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Aleksander Skardal, Ph.D.Wake Forest School of Medicine

Aleksander Skardal, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-1649

Email: askardal@wakehealth.edu

Education & Training

  • B.Sc., Johns Hopkins University, 2005
  • Fellowship, WFU School of Medicine, 2014
Aleksander Skardal, Ph.D.

Aleksander Skardal, Ph.D.

Assistant Professor, Institute for Regenerative Medicine
Cancer Biology

Research Interests

Organoids; Hyaluronic Acid; Hydrogels; Models, Biological; Tissue Engineering
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Contact Information

Academic: 336-713-1649

Email: askardal@wakehealth.edu

Recent Publications

In vitro patient-derived 3D mesothelioma tumor organoids facilitate patient-centric therapeutic screening. Mazzocchi AR, Rajan SAP, Votanopoulos KI, Hall AR, Skardal A.. Sci Rep. 2018;8(1):2886.

Hyaluronan chemistries for three-dimensional matrix applications. Serban MA, Skardal A.. Matrix Biol. 2018;():.

Applications of bioengineered 3D tissue and tumor organoids in drug development and precision medicine: current and future. Devarasetty M, Mazzocchi AR, Skardal A.. BioDrugs. 2018;32(1):53-68.

Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor. Rivas F, Zahid OK, Reesink HL, Peal BT, Nixon AJ, DeAngelis PL, Skardal A, Rahbar E, Hall AR.. Nat Commun. 2018;9(1):1037.

A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery. Skardal A, Murphy SV, Crowell K, Mack D, Atala A, Soker S.. J Biomed Mater Res B Appl Biomater. 2017;105(7):1986-2000.

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors. Zhang YS, Aleman J, Shin SR, Kilic T, Kim D, Mousavi Shaegh SA, Massa S, Riahi R, Chae S, Hu N, Avci H, Zhang W, Silvestri A, Sanati Nezhad A, Manbohi A, De Ferrari F, Polini A, Calzone G, Shaikh N, Alerasool P, Budina E, Kang J, Bhise N, Ribas J,.. Proc Natl Acad Sci U S A. 2017;114(12):E2293-2302.

Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy. Devarasetty M, Wang E, Soker S, Skardal A.. Biofabrication. 2017;9(2):021002.

Optical tracking and digital quantification of beating behavior in bioengineered human cardiac organoids. Devarasetty M, Forsythe S, Shupe TD, Soker S, Bishop CE, Atala A, Skardal A.. Biosensors (Basel). 2017;7(3):E24.

Tissue-specific extracellular matrix promotes myogenic differentiation of human muscle progenitor cells on gelatin and heparin conjugated alginate hydrogels. Yi H, Forsythe S, He Y, Liu Q, Xiong G, Wei S, Li G, Atala A, Skardal A, Zhang Y.. Acta Biomater. 2017;62():222-233.

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform. Skardal A, Murphy SV, Devarasetty M, Mead I, Kang HW, Seol YJ, Shrike Zhang Y, Shin SR, Zhao L, Aleman J, Hall AR, Shupe TD, Kleensang A, Dokmeci MR, Jin Lee S, Jackson JD, Yoo JJ, Hartung T, Khademhosseini A, Soker S, Bishop CE, Atala A.. Sci Rep. 2017;7(1):8837.

Bioengineered submucosal organoids for in vitro modeling of colorectal cancer. Devarasetty M, Skardal A, Cowdrick K, Marini F, Soker S.. Tissue Eng Part A. 2017;23(19-20):1026-1041.

Solubilized amnion membrane hyaluronic acid hydrogel accelerates full-thickness wound healing. Murphy SV, Skardal A, Song L, Sutton K, Haug R, Mack DL, Jackson J, Soker S, Atala A.. Stem Cells Transl Med. 2017;6(11):2020-2032.

Exploring normal and malignant hematopoietic stem/progenitos cell-niche interactions using a novel bone marrow-on-a-chip platform [abstract]. Aleman J, George SK, Porada CD, Almeida-Porada G, Skardal A.. Tissue Eng Part A. 2017;23(Suppl 1):S152.

Rheology vs alignment: two operators of the mechanical tumor microenvironment [abstract]. Devarasetty M, Skardal A, Soker S.. Tissue Eng Part A. 2017;23(Suppl 1):S59.

Drug and environmental toxin screening in bioengineered liver and cardiac tissue analogs [abstract]. Forsythe S, Devarasetty M, Shupe T, Bishop C, Soker S, Atala A, Skardal A.. Tissue Eng Part A. 2017;23(Suppl 1):S83.

A tumor-on-a-chip platform for screening precision driven medicines [abstract]. Forsythe S, Mehta N, Devarasetty M, Mazzochi A, Votanopoulos K, Gmeiner W, Skardal A.. Tissue Eng Part A. 2017;23(Suppl 1):S23.

Hyaluronan-collagen type-I hybrid bioink for 3D printed microenvironments [abstract]. Mazzocchi A, Soker S, Skardal A.. Tissue Eng Part A. 2017;23(Suppl 1):S12-S13.

An in vitro model of glioblastoma [abstract]. Sivakumar H, Skardal A.. Tissue Eng Part A. 2017;23(Suppl 1):S59.

Primary patient mesothelioma organoids for genetic mutation-driven experimental 3-deazaneplanocin a treatment [abstract]. Mazzocchi A, Rajan S, Votanopoulos K, Hall A, Skardal A.. Tissue Eng Part A. 2017;23(Suppl 1):S27.

Primary patient tumor organoids for personalized drug treatment [abstract]. Mazzocchi A, Votanopoulos K, Soker S, Skardal A.. Tissue Eng Part A. 2017;23(Suppl 1):S81.

Adhesive film-based microfluidic device for motility assessment of cancer cells [abstract]. Rajan S, Hambright P, Skardal A, Hall AR.. Tissue Eng Part A. 2017;23(Suppl 1):S115-S116.

Tumor-on-a-chip microfluidic devices for personalized cancer drug testing [abstract]. Rajan S, Mazzocchi AR, Skardal A, Hall AR.. Tissue Eng Part A. 2017;23(Suppl 1):S27.

Adhesive film based multi-organoid body-on-a-chip platform for assessing drug efficiency and toxicity [abstract]. Rajan S, Aleman J, Wan M, Zarandi NP, Gandhi U, Nzou G, Bishop CE, Sadri-Ardekani H, Murphy S, Atala A, Skardal A, Hall AR.. Tissue Eng Part A. 2017;23(Suppl 1):S116.

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform [abstract]. Devarasetty M, Forsythe S, Murphy S, Shupe T, Lee S, Jackson J, Yoo J, Soker S, Bishop C, Atala A, Skardal A.. Tissue Eng Part A. 2017;23(Suppl 1):S32.

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening. Skardal A, Devarasetty M, Forsythe S, Atala A, Soker S.. Biotechnol Bioeng. 2016;113(9):2020-2032.

Bioprinting cellularized constructs using a tissue-specific hydrogel bioink [video article]. Skardal A, Devarasetty M, Kang HW, Seol YJ, Forsythe SD, Bishop C, Shupe T, Soker S, Atala A.. J Vis Exp. 2016;(110):e53606.

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling. Skardal A, Shupe T, Atala A.. Drug Discov Today. 2016;21(9):1399-1411.

Multiple organ-on-a-chip platform for metastasis dynamic studies [abstract]. Aleman J, Skardal A.. Tissue Eng Part A. 2016;22(Suppl 1):S36.

Lego-inspired organ-on-a-chip gelatin methacryloyl microfluidic system [abstract]. Aleman J, Zhang Y, Skardal A, Khademhosseini A.. Tissue Eng Part A. 2016;22(Suppl 1):S65.

A 3D submucosal microenvironment for investigation of topography induced effects in colorectal cancer cells [abstract]. Devarasetty M, Skardal A, Soker S.. Tissue Eng Part A. 2016;22(Suppl 1):S132.

Microfluidic device for motility and biochemical assessment in parallel drug testing [abstract]. Rajan S, Hambright P, Skardal A, Hall AR.. Tissue Eng Part A. 2016;22(Suppl 1):S132-S133.

An in vitro model of glioblastoma and the brain tumor microenvironment [abstract]. Sivakumar H, Devarasetty M, Skardal A.. Tissue Eng Part A. 2016;22(Suppl 1):S44.

A tumor-on-a-chip platform for screening precision medicine-driven therapies [abstract]. Forsythe S, Mehta N, Alistar A, Hall A, Skardal A.. Tissue Eng Part A. 2016;22(Suppl 1):S35-S36.

A bioengineered multi-organoid body-on-a-chip platform for advanced drug screening [abstract]. Devarasetty M, Forsythe S, Murphy, S, Shupe T, Lee S, Jackson J, Yoo J, Soker S, Bishop C, Skardal A, Atala A.. Tissue Eng Part A. 2016;22(Suppl 1):S22-S23.

Biomaterials for integration with 3-D bioprinting. Skardal A, Atala A.. Ann Biomed Eng. 2015;43(3):730-746.

Liver-tumor hybrid organoids for modeling tumor growth and drug response in vitro. Skardal A, Devarasetty M, Rodman C, Atala A, Soker S.. Ann Biomed Eng. 2015;43(10):2361-2373.

A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs. Skardal A, Devarasetty M, Kang HW, Mead I, Bishop C, Shupe T, Lee SJ, Jackson J, Yoo J, Soker S, Atala A.. Acta Biomater. 2015;25():24-34.

Bioprinting essentials of cell and protein viability. Skardal A. In: Atala A, Yoo JJ, eds. Essentials of 3D biofabrication and translation. London (UK): Elsevier/Academic Press;2015: 1-17.

Ultra-thin tissue-tumor organoid microfluidic platforms for in vitro diagnostics [abstract]. Devarasetty M, Forsythe S, Soker S, Hall A, Skardal A.. Tissue Eng Part A. 2015;21(Suppl 1):S262-S263.

A 3D stratified colon model for colorectal cancer progression [abstract]. Devarasetty M, Skardal A, Soker S.. Tissue Eng Part A. 2015;21(Suppl 1):S196.

Amnion membrane hydrogel accelerates skin wound healing [abstract]. Murphy S, Skardal A, Sutton K, Reid T, Song L, Jackson J, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S155.

In situ patterned micro 3D liver constructs for parallel toxicology testing in a fluidic device. Skardal A, Devarasetty M, Soker S, Hall AR.. Biofabrication. 2015;7(3):031001.

3-D bioprinting of tissue organoids for body-on-a-chip drug screening platform [abstract]. Seol Y, Kang H, Lee S, Jackson JD, Skardal A, Shupe T, Soker S, Bishop C, Yoo JJ, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S369.

A hydrogel bioink toolkit for bioprinting tissue constructs while mimicking native tissue biochemical and mechanical properties [abstract]. Skardal A, Devarasetty M, Kang H, Mead I, Bishop C, Shupe T, Lee S, Jackson J, Yoo J, Soker S, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S212.

Physiologically relevant drug testing in vitro - an integrated multiple organoid-on-a-chip approach [abstract]. Skardal A, Kleensang A, Devarasetty M, Kang H, Mead I, Bishop C, Shupe T, Lee S, Jackson J, Yoo J, Hartung T, Soker S, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S362.

Bio-functionalized alginate hydrogels for improved cell-matrix interactions and growth factor sequestration kinetics [abstract]. Yi H, Forsythe S, Zhang Y, Skardal A.. Tissue Eng Part A. 2015;21(Suppl 1):S187.

Stiffness of hyaluronic acid gels containing liver extracellular matrix supports human hepatocyte function and alters cell morphology. Deegan DB, Zimmerman C, Skardal A, Atala A, Shupe TD.. J Mech Behav Biomed Mater. 2015;55():87-103.

Heparin-modified gelatin scaffolds for human corneal endothelial cell transplantation. Niu G, Choi JS, Wang Z, Skardal A, Giegengack M, Soker S.. Biomaterials. 2014;35(13):4005-4014.

A metastasis-on-a-chip system for modeling colon carcinoma migration and invasion in vitro [abstract]. Devarasetty M, Atala A, Soker S, Skardal A.. Tissue Eng Part A. 2014;20(Suppl 1):S15.

Modeling the colon-tumor microenvironment using multicellular hydrogel strata [abstract]. Devarasetty M, Skardal A, Soker S.. Tissue Eng Part A. 2014;20(Suppl 1):S77.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Aleksander Skardal, Ph.D.

Aleksander Skardal, Ph.D.

Assistant Professor, Institute for Regenerative Medicine
Cancer Biology

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