shaw EG, Tatter SB. Radiosurgical management of trigeminal neuralgia. Neurosurg Clin N Am. 2013;24(4):613-621.

Hall D, Wilkerson J, Lovato J, Sink K, Chamberlain D, Clarke P, Villalba J, Alli R, Williams J, Rogers S, Shaw E. Mental health symptoms in people with cognitive impairment and memory loss and their caregivers: initial finding and implications for counselors and geriatricians [abstract]. Alzheimers Dement. 2013;9(4 Suppl):P485-P486.

Sink K, Lovato J, Chamberlain D, Alli R, Clarke P, Hall D, Villalba J, Shaw E. High neuroticism in caregivers is associated with greater burden independent of degree of cognitive impairment or neuropsychiatric symptoms [abstract]. Alzheimers Dement. 2013;9(4 Suppl):P493.

Alli R, Hall D, Clarke P, Hugenschmidt C, Rogers S, Sink K, Villalba J, Williams J, Wilson V, Shaw E. An interdisciplinary counseling center for individuals, couples and families afftected by MCI and dementia [abstract]. Alzheimers Dement. 2013;9(4 Suppl):P646.

Shaw E, Hall D, Lovato J, Alli R, Clarke P, Villalba J, Sink K. Caregiver Burden Scale item analysis: implications for mental health counseling approaches [abstract]. Alzheimers Dement. 2013;9(4 Suppl):P646.

Neth B, Colmer HG IV, Hugenschmidt C, Fitzsimmons S, Shaw E, Alli R, Sun D, Henningsen D, Mugweru J, Sink K. A brain fitness program for people with dementia concurrent with a support group for their caregivers is feasible [abstract]. Alzheimers Dement. 2013;9(4 Suppl):P647-P648.

Clarke PB, Shaw EG, Villalba JA, Alli R, Sink KM. Therapeutic interactions to enhance the mental health and wellness of dementia caregivers and patients. J Gerontol Nurs. 2013;39(11):7-10.

Kuhn E, Taksler GB, Dayton O, Loganathan A, Bourland J, Ellis TL [deceased], Laxton AW, Shaw EG, Chan MD, Tatter SB. Adverse toxicity after stereotactic radiosurgery for treatment of meningiomas [abstract]. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl):S259.

Randolph D, Peiffer AM, Klepin H, Ayala-Peacock DN, Lester SC, Laxton AW, Tatter SB, Shaw EG, Chan MD. Impact of radiosurgical management of geriatric patients with brain metastases: clinical and quality of life outcomes [abstract]. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl):S609.

Kuremsky JG, Urbanic JJ, Petty WJ, Lovato JF, Bourland JD, Tatter SB, Ellis TL [deceased], McMullen KP, Shaw EG, Chan MD. Tumor histology predicts patterns of failure and survival in patients with brain metastases from lung cancer treated with gamma knife radiosurgery. Neurosurgery. 2013;73(4):641-647.

Vitolins MZ, Griffin L, Tomlinson WV, Vuky J, Adams PT, Moose D, Frizzell B, Lesser GJ, Naughton M, Radford JE Jr, Shaw EG. Randomized trial to assess the impact of venlafaxine and soy protein on hot flashes and quality of life in men with prostate cancer. J Clin Oncol. 2013;31(32):4092-4098.

Okada H, Butterfield L, Hamilton R, Drappatz J, Engh J, Amankulor N, Lively M, Chan M, Salazar A, Potter D, Shaw E, Lieberman F. Robust induction of type-1 CD8(+) T-cell responses INWHOgrade II low-grade glioma patients receiving peptide-based vaccines in combination with poly-ICLC [abstract]. Neuro Oncol. 2013;15(Suppl 3):71.

Peiffer AM, Burke A, Leyer CM, Shing E, Kearns WT, Hinson WH, Case D, Rapp SR, Shaw EG, Chan MD. Normal tissue complication probability (Ntcp) model of radiation-induced mood disruption [abstract]. Neuro Oncol. 2013;15(Suppl 3):230.

Hopewell JW, Bourland JD, Shaw EG. Michael E. Robbins, Ph.D. 1954-2012 [in memoriam]. Radiat Res. 2013;179(5):615-616.

Shaw EG, Case D, Bryant D, Grisell D, Lesser G, Monitto DC, Naughton MJ, Rapp SR, Sovano SR, Shah S, Chan MD. Phase II double-blind placebo-controlled study of armodafinil for brain radiation induced fatigue [abstract]. J Clin Oncol. 2013;31(15 Suppl):9505.

Urbanic JJ, Case D, Naughton MJ, Hu JJ, Enevold G, Beech B, Weaver KE, Danhauer S, Rapp SR, Sheidler V, Vitolins M, Lesser G, Shaw EG. Minority accrual on a prospective study targeting a diverse US breast cancer population: an analysis of Wake Forest CCOP research base protocol 97609 [abstract]. J Clin Oncol. 2013;31(15 Suppl):6564.

Rapp SR, Case D, Peiffer A, Naughton MJ, Stieber VW, Bayer GK, Bilodeau PA, Moore DF, Falchuk SC, Needles BM , Piephoff J, Edenfield WJ, Giguere JK, Erickson N, Loghin ME, Shaw EG. Phase III randomized, double-blind, placebo-controlled trial of donepezil in irradiated brain tumor survivors [abstract]. J Clin Oncol. 2013;31(15 Suppl):2006.

Case D, Naughton MJ, Stieber VW, Bayer GK, Bilodeau PA, Moore DF, Falchuk SC, Needles BM, Piephoff J, Edenfield WJ, Giguere JK, Erickson N, Loghin ME, Shaw EG, Rapp SR. Quality of life (QOL) and cognitive status among irradiated brain tumor survivors treated with donepezil or placebo [abstract]. J Clin Oncol. 2013;31(15 Suppl):2051.

Monjazeb AM, Ayala D, Jensen C, Case LD, Bourland JD, Ellis TL, McMullen KP, Chan MD, Tatter SB, Lesser GJ, Shaw EG. A phase I dose escalation study of hypofractionated IMRT field-in-field boost for newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 2012;82(2):743-748.

Ruiz J, Case D, Enevold G, Rosdhal R, Tatter SB, Ellis TL, McQuellon RP, McMullen KP, Stieber VW, Shaw EG, Lesser GJ. A phase II trial of thalidomide and procarbazine in adult patients with recurrent or progressive malignant gliomas. J Neurooncol. 2012;106(3):611-617.

Marshall K, Chan MD, McCoy TP, Aubuchon AC, Bourland JD, McMullen KP, deGuzman AF, Munley MT, Shaw EG, Tatter SB, Ellis TL. Predictive variables for the successful treatment of trigeminal neuralgia with gamma knife radiosurgery. Neurosurgery. 2012;70(3):566-573.

Harris S, Chan MD, Lovato JF, Ellis TL, Tatter SB, Bourland JD, Munley MT, deGuzman AF, Shaw EG, Urbanic JJ, McMullen KP. Gamma knife stereotactic radiosurgery as salvage therapy after failure of whole-brain radiotherapy in patients with small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2012;83(1):e53-e59.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Gerontology and Geriatric Medicine

Clinical Interests

General Radiation Oncology, Radiation Therapy for Brain Tumors and Spinal Cord Tumors in Adults and Children, Radiation-Induced Brain Injury, Radiation Oncology, Gamma Knife
Edward G. Shaw, M.D.

Edward G. Shaw, M.D.

Professor, Gerontology and Geriatric Medicine

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