Sean L. Simpson, Ph.D.Wake Forest School of Medicine

Sean L. Simpson, Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-8369 | Department: 336-716-2011


Additional Languages


Education & Training

  • B.A., Harvard University, 2002
  • Ph.D., University of North Carolina-Chapel Hill, 2008


  • Am Statistical Assoc
  • Biometric Society
Sean L. Simpson, Ph.D.

Sean L. Simpson, Ph.D.

Associate Professor, Biostatistical Sciences
Maya Angelou Center for Health Equity

Research Interests

mental disorders/psychiatry/ps, neurosciences/behavior, radiology imaging/nuclear medi, statistics/mathematics

Contact Information

Academic: 336-716-8369 | Department: 336-716-2011


Recent Publications

Fetterhoff D, Opris I, Simpson SL, Deadwyler SA, Hampson RE, Kraft RA. Multifractal analysis of information processing in hippocampal neural ensembles during working memory under Delta(9)-tetrahydrocannabinol administration. J Neurosci Methods. 2015;244():136-153.

Moussa MN, Simpson SL, Mayhugh RE, Grata ME, Burdette JH, Porrino LJ, Laurienti PJ. Long-term moderate alcohol consumption does not exacerbate age-related cognitive decline in healthy, community-dwelling older adults. Front Aging Neurosci. 2015;6():341.

Simpson SL, Laurienti PJ. A two-part mixed-effects modeling framework for analyzing whole-brain network data. Neuroimage. 2015;113():310-319.

Stanley ML, Simpson SL, Dagenbach D, Lyday RG, Burdette JH, Laurienti PJ. Changes in brain network efficiency and working memory performance in aging. PLoS One. 2015;10(4):e0123950.

Paolini BM, Laurienti PJ, Simpson SL, Burdette JH, Lyday RG, Rejeski WJ. Global integration of the hot-state brain network of appetite predicts short term weight loss in older adult. Front Aging Neurosci. 2015;7():70.

Telesford QK, Simpson SL, Kolaczyk ED. Editorial: complexity and emergence in brain network analyses. Front Comput Neurosci. 2015;9():65.

Ip EH, Zhang Q, Sowinski T, Simpson SL. Analysis of feedback mechanisms with unknown delay using sparse multivariate autoregressive method. PLoS One. 2015;10(8):e0131371.

Simpson SL, Edwards LJ, Styner MA, Muller KE. Kronecker product linear exponent AR(1) correlation structures for multivariate repeated measures. PLoS One. 2014;9(2):e88864.

Edwards LJ, Simpson SL. An analysis of 24-h ambulatory blood pressure monitoring data using orthonormal polynomials in the linear mixed model. Blood Press Monit. 2014;19(3):153-163.

McCrory MC, Gower EW, Simpson SL, Nakagawa TA, Mou SS, Morris PE. Off-hours admission to pediatric intensive care and mortality. Pediatrics. 2014;134(5):e1345-1353.

Simpson SL, Edwards LJ. A circular LEAR correlation structure for cyclical longitudinal data. Stat Methods Med Res. 2013;22(3):296-306.

Bruce MA, Beech BM, Crook ED, Sims M, Griffith DM, Simpson SL, Ard J, Norris KC. Sex, weight status, and chronic kidney disease among African Americans: the Jackson Heart Study. J Investig Med. 2013;61(4):701-707.

Simpson SL, Bowman FD, Laurienti PJ. Analyzing complex functional brain networks: fusing statistics and network science to understand the brain. Stat Surv. 2013;7():1-36.

Simpson SL, Lyday RG, Hayasaka S, Marsh AP, Laurienti PJ. A permutation testing framework to compare groups of brain networks. Front Comput Neurosci. 2013;7():171.

Vaughan L, Leng I, Dagenbach D, Resnick SM, Rapp SR, Jennings JM, Brunner RL, Simpson SL, Beavers DP, Coker LH, Gaussoin SA, Sink KM, Espeland MA. Intraindividual variability in domain-specific cognition and risk of mild cognitive impairment and dementia. Curr Gerontol Geriatr Res. 2013;():495793.

McCrory M, Gower E, Morris P, Simpson S. Off-hours admission and mortality in pediatric intensive care [abstract]. Crit Care Med. 2013;41(12 Suppl 1):A135.

Simpson SL, Moussa MN, Laurienti PJ. An exponential random graph modeling approach to creating group-based representative whole-brain connectivity networks. Neuroimage. 2012;60(2):1117-1126.

Webb BC, Simpson SL, Hairston KG. From politics to parity: using a health disparities index to guide legislative efforts for health equity. Am J Public Health. 2011;101(3):554-560.

Simpson SL, Hayasaka S, Laurienti PJ. Exponential random graph modeling for complex brain networks. PLoS ONE. 2011;6(5):e20039.

Telesford QK, Simpson SL, Burdette JH, Hayasaka S, Laurienti PJ. The brain as a complex system: using network science as a tool for understanding the brain. Brain Connect. 2011;1(4):295-308.

Thomas KB, Simpson SL, Tarver WL, Gwede CK. Is social support from family associated with PSA testing? An exploratory analysis using the Health Information National Trends Survey (HINTS) 2005. Am J Mens Health. 2010;4(1):50-59.

Simpson SL, Edwards LJ, Muller KE, Sen PK, Styner MA. A linear exponent AR1 family of correlation structures. Stat Med. 2010;29(17):1825-1838.

Slager RE, Simpson SL, LeVan TD, Poole JA, Sandler DP, Hopping JA. Rhinitis associated with pesticide use among private pesticide applicators in the Agricultural Health Study. J Toxicol Environ Health A. 2010;73(20):1382-1393.

Telesford QK, Morgan AR, Hayasaka S, Simpson SL, Barret W, Kraft RA, Mozolic JL, Laurienti PJ. Reproducibility of graph metrics in fMRI networks. Front Neuroinform. 2010;4():117.

Simpson SL. An adjusted likelihood ration test for separability in unbalanced multivariate repeated measures data. Stat Methodol. 2010;7():511-519.

Johnson JL, Muller KE, Slaughter JC, Gurka MJ, Gribbin MJ, Simpson SL. POWERLIB: SAS/IML software for computing power in multivariate linear models. J Stat Softw. 2009;30(5):1-27.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Biostatistical Sciences

Sean L. Simpson, Ph.D.

Sean L. Simpson, Ph.D.

Associate Professor, Biostatistical Sciences
Maya Angelou Center for Health Equity

Quick Reference

Request an Appointment
New Patients


Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
USNWR 2015-2016Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.