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Carol A. Shively, Ph.D.Wake Forest School of Medicine

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Education & Training

  • B.A., Hiram College , 1979
  • M.A., University of California-Davis , 1981
  • Ph.D., University of California-Davis , 1983
  • Fellowship, WFU School of Medicine, 1986

Memberships

  • Intl Society Of Psychoneuroend
  • North Am Menopause Soc
  • Soc Of Behavioral Medicine
  • Society for Neuroscience
  • Am Psychological Assn
  • Aha - Council On Arteriosclero
  • Am Soc Of Primatologists
  • Int'L Primatological Soc.
Carol A. Shively, Ph.D.

Carol A. Shively, Ph.D.

Professor, Pathology-Comparative Medicine
Hypertension and Vascular Research Center
Office of Women in Medicine and Science
Sticht Center on Aging
Center for Comparative Medicine Research
Center for Integrative Medicine
Physiology & Pharmacology
Translational Science Institute

Research Interests

aging, atherosclerosis/thrombosis, mental disorders/psychiatry/ps, neurosciences/behavior, women's health issues

Contact Information

Academic: 336-716-1524 | Department: 336-716-1524

Email: cshively@wakehealth.edu

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Recent Publications

Groban L, Kitzman DW, Register TC, Shively CA. Effect of depression and sertraline treatment on cardiac function in female nonhuman primates. Psychosom Med. 2014;76(2):137-146.

Shively CA, Register TC, Higley JD, Willard SL. Sertraline effects on cerebrospinal fluid monoamines and species-typical socioemotional behavior of female cynomolgus monkeys. Psychopharmacology (Berl). 2014;231(7):1409-1416.

Willard SL, Hemby SE, Register TC, McIntosh S, Shively CA. Altered expression of glial and synaptic markers in the anterior hippocampus of behaviorally depressed female monkeys. Neurosci Lett. 2014;563():1-5.

Murphy RA, Register TC, Shively CA, Carr JJ, Ge Y, Heilbrun ME, Cummings SR, Koster A, Nevitt MC, Satterfield S, Tylvasky FA, Strotmeyer ES, Newman AB, Simonsick EM, Scherzinger A, Goodpaster BH, Launer LJ, Eiriksdottir G,. Adipose tissue density, a novel biomarker predicting mortality risk in older adults. J Gerontol A Biol Sci Med Sci. 2014;69(1):109-117.

Silverstein MG, Kaplan JR, Appt SE, Register TC, Shively CA. Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis). Menopause. 2014;21(10):.

Willard SL, Borgmann-Winter KE, Wang HY, MacDonald ML, Shively CA, Hahn CG. Molecular mechanisms of synaptic dysfunction in a female monkey model of depression [abstract]. Biol Psychiatry. 2014;75(9 Suppl):321S.

Silverstein MG, El-Amin CK, Shively CA. Selective serotonin reuptake inhibitor and bleeding in a cynomolgus macaque (Macaca fascicularis). Comp Med. 2014;64(3):221-223.

Choi SJ, Shively CA, Register TC, Feng X, Stehle J, High K, Ip E, Kritchevsky SB, Nicklas B, Delbono O. Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys.. J Gerontol A Biol Sci Med Sci. 2013;68(3):258-267.

Feneran AN, O'Donnell R, Press A, Yosipovitch G, Cline M, Dugan G, Papoiu AD, Nattkemper LA, Chan YH, Shively CA. Monkey see, monkey do: contagious itch in nonhuman primates. Acta Derm Venereol. 2013;93(1):27-29.

Sophonsritsuk A, Appt SE, Clarkson TB, Shively CA, Espeland MA, Register TC. Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause. Menopause. 2013;20(5):540-547.

Willard S, Johnston WD, Clark A, Uberseder B, Neely D, Massey A, Daunais J, Williamson J, Register TC, Bourland JD, Shively C. Long term sertraline treatment decreases volumes of hippocampus and anterior cingulate cortex in an adult female primate model of depression [abstract]. Biol Psychiatry. 2013;73(9 Suppl):235S.

Willard SL, Borgmann-Winter KE, MacDonald ML, Shively CA, Hahn CG. Altered composition of the postsynaptic density in behaviorally depressed adult female cynomolgus macaques [abstract]. Biol Psychiatry. 2013;73(9 Suppl):154S.

Nattkemper LA, Zhao ZQ, Nichols AJ, Papoiu AD, Shively CA, Chen ZF, Yosipovitch G. Overexpression of the gastrin-releasing Peptide in cutaneous nerve fibers and its receptor in the spinal cord in primates with chronic itch [letter]. J Invest Dermatol. 2013;133(10):2489-2492.

Kalinin S, Willard SL, Shively CA, Kaplan JR, Register TC, Jorgensen MJ, Polak PE, Rubinstein I, Feinstein DL. Development of amyloid burden in African Green monkeys. Neurobiol Aging. 2013;34(10):2361-2369.

Li X, Xu F, Xie L, Ji Y, Cheng K, Zhou Q, Wang T, Shively C, Wu Q, Gong W, Fang L, Zhan Q, Melgiri ND, Xie P. Depression-like behavioral phenotypes by social and social plus visual isolation in the adult female Macaca fascicularis. PLoS One. 2013;8(9):e73293.

Plate JF, Bates CM, Mannava S, Smith TL, Jorgensen MJ, Register TC, Stehle JR, High KP, Shively CA, Kaplan JR, Saul KR, Tuohy CJ. Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates. J Shoulder Elbow Surg. 2013;22(8):1019-1029.

Willard SL, Riddle DR, Forbes ME, Shively CA. Cell number and neuropil alterations in subregions of the anterior hippocampus in a female monkey model of depression. Biol Psychiatry. 2013;74(12):890-897.

Shively CA, Kritchevsky SB, Register TC. Aging and physical function in nonhuman primates: a translational model [abstract]. Gerontologist. 2013;53(Suppl 1):249.



Willard SL, Shively CA. Modeling depression in adult female cynomolgus monkeys (Macaca fascicularis). Am J Primatol. 2012;74(6):528-542.

Feneran AN, O'Donnell R, Press A, Yosipovitch G, Cline M, Dugan G, Papoiu A, Nattkemper L, Chan Y, Shively CA. Monkey see, monkey do: contagious itch in nonhuman primates [abstract]. J Invest Dermatol. 2012;132(Suppl 1):S39.

Shively C. Sertraline has wide-ranging effects on socioemotional behavior in a female nonhuman primate model of depression [abstract]. Biol Psychiatry. 2012;71(8 Suppl):134S.

Shively CA, Willard SL, Register TC, Bennett AJ, Pierre PJ, Laudenslager ML, Kitzman DW, Childers MK, Grange RW, Kritchevsky SB. Aging and physical mobility in group-housed Old World monkeys. Age (Dordr). 2012;34(5):1123-1131.

Willard SL, Riddle DR, Forbes ME, Hemby SE, McIntosh S, Uberseder B, Shively CA. Cellular and molecular factors contributing to hippocampus size in an adult female monkey model of depression [abstract]. Soc Neurosci Abstr. 2012;2012(Neuroscience Meeting Planner):.

Willard SL, Daunais JB, Cline JM, Shively CA. Hippocampal volume in postmenopausal cynomolgus macaques with behavioral depression. Menopause. 2011;18(5):582-586.

Shively CA, Willard SL, Higley JD, Register TC. The effects of sertraline HCl on depressed adult female nonhuman primates [abstract]. Biol Psychiatry. 2011;69(9 Suppl):128S.

Willard SL, Register TC, Kritchevsky SB, Shively CA. Effects of menstrual cycle and social stress on circulating brain-derived neurotrophic factor in female monkeys [abstract]. Biol Psychiatry. 2011;69(9 Suppl):219S-220S.

Chilton FH, Lee TC, Willard SL, Ivester P, Sergeant S, Register TC, Shively CA. Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet. Physiol Behav. 2011;104(2):222-227.

Schnatz PF, Nudy M, Shively CA, Powell A, O'Sullivan DM. A prospective analysis of the association between cardiovascular disease and depression in middle-aged women. Menopause. 2011;18(10):1096-1100.

Shively CA, Willard SL. The slippery slope between social stress and depression in adult female cynomolgus monkeys (Macaca fascicularis) [abstract]. Am J Primatol. 2011;73(Suppl 1):103.

Willard SL, Register TC, Bennett AJ, Pierre PJ, Laudenslager ML, Kitzman DW, Childers MK, Grange RW, Kritschevsky SB [sic] [Kritchevsky SB], Shively CA. Developing models of aging and physical function in three species of old world monkeys [abstract]. Am J Primatol. 2011;73(Suppl 1):81.

Tamashiro KL, Sakai RR, Shively CA, Karatsoreos IN, Reagan LP. Chronic stress, metabolism, and metabolic syndrome. Stress. 2011;14(5):468-474.

Willard SL, Riddle DR, Forbes ME, Shively CA. Effects of behavioral depression on cell number, size and density in the hippocampus of adult female cynomolgus macaques [abstract]. Soc Neurosci Abstr. 2011;2011(Neuroscience Meeting Planner):.

Maki PM, Freeman EW, Greendale GA, Henderson VW, Newhouse PA, Schmidt PJ, Scott NF, Shively CA, Soares CN. Summary of the National Institute on Aging-sponsored conference on depressive symptoms and cognitive complaints in the menopausal transition. Menopause. 2010;17(4):815-822.

Willard SL, Daunais JB, Shively CA. Magnetic resonance imaging of whole, anterior and posterior hippocampal volumes in behaviorally depressed cynomolgus macaques [abstract]. Biol Psychiatry. 2010;67(9 Suppl):52S.

Willard SL, Shively CA. Social factors influence behavior, pathophysiology, and disease susceptibility in adult female cynomolgus macaques (Macaca fascicularis) [abstract]. Am J Primatol. 2010;72(Suppl 1):44.

Schnatz PF, Shively CA, Millan L, Powell A, O'Sullivan DM, Clarkson TB. The association of cardiovascular disease and depression in menopausal age women: translational findings [abstract]. Menopause. 2010;17(6):1240.

Shively CA. Sex hormones, mood, and cognition In: Koob GF, Le Moal M, Thompson RF, eds. Encyclopedia of behavioral neuroscience, vol 3. London (UK): Academic Press;2010: 196-200.

Shively CA, Musselman DL, Willard SL. Stress, depression, and coronary artery disease: modeling comorbidity in female primates. Neurosci Biobehav Rev. 2009;33(2):133-144.

Sgoifo A, Montano N, Shively C, Thayer J, Steptoe A. The inevitable link between heart and behavior: new insights from biomedical research and implications for clinical practice [editorial]. Neurosci Biobehav Rev. 2009;33(2):61-62.

Shively CA, Register TC, Clarkson TB. Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptation. Am J Primatol. 2009;71(9):742-751.


Shively CA, Register TC, Clarkson TB. Social stress, visceral obesity, and coronary artery atherosclerosis in female primates.. Obesity (Silver Spring). 2009;17(8):1513-1520.

Willard SL, Friedman DP, Henkel CK, Shively CA. Anterior hippocampal volume is reduced in behaviorally depressed female cynomolgus macaques. Psychoneuroendocrinology. 2009;34(10):1469-1475.

Shively CA, Register TC, Kritchevsky S, Carr JJ, Kaplan JR, Jorgensen MJ, Bennett AJ. A primate model of physical function [abstract]. Gerontologist. 2009;49(Suppl 2):65-66.

Willard SL, Glover EJ, Friedman DP, Henkel CK, Shively CA. Anterior hippocampal volume is reduced in behaviorally depressed female macaca fascicularis living in social groups [abstract]. Am J Primatol. 2008;70(Suppl 1):25.

Shively CA, Register TC, Willard SL. Behavioral adaptation to social rank change in adult female macaca fascicularis [abstract]. Am J Primatol. 2008;70(Suppl 1):62.

Arifin E, Shively CA, Register TC, Cline JM. Polycystic ovary syndrome with endometrial hyperplasia in a cynomolgus monkey (Macaca fascicularis). Vet Pathol. 2008;45(4):512-515.

Shively CA, Register TC, Adams MR, Golden DL, Willard SL, Clarkson TB. Depressive behavior and coronary artery atherogenesis in adult female cynomolgus monkeys. Psychosom Med. 2008;70(6):637-645.

Shively CA, Register TC, Adams MR, Golden DL, Willard SL, Clarkson TB. Depressive behavior and coronary artery atherogenesis in adult female cynomolgus monkeys [abstract]. Menopause. 2008;15(6):1211.

Shively CA, Mietus JE, Grant KA, Goldberger AL, Bennett AJ, Willard SL. Effects of chronic moderate alcohol consumption and novel environment on heart rate variability in primates (Macaca fascicularis). Psychopharmacology (Berl). 2007;192(2):183-191.

Willard SL, Shively CA. Effects of social status on differences in mothering style in Macaca fascicularis [abstract]. Am J Primatol. 2007;69(Suppl 1):64.

Shively CA, Clarkson TB. Contributions of a macaque model of women's health [abstract]. Am J Primatol. 2007;69(Suppl 1):69-70.

Register TC, Walker SE, Shively CA, Adams MR, Kaplan JR, Appt SE, Clarkson TB. Inflammation and atherogenesis in female cynomolgus macaques (Macaca fascicularis) [abstract]. Am J Primatol. 2007;69(Suppl 1):72.

Shively CA, Register TC, Adams MR, Golden DL, Willard SL, Clarkson TB. Depression and coronary artery atherosclerosis in adult female Macaca fascicularis [abstract]. Am J Primatol. 2007;69(Suppl 1):73.

Glover EJ, Willard SL, Davenport AT, Thompson J, Friedman DP, Higley JD, DePetrillo PB, Singley E, Shively CA. 5-HT1A receptor binding is increased in the hippocampus of depressed cynomolgus macaques (Macaca fascicularis) [abstract]. Am J Primatol. 2007;69(Suppl 1):105.

Shively CA, Wood CE, Register TC, Willard SL, Lees CJ, Chen H, Sitruk-Ware RL, Tsong Y-Y, Cline JM. Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys. Psychoneuroendocrinology. 2007;32(8-10):981-990.

Willard SL, Glover EJ, Friedman DP, Henkel CK, Shively CA. Reduced anterior hippocampal volume in behaviorally depressed female cynomolgus macaques (Macaca fascicularis) [abstract]. Soc Neurosci Abstr. 2007;2007(Abstr Viewer):.

Shively CA. Reproduction, effects of social stress on In: Fink G, ed. Encyclopedia of stress, vol 3. 2nd ed. Boston: Elsevier/Academic Press;2007: 360-365.

Shively CA, Register TC, Friedman DP, Gage HD, Bounds MC, Clarkson TB. Neurobiological substrates of a relationship between depression and atherosclerosis in adult female cynomolgus monkeys (Macaca fascicularis) [abstract]. Am J Primatol. 2006;68(Suppl 1):36-37.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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