Profile

Shay Soker, Ph.D.Wake Forest School of Medicine

Shay Soker, Ph.D.

Professor,


Contact Information

Academic: 336-713-7295 | Department: 336-716-2011

Email: ssoker@wakehealth.edu

Additional Languages

Hebrew

Education & Training

  • B.Sc., Hebrew University Hadassah Med-Israel, 1985
  • M.Sc., Hebrew University Hadassah Med-Israel, 1987
  • Ph.D., Technion-Israel Inst of Tech, 1993
  • Fellowship, Childrens Hospital Of Boston, 1997
Shay Soker, Ph.D.

Shay Soker, Ph.D.

Professor, Institute for Regenerative Medicine
Center for Public Health Genomics
Center on Diabetes, Obesity, and Metabolism

Research Interests

Tissue Engineering; Stem Cells; Amniotic Fluid; Tissue Scaffolds; Regenerative Medicine
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Contact Information

Academic: 336-713-7295 | Department: 336-716-2011

Email: ssoker@wakehealth.edu

Recent Publications

The human pancreas as a source of protolerogenic extracellular matrix scaffold for a new-generation bioartificial endocrine pancreas. Peloso A, Urbani L, Cravedi P, Katari R, Maghsoudlou P, Fallas ME, Sordi V, Citro A, Purroy C, Niu G, McQuilling JP, Sittadjody S, Farney AC, Iskandar SS, Zambon JP, Rogers J, Stratta RJ, Opara EC, Piemonti L, Furdui CM, Soker S, De Coppi P, Orlando G.. Ann Surg. 2016;264(1):169-179.

Fluid flow regulation of revascularization and cellular organization in a bioengineered liver platform. Baptista PM, Moran EC, Vyas D, Ribeiro MH, Atala A, Sparks J, Soker S.. Tissue Eng Part C Methods. 2016;22(3):199-207.

Differentiation of human dental pulp stem cells into dopaminergic neuron-like cells in vitro. Chun SY, Soker S, Jang YJ, Kwon TG, Yoo ES.. J Korean Med Sci. 2016;31(2):171-177.

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening. Skardal A, Devarasetty M, Forsythe S, Atala A, Soker S.. Biotechnol Bioeng. 2016;113(9):2020-2032.

The combined effect of PDX1, epidermal growth factor and poly-L-ornithine on human amnion epithelial cells' differentiation. Balaji S, Zhou Y, Ganguly A, Opara EC, Soker S.. BMC Dev Biol. 2016;16(1):8.

Fluorescent cell imaging in regenerative medicine. Sapoznik E, Niu G, Zhou Y, Murphy SV, Soker S.. Biomed Eng Comput Biol. 2016;7(Suppl 1):29-33.

Bioprinting cellularized constructs using a tissue-specific hydrogel bioink [video article]. Skardal A, Devarasetty M, Kang HW, Seol YJ, Forsythe SD, Bishop C, Shupe T, Soker S, Atala A.. J Vis Exp. 2016;(110):.

Tissue engineered blood vessels. Atala A, Soker S, Yoo J, inventors; Wake Forest University Health Sciences, assignee.. European patent office EP 1863547. 2016 May 11. 2016;():.

Regeneration of pancreatic islets by amniotic fluid stem cell therapy. Atala A, Milanesi A, Soker S, inventors; Wake Forest University Health Sciences, assignee.. European patent office EP 1833494. 2016 May 18. 2016;():.

A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery. Skardal A, Murphy SV, Crowell K, Mack D, Atala A, Soker S.. J Biomed Mater Res B Appl Biomater. 2016;():.

Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid-derived stem cells to insulin-producing clusters. Chun SY, Mack DL, Moorefield E, Oh SH, Kwon TG, Pettenati MJ, Yoo JJ, Coppi PD, Atala A, Soker S.. J Tissue Eng Regen Med. 2015;9(5):540-549.

Bioengineered transplantable porcine livers with re-endothelialized vasculature. Ko IK, Peng L, Peloso A, Smith CJ, Dhal A, Deegan DB, Zimmerman C, Clouse C, Zhao W, Shupe TD, Soker S, Yoo JJ, Atala A.. Biomaterials. 2015;40():72-79.

Discarded human pancreas as source of ECM scaffold for a new generation bio-artificial endocrine pancreas [abstract]. Peloso A, Katari R, Urbani L, Maghsoudlou P, Fallas MEA, Citro A, Delario G, Willis C, Farney A, Rogers J, Stratta R, Peimonti L, Soker S, Orlando G.. Am J Transplant. 2015;15(Suppl 1):49.

Semi-xenotransplantation: the regenerative medicine-based approach to immunosuppression-free transplantation and to meet the organ demand. Salvatori M, Peloso A, Katari R, Soker S, Lerut JP, Stratta RJ, Orlando G.. Xenotransplantation. 2015;22(1):1-6.

Liver-tumor hybrid organoids for modeling tumor growth and drug response in vitro. Skardal A, Devarasetty M, Rodman C, Atala A, Soker S.. Ann Biomed Eng. 2015;43(10):2361-2373.

Enhancement of angiogenesis to grafts using cells engineered to produce growth factors. Atala AJ, Soker S, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 8,940,292. 2015 Jan 27. 2015;():.

Regeneration of pancreatic islets by amniotic fluid stem cell therapy. Atala AJ, Milanesi A, Soker S, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 9,056,093. 2015 June 16. 2015;():.

Transcriptional profiling of stem cells and their multilineage differentiation. Hipp J, Soker S, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 9,062,346. 2015 June 23. 2015;():.

Current achievements and future perspectives in whole-organ bioengineering. Peloso A, Dhal A, Zambon JP, Li P, Orlando G, Atala A, Soker S.. Stem Cell Res Ther. 2015;6():107.

Renal extracellular matrix scaffolds from discarded kidneys maintain glomerular morphometry and vascular resilience and retains critical growth factors. Peloso A, Petrosyan A, Da Sacco S, Booth C, Zambon JP, O'Brien T, Aardema C, Robertson J, De Filippo RE, Soker S, Stratta RJ, Perin L, Orlando G.. Transplantation. 2015;99(9):1807-1816.

Bioengineered multilayered human corneas from discarded human corneal tissue. Zhang Z, Niu G, Choi JS, Giegengack M, Atala A, Soker S.. Biomed Mater. 2015;10(3):035012.

A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs. Skardal A, Devarasetty M, Kang HW, Mead I, Bishop C, Shupe T, Lee SJ, Jackson J, Yoo J, Soker S, Atala A.. Acta Biomater. 2015;25():24-34.

Adaptive mode control based on a fiber Bragg grating. Lu P, Wang A, Soker S, Xu Y.. Opt Lett. 2015;40(15):3488-3491.

Age and gender dependent differences in skeletal muscle regeneration after compression injury in rats [abstract]. Criswell T, Zhou Y, Soker S, Yosef B.. Tissue Eng Part A. 2015;21(Suppl 1):S68.

Ultra-thin tissue-tumor organoid microfluidic platforms for in vitro diagnostics [abstract]. Devarasetty M, Forsythe S, Soker S, Hall A, Skardal A.. Tissue Eng Part A. 2015;21(Suppl 1):S262-S263.

A 3D stratified colon model for colorectal cancer progression [abstract]. Devarasetty M, Skardal A, Soker S.. Tissue Eng Part A. 2015;21(Suppl 1):S196.

Implantation of re-endothelialized porcine liver constructs for whole organ engineering [abstract]. Ko I, Li P, Pelso A, Smith C, Dhal A, Clouse C, Zhao W, Shupe T, Soker S, Yoo JJ, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S85.

Renal ECM scaffolds from discarded kidneys are bioactive, pro-tolerogenic, cyto-compatible and feature an intact, patent and resilient vascular feature an intact, patent and resilient vasculature [abstract]. Orlando G, Pelso A, Petrosyan A, Da Sacco S, Cravedi P, Zambon J, Soker S, DeFilippo RE, Stratta R, Perin L.. Tissue Eng Part A. 2015;21(Suppl 1):S103-S104.

Development of techniques for pancreatic beta-cell engineering [abstract]. Niu G, McQuilling J, Peloso A, Opara EC, Orlando G, Soker S.. Tissue Eng Part A. 2015;21(Suppl 1):S289.

In situ patterned micro 3D liver constructs for parallel toxicology testing in a fluidic device. Skardal A, Devarasetty M, Soker S, Hall AR.. Biofabrication. 2015;7(3):031001.

3D in vitro liver tissue model of human liver organogenesis: a platform to study developmental diseases [abstract]. Vyas D, Brovold M, Baptista P, Moran E, Soker S.. Tissue Eng Part A. 2015;21(Suppl 1):S272.

Liver extracellular matrix enhances growth, function and maturation of induced pluripotent stem cell derived hepatocytes [abstract]. Wertheim JA, Wang B, Jakus AE, Baptista PM, Soker S, Soto-Gutierrez A, Abecassis MM, Shah RN.. Tissue Eng Part A. 2015;21(Suppl 1):S19.

Monitoring skeletal myotube formation on opaque scaffolds using optical imaging [abstract]. Sapoznik E, Niu G, Lu P, Zhou Y, Xu Y, Soker S.. Tissue Eng Part A. 2015;21(Suppl 1):S393.

3-D bioprinting of tissue organoids for body-on-a-chip drug screening platform [abstract]. Seol Y, Kang H, Lee S, Jackson JD, Skardal A, Shupe T, Soker S, Bishop C, Yoo JJ, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S369.

A hydrogel bioink toolkit for bioprinting tissue constructs while mimicking native tissue biochemical and mechanical properties [abstract]. Skardal A, Devarasetty M, Kang H, Mead I, Bishop C, Shupe T, Lee S, Jackson J, Yoo J, Soker S, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S212.

Physiologically relevant drug testing in vitro - an integrated multiple organoid-on-a-chip approach [abstract]. Skardal A, Kleensang A, Devarasetty M, Kang H, Mead I, Bishop C, Shupe T, Lee S, Jackson J, Yoo J, Hartung T, Soker S, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S362.

The effect of angiotensin-(1-7) on the recovery of muscle function after injury [abstract]. Zhou Y, Yoseph B, Soker S, Criswell T.. Tissue Eng Part A. 2015;21(Suppl 1):S319-S320.

The human pancreas as a source of pro-tolerogenic extracellular matrix scaffold for a new generation bio-artificial endocrine pancreas [abstract]. Peloso A, Orlando G, Urbani L, Cravedi P, Sordi V, Guoguang N, Citro A, Mcquilling J, Farney A, Iskandar S, Rogers J, Stratta R, Opara E, Piemonti L, Soker S, De Coppi P, Petrosyan A.. Tissue Eng Part A. 2015;21(Suppl 1):S141.

Transplantation of adult human muscle progenitor cells into rats with compartment syndrome injury [abstract]. Zhou Y, Yoseph B, Soker S, Criswell T.. Tissue Eng Part A. 2015;21(Suppl 1):S329-S330.

N-acetylcysteine reduces fibrosis and improve both muscle regeneration and function in compression induced injury [abstract]. Yoseph B, Zhou Y, Criswell T, Soker S.. Tissue Eng Part A. 2015;21(Suppl 1):S297.

Self-assembled liver organoids recapitulate hepato-biliary organogenesis in vitro [abstract]. Baptista PM, Vyas D, Moran E, Atala A, Reid L, Soker S.. J Hepatol. 2015;62(Suppl 2):S460-S461.

Renal ECM scaffolds from discarded kidneys are bioactive, pro-tolerogenic, cyto-compatible and feature an intact, patient and resilient vascular feature an intact, patent and resilient vasculature [abstract]. Orlando G, Peloso A, Petrosyan A, Da Sacco S, Cravedi P, Zambon JP, O'Brien T, Aardema C, Robertson J, De Filippo RE, Soker S, Stratta RJ, Laura P.. Transpl Int. 2015;28(Suppl 4):15-16.

The human pancreas as a source of protolerogenic extracellular matrix scaffold for a new generation bioartificial endocrine pancreas [abstract]. Orlando G, Peloso A, Urbani L, Cravedi P, Katari R, Maghsoudlou P, Fallas EMA, Sordi V, Purroy C, Niu GG, Mcquilling JP, Sivanandane S, Farney AC, Iskandar SS, Rogers J, Stratta RJ, Opara EC, Piemonti L, Soker S, De Coppi P.. Transpl Int. 2015;28(Suppl 4):129.

A new approach to expand cord blood derived hematopoietic stem cells, using bioengineered human fetal liver tissue 3D-constructs [abstract]. Mokhtari S, Baptista P, Vyas D, Freeman CJ, Moran E, Porada CD, Soker S, Almeida-Porada G.. Blood. 2015;126(23):3097.

Electrospun cell matrices. Atala A, Yoo J, Lim G, Czerw R, Soker S, Stitzel J, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 9,163,331. 2015 Oct 20. 2015;():.

Peripheral blood stem cells. Wang Z, Schuch G, Williams JK, Soker S. In: Lanza R, Atala A. eds. Essentials of stem cell biology. 3rd ed. San Diego (CA): Academic Press;2014: 227-244.

Heparin-modified gelatin scaffolds for human corneal endothelial cell transplantation. Niu G, Choi JS, Wang Z, Skardal A, Giegengack M, Soker S.. Biomaterials. 2014;35(13):4005-4014.

Whole-organ bioengineering: current tales of modern alchemy. Moran EC, Dhal A, Vyas D, Lanas A, Soker S, Baptista PM.. Transl Res. 2014;163(4):259-267.

Bioengineered blood vessels [editorial]. Niu G, Sapoznik E, Soker S.. Expert Opin Biol Ther. 2014;14(4):403-410.

Adaptive control of waveguide modes in a two-mode-fiber. Lu P, Shipton M, Wang A, Soker S, Xu Y.. Opt Express. 2014;22(3):2955-2964.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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