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Shay Soker, Ph.D.Wake Forest School of Medicine

Shay Soker, Ph.D.

Professor,


Precision Medicine

Contact Information

Academic: 336-713-7295

Email: ssoker@wakehealth.edu

Additional Languages

Hebrew

Education & Training

  • B.Sc., Hebrew University Hadassah Med-Israel, 1985
  • M.Sc., Hebrew University Hadassah Med-Israel, 1987
  • Ph.D., Technion-Israel Inst of Tech, 1993
  • Fellowship, Childrens Hospital Of Boston, 1997
Shay Soker, Ph.D.

Shay Soker, Ph.D.

Professor, Institute for Regenerative Medicine
Center for Public Health Genomics
Center on Diabetes, Obesity, and Metabolism
Precision Medicine
Cancer Biology

Research Interests

Tissue Engineering; Tissue Scaffolds; Stem Cells; Bioengineering; Endothelial Cells
More »

Contact Information

Academic: 336-713-7295

Email: ssoker@wakehealth.edu

Recent Publications

Self-assembled liver organoids recapitulate hepato-biliary organogenesis in vitro. Vyas D, Baptista PM, Brovold M, Moran E, Brovold M, Gaston B, Booth C, Samuel M, Atala A, Soker S.. Hepatology. 2018;67(2):750-761.

Shear stress upregulates regeneration-related immediate early genes in liver progenitors in 3D ECM-like microenvironments. Nishii K, Brodin E, Renshaw T, Weesner R, Moran E, Soker S, Sparks JL.. J Cell Physiol. 2018;233(5):4272-4281.

A real-time monitoring platform of myogenesis regulators using double fluorescent labeling. Sapoznik E, Niu G, Zhou Y, Prim PM, Criswell TL, Soker S.. PLoS One. 2018;13(2):e0192654.

Evaluating interaction of cord blood hematopoietic stem/progenitor cells with functionally integrated three-dimensional microenvironments. Mokhtari S, Baptista PM, Vyas DA, Freeman CJ, Moran E, Brovold M, Llamazares GA, Lamar Z, Porada CD, Soker S, Almeida-Porada G.. Stem Cells Transl Med. 2018;7(3):271-282.

A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery. Skardal A, Murphy SV, Crowell K, Mack D, Atala A, Soker S.. J Biomed Mater Res B Appl Biomater. 2017;105(7):1986-2000.

In vitro and in vivo assessment of direct effects of simulated solar and galactic cosmic radiation on human hematopoietic stem/progenitor cells. Rodman C, Almeida-Porada G, George SK, Moon J, Soker S, Pardee T, Beaty M, Guida P, Sajuthi SP, Langefeld CD, Walker SJ, Wilson PF, Porada CD.. Leukemia. 2017;31(6):1398-1407.

Acellular urethra bioscaffold: decellularization of whole urethras for tissue engineering applications. Simoes IN, Vale P, Soker S, Atala A, Keller D, Noiva R, Carvalho S, Peleteiro C, Cabral JM, Eberli D, da Silva CL, Baptista PM.. Sci Rep. 2017;7():41934.

Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy. Devarasetty M, Wang E, Soker S, Skardal A.. Biofabrication. 2017;9(2):021002.

Combinations of activin A or nicotinamide with the pancreatic transcription factor PDX1 support differentiation of human amnion epithelial cells toward a pancreatic lineage. Balaji S, Zhou Y, Opara EC, Soker S.. Cell Reprogram. 2017;19(4):255-262.

Optical tracking and digital quantification of beating behavior in bioengineered human cardiac organoids. Devarasetty M, Forsythe S, Shupe TD, Soker S, Bishop CE, Atala A, Skardal A.. Biosensors (Basel). 2017;7(3):E24.

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform. Skardal A, Murphy SV, Devarasetty M, Mead I, Kang HW, Seol YJ, Shrike Zhang Y, Shin SR, Zhao L, Aleman J, Hall AR, Shupe TD, Kleensang A, Dokmeci MR, Jin Lee S, Jackson JD, Yoo JJ, Hartung T, Khademhosseini A, Soker S, Bishop CE, Atala A.. Sci Rep. 2017;7(1):8837.

Bioengineered submucosal organoids for in vitro modeling of colorectal cancer. Devarasetty M, Skardal A, Cowdrick K, Marini F, Soker S.. Tissue Eng Part A. 2017;23(19-20):1026-1041.

Solubilized amnion membrane hyaluronic acid hydrogel accelerates full-thickness wound healing. Murphy SV, Skardal A, Song L, Sutton K, Haug R, Mack DL, Jackson J, Soker S, Atala A.. Stem Cells Transl Med. 2017;6(11):2020-2032.

The impact of age on skeletal muscle progenitor cell survival and fate after injury. Zhou Y, Lovell D, Bethea M, Yoseph B, Poteracki J, Soker S, Criswell T.. Tissue Eng Part C Methods. 2017;23(12):1012-1021.

An in vitro model of fibrosis-induced abnormal development of the biliary tract [abstract]. Brovold M, Soker S.. Tissue Eng Part A. 2017;23(Suppl 1):S116.

Rheology vs alignment: two operators of the mechanical tumor microenvironment [abstract]. Devarasetty M, Skardal A, Soker S.. Tissue Eng Part A. 2017;23(Suppl 1):S59.

Drug and environmental toxin screening in bioengineered liver and cardiac tissue analogs [abstract]. Forsythe S, Devarasetty M, Shupe T, Bishop C, Soker S, Atala A, Skardal A.. Tissue Eng Part A. 2017;23(Suppl 1):S83.

Hyaluronan-collagen type-I hybrid bioink for 3D printed microenvironments [abstract]. Mazzocchi A, Soker S, Skardal A.. Tissue Eng Part A. 2017;23(Suppl 1):S12-S13.

The effect of exercise on skeletal muscle regeneration after compartment syndrome injury [abstract]. Zhou Y, Sharma N, Dukes D, Poteracki J, Moschouris K, El-Akabawy N, Fair T, Soker S, Criswell T.. Tissue Eng Part A. 2017;23(Suppl 1):S69.

Primary patient tumor organoids for personalized drug treatment [abstract]. Mazzocchi A, Votanopoulos K, Soker S, Skardal A.. Tissue Eng Part A. 2017;23(Suppl 1):S81.

The effect of SDF1 alpha on skeletal muscle regeneration after compartment syndrome injury [abstract]. Moschouris KE, Sharma N, Zhou Y, Dukes D, Poteracki JM, Soker S, Criswell T.. Tissue Eng Part A. 2017;23(Suppl 1):S69.

Development of fasciotomy procedure in a rat model of compartment syndrome [abstract]. Poteracki JM, Moschouris K, Dukes D, Zhou Y, Soker S, Criswell TL.. Tissue Eng Part A. 2017;23(Suppl 1):S69-S70.

Multi target labeling to monitor myoblast differentiation [abstract]. Sapoznik E, Zhou Y, Ashry I, Xu Y, Soker S.. Tissue Eng Part A. 2017;23(Suppl 1):S17.

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform [abstract]. Devarasetty M, Forsythe S, Murphy S, Shupe T, Lee S, Jackson J, Yoo J, Soker S, Bishop C, Atala A, Skardal A.. Tissue Eng Part A. 2017;23(Suppl 1):S32.

Fluorescent imaging of endothelial cells in bioengineered blood vessels: the impact of crosslinking of the scaffold. Niu G, Sapoznik E, Lu P, Criswell T, Mohs AM, Wang G, Lee SJ, Xu Y, Soker S.. J Tissue Eng Regen Med. 2016;10(11):955-966.

The human pancreas as a source of protolerogenic extracellular matrix scaffold for a new-generation bioartificial endocrine pancreas. Peloso A, Urbani L, Cravedi P, Katari R, Maghsoudlou P, Fallas ME, Sordi V, Citro A, Purroy C, Niu G, McQuilling JP, Sittadjody S, Farney AC, Iskandar SS, Zambon JP, Rogers J, Stratta RJ, Opara EC, Piemonti L, Furdui CM, Soker S, De Coppi P, Orlando G.. Ann Surg. 2016;264(1):169-179.

Fluid flow regulation of revascularization and cellular organization in a bioengineered liver platform. Baptista PM, Moran EC, Vyas D, Ribeiro MH, Atala A, Sparks J, Soker S.. Tissue Eng Part C Methods. 2016;22(3):199-207.

Differentiation of human dental pulp stem cells into dopaminergic neuron-like cells in vitro. Chun SY, Soker S, Jang YJ, Kwon TG, Yoo ES.. J Korean Med Sci. 2016;31(2):171-177.

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening. Skardal A, Devarasetty M, Forsythe S, Atala A, Soker S.. Biotechnol Bioeng. 2016;113(9):2020-2032.

The combined effect of PDX1, epidermal growth factor and poly-L-ornithine on human amnion epithelial cells' differentiation. Balaji S, Zhou Y, Ganguly A, Opara EC, Soker S.. BMC Dev Biol. 2016;16():8.

Fluorescent cell imaging in regenerative medicine. Sapoznik E, Niu G, Zhou Y, Murphy SV, Soker S.. Biomed Eng Comput Biol. 2016;7(Suppl 1):29-33.

Bioprinting cellularized constructs using a tissue-specific hydrogel bioink [video article]. Skardal A, Devarasetty M, Kang HW, Seol YJ, Forsythe SD, Bishop C, Shupe T, Soker S, Atala A.. J Vis Exp. 2016;(110):e53606.

Tissue engineered blood vessels. Atala A, Soker S, Yoo J, inventors; Wake Forest University Health Sciences, assignee.. European patent office EP 1863547. 2016 May 11. 2016;():.

Regeneration of pancreatic islets by amniotic fluid stem cell therapy. Atala A, Milanesi A, Soker S, inventors; Wake Forest University Health Sciences, assignee.. European patent office EP 1833494. 2016 May 18. 2016;():.

Sustained depolarization of the resting membrane potential regulates muscle progenitor cell growth and maintains stem cell properties in vitro. Fennelly C, Wang Z, Criswell T, Soker S.. Stem Cell Rev. 2016;12(6):634-644.

Functional maturation of induced pluripotent stem cell hepatocytes in extracellular matrix-a comparative analysis of bioartificial liver microenvironments. Wang B, Jakus AE, Baptista PM, Soker S, Soto-Gutierrez A, Abecassis MM, Shah RN, Wertheim JA.. Stem Cells Transl Med. 2016;5(9):1257-1267.

An in vitro system to model the effects of fibrosis on liver development [abstract]. Brovold M, Soker S.. Tissue Eng Part A. 2016;22(Suppl 1):S93.

A 3D submucosal microenvironment for investigation of topography induced effects in colorectal cancer cells [abstract]. Devarasetty M, Skardal A, Soker S.. Tissue Eng Part A. 2016;22(Suppl 1):S132.

Extracellular matrix proteins support a native phenotype of human liver endothelial cells and increase their proliferation in vitro [abstract]. Dhal A, Zhou Y, Soker S.. Tissue Eng Part A. 2016;22(Suppl 1):S60.

In vitro proliferation of porcine pancreatic islet cells for beta-cell therapy applications. Niu G, McQuilling JP, Zhou Y, Opara EC, Orlando G, Soker S.. J Diabetes Res. 2016;2016():5807876.

Novel fluorescent imaging assessing scaffold based muscle differentiation [abstract]. Sapoznik E, Niu G, Zhou Y, Xu Y, Soker S.. Tissue Eng Part A. 2016;22(Suppl 1):S32-S33.

The effect of intramuscular VEGF treatment on skeletal muscle regeneration after compartment syndrome injury [abstract]. Sharma N, Zhou Y, Ingram RF, Soker S, Criswell T.. Tissue Eng Part A. 2016;22(Suppl 1):S84.

Bioengineering islet organoids from expanded porcine pancreatic cells [abstract]. Niu G, Enck KM, Tamburrini R, Zhou Y, Opara E, Orlando G, Soker S.. Tissue Eng Part A. 2016;22(Suppl 1):S152.

Age and gender differences in skeletal muscle regeneration after compression injury in rats [abstract]. Zhou Y, Yoseph B, Soker S, Criswell T.. Tissue Eng Part A. 2016;22(Suppl 1):S84.

Angiotensin-(1-7) treatment aids in the recovery of skeletal muscle function after acute injury in rats [abstract]. Zhou Y, Yoseph B, Soker S, Criswell T.. Tissue Eng Part A. 2016;22(Suppl 1):S83-S84.

A bioengineered multi-organoid body-on-a-chip platform for advanced drug screening [abstract]. Devarasetty M, Forsythe S, Murphy, S, Shupe T, Lee S, Jackson J, Yoo J, Soker S, Bishop C, Skardal A, Atala A.. Tissue Eng Part A. 2016;22(Suppl 1):S22-S23.

The effect of exercise on skeletal muscle regeneration after compartment syndrome injury [abstract]. Zhou Y, Sharma N, Pu T, Dukes D, Soker S, Criswell T.. Tissue Eng Part A. 2016;22(Suppl 1):S116.

The human pancreas as a source of protolerogenic extracellular matrix scaffold for a new-generation bioartificial endocrine pancreas [abstract]. Tamburrini R, Peloso A, Urbani L, Cravedi P, Maghsoudlou P, Fallas MA, Sordi V, Citro A, Purroy C, Niu G, McQuilling J, Sittadjody S, Zambon J, Stratta R, Opara E, Piemonti L, Soker S, De Coppi P, Orlando G.. Tissue Eng Part A. 2016;22(Suppl 1):S15-S16.

Recellularization of porcine liver scaffolds using primary porcine endothelial cells and hepatocytes [abstract]. Yu H, Dhal A, Zhou Y, Ko I, Kim J, Kim I, Clouse C, Zhao W, Shupe T, Atala A, Soker S, Yoo J.. Tissue Eng Part A. 2016;22(Suppl 1):S47.

Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid-derived stem cells to insulin-producing clusters. Chun SY, Mack DL, Moorefield E, Oh SH, Kwon TG, Pettenati MJ, Yoo JJ, Coppi PD, Atala A, Soker S.. J Tissue Eng Regen Med. 2015;9(5):540-549.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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