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Shay Soker, Ph.D.Wake Forest School of Medicine

Shay Soker, Ph.D.

Professor,



Contact Information

Academic: 336-713-7295 | Department: 336-713-1493

Email: ssoker@wakehealth.edu

Additional Languages

Hebrew

Education & Training

  • B.Sc., Hebrew University Hadassah Med-Israel, 1985
  • M.Sc., Hebrew University Hadassah Med-Israel, 1987
  • Ph.D., Technion-Israel Inst of Tech, 1993
  • Fellowship, Childrens Hospital Of Boston, 1997
Shay Soker, Ph.D.

Shay Soker, Ph.D.

Professor, Institute for Regenerative Medicine
Center for Public Health Genomics
Center on Diabetes, Obesity, and Metabolism
Cancer Biology

Research Interests

Tissue Engineering; Stem Cells; Tissue Scaffolds; Bioengineering; Neovascularization, Physiologic
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Contact Information

Academic: 336-713-7295 | Department: 336-713-1493

Email: ssoker@wakehealth.edu

Recent Publications

A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery. Skardal A, Murphy SV, Crowell K, Mack D, Atala A, Soker S.. J Biomed Mater Res B Appl Biomater. 2017;105(7):1986-2000.

In vitro and in vivo assessment of direct effects of simulated solar and galactic cosmic radiation on human hematopoietic stem/progenitor cells. Rodman C, Almeida-Porada G, George SK, Moon J, Soker S, Pardee T, Beaty M, Guida P, Sajuthi SP, Langefeld CD, Walker SJ, Wilson PF, Porada CD.. Leukemia. 2017;31(6):1398-1407.

Acellular urethra bioscaffold: decellularization of whole urethras for tissue engineering applications. Simoes IN, Vale P, Soker S, Atala A, Keller D, Noiva R, Carvalho S, Peleteiro C, Cabral JM, Eberli D, da Silva CL, Baptista PM.. Sci Rep. 2017;7():41934.

Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy. Devarasetty M, Wang E, Soker S, Skardal A.. Biofabrication. 2017;9(2):021002.

Combinations of activin A or nicotinamide with the pancreatic transcription factor PDX1 support differentiation of human amnion epithelial cells toward a pancreatic lineage. Balaji S, Zhou Y, Opara EC, Soker S.. Cell Reprogram. 2017;19(4):255-262.

Optical tracking and digital quantification of beating behavior in bioengineered human cardiac organoids. Devarasetty M, Forsythe S, Shupe TD, Soker S, Bishop CE, Atala A, Skardal A.. Biosensors (Basel). 2017;7(3):E24.

Fluorescent imaging of endothelial cells in bioengineered blood vessels: the impact of crosslinking of the scaffold. Niu G, Sapoznik E, Lu P, Criswell T, Mohs AM, Wang G, Lee SJ, Xu Y, Soker S.. J Tissue Eng Regen Med. 2016;10(11):955-966.

The human pancreas as a source of protolerogenic extracellular matrix scaffold for a new-generation bioartificial endocrine pancreas. Peloso A, Urbani L, Cravedi P, Katari R, Maghsoudlou P, Fallas ME, Sordi V, Citro A, Purroy C, Niu G, McQuilling JP, Sittadjody S, Farney AC, Iskandar SS, Zambon JP, Rogers J, Stratta RJ, Opara EC, Piemonti L, Furdui CM, Soker S, De Coppi P, Orlando G.. Ann Surg. 2016;264(1):169-179.

Fluid flow regulation of revascularization and cellular organization in a bioengineered liver platform. Baptista PM, Moran EC, Vyas D, Ribeiro MH, Atala A, Sparks J, Soker S.. Tissue Eng Part C Methods. 2016;22(3):199-207.

Differentiation of human dental pulp stem cells into dopaminergic neuron-like cells in vitro. Chun SY, Soker S, Jang YJ, Kwon TG, Yoo ES.. J Korean Med Sci. 2016;31(2):171-177.

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening. Skardal A, Devarasetty M, Forsythe S, Atala A, Soker S.. Biotechnol Bioeng. 2016;113(9):2020-2032.

The combined effect of PDX1, epidermal growth factor and poly-L-ornithine on human amnion epithelial cells' differentiation. Balaji S, Zhou Y, Ganguly A, Opara EC, Soker S.. BMC Dev Biol. 2016;16():8.

Fluorescent cell imaging in regenerative medicine. Sapoznik E, Niu G, Zhou Y, Murphy SV, Soker S.. Biomed Eng Comput Biol. 2016;7(Suppl 1):29-33.

Bioprinting cellularized constructs using a tissue-specific hydrogel bioink [video article]. Skardal A, Devarasetty M, Kang HW, Seol YJ, Forsythe SD, Bishop C, Shupe T, Soker S, Atala A.. J Vis Exp. 2016;(110):e53606.

Tissue engineered blood vessels. Atala A, Soker S, Yoo J, inventors; Wake Forest University Health Sciences, assignee.. European patent office EP 1863547. 2016 May 11. 2016;():.

Regeneration of pancreatic islets by amniotic fluid stem cell therapy. Atala A, Milanesi A, Soker S, inventors; Wake Forest University Health Sciences, assignee.. European patent office EP 1833494. 2016 May 18. 2016;():.

Sustained depolarization of the resting membrane potential regulates muscle progenitor cell growth and maintains stem cell properties in vitro. Fennelly C, Wang Z, Criswell T, Soker S.. Stem Cell Rev. 2016;12(6):634-644.

Functional maturation of induced pluripotent stem cell hepatocytes in extracellular matrix-a comparative analysis of bioartificial liver microenvironments. Wang B, Jakus AE, Baptista PM, Soker S, Soto-Gutierrez A, Abecassis MM, Shah RN, Wertheim JA.. Stem Cells Transl Med. 2016;5(9):1257-1267.

An in vitro system to model the effects of fibrosis on liver development [abstract]. Brovold M, Soker S.. Tissue Eng Part A. 2016;22(Suppl 1):S93.

A 3D submucosal microenvironment for investigation of topography induced effects in colorectal cancer cells [abstract]. Devarasetty M, Skardal A, Soker S.. Tissue Eng Part A. 2016;22(Suppl 1):S132.

Extracellular matrix proteins support a native phenotype of human liver endothelial cells and increase their proliferation in vitro [abstract]. Dhal A, Zhou Y, Soker S.. Tissue Eng Part A. 2016;22(Suppl 1):S60.

In vitro proliferation of porcine pancreatic islet cells for beta-cell therapy applications. Niu G, McQuilling JP, Zhou Y, Opara EC, Orlando G, Soker S.. J Diabetes Res. 2016;2016():5807876.

Novel fluorescent imaging assessing scaffold based muscle differentiation [abstract]. Sapoznik E, Niu G, Zhou Y, Xu Y, Soker S.. Tissue Eng Part A. 2016;22(Suppl 1):S32-S33.

The effect of intramuscular VEGF treatment on skeletal muscle regeneration after compartment syndrome injury [abstract]. Sharma N, Zhou Y, Ingram RF, Soker S, Criswell T.. Tissue Eng Part A. 2016;22(Suppl 1):S84.

Bioengineering islet organoids from expanded porcine pancreatic cells [abstract]. Niu G, Enck KM, Tamburrini R, Zhou Y, Opara E, Orlando G, Soker S.. Tissue Eng Part A. 2016;22(Suppl 1):S152.

Age and gender differences in skeletal muscle regeneration after compression injury in rats [abstract]. Zhou Y, Yoseph B, Soker S, Criswell T.. Tissue Eng Part A. 2016;22(Suppl 1):S84.

Angiotensin-(1-7) treatment aids in the recovery of skeletal muscle function after acute injury in rats [abstract]. Zhou Y, Yoseph B, Soker S, Criswell T.. Tissue Eng Part A. 2016;22(Suppl 1):S83-S84.

A bioengineered multi-organoid body-on-a-chip platform for advanced drug screening [abstract]. Devarasetty M, Forsythe S, Murphy, S, Shupe T, Lee S, Jackson J, Yoo J, Soker S, Bishop C, Skardal A, Atala A.. Tissue Eng Part A. 2016;22(Suppl 1):S22-S23.

The effect of exercise on skeletal muscle regeneration after compartment syndrome injury [abstract]. Zhou Y, Sharma N, Pu T, Dukes D, Soker S, Criswell T.. Tissue Eng Part A. 2016;22(Suppl 1):S116.

The human pancreas as a source of protolerogenic extracellular matrix scaffold for a new-generation bioartificial endocrine pancreas [abstract]. Tamburrini R, Peloso A, Urbani L, Cravedi P, Maghsoudlou P, Fallas MA, Sordi V, Citro A, Purroy C, Niu G, McQuilling J, Sittadjody S, Zambon J, Stratta R, Opara E, Piemonti L, Soker S, De Coppi P, Orlando G.. Tissue Eng Part A. 2016;22(Suppl 1):S15-S16.

Recellularization of porcine liver scaffolds using primary porcine endothelial cells and hepatocytes [abstract]. Yu H, Dhal A, Zhou Y, Ko I, Kim J, Kim I, Clouse C, Zhao W, Shupe T, Atala A, Soker S, Yoo J.. Tissue Eng Part A. 2016;22(Suppl 1):S47.

Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid-derived stem cells to insulin-producing clusters. Chun SY, Mack DL, Moorefield E, Oh SH, Kwon TG, Pettenati MJ, Yoo JJ, Coppi PD, Atala A, Soker S.. J Tissue Eng Regen Med. 2015;9(5):540-549.

Bioengineered transplantable porcine livers with re-endothelialized vasculature. Ko IK, Peng L, Peloso A, Smith CJ, Dhal A, Deegan DB, Zimmerman C, Clouse C, Zhao W, Shupe TD, Soker S, Yoo JJ, Atala A.. Biomaterials. 2015;40():72-79.

Discarded human pancreas as source of ECM scaffold for a new generation bio-artificial endocrine pancreas [abstract]. Peloso A, Katari R, Urbani L, Maghsoudlou P, Fallas MEA, Citro A, Delario G, Willis C, Farney A, Rogers J, Stratta R, Peimonti L, Soker S, Orlando G.. Am J Transplant. 2015;15(Suppl 1):49.

Semi-xenotransplantation: the regenerative medicine-based approach to immunosuppression-free transplantation and to meet the organ demand. Salvatori M, Peloso A, Katari R, Soker S, Lerut JP, Stratta RJ, Orlando G.. Xenotransplantation. 2015;22(1):1-6.

Liver-tumor hybrid organoids for modeling tumor growth and drug response in vitro. Skardal A, Devarasetty M, Rodman C, Atala A, Soker S.. Ann Biomed Eng. 2015;43(10):2361-2373.

Enhancement of angiogenesis to grafts using cells engineered to produce growth factors. Atala AJ, Soker S, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 8,940,292. 2015 Jan 27. 2015;():.

Regeneration of pancreatic islets by amniotic fluid stem cell therapy. Atala AJ, Milanesi A, Soker S, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 9,056,093. 2015 June 16. 2015;():.

Transcriptional profiling of stem cells and their multilineage differentiation. Hipp J, Soker S, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 9,062,346. 2015 June 23. 2015;():.

Current achievements and future perspectives in whole-organ bioengineering. Peloso A, Dhal A, Zambon JP, Li P, Orlando G, Atala A, Soker S.. Stem Cell Res Ther. 2015;6():107.

Renal extracellular matrix scaffolds from discarded kidneys maintain glomerular morphometry and vascular resilience and retains critical growth factors. Peloso A, Petrosyan A, Da Sacco S, Booth C, Zambon JP, O'Brien T, Aardema C, Robertson J, De Filippo RE, Soker S, Stratta RJ, Perin L, Orlando G.. Transplantation. 2015;99(9):1807-1816.

Bioengineered multilayered human corneas from discarded human corneal tissue. Zhang Z, Niu G, Choi JS, Giegengack M, Atala A, Soker S.. Biomed Mater. 2015;10(3):035012.

A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs. Skardal A, Devarasetty M, Kang HW, Mead I, Bishop C, Shupe T, Lee SJ, Jackson J, Yoo J, Soker S, Atala A.. Acta Biomater. 2015;25():24-34.

Adaptive mode control based on a fiber Bragg grating. Lu P, Wang A, Soker S, Xu Y.. Opt Lett. 2015;40(15):3488-3491.

Age and gender dependent differences in skeletal muscle regeneration after compression injury in rats [abstract]. Criswell T, Zhou Y, Soker S, Yosef B.. Tissue Eng Part A. 2015;21(Suppl 1):S68.

Ultra-thin tissue-tumor organoid microfluidic platforms for in vitro diagnostics [abstract]. Devarasetty M, Forsythe S, Soker S, Hall A, Skardal A.. Tissue Eng Part A. 2015;21(Suppl 1):S262-S263.

A 3D stratified colon model for colorectal cancer progression [abstract]. Devarasetty M, Skardal A, Soker S.. Tissue Eng Part A. 2015;21(Suppl 1):S196.

Implantation of re-endothelialized porcine liver constructs for whole organ engineering [abstract]. Ko I, Li P, Pelso A, Smith C, Dhal A, Clouse C, Zhao W, Shupe T, Soker S, Yoo JJ, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S85.

Renal ECM scaffolds from discarded kidneys are bioactive, pro-tolerogenic, cyto-compatible and feature an intact, patent and resilient vascular feature an intact, patent and resilient vasculature [abstract]. Orlando G, Pelso A, Petrosyan A, Da Sacco S, Cravedi P, Zambon J, Soker S, DeFilippo RE, Stratta R, Perin L.. Tissue Eng Part A. 2015;21(Suppl 1):S103-S104.

Development of techniques for pancreatic beta-cell engineering [abstract]. Niu G, McQuilling J, Peloso A, Opara EC, Orlando G, Soker S.. Tissue Eng Part A. 2015;21(Suppl 1):S289.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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