Profile

Shay Soker, Ph.D.Wake Forest School of Medicine

Additional Languages

Hebrew

Education & Training

  • B.Sc., Hebrew University Hadassah Med-Israel, 1985
  • M.Sc., Hebrew University Hadassah Med-Israel, 1987
  • Ph.D., Technion-Israel Inst of Tech, 1993
  • Fellowship, Childrens Hospital Of Boston, 1997
Shay Soker, Ph.D.

Shay Soker, Ph.D.

Professor, Institute for Regenerative Medicine
Comprehensive Cancer Center
Hypertension and Vascular Research Center
Sticht Center on Aging
Center for Diabetes Research
Cancer Biology
Physiology & Pharmacology
Urology
Translational Science Institute

Research Interests

aging, biotechnology, cancer/oncogenesis, cell growth, differentiation,d, critical/intensive care medici, diabetes, drugs/therapeutic agents pharm, education outreach, engineering/bioengineering, environmental sciences, model development, radiology imaging/nuclear medi, surgery/trauma/burns/trauma, transplantation

Contact Information

Academic: 336-713-7295 | Department: 336-716-2011

Email: ssoker@wakehealth.edu

Recent Publications

Chun SY, Mack DL, Moorefield E, Oh SH, Kwon TG, Pettenati MJ, Yoo JJ, Coppi PD, Atala A, Soker S. Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid-derived stem cells to insulin-producing clusters. J Tissue Eng Regen Med. 2015;9(5):540-549.

Ko IK, Peng L, Peloso A, Smith CJ, Dhal A, Deegan DB, Zimmerman C, Clouse C, Zhao W, Shupe TD, Soker S, Yoo JJ, Atala A. Bioengineered transplantable porcine livers with re-endothelialized vasculature. Biomaterials. 2015;40():72-79.

Peloso A, Katari R, Urbani L, Maghsoudlou P, Fallas MEA, Citro A, Delario G, Willis C, Farney A, Rogers J, Stratta R, Peimonti L, Soker S, Orlando G. Discarded human pancreas as source of ECM scaffold for a new generation bio-artificial endocrine pancreas [abstract]. Am J Transplant. 2015;15(Suppl 1):49.

Salvatori M, Peloso A, Katari R, Soker S, Lerut JP, Stratta RJ, Orlando G. Semi-xenotransplantation: the regenerative medicine-based approach to immunosuppression-free transplantation and to meet the organ demand. Xenotransplantation. 2015;22(1):1-6.

Skardal A, Devarasetty M, Rodman C, Atala A, Soker S. Liver-tumor hybrid organoids for modeling tumor growth and drug response in vitro. Ann Biomed Eng. 2015;():.

Atala AJ, Soker S, inventors; Wake Forest University Health Sciences, assignee. Enhancement of angiogenesis to grafts using cells engineered to produce growth factors. United States patent US 8,940,292. 2015 Jan 27. 2015;():.

Atala AJ, Milanesi A, Soker S, inventors; Wake Forest University Health Sciences, assignee. Regeneration of pancreatic islets by amniotic fluid stem cell therapy. United States patent US 9,056,093. 2015 June 16. 2015;():.

Hipp J, Soker S, inventors; Wake Forest University Health Sciences, assignee. Transcriptional profiling of stem cells and their multilineage differentiation. United States patent US 9,062,346. 2015 June 23. 2015;():.

Peloso A, Dhal A, Zambon JP, Li P, Orlando G, Atala A, Soker S. Current achievements and future perspectives in whole-organ bioengineering. Stem Cell Res Ther. 2015;6():107.

Peloso A, Petrosyan A, Da Sacco S, Booth C, Zambon JP, O'Brien T, Aardema C, Robertson J, De Filippo RE, Soker S, Stratta RJ, Perin L, Orlando G. Renal extracellular matrix scaffolds from discarded kidneys maintain glomerular morphometry and vascular resilience and retains critical growth factors. Transplantation. 2015;():.

Wang Z, Schuch G, Williams JK, Soker S. Peripheral blood stem cells In: Lanza R, Atala A. eds. Essentials of stem cell biology. 3rd ed. San Diego (CA): Academic Press;2014: 227-244.

Niu G, Choi JS, Wang Z, Skardal A, Giegengack M, Soker S. Heparin-modified gelatin scaffolds for human corneal endothelial cell transplantation. Biomaterials. 2014;35(13):4005-4014.

Moran EC, Dhal A, Vyas D, Lanas A, Soker S, Baptista PM. Whole-organ bioengineering: current tales of modern alchemy. Transl Res. 2014;163(4):259-267.

Niu G, Sapoznik E, Soker S. Bioengineered blood vessels [editorial]. Expert Opin Biol Ther. 2014;14(4):403-410.

Lu P, Shipton M, Wang A, Soker S, Xu Y. Adaptive control of waveguide modes in a two-mode-fiber. Opt Express. 2014;22(3):2955-2964.

Raya-Rivera AM, Esquiliano D, Fierro-Pastrana R, Lopez-Bayghen E, Valencia P, Ordorica-Flores R, Soker S, Yoo JJ, Atala A. Tissue-engineered autologous vaginal organs in patients: a pilot cohort study. Lancet. 2014;384(9940):329-336.

Orlando G, Soker S, Stratta RJ, Atala A. Will regenerative medicine replace transplantation? In: Turka LA, Wood KJ, eds. Transplantation. New York: Cold Spring Harbor Laboratory Press;2014: 407-420.

Niu G, Sapoznik E, Lu P, Criswell T, Mohs AM, Wang G, Lee SJ, Xu Y, Soker S. Fluorescent imaging of endothelial cells in bioengineered blood vessels: the impact of crosslinking of the scaffold. J Tissue Eng Regen Med. 2014;():.

Katari R, Peloso A, Zambon JP, Soker S, Stratta RJ, Atala A, Orlando G. Renal bioengineering with scaffolds generated from human kidneys. Nephron Exp Nephrol. 2014;126(2):119.

Orlando G, Gianello P, Salvatori M, Stratta RJ, Soker S, Ricordi C, Dominguez-Bendala J. Cell replacement strategies aimed at reconstitution of the beta-cell compartment in type 1 diabetes. Diabetes. 2014;63(5):1433-1444.

Wang Z, Cheung D, Zhou Y, Han C, Fennelly C, Criswell T, Soker S. An in vitro culture system that supports robust expansion and maintenance of in vivo engraftment capabilities for myogenic progenitor cells from adult mice. Biores Open Access. 2014;3(3):79-87.

Atala AJ, Yoo JJ, Lim HJ, Czerw, Soker S, inventors; Wake Forest University Health Sciences, assignee. Production of tissue engineered digits and limbs. United States patent US 8728463. 2014 May 20. 2014;():.

Greven M, Laber P, Soker S, Walter KA, Williams JK, inventors; Wake Forest University Health Sciences, assignee. Corneal endothelial scaffolds and methods of use. United States patent US 8628572. 2014 Jan 14. 2014;():.

Choi JS, Kim EY, Kim MJ, Khan FA, Giegengack M, D'Agostino R Jr, Criswell T, Khang G, Soker S. Factors affecting successful isolation of human corneal endothelial cells for clinical use. Cell Transplant. 2014;23(7):845-854.

Orlando G, Sedrakyan S, Peloso A, Wang Z, Farney A, Delario G, Rogers J, Stratta R, Soker S, Perin L. ECM scaffolds from discarded human kidneys perform as bio-system when seeded with multipotent progenitor cells [abstract]. Transplantation. 2014;98(Suppl 1):304.

Peloso A, Katari R, Booth C, Wang Z, Zambon J, Farney A, Rogers J, Delario G, Stratta R, Soker S, Orlando G. ECM scaffolds from discarded human kidneys retain growth factors along with intact microstructural morphologies of the innate vasculature [abstract]. Transplantation. 2014;98(Suppl 1):304.

Sanders BP, Orlando G, Peloso A, Katari RS, Iskandar SS, Farney AC, Rogers J, Soker S, Stratta RJ. Osseus metaplasia in kidney allografts as a paradigm of regenerative medicine principles. Exp Clin Transplant. 2014;12(4):371-373.

Simoes IN, Vale P, Soker S, Atala A, Noiva R, Carrapico B, Peleteiro C, Cabral JS, Da Silva CL, Baptista P. Urinary rhabdosphincter bioengineering - a decellularized matrix for modeling stress urinary incontinence in vitro [abstract]. J Tissue Eng Regen Med. 2014;8(Suppl 1):380.

Zhou Y, Lovell D, Bethea M, Wang Z, Christ GJ, Soker S, Criswell T. Age-dependent changes cooperatively impact skeletal muscle regeneration after compartment syndrome injury. Am J Pathol. 2014;184(8):2225-2236.

Devarasetty M, Atala A, Soker S, Skardal A. A metastasis-on-a-chip system for modeling colon carcinoma migration and invasion in vitro [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S15.

Devarasetty M, Skardal A, Soker S. Modeling the colon-tumor microenvironment using multicellular hydrogel strata [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S77.

Moran EC, Baptista PM, Sparks JL, Soker S. Perfusion driven shear stress leads to self-organization of bioengineered livers [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S15-S16.

Moran EC, Gaston B, Baptista PM, Atala A, Soker S. Acellular liver scaffolds as a model to study colon cancer metastasis [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S28-S29.

Niu G, Sapoznik E, Lu P, Criswell T, Mohs A, Xu Y, Soker S. Influence of dopamine coating on auto-fluorescence for improved molecular imaging [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S57.

Niu G, Zhang Z, Giegengack M, Soker S. Bioengineering human corneal endothelium with electrospun scaffold [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S57.

Skardal A, Devarasetty M, Atala A, Soker S, Hall A. A microfluidic platform for parallel analysis of in situ patterned 3-D liver organoids [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S68-S69.

Skardal A, Devarasetty M, Rodman C, Atala A, Soker S. An in vitro 3-D liver-tumor hybrid organoid system for modeling metastasis and drug resistance [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S15.

Sapoznik E, Niu G, Lu P, Zhou Y, Criswell T, Marini F, Xu Y, Soker S. Fiber-based imaging on electrospun scaffold [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S61.

Skardal A, Mead I, Devarasetty M, Kang H, Shupe T, Lee S, Jackson JD, Bishop CE, Yoo JJ, Soker S, Atala A. Integration of 3-D organoid bioprinting and microfluidic device technology for functional primary cell-based liver-on-a-chip operation [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S43.

Vyas D, Baptista PM, Moran E, Soker S. Recapitulation of human hepato-biliary organogenesis in self-assembled liver organoid culture [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S29.

Wang B, Jakus A, Baptista P, Soker S, Soto-Gutierrez A, Abecassis M, Shah R, Wertheim J. Three-dimensional micro-bioscaffolds enhance protein expression in induced pluripotent stem cell-derived hepatocytes [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S127-S128.

Wang Z, Cheung D, Zhou Y, Han C, Criswell T, Soker S. Long-term expanded adult myogenic progenitor cells exhibits robust expansion and maintenance of in vivo engraftment capabilities [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S23-S24.

Yoseph B, Zhou Y, Bethea M, Soker S, Criswell T. Anti-oxidant therapy for skeletal muscle regeneration after compression injury in rats [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S9.

Zhou Y, Lovell D, Bethea M, Soker S, Criswell T. Age and gender dependent differences in skeletal muscle regeneration after compression injury in rats [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S77.

Zhou Y, Lovell D, Bethea M, Soker S, Criswell T. Age-dependent differences in skeletal muscle regeneration in response to cell therapy after injury [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S76-S77.

Zhou Y, Soker S, Criswell T. Isolation and characterization of rat skeletal muscle-derived vascular endothelial cells [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S57.

Ko I, Smith CJ, Li P, Peloso A, Dhal A, Clouse C, Zhao W, Shupe T, Atala A, Soker S, Yoo JJ. Re-endothelialization of acellular liver scaffolds for whole organ engineering [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S98.

Ko IK, Abolbashari M, Huling J, Kim C, Mirmalek-Sani S, Moradi M, Orlando G, Jackson JD, Aboushwareb T, Soker S, Yoo JJ, Atala A. Enhanced re-endothelialization of acellular kidney scaffolds for whole organ engineering via antibody conjugation of vasculatures. Technol. 2014;2(3):243-253.

Criswell TL, Corona BT, Wang Z, Zhou Y, Niu G, Xu Y, Christ GJ, Soker S. The role of endothelial cells in myofiber differentiation and the vascularization and innervation of bioengineered muscle tissue in vivo. Biomaterials. 2013;34(1):140-149.

Skardal A, Mack D, Atala A, Soker S. Substrate elasticity controls cell proliferation, surface marker expression and motile phenotype in amniotic fluid-derived stem cells. J Mech Behav Biomed Mater. 2013;17():307-316.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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