Profile

Gregory S. Shelness, Ph.D.

Gregory S. Shelness, Ph.D.

Professor, Pathology-Lipid Sciences
Comprehensive Cancer Center

Contact Information

Academic: 336-716-3282 | Department: 336-716-3282

Email: gshelnes@wakehealth.edu

Education & Training

  • B.A., SUNY-Purchase , 1979
  • Ph.D., SUNY-Stony Brook , 1984
  • Fellowship, Rockefeller University, 1989
Gregory S. Shelness, Ph.D.

Gregory S. Shelness, Ph.D.

Professor, Pathology-Lipid Sciences Comprehensive Cancer Center

Research Interests

metabolism

Contact Information

Academic: 336-716-3282 | Department: 336-716-3282

Email: gshelnes@wakehealth.edu

Recent Publications

Liu M, Chung S, Shelness GS, Parks JS. Hepatic ABCA1 and VLDL triglyceride production. Biochim Biophys Acta. 2012;1821(5):770-777.

Parks JS, Chung S, Shelness GS. Hepatic ABC transporters and triglyceride metabolism. Curr Opin Lipidol. 2012;23(3):196-200.

Weinberg RB, Gallagher JW, Fabritius MA, Shelness GS. ApoA-IV modulates the secretory trafficking of apoB and the size of triglyceride-rich lipoproteins. J Lipid Res. 2012;53(4):736-743.

Avraham-Davidi I, Ely Y, Pham VN, Castranova D, Grunspan M, Malkinson G, Gibbs-Bar L, Mayseless O, Allmog G, Lo B, Warren CM, Chen TT, Ungos J, Kidd K, Shaw K, Rogachev I, Wan W, Murphy PM, Farber SA,. ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nat Med. 2012;18(6):967-973.

Khatun I, Zeissig S, Iqbal J, Wang M, Curiel D, Shelness GS, Blumberg RS, Hussain MM. Phospholipid transfer activity of microsomal triglyceride transfer protein produces apolipoprotein B and reduces hepatosteatosis while maintaining low plasma lipids in mice. Hepatology. 2012;55(5):1356-1368.

Blade AM, Fabritius MA, Hou L, Weinberg RB, Shelness GS. Biogenesis of apolipoprotein A-V and its impact on VLDL triglyceride secretion. J Lipid Res. 2011;52(2):237-244.

Mulya A, Seo J, Brown AL, Gebre AK, Boudyguina E, Shelness GS, Parks JS. Apolipoprotein M expression increases the size of nascent pre beta HDL formed by ATP binding cassette transporter A1. J Lipid Res. 2010;51(3):514-524.

Chung S, Timmins JM, Duong M, Degirolamo C, Rong S, Sawyer JK, Singaraja RR, Rudel LL, Shelness GS, Parks JS, et al. Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism. J Biol Chem. 2010;285(16):12197-209.

Chung S, Gebre AK, Seo J, Shelness GS, Parks JS. A novel role for ABCA1-generated large pre-beta migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion. J Lipid Res. 2010;51(4):729-742.

Cheng D, MacArthur PS, Rong S, Parks JS, Shelness GS. Alternative splicing attenuates transgenic expression directed by the apolipoprotein E promoter-enhancer based expression vector pLIV11. J Lipid Res. 2010;51(4):849-855.

Chung S, Rong S, Degirolamo C, Brown AW, Bi X, Forrest L, Temel R, Shelness GS, Parks JS. Hepatocyte-specific knockout of ABCA1 alleviates liver lipid accumulation but exacerbates hepatic insulin resistance and inflammation [abstract]. Arterioscler Thromb Vasc Biol. 2010;30(11):e187.

Khatun I, Iqbal J, Wang MH, Zeissig S, Blumberg R, Curiel D, Shelness GS, Hussain MM. Phospholipid transfer activity of microsomal triglyceride transfer protein promotes assembly of phospholipid-rich ApoB-containing lipoproteins in mice [abstract]. Arterioscler Thromb Vasc Biol. 2010;30(11):e193-e194.

Ledford AS, Cook VA [sic] [Cook VR], Shelness GS, Weinberg RB. Structural and dynamic interfacial properties of the lipoprotein initiating domain of apolipoprotein B. J Lipid Res. 2009;50(1):108-115.

Degirolamo C, Shelness GS, Rudel LL. LDL cholesteryl oleate as a predictor for atherosclerosis: evidence from human and animal studies on dietary fat. J Lipid Res. 2009;50(Suppl):S434-S439.

Chung S, Timmins JM, Duong M, Rong S, Sawyer JK, Maeda N, Rudel LL, Shelness GS, Parks JS. Targeted deletion of hepatocyte ABCA1 induces futile cycling of VLDL production and clearance in C57BL/6 mice [abstract]. Arterioscler Thromb Vasc Biol. 2009;29(7):e36.

MacArthur PS, Shelness GS. Mechanism of neutral lipid translocation across the endoplasmic reticulum membrane [abstract]. Arterioscler Thromb Vasc Biol. 2009;29(7):e105.

Seo J, Mulya A, Gebre AK, Tall A, Shelness GS, Parks JS. ApoM expression causes formation of larger nascent HDL particles and preferential cholesterol efflux from late endosomes by ABCA1 [abstract]. Arterioscler Thromb Vasc Biol. 2009;29(7):e71.

Blade AM, Hou L, Shelness GS. Biogenesis and posttranscriptional regulation of apolipoprotein [abstract]. Arterioscler Thromb Vasc Biol. 2008;28(6):e-59.

Chung S, Timmins J, Duong M, Seo J, Gebre A, Boudyguina E, Shah R, Sawyer J, Rudel L, Shelness G, Parks JS, et al. Hepatic-specific deletion of ABCA1 promotes PI3 kinase-dependent VLDL maturation: a novel role for ABCA1 in the regulation of VLDL triglyceride assembly [abstract]. Arterioscler Thromb Vasc Biol. 2008;28(6):e-93-e-94.

Chung S, Timmins JM, Duong M, Seo J, Gebre A, Boudyguina E, Rudel LL, Shelness G, Shah R, Sawyer J, Parks JS, et al. A novel role for Abca1-generated large nascent HDL in the regulation of VLDL triglyceride secretion [abstract]. Circulation. 2008;118(18 Suppl 2):S558.

Temel RE, Hou L, Rudel LL, Shelness GS. ACAT2 stimulates cholesteryl ester secretion in apoB-containing lipoproteins. J Lipid Res. 2007;48(7):1618-1627.

Brown JM, Chung S, Das A, Shelness GS, Rudel LL, Yu L. CGI-58 facilitates the mobilization of cytoplasmic triglyceride for lipoprotein secretion in hepatoma cells. J Lipid Res. 2007;48(10):2295-2305.

Mohler PJ, Zhu M-Y, Blade AM, Ham A-JL, Shelness GS, Swift LL. Identification of a novel isoform of microsomal triglyceride transfer protein. J Biol Chem. 2007;282(37):26981-88.

Brown JM, Shelness GS, Rudel LL. Monounsaturated fatty acids and atherosclerosis: opposing views from epidemiology and experimental animal models. Curr Atheroscler Rep. 2007;9(6):494-500.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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