Thomas L. Smith, Ph.D.Wake Forest School of Medicine

Thomas L. Smith, Ph.D.


Contact Information

Academic: 336-716-2093 | Department: 336-716-8200

Education & Training

  • B.S., Texas A&M University, 1971
  • M.S., Texas A&M University, 1975
  • Ph.D., Wake Forest University, 1979
  • Fellowship, University of Mississippi Scho, 1980


  • Am Academy Of Orthopaedic Surg
  • Microcirculatory Society
  • Orthopaedic Research Society
  • Sigma Xi - Research Society
  • Society for Neuroscience
  • Am Heart Association
  • Am Physiological Society
  • Am Soc Of Reconstructive Micro
Thomas L. Smith, Ph.D.

Thomas L. Smith, Ph.D.

Professor, Orthopaedics
Hypertension and Vascular Research Center
Institute for Regenerative Medicine
Physiology & Pharmacology

Research Interests

critical/intensive care medici, health services, research/outc, neurosciences/behavior, surgery/trauma/burns/trauma

Contact Information

Academic: 336-716-2093 | Department: 336-716-8200

Recent Publications

Carver KA, Smith TL, Gallagher PE, Tallant EA. Angiotensin-(1-7) prevents angiotensin II-induced fibrosis in cremaster microvessels. Microcirculation. 2015;22(1):19-27.

Santago AC II, Plate JF, Shively CA, Register TC, Smith TL, Saul KR. Age-related structural changes in upper extremity muscle tissue in a nonhuman primate model. J Shoulder Elbow Surg. 2015;():.

Plate JF, Pace LA, Seyler TM, Moreno RJ, Smith TL, Tuohy CJ, Mannava S. Age-related changes affect rat rotator cuff muscle function. J Shoulder Elbow Surg. 2014;23(1):91-98.

Kowalczewski CJ, Tombyln S, Wasnick DC, Hughes MR, Ellenburg MD, Callahan MF, Smith TL, Van Dyke ME, Burnett LR, Saul JM. Reduction of ectopic bone growth in critically-sized rat mandible defects by delivery of rhBMP-2 from kerateine biomaterials. Biomaterials. 2014;35(10):3220-3228.

Pace LA, Plate JF, Mannava S, Barnwell JC, Koman LA, Li Z, Smith TL, Van Dyke M. A human hair keratin hydrogel scaffold enhances median nerve regeneration in nonhuman primates: an electrophysiological and histological study. Tissue Eng Part A. 2014;20(3-4):507-517.

Plate JF, Brown PJ, Walters J, Clark JA, Smith TL, Freehill MT, Tuohy CJ, Stitzel JD, Mannava S. Advanced age diminishes tendon-to-bone healing in a rat model of rotator cuff repair. Am J Sports Med. 2014;42(4):859-868.

Yamaleyeva LM, Merrill DC, Ebert TJ, Smith TL, Mertz HL, Brosnihan KB. Hemodynamic responses to angiotensin-(1-7) in women in their third trimester of pregnancy. Hypertens Pregnancy. 2014;33(4):375-388.

Bracey DN, Willey JS, Tallant EA, Gallagher PE, Wiggins WF, Callahan MF, Smith TL, Emory CL. The endogenous peptide angiotensin-(1-7) prevents radiation-induced muscle fibrosis: an in vivo murine model [abstract]. In: Proceedings of the 2014 Annual Meeting of the American Academy of Orthopaedic Surgeons; 2014 March 15-18; New Orleans (LA). 2014;():.

Hutchinson ID, Olson J, Lindburg CA, Payne V, Collins B, Smith TL, Munley MT, Wheeler KT, Willey JS. Total-body irradiation produces late degenerative joint damage in rats. Int J Radiat Biol. 2014;90(9):821-830.

Birbrair A, Zhang T, Files DC, Mannava S, Smith T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Stem Cell Res Ther. 2014;5(6):122.

Gmeiner WH, Willingham MC, Bourland JD, Hatcher HC, Smith TL, D'Agostino RB Jr, Blackstock W. F10 inhibits growth of PC3 xenografts and enhances the effects of radiation therapy. J Clin Oncol Res. 2014;2(4):1028.

Krishnan B, Smith TL, Dubey P, Zapadka ME, Torti FM, Willingham MC, Tallant EA, Gallagher PE. Angiotensin-(1-7) attenuates metastatic prostate cancer and reduces osteoclastogenesis. Prostate. 2013;73(1):71-82.

de Guzman RC, Saul JM, Ellenburg MD, Merrill MR, Coan HB, Smith TL, Van Dyke ME. Bone regeneration with BMP-2 delivered from keratose scaffolds. Biomaterials. 2013;34(6):1644-1656.

Kim J, Jeong SY, Ju YM, Yoo JJ, Smith TL, Khang G, Lee SJ, Atala A. In vitro osteogenic differentiation of human amniotic fluid-derived stem cells on a poly(lactide-co-glycolide) (PLGA)-bladder submucosa matrix (BSM) composite scaffold for bone tissue engineering. Biomed Mater. 2013;8(1):014107.

Langfitt M, Webb LX, Onwuchuruba C, Callahan M, Smith TL. Microvascular effects of subatmospheric pressure in striated muscle. J Reconstr Microsurg. 2013;29(2):117-124.

Plate JF, Wiggins WF, Haubruck P, Scott AT, Smith TL, Saul KR, Mannava S. Normal aging alters in vivo passive biomechanical response of the rat gastrocnemius-Achilles muscle-tendon unit. J Biomech. 2013;46(3):450-455.

Plate JF, Haubruck P, Walters J, Mannava S, Smith BP, Smith TL, Tuohy CJ. Rotator cuff injuries in professional and recreational athletes. J Surg Orthop Adv. 2013;22(2):134-142.

Pace LA, Plate JF, Smith TL, Van Dyke ME. The effect of human hair keratin hydrogel on early cellular response to sciatic nerve injury in a rat model. Biomaterials. 2013;34(24):5907-5914.

Mannava S, Plate JF, Tuohy CJ, Seyler TM, Whitlock PW, Curl WW, Smith TL, Saul KR. The science of rotator cuff tears: translating animal models to clinical recommendations using simulation analysis. Knee Surg Traumatol Arthrosc. 2013;21(7):1610-1619.

Forrest LM, Lough CM, Chung S, Boudyguina EY, Gebre AK, Smith TL, Colvin PL, Parks JS. Echium oil reduces plasma triglycerides by increasing intravascular lipolysis in apoB100-only low density lipoprotein (LDL) receptor knockout mice. Nutrients. 2013;5(7):2629-2645.

Whitlock PW, Seyler TM, Northam CN, Smith TL, Poehling GG, Koman LA, Van Dyke ME. Effect of cyclic strain on tensile properties of a naturally derived, decellularized tendon scaffold seeded with allogeneic tenocytes and associated messenger RNA expression. J Surg Orthop Adv. 2013;22(3):224-232.

Nunez FA, Callahan MF, Trach S, Burnett LR, Kislukhin V, Smith TL, Van Dyke M. Hemodynamic recovery after hypovolemic shock with lactated Ringer's and keratin resuscitation fluid (KRF), a novel colloid. Artif Cells Nanomed Biotechnol. 2013;41(5):293-303.

Plate JF, Bates CM, Mannava S, Smith TL, Jorgensen MJ, Register TC, Stehle JR, High KP, Shively CA, Kaplan JR, Saul KR, Tuohy CJ. Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates. J Shoulder Elbow Surg. 2013;22(8):1019-1029.

Bracey D, Willey JS, Tallant EA, Gallagher PD [sic] [Gallagher PE], Smith TL, Callahan MF, Emory CL. The endogenous peptide angiotensin-(1-7) prevents radiation-induced muscle fibrosis: an in vivo murine model [abstract]. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl):S167.

Bracey DN, Willey JS, Tallant EA, Gallagher PE, Smith TL, Callahan MF, Emory CL. Angiotensin-(1-7) prevents radiation-induced muscle fibosis: an in vivo murine model [abstract]. In: Proceedings of the 2013 Annual Meeting of the Southern Orthopedic Association; 2013 July 30-August 2; Palm Beach (FL). 2013;():.

Burnett L, Callahan M, Smith TL, Van Dyke ME, inventors; Wake Forest University Health Sciences, assignee. Keratin biomaterials for treatment of ischemia. United States patent US 8545893. 2013 Oct 1. 2013;():.

Stone AV, Koman LA, Callahan MF, Eckman DM, Smith BP, Plate JF, Smith TL. The effect of botulinum neurotoxin-A on blood flow in rats: a potential mechanism for treatment of Raynaud phenomenon. J Hand Surg [Am]. 2012;37(4):795-802.

Rong S, Cao Q, Liu M, Seo J, Jia L, Boudyguina E, Gebre AK, Colvin PL, Smith TL, Murphy RC, Mishra N, Parks JS. Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis. J Lipid Res. 2012;53(4):686-695.

Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN, Breuer C, Burnett L, Christ G, Farney A, Figliuzzi M, Holmes JH IV, Koch K, Macchiarini P, Mirmalek Sani S-H, Opara E, Remuzzi A, Rogers J, Saul JM, Seliktar D,. Regenerative medicine as applied to general surgery. Ann Surg. 2012;255(5):867-880.

Moran EC, Raghunathan S, Evans DW, Vavalle NA, Sparks JL, Leroith T, Smith TL. Porohyperviscoelastic model simultaneously predicts parenchymal fluid pressure and reaction force in perfused liver. J Biomech Eng. 2012;134(9):091002.

Haubruck P, Mannava S, Plate JF, Callahan MF, Wiggins WF, Schmidmaier G, Tuohy CJ, Saul KR, Smith TL. Botulinum neurotoxin A injections influence stretching of the gastrocnemius muscle-tendon unit in an animal model. Toxins. 2012;4(8):605-619.

Whitlock PW, Seyler TM, Parks GD, Ornelles DA, Smith TL, Van Dyke ME, Poehling GG. A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructural properties, and cell infiltration. J Bone Joint Surg Am. 2012;94(16):1458-1467.

Nunez FA, Kislukin V, Smith TL, Callahan MF, Burnett L, VanDyke ME. Hemodynamic response after hypovolemic shock and resuscitation with low-volume 6% hetastarch (HS) and high-volume lactated Ringer's (LR) solution [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):1132.8.

Carver KA, Smith TL, Gallagher PE, Tallant EA. Vascular remodeling by angiotensin peptide hormones alters reactivity of the microcirculation [abstract]. Hypertension. 2012;60(3 Suppl):530.

Delo DM, Guan X, Wang Z, Groban L, Callahan M, Smith T, Sane DC, Payne RM, Atala A, Soker S. Calcification after myocardial infarction is independent of amniotic fluid stem cell injection. Cardiovasc Pathol. 2011;20(2):e69-e78.

Mannava S, Callahan MF, Trach SM, Wiggins WF, Smith BP, Koman LA, Smith TL, Tuohy CJ. Chemical denervation with botulinum neurotoxin a improves the surgical manipulation of the muscle-tendon unit: an experimental study in an animal model. J Hand Surg [Am]. 2011;36(2):222-231.

Hill PS, Apel PJ, Barnwell J, Smith T, Koman LA, Atala A, Van Dyke M. Repair of peripheral nerve defects in rabbits using keratin hydrogel scaffolds. Tissue Eng Part A. 2011;17(11-12):1499-1505.

Mannava S, Wiggins WF, Saul KR, Stitzel JD, Smith BP, Koman LA, Smith TL, Tuohy CJ. Contributions of neural tone to in vivo passive muscle-tendon unit biomechanical properties in a rat rotator cuff animal model. Ann Biomed Eng. 2011;39(7):1914-1924.

Saul KR, Hayon S, Smith TL, Tuohy CJ, Mannava S. Postural dependence of passive tension in the supraspinatus following rotator cuff repair: a simulation analysis. Clin Biomech (Bristol, Avon). 2011;26(8):804-810.

Koman LA, Poehling GG, Smith BP, Smith TL, Chloros G. Complex regional pain syndrome In: Wolfe SW, Hotchkiss RN, Pederson WC, Kozin SH, eds. Green's operative hand surgery, vol 2. 6th ed. Philadelphia: Elsevier/Churchill Livingstone;2011: 1959-1988.

Koman LA, Smith BP, Smith TL, Ruch DS, Li Z. Vascular disorders In: Wolfe SW, Hotchkiss RN, Pederson WC, Kozin SH, eds. Green's operative hand surgery, vol 2. 6th ed. Philadelphia: Elsevier/Churchill Livingstone;2011: 2197-2240.

Patterson RW, Li Z, Smith BP, Smith TL, Koman LA. Complex regional pain syndrome of the upper extremity. J Hand Surg [Am]. 2011;36(9):1553-1562.

Stone AV, Ma J, Callahan MF, Smith BP, Garrett JP, Smith TL, Koman LA. Dose- and volume dependent-response to intramuscular injection of botulinum neurotoxin-A optimizes muscle force decrement in mice. J Orthop Res. 2011;29(11):1764-1770.

Mannava S, Plate JF, Whitlock PW, Callahan MF, Seyler TM, Koman LA, Smith TL, Tuohy CJ. Evaluation of in vivo rotator cuff muscle function after acute and chronic detachment of the supraspinatus tendon: an experimental study in an animal model. J Bone Joint Surg Am. 2011;93(18):1702-1711.

Mannava S, Plate JF, Stone AV, Smith TL, Smith BP, Koman LA, Tuohy CJ. Recent advances for the management of Raynaud phenomenon using botulinum neurotoxin A. J Hand Surg [Am]. 2011;36(10):1708-1710.

Carver KA, Smith TL, Gallagher PE, Tallant EA. Angiotensin-(1-7) attenuates angiotensin II-induced fibrosis through a reduction in connective tissue growth factor [abstract]. Hypertension. 2011;58(5):e178.

Nunez F, Trach S, Burnett L, Handa R, Van Dyke M, Callahan M, Smith T. Vasoactive properties of keratin-derived compounds. Microcirculation. 2011;18(8):663-669.

Smith TL, Callahan MF, Blum K, DiNubile NA, Chen TJH, Waite RL. H-Wave effects on blood flow and angiogenesis in longitudinal studies in rats. J Surg Orthop Adv. 2011;20(4):255-259.

Koman LA, Li Z, Smith BP, Smith TL. Complex regional pain syndrome: types I and II In: Skirven TM, Osterman AL, Fedorczyk J, Amadio PC, eds. Rehabilitation of the hand and upper extremity. 6th ed. Philadelphia: Elsevier Mosby;2011: 1470-1478.

Deal DN, Ma J, Apel P, Novak V, Carlson CS, Parker JB, Olson EJ, Rieser GR, Smith TL, Shilt JS. Effect of intra-articular pressurization associated with arthroscopy on the immature physis: investigation in an animal model. J Pediatr Orthop. 2010;30(1):21-25.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Orthopaedics

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