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Aleksander Skardal, Ph.D.Wake Forest School of Medicine

Aleksander Skardal, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-1649 | Department: 336-713-1493

Email: askardal@wakehealth.edu

Education & Training

  • B.Sc., Johns Hopkins University, 2005
  • Fellowship, WFU School of Medicine, 2014
Aleksander Skardal, Ph.D.

Aleksander Skardal, Ph.D.

Assistant Professor, Institute for Regenerative Medicine
Cancer Biology

Research Interests

Hyaluronic Acid; Hydrogels; Hydrogel; Tissue Engineering; Tissue Scaffolds
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Contact Information

Academic: 336-713-1649 | Department: 336-713-1493

Email: askardal@wakehealth.edu

Recent Publications

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors. Zhang YS, Aleman J, Shin SR, Kilic T, Kim D, Mousavi Shaegh SA, Massa S, Riahi R, Chae S, Hu N, Avci H, Zhang W, Silvestri A, Sanati Nezhad A, Manbohi A, De Ferrari F, Polini A, Calzone G, Shaikh N, Alerasool P, Budina E, Kang J, Bhise N, Ribas J,.. Proc Natl Acad Sci U S A. 2017;114(12):E2293-2302.

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening. Skardal A, Devarasetty M, Forsythe S, Atala A, Soker S.. Biotechnol Bioeng. 2016;113(9):2020-2032.

Bioprinting cellularized constructs using a tissue-specific hydrogel bioink [video article]. Skardal A, Devarasetty M, Kang HW, Seol YJ, Forsythe SD, Bishop C, Shupe T, Soker S, Atala A.. J Vis Exp. 2016;(110):e53606.

A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery. Skardal A, Murphy SV, Crowell K, Mack D, Atala A, Soker S.. J Biomed Mater Res B Appl Biomater. 2016;():.

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling. Skardal A, Shupe T, Atala A.. Drug Discov Today. 2016;21(9):1399-1411.

Multiple organ-on-a-chip platform for metastasis dynamic studies [abstract]. Aleman J, Skardal A.. Tissue Eng Part A. 2016;22(Suppl 1):S36.

Lego-inspired organ-on-a-chip gelatin methacryloyl microfluidic system [abstract]. Aleman J, Zhang Y, Skardal A, Khademhosseini A.. Tissue Eng Part A. 2016;22(Suppl 1):S65.

A 3D submucosal microenvironment for investigation of topography induced effects in colorectal cancer cells [abstract]. Devarasetty M, Skardal A, Soker S.. Tissue Eng Part A. 2016;22(Suppl 1):S132.

Microfluidic device for motility and biochemical assessment in parallel drug testing [abstract]. Rajan S, Hambright P, Skardal A, Hall AR.. Tissue Eng Part A. 2016;22(Suppl 1):S132-S133.

An in vitro model of glioblastoma and the brain tumor microenvironment [abstract]. Sivakumar H, Devarasetty M, Skardal A.. Tissue Eng Part A. 2016;22(Suppl 1):S44.

A tumor-on-a-chip platform for screening precision medicine-driven therapies [abstract]. Forsythe S, Mehta N, Alistar A, Hall A, Skardal A.. Tissue Eng Part A. 2016;22(Suppl 1):S35-S36.

A bioengineered multi-organoid body-on-a-chip platform for advanced drug screening [abstract]. Devarasetty M, Forsythe S, Murphy, S, Shupe T, Lee S, Jackson J, Yoo J, Soker S, Bishop C, Skardal A, Atala A.. Tissue Eng Part A. 2016;22(Suppl 1):S22-S23.

Biomaterials for integration with 3-D bioprinting. Skardal A, Atala A.. Ann Biomed Eng. 2015;43(3):730-746.

Liver-tumor hybrid organoids for modeling tumor growth and drug response in vitro. Skardal A, Devarasetty M, Rodman C, Atala A, Soker S.. Ann Biomed Eng. 2015;43(10):2361-2373.

A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs. Skardal A, Devarasetty M, Kang HW, Mead I, Bishop C, Shupe T, Lee SJ, Jackson J, Yoo J, Soker S, Atala A.. Acta Biomater. 2015;25():24-34.

Bioprinting essentials of cell and protein viability. Skardal A. In: Atala A, Yoo JJ, eds. Essentials of 3D biofabrication and translation. London (UK): Elsevier/Academic Press;2015: 1-17.

Ultra-thin tissue-tumor organoid microfluidic platforms for in vitro diagnostics [abstract]. Devarasetty M, Forsythe S, Soker S, Hall A, Skardal A.. Tissue Eng Part A. 2015;21(Suppl 1):S262-S263.

A 3D stratified colon model for colorectal cancer progression [abstract]. Devarasetty M, Skardal A, Soker S.. Tissue Eng Part A. 2015;21(Suppl 1):S196.

Amnion membrane hydrogel accelerates skin wound healing [abstract]. Murphy S, Skardal A, Sutton K, Reid T, Song L, Jackson J, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S155.

In situ patterned micro 3D liver constructs for parallel toxicology testing in a fluidic device. Skardal A, Devarasetty M, Soker S, Hall AR.. Biofabrication. 2015;7(3):031001.

3-D bioprinting of tissue organoids for body-on-a-chip drug screening platform [abstract]. Seol Y, Kang H, Lee S, Jackson JD, Skardal A, Shupe T, Soker S, Bishop C, Yoo JJ, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S369.

A hydrogel bioink toolkit for bioprinting tissue constructs while mimicking native tissue biochemical and mechanical properties [abstract]. Skardal A, Devarasetty M, Kang H, Mead I, Bishop C, Shupe T, Lee S, Jackson J, Yoo J, Soker S, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S212.

Physiologically relevant drug testing in vitro - an integrated multiple organoid-on-a-chip approach [abstract]. Skardal A, Kleensang A, Devarasetty M, Kang H, Mead I, Bishop C, Shupe T, Lee S, Jackson J, Yoo J, Hartung T, Soker S, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S362.

Bio-functionalized alginate hydrogels for improved cell-matrix interactions and growth factor sequestration kinetics [abstract]. Yi H, Forsythe S, Zhang Y, Skardal A.. Tissue Eng Part A. 2015;21(Suppl 1):S187.

Stiffness of hyaluronic acid gels containing liver extracellular matrix supports human hepatocyte function and alters cell morphology. Deegan DB, Zimmerman C, Skardal A, Atala A, Shupe TD.. J Mech Behav Biomed Mater. 2015;55():87-103.

Heparin-modified gelatin scaffolds for human corneal endothelial cell transplantation. Niu G, Choi JS, Wang Z, Skardal A, Giegengack M, Soker S.. Biomaterials. 2014;35(13):4005-4014.

A metastasis-on-a-chip system for modeling colon carcinoma migration and invasion in vitro [abstract]. Devarasetty M, Atala A, Soker S, Skardal A.. Tissue Eng Part A. 2014;20(Suppl 1):S15.

Modeling the colon-tumor microenvironment using multicellular hydrogel strata [abstract]. Devarasetty M, Skardal A, Soker S.. Tissue Eng Part A. 2014;20(Suppl 1):S77.

Amnion hydrogel accelerates skin wound healing [abstract]. Murphy SV, Skardal A, Sutton K, Reid T, Rebecca H, Song L, Jackson J, Atala A.. Tissue Eng Part A. 2014;20(Suppl 1):S85.

A microfluidic platform for parallel analysis of in situ patterned 3-D liver organoids [abstract]. Skardal A, Devarasetty M, Atala A, Soker S, Hall A.. Tissue Eng Part A. 2014;20(Suppl 1):S68-S69.

An in vitro 3-D liver-tumor hybrid organoid system for modeling metastasis and drug resistance [abstract]. Skardal A, Devarasetty M, Rodman C, Atala A, Soker S.. Tissue Eng Part A. 2014;20(Suppl 1):S15.

Integration of 3-D organoid bioprinting and microfluidic device technology for functional primary cell-based liver-on-a-chip operation [abstract]. Skardal A, Mead I, Devarasetty M, Kang H, Shupe T, Lee S, Jackson JD, Bishop CE, Yoo JJ, Soker S, Atala A.. Tissue Eng Part A. 2014;20(Suppl 1):S43.

Substrate elasticity controls cell proliferation, surface marker expression and motile phenotype in amniotic fluid-derived stem cells. Skardal A, Mack D, Atala A, Soker S.. J Mech Behav Biomed Mater. 2013;17():307-316.

Evaluation of hydrogels for bio-printing applications. Murphy SV, Skardal A, Atala A.. J Biomed Mater Res A. 2013;101(1):272-284.

How stiff is it? Characterizing the micro-scale elastic modulus of hydrogels for use in regenerative medicine [abstract]. Markert CD, Guo X, Skardal A, Bharadwaj S, Zhang Y, Bonin K, Guthold M.. FASEB J. 2013;27():1217.21.

Characterizing the micro-scale elastic modulus of hydrogels for use in regenerative medicine. Markert CD, Guo X, Skardal A, Wang Z, Bharadwaj S, Zhang Y, Bonin K, Guthold M.. J Mech Behav Biomed Mater. 2013;27():115-127.

Tissue specific synthetic ECM hydrogels for 3-D in vitro maintenance of hepatocyte function. Skardal A, Smith L, Bharadwaj S, Atala A, Soker S, Zhang Y.. Biomaterials. 2012;33(18):4565-4575.

Bioprinted amniotic fluid-derived stem cells accelerate wound healing in skin [abstract]. Mack DL, Skardal A, Yoo J, Soker S.. Mol Ther. 2012;20(Suppl 1):S285.

Bioprinted amniotic fluid-derived stem cells accelerate healing of large skin wounds. Skardal A, Mack D, Kapetanovic E, Atala A, Jackson JD, Yoo J, Soker S.. Stem Cells Transl Med. 2012;1(11):792-802.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Aleksander Skardal, Ph.D.

Aleksander Skardal, Ph.D.

Assistant Professor, Institute for Regenerative Medicine
Cancer Biology

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