Sean L. Simpson, Ph.D.Wake Forest School of Medicine

Sean L. Simpson, Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-8369 | Department: 336-716-2011


Additional Languages


Education & Training

  • B.A., Harvard University, 2002
  • Ph.D., University of North Carolina-Chapel Hill, 2008


  • Am Statistical Assoc
  • Biometric Society
Sean L. Simpson, Ph.D.

Sean L. Simpson, Ph.D.

Associate Professor, Biostatistical Sciences

Research Interests

mental disorders/psychiatry/ps, neurosciences/behavior, radiology imaging/nuclear medi, statistics/mathematics

Contact Information

Academic: 336-716-8369 | Department: 336-716-2011


Recent Publications

Fetterhoff D, Opris I, Simpson SL, Deadwyler SA, Hampson RE, Kraft RA. Multifractal analysis of information processing in hippocampal neural ensembles during working memory under Delta(9)-tetrahydrocannabinol administration. J Neurosci Methods. 2015;244():136-153.

Moussa MN, Simpson SL, Mayhugh RE, Grata ME, Burdette JH, Porrino LJ, Laurienti PJ. Long-term moderate alcohol consumption does not exacerbate age-related cognitive decline in healthy, community-dwelling older adults. Front Aging Neurosci. 2015;6():341.

Simpson SL, Laurienti PJ. A two-part mixed-effects modeling framework for analyzing whole-brain network data. Neuroimage. 2015;113():310-319.

Stanley ML, Simpson SL, Dagenbach D, Lyday RG, Burdette JH, Laurienti PJ. Changes in brain network efficiency and working memory performance in aging. PLoS One. 2015;10(4):e0123950.

Paolini BM, Laurienti PJ, Simpson SL, Burdette JH, Lyday RG, Rejeski WJ. Global integration of the hot-state brain network of appetite predicts short term weight loss in older adult. Front Aging Neurosci. 2015;7():70.

Telesford QK, Simpson SL, Kolaczyk ED. Editorial: complexity and emergence in brain network analyses. Front Comput Neurosci. 2015;9():65.

Ip EH, Zhang Q, Sowinski T, Simpson SL. Analysis of feedback mechanisms with unknown delay using sparse multivariate autoregressive method. PLoS One. 2015;10(8):e0131371.

Simpson SL, Laurienti PJ. Disentangling brain graphs: a note on the conflation of network and connectivity analyses. Brain Connect. 2015;():.

Simpson SL, Burdette JH, Laurienti PJ. The brain science interface. Signif (Oxf). 2015;12(4):34-39.

Simpson SL, Edwards LJ, Styner MA, Muller KE. Kronecker product linear exponent AR(1) correlation structures for multivariate repeated measures. PLoS One. 2014;9(2):e88864.

Edwards LJ, Simpson SL. An analysis of 24-h ambulatory blood pressure monitoring data using orthonormal polynomials in the linear mixed model. Blood Press Monit. 2014;19(3):153-163.

McCrory MC, Gower EW, Simpson SL, Nakagawa TA, Mou SS, Morris PE. Off-hours admission to pediatric intensive care and mortality. Pediatrics. 2014;134(5):e1345-1353.

Simpson SL, Edwards LJ. A circular LEAR correlation structure for cyclical longitudinal data. Stat Methods Med Res. 2013;22(3):296-306.

Bruce MA, Beech BM, Crook ED, Sims M, Griffith DM, Simpson SL, Ard J, Norris KC. Sex, weight status, and chronic kidney disease among African Americans: the Jackson Heart Study. J Investig Med. 2013;61(4):701-707.

Simpson SL, Bowman FD, Laurienti PJ. Analyzing complex functional brain networks: fusing statistics and network science to understand the brain. Stat Surv. 2013;7():1-36.

Simpson SL, Lyday RG, Hayasaka S, Marsh AP, Laurienti PJ. A permutation testing framework to compare groups of brain networks. Front Comput Neurosci. 2013;7():171.

Vaughan L, Leng I, Dagenbach D, Resnick SM, Rapp SR, Jennings JM, Brunner RL, Simpson SL, Beavers DP, Coker LH, Gaussoin SA, Sink KM, Espeland MA. Intraindividual variability in domain-specific cognition and risk of mild cognitive impairment and dementia. Curr Gerontol Geriatr Res. 2013;():495793.

McCrory M, Gower E, Morris P, Simpson S. Off-hours admission and mortality in pediatric intensive care [abstract]. Crit Care Med. 2013;41(12 Suppl 1):A135.

Simpson SL, Moussa MN, Laurienti PJ. An exponential random graph modeling approach to creating group-based representative whole-brain connectivity networks. Neuroimage. 2012;60(2):1117-1126.

Webb BC, Simpson SL, Hairston KG. From politics to parity: using a health disparities index to guide legislative efforts for health equity. Am J Public Health. 2011;101(3):554-560.

Simpson SL, Hayasaka S, Laurienti PJ. Exponential random graph modeling for complex brain networks. PLoS ONE. 2011;6(5):e20039.

Telesford QK, Simpson SL, Burdette JH, Hayasaka S, Laurienti PJ. The brain as a complex system: using network science as a tool for understanding the brain. Brain Connect. 2011;1(4):295-308.

Thomas KB, Simpson SL, Tarver WL, Gwede CK. Is social support from family associated with PSA testing? An exploratory analysis using the Health Information National Trends Survey (HINTS) 2005. Am J Mens Health. 2010;4(1):50-59.

Simpson SL, Edwards LJ, Muller KE, Sen PK, Styner MA. A linear exponent AR1 family of correlation structures. Stat Med. 2010;29(17):1825-1838.

Slager RE, Simpson SL, LeVan TD, Poole JA, Sandler DP, Hopping JA. Rhinitis associated with pesticide use among private pesticide applicators in the Agricultural Health Study. J Toxicol Environ Health A. 2010;73(20):1382-1393.

Telesford QK, Morgan AR, Hayasaka S, Simpson SL, Barret W, Kraft RA, Mozolic JL, Laurienti PJ. Reproducibility of graph metrics in fMRI networks. Front Neuroinform. 2010;4():117.

Simpson SL. An adjusted likelihood ration test for separability in unbalanced multivariate repeated measures data. Stat Methodol. 2010;7():511-519.

Johnson JL, Muller KE, Slaughter JC, Gurka MJ, Gribbin MJ, Simpson SL. POWERLIB: SAS/IML software for computing power in multivariate linear models. J Stat Softw. 2009;30(5):1-27.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Biostatistical Sciences

Sean L. Simpson, Ph.D.

Sean L. Simpson, Ph.D.

Associate Professor, Biostatistical Sciences

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