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Perry Shen, M.D.

Perry Shen, M.D.

Program Director, Surgical Sciences-Oncology
Professor, Surgery, General
Comprehensive Cancer Center

Clinical Specialties

Sarcoma, Hepatobiliary Surgery, Minimally Invasive Liver and Pancreatic Resection, Gastrointestinal Oncology Surgery, Peritoneal Surface Malignancies, Pancreatic Surgery, Melanoma

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-4276
Department: 336-716-0545

Email: pshen@wakehealth.edu

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Insurance Accepted »

Education & Training

  • B.A., University of California-Irvine , 1988
  • M.D., University of Southern California Sch of Medicine , 1992
  • B.S., University of California-Irvine , 1988
  • Internship, Obstetrics & Gynecology, J Hopkins-Balti Cty Hosps, 1993
  • Residency, Surgery, U Southern Calif Affil Hosps, 1998
  • Fellowship, John Wayne Cancer Institute, St. John's Health Center, 2000

Board Certifications

  • American Board of Surgery, Surgery

Memberships

  • Am Assn Of Cancer Research
  • North Carolina Medical Assn
  • North Carolina Surgical Assn
  • Soc for Sur Of Alimentary Trac
  • Soc Of Surgical Oncology
  • Southeastern Surgical Congress
  • Southern Surgical Society
  • Society of Graduate Surgeons
  • Am Hepato-Pancreato-Biliary
  • Am Coll Of Surgeons
  • Am Medical Assn
  • Am Soc Of Clinical Oncology
  • Assn Of Academic Surgery
  • Forsyth-Davie-Stokes Medical S

NPI Number

  • 1417932575
Perry Shen, M.D.

Perry Shen, M.D.

Program Director, Surgical Sciences-Oncology
Professor, Surgery, General Comprehensive Cancer Center

Contact Information

Academic: 336-716-0545 | Department: 336-716-0545

Email: pshen@wakehealth.edu

Media Medical Expert »

Recent Publications

Votanopoulos K, Ihemelandu C, Shen P, Stewart J, Russell G, Levine EA. A comparison of hematologic toxicity profiles after heated intraperitoneal chemotherapy with oxaliplatin and mitomycin C. J Surg Res. 2013;179(1):e133-e139.

Addington E, Russell G, Tedeschi R, Levine E, Shen P, Stewart J, Danhauer S, Duckworth K, McQuellon R. Post-traumatic growth is sustained two years after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy [abstract]. Psychooncology. 2013;22(Suppl 2):54.

Sirintrapun J, Blackham A, Russell G, Stewart J, Shen P, Levine E, Geisinger K, Bergman S, Cimic A. Significance of signet-ring cells in extracellular mucin pools versus tissue in high-grade mucinous carcinoma peritonei [abstract]. Lab Invest. 2013;93(Suppl 1):180A.

Votanopoulos KI, Swett K, Blackham AU, Ihemelandu C, Shen P, Stewart JH, Levine EA. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from rectal cancer. Ann Surg Oncol. 2013;20(4):1088-1092.

Mann GN, Mann LV, Levine EA, Shen P. Primary leiomyosarcoma of the inferior vena cava: a 2-institution analysis of outcomes. Surgery. 2012;151(2):261-267.

Howard-McNatt M, Geisinger KR, Stewart JH IV, Shen P, Levine EA. Is intraoperative imprint cytology evaluation still feasible for the evaluation of sentinel lymph nodes for lobular carcinoma of the breast?. Ann Surg Oncol. 2012;19(3):929-934.

Craven B, Shen P, Levine E, Votanopoulos K, Stewart J, Mirzazadeh M. Urologic recostructive [sic] procedures in cytoreductive surgery (CRS) and intraperitoneal hyperthermic chemotherapy (HIPEC) for peritoneal surface malignancy in 934 consecutive procedures [abstract]. Neurourol Urodyn. 2012;31(2):287.

McQuellon R, Duckworth K, Russell G, Shen P, Stewart J, Votanopoulos K, Levine E. After screening for depression in a high risk medical population: then what? [abstract]. Psychooncology. 2012;21(Suppl 1):126-127.

Levine EA, Blazer DG III, Kim MK, Shen P, Stewart JH IV, Guy C, Hsu DS. Gene expression profiling of peritoneal metastases from appendiceal and colon cancer demonstrates unique biologic signatures and predicts patient outcomes. J Am Coll Surg. 2012;214(4):599-607.

Cao C, Yan TD, Deraco M, Elias D, Glehen O, Levine EA, Moran BJ, Morris DL, Chua TC, Piso P, Sugarbaker PH, Baratti D, Kusamura S, Gilly FN, Shen P, Mohamed F. Importance of gender in diffuse malignant peritoneal mesothelioma. Ann Oncol. 2012;23(6):1494-1498.

Duckworth KE, McQuellon RP, Russell GB, Cashwell CS, Shen P, Stewart JH IV, Levine EA. Patient rated outcomes and survivorship following cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CS + HIPEC). J Surg Oncol. 2012;106(4):376-380.

Newman NA, Votanopoulos KL, Stewart JH, Shen P, Levine EA. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal cancer. Minerva Chir. 2012;67(4):309-318.

Votanopoulos KI, Shen P, Stewart JH IV, Levine EA. Current status and future directions in appendiceal cancer with peritoneal dissemination. Surg Oncol Clin N Am. 2012;21(4):599-609.

Votanopoulos KI, Ihemelandu C, Shen P, Stewart JH, Russell GB, Levine EA. Outcomes of repeat cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal surface malignancy. J Am Coll Surg. 2012;215(3):412-417.

Stojadinovic A, Nissan A, Wainberg Z, Shen P, McCarter M, Protic M, Howard RS, Steele SR, Peoples GE, Bilchik A. Time-dependent trends in lymph node yield and impact on adjuvant therapy decisions in colon cancer surgery: an international multi-institutional study. Ann Surg Oncol. 2012;19(13):4178-4185.

Baker JJ, Newman NA, Levine EA, Deal AM, Frank JS, Stewart JH, Shen P, Meyers MO. Utility of routine PET/CT for initial staging of patients with sentinel lymph node positive melanoma [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S127.

Blackham A, Russell GB, Stewart JH, Votanopoulos K, Levine EA, Shen P. Decreased survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy compared to hepatic resection for metastatic colorectal cancer [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S95-S96.

Griffith KF, Levine EA, Shen P, Stewart JH, Votanopoulas KI [sic] [Votanopoulos KI], Russell GB, Geisinger K. Appendiceal neuroendocrine tumors with peritoneal surface dissemination treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S109.

Ihemelandu CU, Shen P, Stewart JH, Votanopoulos K, McQuellon R, Russell G, Levine EA. Predicting postoperative morbidity following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CS plus HIPEC) with preoperative FACT - C (Functional Assessment of Cancer Therapy) and patient rated performance status [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S16.

Ihemelandu CU, Russell G, Shen P, Stewart JH, Votanopoulos K, Levine EA. Impact of lymph node metastasis on survival outcome for patients diagnosed with mucinous carcinoma of the appendix: the role of right hemicolectomy [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S98.

Shen P, Gahagan J, Stewart JH, Votanopoulus K [sic] [Votanopoulos K], Swett K, Levine EA. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis: analysis of postoperative morbidity and mortality from a high volume center [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S141.

Votanopoulos KI, Shen P, Stewart JH, Russell G, Levine EA, Newman NA. Cytoreductive surgery (CS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in the elderly [abstract]. Ann Surg Oncol. 2012;19(Suppl 1):S100-S101.

Yan TD, Deraco M, Elias D, Glehen O, Levine EA, Moran BJ, Morris DL, Chua TC, Piso P, Shen P, et al. A novel tumor-node-metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi-institutional database. Cancer. 2011;117(9):1855-1863.

Becher RD, Shen P, Stewart JH, Russell G, Bradley JF, Levine EA. Splenectomy ameliorates hematologic toxicity of hyperthermic intraperitoneal chemotherapy. J Gastrointest Oncol. 2011;2(2):70-76.

Duckworth K, McQuellon R, Russell G, Levine E, Shen P, Stewart J, Cromer M, Cashwell C. Quality of life and sleep quality of long-term survivors of cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy [abstract]. Psychooncology. 2011;20(Suppl 1):79-80.

Ihemelandu CU, Shen P, Stewart JH, Votanopoulos K, Levine EA. Management of peritoneal carcinomatosis from colorectal cancer. Semin Oncol. 2011;38(4):568-575.

Parson EN, Lentz S, Russell G, Shen P, Levine EA, Stewart JH IV. Outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface dissemination from ovarian neoplasms. Am J Surg. 2011;202(4):481-486.

Hill AR, McQuellon RP, Russell GB, Shen P, Stewart JH IV, Levine EA. Survival and quality of life following cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis of colonic origin. Ann Surg Oncol. 2011;18(13):3673-3679.

Wasif N, Faries MB, Saha S, Turner RR, Wiese D, McCarter MD, Shen P, Stojadinovic A, Bilchik AJ. Predictors of occult nodal metastasis in colon cancer: results from a prospective multicenter trial. Surgery. 2010;147(3):352-357.

Becher RD, Shen P, Stewart JH, Russell G, Bradley T, Levine EA. Splenectomy ameliorates hematologic toxicity of intraperitoneal hyperthermic chemotherapy [abstract]. Ann Surg Oncol. 2010;17(Suppl 1):S83-S84.

Hill AR, McQuellon RP, Russell GB, Shen P, Stewart JH, Levine EA. Survival and health-related quality of life following cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for disseminated peritoneal cancer of colonic origin [abstract]. Ann Surg Oncol. 2010;17(Suppl 1):S9.

Parson N, Shen P, Russell GB, Lentz SS, Levine EA, Stewart JH. Outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface dissemination from ovarian neoplasms [abstract]. Ann Surg Oncol. 2010;17(Suppl 1):S120.

Votanopoulos KI, Shen P, Stewart JH, Russell G, Levine EA. A comparison of hematologic toxicity profiles after heated intraperitoneal chemotherapy with oxaliplatin and mitomycin-C [abstract]. Ann Surg Oncol. 2010;17(Suppl 1):S85.

Beard HR, Cantrell EF, Russell GB, Howard-McNatt M, Shen P, Levine EA. Outcome after mastectomy for ipsilateral breast tumor recurrence after breast conserving surgery. Am Surg. 2010;76(8):829-834.

Bilchik A, Nissan A, Wainberg Z, Shen P, McCarter M, Protic M, Howard R, Elashoff D, Tyler J, Peoples GE, et al. Surgical quality and nodal ultrastaging is associated with long-term disease-free survival in early colorectal cancer: an analysis of 2 international multicenter prospective trials. Ann Surg. 2010;252(3):467-476.

Blackham AU, Shen P, Stewart JH, Russell GB, Levine EA. Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for malignant peritoneal mesothelioma: mitomycin versus cisplatin. Ann Surg Oncol. 2010;17(10):2720-2727.

Esquivel J, Chua TC, Stojadinovic A, Melero JT, Levine EA, Gutman M, Howard R, Piso P, Shen P, Stewart JH, et al. Accuracy and clinical relevance of computed tomography scan interpretation of peritoneal cancer index in colorectal cancer peritoneal carcinomatosis: a multi-institutional study. J Surg Oncol. 2010;102(6):565-570.

Rohani P, Scotti SD, Shen P, Stewart JH, Russell GB, Cromer M, Levine EA. Use of FDG-PET imaging for patients with disseminated cancer of the appendix. Am Surg. 2010;76(12):1338-1344.

McQuellon R, Russell G, Campbell C, Duckworth K, Shen P, Stewart J, Fenstermaker J, Pruitt L, Cromer M, Levine E, et al. Assessing depressive symptoms with the Center for Epidemiologic Studies Depression Scale prior to cytoreductive surgery + intraperitoneal hyperthermic chemotherapy [abstract]. Psychooncology. 2009;18(Suppl 1):S42-S43.

Moore P, Hundley J, Hundley J, Levine EA, Williford P, Sangueza O, McCoy T, Shen P. Does shave biopsy accurately predict the final Breslow depth of primary cutaneous melanoma?. Am Surg. 2009;75(5):369-373.


Wood BC, David LR, Defranzo AJ, Stewart JH, Shen P, Geisinger KR, Marks MW, Levine EA. Impact of sentinel lymph node biopsy on immediate breast reconstruction after mastectomy. Am Surg. 2009;75(7):551-556.

Godat LN, Horton JK, Shen P, Stewart JH, Wentworth S, Levine EA. Recurrence after mastectomy for ductal carcinoma in situ. Am Surg. 2009;75(7):592-597.

Wong SL, Young YD, Geisinger KR, Shen P, Stewart JH, Sangueza O, Pichardo-Geisinger R, Levine EA. Intraoperative imprint cytology for evaluation of sentinel lymph nodes from Merkel cell carcinoma. Am Surg. 2009;75(7):615-619.

Becher RD, Shen P, Stewart JH, Geisinger KR, McCarthy LR, Levine EA. Sentinel lymph node mapping for gastric adenocarcinoma. Am Surg. 2009;75(8):710-714.




Stewart JH IV, Shen P, Levine EA. Translation considerations for hyperthermic intraperitoneal chemotherapy. Curr Probl Cancer. 2009;33(3):194-202.

Stewart JH IV, Levine EA, Shen P. The current role of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of appendiceal tumors. Curr Probl Cancer. 2009;33(3):142-153.

Yan TD, Deraco M, Baratti D, Kusamura S, Elias D, Glehen O, Gilly FN, Levine EA, Shen P, Mohamed F, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: multi-institutional experience. J Clin Oncol. 2009;27(36):6237-6242.

Gmeiner WH, Hellmann GM, Shen P. Tissue-dependent and -independent gene expression changes in metastatic colon cancer. Oncol Rep. 2008;19(1):245-251.

McQuellon RP, Russell GB, Shen P, Stewart JH IV, Saunders W, Levine EA. Survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin. Ann Surg Oncol. 2008;15(1):125-133.

Shen P, Thai K, Stewart JH, Howerton R, Loggie BW, Russell G, Levine EA. Isolated metastases of colorectal cancer to the liver or peritoneum: outcomes associated with optimal surgical treatment [abstract]. Ann Surg Oncol. 2008;15(Suppl 2):6.

Stewart JH, Shen P, Fenstermaker J, McWilliams L, Merkle E, Jones B, Levine EA. A phase I trial of intraperitoneal hyperthermic chemoperfusion with oxaliplatin for the treatment of peritoneal surface dissemination of colorectal and appendiceal cancer [abstract]. Ann Surg Oncol. 2008;15(Suppl 2):23.

Stewart JH IV, Shen P, Russell G, Fenstermaker J, McWilliams L, Coldrun FM, Levine KE, Jones BT, Levine EA. A phase I trial of oxaliplatin for intraperitoneal hyperthermic chemoperfusion for the treatment of peritoneal surface dissemination from colorectal and appendiceal cancers. Ann Surg Oncol. 2008;15(8):2137-2145.

Shen P, Stewart JH, Levine EA. Metastases of colorectal cancer to the liver and peritoneum: comparison of surgical paradigms. Expert Rev Anticancer Ther. 2008;8(11):1797-1808.

Stewart JH IV, Shen P, Levine EA. Intraperitoneal hyperthermic chemotherapy: an evolving paradigm for the treatment of peritoneal surface malignancies. Expert Rev Anticancer Ther. 2008;8(11):1809-1818.

Koyanagi K, Bilchik AJ, Saha S, Turner RR, Wiese D, McCarter M, Shen P, Deacon L, Elashoff D, Hoon DSB. Prognostic relevance of occult nodal micrometastases and circulating tumor cells in colorectal cancer in a prospective multicenter trial. Clin Cancer Res. 2008;14(22):7391-7396.

Shen P, Thai K, Stewart JH, Howerton R, Loggie BW, Russell GB, Levine EA. Peritoneal surface disease from colorectal cancer: comparison with the hepatic metastases surgical paradigm in optimally resected patients. Ann Surg Oncol. 2008;15(12):3422-3432.

Shen P, Jackson L, Carter JE, Levine EA. Surgical therapy for metastatic carcinomas of unknown origin In: Wick MR, ed. Metastatic carcinomas of unknown origin. New York: Demos Medical Publishing;2008: 225-240.

Geisinger KR, Levine EA, Shen P, Bradley RF. Pleuropulmonary involvement in pseudomyxoma peritonei: morphologic assessment and literature review. Am J Clin Pathol. 2007;127(1):135-143.

Shen P, Martin S. Nutrition and wound healing in cancer In: Molnar J, ed. Nutrition and wound healing. Boca Raton (FL): CRC Press;2007: 261-300.

McQuellon RP, Danhauer SC, Russell GB, Shen P, Fenstermaker J, Stewart JH, Levine EA. Monitoring health outcomes following cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis. Ann Surg Oncol. 2007;14(3):1105-1113.

McQuellon RP, Russell GB, Shen P, Stewart JH, Saunders WW, Levine EA. Survival and quality of life (QOL) after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy (IPHC) for disseminated peritoneal cancer (PC) of appendiceal origin [abstract]. Ann Surg Oncol. 2007;14(2 Suppl):30-31.

Shen P, Geisinger KR, Zagoria R, Levine EA. Pathologic correlation study of microwave coagulation therapy for hepatic malignancies using a three-ring probe. J Gastrointest Surg. 2007;11(5):603-611.

Soo V, Bradley T, Shen P, Stewart JH, Russell GB, Levine EA. Splenectomy ameliorates hematologic toxicity of intraperitoneal hyperthermic chemotherapy [abstract]. Ann Surg Oncol. 2007;14(2 Suppl):116.

Stewart JH, Bertoni AE, Staten J, Shen P, Levine EA, Gross CP. Participation in surgical oncology clinical trials: gender, race/ethnicity and age-based disparities [abstract]. Ann Surg Oncol. 2007;14(2 Suppl):29.

Levine EA, Stewart JH IV, Russell GB, Geisinger KR, Loggie BL, Shen P. Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal surface malignancy: experience with 501 procedures. J Am Coll Surg. 2007;204(5):943-955.

Soo V, Shen P, Pichardo R, Azzazy H, Stewart JH, Geisinger KR, Levine EA. Intraoperative evaluation of sentinel lymph nodes for metastatic melanoma by imprint cytology. Ann Surg Oncol. 2007;14(5):1612-1617.

Stewart JH, Shen P, Levine EA. Patient selection for cytoreduction and hyperthermic intraperitoneal chemoperfusion In: Ceelen WP, ed. Peritoneal carcinomatosis: a multidisciplinary approach. New York: Springer;2007: 215-225.

Stewart JH, Shen P, Levine EA. Patient selection for cytoreduction and hyperthermic intraperitoneal chemoperfusion. Cancer Treat Res. 2007;134():215-229.

Bilchik AJ, Hoon DSB, Saha S, Turner RR, Wiese D, DiNome M, Koyanagi K, McCarter M, Shen P, Iddings D, et al. Prognostic impact of micrometastases in colon cancer: interim results of a prospective multicenter trial. Ann Surg. 2007;246(4):568-577.

Kilpatrick LA, Shen P, Stewart JH, Levine EA. Use of sentinel lymph node biopsy for melanoma of the head and neck. Am Surg. 2007;73(8):754-758.

Chu C, Bodin S, Pomper G, McCoy T, Shen P. Comparison of intraoperative blood salvage versus conventional methods to lower central venous pressure in patients undergoing liver resection for primary and secondary hepatic malignancies [abstract]. HPB (Oxford). 2007;9(Suppl 1):57-58.

Thomas KA, Lechner J, Shen P, Waters GS, Geisinger KR, Levine EA. Use of sentinel node mapping for cancer of the colon: 'to map or not to map'. Am Surg. 2006;72(7):606-611.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Surgery, General

Clinical Specialties

Sarcoma, Hepatobiliary Surgery, Minimally Invasive Liver and Pancreatic Resection, Gastrointestinal Oncology Surgery, Peritoneal Surface Malignancies, Pancreatic Surgery, Melanoma

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