Profile

Shay Soker, Ph.D.Wake Forest School of Medicine

Additional Languages

Hebrew

Education & Training

  • B.Sc., Hebrew University Hadassah Med-Israel, 1985
  • M.Sc., Hebrew University Hadassah Med-Israel, 1987
  • Ph.D., Technion-Israel Inst of Tech, 1993
  • Fellowship, Childrens Hospital Of Boston, 1997
Shay Soker, Ph.D.

Shay Soker, Ph.D.

Professor, Institute for Regenerative Medicine
Center for Diabetes Research
Comprehensive Cancer Center
Hypertension and Vascular Research Center
Sticht Center on Aging
Center for Public Health Genomics
Center on Diabetes, Obesity, and Metabolism
Translational Science Institute
Physiology & Pharmacology
Cancer Biology
Urology

Research Interests

aging, biotechnology, cancer/oncogenesis, cell growth, differentiation,d, critical/intensive care medici, diabetes, drugs/therapeutic agents pharm, education outreach, engineering/bioengineering, environmental sciences, model development, radiology imaging/nuclear medi, surgery/trauma/burns/trauma, transplantation

Contact Information

Academic: 336-713-7295 | Department: 336-716-2011

Email: ssoker@wakehealth.edu

Recent Publications

Chun SY, Mack DL, Moorefield E, Oh SH, Kwon TG, Pettenati MJ, Yoo JJ, Coppi PD, Atala A, Soker S. Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid-derived stem cells to insulin-producing clusters. J Tissue Eng Regen Med. 2015;9(5):540-549.

Ko IK, Peng L, Peloso A, Smith CJ, Dhal A, Deegan DB, Zimmerman C, Clouse C, Zhao W, Shupe TD, Soker S, Yoo JJ, Atala A. Bioengineered transplantable porcine livers with re-endothelialized vasculature. Biomaterials. 2015;40():72-79.

Peloso A, Katari R, Urbani L, Maghsoudlou P, Fallas MEA, Citro A, Delario G, Willis C, Farney A, Rogers J, Stratta R, Peimonti L, Soker S, Orlando G. Discarded human pancreas as source of ECM scaffold for a new generation bio-artificial endocrine pancreas [abstract]. Am J Transplant. 2015;15(Suppl 1):49.

Salvatori M, Peloso A, Katari R, Soker S, Lerut JP, Stratta RJ, Orlando G. Semi-xenotransplantation: the regenerative medicine-based approach to immunosuppression-free transplantation and to meet the organ demand. Xenotransplantation. 2015;22(1):1-6.

Skardal A, Devarasetty M, Rodman C, Atala A, Soker S. Liver-tumor hybrid organoids for modeling tumor growth and drug response in vitro. Ann Biomed Eng. 2015;43(10):2361-2373.

Atala AJ, Soker S, inventors; Wake Forest University Health Sciences, assignee. Enhancement of angiogenesis to grafts using cells engineered to produce growth factors. United States patent US 8,940,292. 2015 Jan 27. 2015;():.

Atala AJ, Milanesi A, Soker S, inventors; Wake Forest University Health Sciences, assignee. Regeneration of pancreatic islets by amniotic fluid stem cell therapy. United States patent US 9,056,093. 2015 June 16. 2015;():.

Hipp J, Soker S, inventors; Wake Forest University Health Sciences, assignee. Transcriptional profiling of stem cells and their multilineage differentiation. United States patent US 9,062,346. 2015 June 23. 2015;():.

Peloso A, Dhal A, Zambon JP, Li P, Orlando G, Atala A, Soker S. Current achievements and future perspectives in whole-organ bioengineering. Stem Cell Res Ther. 2015;6():107.

Peloso A, Petrosyan A, Da Sacco S, Booth C, Zambon JP, O'Brien T, Aardema C, Robertson J, De Filippo RE, Soker S, Stratta RJ, Perin L, Orlando G. Renal extracellular matrix scaffolds from discarded kidneys maintain glomerular morphometry and vascular resilience and retains critical growth factors. Transplantation. 2015;99(9):1807-1816.

Zhang Z, Niu G, Choi JS, Giegengack M, Atala A, Soker S. Bioengineered multilayered human corneas from discarded human corneal tissue. . 2015;10(3):035012.

Skardal A, Devarasetty M, Kang HW, Mead I, Bishop C, Shupe T, Lee SJ, Jackson J, Yoo J, Soker S, Atala A. A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs. Acta Biomater. 2015;25():24-34.

Lu P, Wang A, Soker S, Xu Y. Adaptive mode control based on a fiber Bragg grating. Opt Lett. 2015;40(15):3488-3491.

Criswell T, Zhou Y, Soker S, Yosef B. Age and gender dependent differences in skeletal muscle regeneration after compression injury in rats [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S68.

Devarasetty M, Forsythe S, Soker S, Hall A, Skardal A. Ultra-thin tissue-tumor organoid microfluidic platforms for in vitro diagnostics [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S262-S263.

Devarasetty M, Skardal A, Soker S. A 3D stratified colon model for colorectal cancer progression [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S196.

Ko I, Li P, Pelso A, Smith C, Dhal A, Clouse C, Zhao W, Shupe T, Soker S, Yoo JJ, Atala A. Implantation of re-endothelialized porcine liver constructs for whole organ engineering [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S85.

Orlando G, Pelso A, Petrosyan A, Da Sacco S, Cravedi P, Zambon J, Soker S, DeFilippo RE, Stratta R, Perin L. Renal Ecm scaffolds from discarded kidneys are bioactive, pro-tolerogenic, cyto-compatible and feature an intact, patent and resilient vascular feature an intact, patent and resilient vasculature [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S103-S104.

Niu G, McQuilling J, Peloso A, Opara EC, Orlando G, Soker S. Development of techniques for pancreatic beta-cell engineering [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S289.

Skardal A, Devarasetty M, Soker S, Hall AR. In situ patterned micro 3D liver constructs for parallel toxicology testing in a fluidic device. Biofabrication. 2015;7(3):031001.

Vyas D, Brovold M, Baptista P, Moran E, Soker S. 3D in vitro liver tissue model of human liver organogenesis: a platform to study developmental diseases [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S272.

Wertheim JA, Wang B, Jakus AE, Baptista PM, Soker S, Soto-Gutierrez A, Abecassis MM, Shah RN. Liver extracellular matrix enhances growth, function and maturation of induced pluripotent stem cell derived hepatocytes [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S19.

Sapoznik E, Niu G, Lu P, Zhou Y, Xu Y, Soker S. Monitoring skeletal myotube formation on opaque scaffolds using optical imaging [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S393.

Seol Y, Kang H, Lee S, Jackson JD, Skardal A, Shupe T, Soker S, Bishop C, Yoo JJ, Atala A. 3-D bioprinting of tissue organoids for body-on-a-chip drug screening platform [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S369.

Skardal A, Devarasetty M, Kang H, Mead I, Bishop C, Shupe T, Lee S, Jackson J, Yoo J, Soker S, Atala A. A hydrogel bioink toolkit for bioprinting tissue constructs while mimicking native tissue biochemical and mechanical properties [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S212.

Skardal A, Kleensang A, Devarasetty M, Kang H, Mead I, Bishop C, Shupe T, Lee S, Jackson J, Yoo J, Hartung T, Soker S, Atala A. Physiologically relevant drug testing in vitro - an integrated multiple organoid-on-a-chip approach [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S362.

Zhou Y, Yoseph B, Soker S, Criswell T. The effect of angiotensin-(1-7) on the recovery of muscle function after injury [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S319-S320.

Peloso A, Orlando G, Urbani L, Cravedi P, Sordi V, Guoguang N, Citro A, Mcquilling J, Farney A, Iskandar S, Rogers J, Stratta R, Opara E, Piemonti L, Soker S, De Coppi P, Petrosyan A. The human pancreas as a source of pro-tolerogenic extracellular matrix scaffold for a new generation bio-artificial endocrine pancreas [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S141.

Zhou Y, Yoseph B, Soker S, Criswell T. Transplantation of adult human muscle progenitor cells into rats with compartment syndrome injury [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S329-S330.

Yoseph B, Zhou Y, Criswell T, Soker S. N-acetylcysteine reduces fibrosis and improve both muscle regeneration and function in compression induced injury [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S297.

Baptista PM, Vyas D, Moran E, Atala A, Reid L, Soker S. Self-assembled liver organoids recapitulate hepato-biliary organogenesis in vitro [abstract]. J Hepatol. 2015;62(Suppl 2):S460-S461.

Peloso A, Urbani L, Cravedi P, Katari R, Maghsoudlou P, Fallas ME, Sordi V, Citro A, Purroy C, Niu G, McQuilling JP, Sittadjody S, Farney AC, Iskandar SS, Zambon JP, Rogers J, Stratta RJ, Opara EC, Piemonti L, Furdui CM, Soker S, De Coppi P, Orlando G. The human pancreas as a source of protolerogenic extracellular matrix scaffold for a new-generation bioartificial endocrine pancreas. Ann Surg. 2015;():.

Wang Z, Schuch G, Williams JK, Soker S. Peripheral blood stem cells In: Lanza R, Atala A. eds. Essentials of stem cell biology. 3rd ed. San Diego (CA): Academic Press;2014: 227-244.

Niu G, Choi JS, Wang Z, Skardal A, Giegengack M, Soker S. Heparin-modified gelatin scaffolds for human corneal endothelial cell transplantation. Biomaterials. 2014;35(13):4005-4014.

Moran EC, Dhal A, Vyas D, Lanas A, Soker S, Baptista PM. Whole-organ bioengineering: current tales of modern alchemy. Transl Res. 2014;163(4):259-267.

Niu G, Sapoznik E, Soker S. Bioengineered blood vessels [editorial]. Expert Opin Biol Ther. 2014;14(4):403-410.

Lu P, Shipton M, Wang A, Soker S, Xu Y. Adaptive control of waveguide modes in a two-mode-fiber. Opt Express. 2014;22(3):2955-2964.

Raya-Rivera AM, Esquiliano D, Fierro-Pastrana R, Lopez-Bayghen E, Valencia P, Ordorica-Flores R, Soker S, Yoo JJ, Atala A. Tissue-engineered autologous vaginal organs in patients: a pilot cohort study. Lancet. 2014;384(9940):329-336.

Orlando G, Soker S, Stratta RJ, Atala A. Will regenerative medicine replace transplantation? In: Turka LA, Wood KJ, eds. Transplantation. New York: Cold Spring Harbor Laboratory Press;2014: 407-420.

Niu G, Sapoznik E, Lu P, Criswell T, Mohs AM, Wang G, Lee SJ, Xu Y, Soker S. Fluorescent imaging of endothelial cells in bioengineered blood vessels: the impact of crosslinking of the scaffold. J Tissue Eng Regen Med. 2014;():.

Katari R, Peloso A, Zambon JP, Soker S, Stratta RJ, Atala A, Orlando G. Renal bioengineering with scaffolds generated from human kidneys. Nephron Exp Nephrol. 2014;126(2):119.

Orlando G, Gianello P, Salvatori M, Stratta RJ, Soker S, Ricordi C, Dominguez-Bendala J. Cell replacement strategies aimed at reconstitution of the beta-cell compartment in type 1 diabetes. Diabetes. 2014;63(5):1433-1444.

Wang Z, Cheung D, Zhou Y, Han C, Fennelly C, Criswell T, Soker S. An in vitro culture system that supports robust expansion and maintenance of in vivo engraftment capabilities for myogenic progenitor cells from adult mice. Biores Open Access. 2014;3(3):79-87.

Atala AJ, Yoo JJ, Lim HJ, Czerw, Soker S, inventors; Wake Forest University Health Sciences, assignee. Production of tissue engineered digits and limbs. United States patent US 8728463. 2014 May 20. 2014;():.

Greven M, Laber P, Soker S, Walter KA, Williams JK, inventors; Wake Forest University Health Sciences, assignee. Corneal endothelial scaffolds and methods of use. United States patent US 8628572. 2014 Jan 14. 2014;():.

Choi JS, Kim EY, Kim MJ, Khan FA, Giegengack M, D'Agostino R Jr, Criswell T, Khang G, Soker S. Factors affecting successful isolation of human corneal endothelial cells for clinical use. Cell Transplant. 2014;23(7):845-854.

Orlando G, Sedrakyan S, Peloso A, Wang Z, Farney A, Delario G, Rogers J, Stratta R, Soker S, Perin L. ECM scaffolds from discarded human kidneys perform as bio-system when seeded with multipotent progenitor cells [abstract]. Transplantation. 2014;98(Suppl 1):304.

Peloso A, Katari R, Booth C, Wang Z, Zambon J, Farney A, Rogers J, Delario G, Stratta R, Soker S, Orlando G. ECM scaffolds from discarded human kidneys retain growth factors along with intact microstructural morphologies of the innate vasculature [abstract]. Transplantation. 2014;98(Suppl 1):304.

Sanders BP, Orlando G, Peloso A, Katari RS, Iskandar SS, Farney AC, Rogers J, Soker S, Stratta RJ. Osseus metaplasia in kidney allografts as a paradigm of regenerative medicine principles. Exp Clin Transplant. 2014;12(4):371-373.

Simoes IN, Vale P, Soker S, Atala A, Noiva R, Carrapico B, Peleteiro C, Cabral JS, Da Silva CL, Baptista P. Urinary rhabdosphincter bioengineering - a decellularized matrix for modeling stress urinary incontinence in vitro [abstract]. J Tissue Eng Regen Med. 2014;8(Suppl 1):380.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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