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Research

Mary G. Sorci-Thomas, Ph.D.

Professor, Pathology-Lipid Sciences
Hypertension and Vascular Research Center

Contact Information

Academic: 336-716-2147 | Department: 336-716-2147

Email: msthomas@wakehealth.edu

Education & Training

Ph.D., Wake Forest University , 1984
B.S., Louisiana State University & A&M College , 1979
Fellowship, Stony Brook School of Medicine, 1987

Mary G. Sorci-Thomas, Ph.D.

Professor, Pathology-Lipid Sciences Hypertension and Vascular Research Center

Research Interests

atherosclerosis/thrombosis, metabolism, structural biology, transgenics

Contact Information

Academic: 336-716-2147 | Department: 336-716-2147

Email: msthomas@wakehealth.edu

Recent Publications

Sorci-Thomas MG, Zabalawi M, Bharadwaj MS, Wilhelm AJ, Owen JS, Asztalos BF, Bhat S, Thomas MJ. Dysfunctional HDL containing L159R ApoA-I leads to exacerbation of atherosclerosis in hyperlipidemic mice. Biochim Biophys Acta. 2012;1821(3):502-512.

Sorci-Thomas MG, Owen JS, Fulp B, Bhat S, Zhu X, Parks JS, Shah D, Jerome WG, Gerelus M, Zabalawi M, Thomas MJ. Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers. J Lipid Res. 2012;53(9):1890-1909.

Sorci-Thomas MG, Thomas MJ. High density lipoprotein biogenesis, cholesterol efflux, and immune cell function. Arterioscler Thromb Vasc Biol. 2012;32(11):2561-2565.

Potteaux S, Gautier EL, Hutchison SB, van Rooijen N, Rader DJ, Thomas MJ, Sorci-Thomas MG, Randolph GJ. Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression. J Clin Invest. 2011;121(5):2025-2036.

Bhat S, Sorci-Thomas MG, Calabresi L, Samuel MP, Thomas MJ. Conformation of dimeric apolipoprotein A-I milano on recombinant lipoprotein particles. Biochemistry. 2010;49(25):5213-5224.

Wilhelm AJ, Zabalawi M, Owen JS, Shah D, Grayson JM, Major AS, Bhat S, Gibbs DP Jr, Thomas MJ, Sorci-Thomas MG. Apolipoprotein A-I modulates regulatory T cells in autoimmune LDLr-/-, ApoA-I-/- mice. J Biol Chem. 2010;285(46):36158-69.

Bhat S, Bhat S [sic], Sorci-Thomas MG, Shah DP, Owen JS, Zabalawi M, Samuel MP, Thomas MJ. Biosynthesis of nascent HDL by ABCA1: what does lipid composition tell us about their formation? [abstract]. Arterioscler Thromb Vasc Biol. 2010;30(11):e281.

Wang WL, Xu H, Shi Y, Nandedkar S, Zhang H, Sorci-Thomas M, Pritchard KA. The role of apolipoprotein A-I and 4F, an ApoA-I mimetic, in attenuation of pulmonary inflammation and airway hyperresponsiveness [abstract]. Arterioscler Thromb Vasc Biol. 2010;30(11):e277.

Wilhelm AJ, Zabalawi M, Grayson JM, Major AS, Owen JS, Bhat S, Gibbs DP, Thomas MJ, Sorci-Thomas MG. Apolipoprotein A-I improves the regulatory T-cell response in autoimmune LDLr-/-, ApoA-I-/- mice [abstract]. Arterioscler Thromb Vasc Biol. 2010;30(11):e269.

Wang W, Xu H, Shi Y, Nandedkar S, Zhang H, Gao H, Feroah T, Weihrauch D, Schulte ML, Sorci-Thomas M, et al. Genetic deletion of apolipoprotein A-I increases airway hyperresponsiveness, inflammation, and collagen deposition in the lung. J Lipid Res. 2010;51(9):2560-2570.

Sorci-Thomas MG, Bhat S, Thomas MJ. Activation of lecithin: cholesterol acyltransferase by HDL ApoA-I central helices. Future Med: Clin Lipidol. 2009;4(1):113-124.

Wilhelm AJ, Zabalawi M, Grayson JM, Weant AE, Major AS, Owen J, Bharadwaj M, Walzem R, Thomas MJ, Sorci-Thomas MG, et al. Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity. Arterioscler Thromb Vasc Biol. 2009;29(6):843-849.

Bhat S, Sorci-Thomas MG, Owen JS, Calabresi L, Thomas MJ. Characterization of nascent HDL formed with wild-type ApoA-I and its mutant forms [abstract]. Arterioscler Thromb Vasc Biol. 2009;29(7):e106-e107.

Carnemolla R, Sontag TJ, Djunaidi AC, Sorci-Thomas M, Reardon CA, Getz GS. The specific amino acid sequence between putative helices 7 and 8 of human apolipoprotein A-I yields nascent high-density lipoprotein (HDL) of different size and density: a potential for individual HDL class generation [abstract]. Arterioscler Thromb Vasc Biol. 2009;29(7):e105-e106.

Wilhelm AJ, Zabalawi M, Grayson JM, Weant AE, Major AS, Owen JS, Thomas MJ, Sorci-Thomas MG. Apolipoprotein A-I: a common link between inflammation, atherosclerosis, and autoimmunity [abstract]. Arterioscler Thromb Vasc Biol. 2009;29(7):e13.

Zabalawi M, Wilhelm AJ, Thomas MJ, Owen J, Bhat S, Remaley AT, Sorci-Thomas MG. Treatment with apoA-I reverses inflammation and cholesterol deposition in the skin and lymph nodes of LDLr-/-, apoA-I-/- mice [abstract]. Arterioscler Thromb Vasc Biol. 2009;29(7):e26.

Wilhelm AJ, Zabalawi M, Grayson J, Weant AE, Sorci-Thomas M. Absence of ApoA-I leads to dysregulation of lymph node immune cell cholesterol homeostasis and increased atherosclerosis in LDLr-/-, ApoA-I-/- mice [abstract]. Arterioscler Thromb Vasc Biol. 2008;28(6):e-65.

Thomas MJ, Bhat S, Sorci-Thomas MG. Three-dimensional models of HDL apoA-I: implications for its assembly and function. J Lipid Res. 2008;49(9):1875-1883.

Owen JS, Bharadwaj MS, Thomas MJ, Bhat S, Samuel MP, Sorci-Thomas MG. Ratio determination of plasma wild-type and L159R apoA-1 using mass spectrometry: tools for studying apoA-1Fin. J Lipid Res. 2007;48(1):226-234.

Zabalawi M, Bharadwaj M, Horton H, Cline M, Willingham M, Thomas MJ, Sorci-Thomas MG. Inflammation and skin cholesterol in LDLr-/-, apoA-I-/- mice: link between cholesterol homeostasis and self-tolerance?. J Lipid Res. 2007;48(1):52-65.

Bharadwaj MS, Zabalawi M, Owen JS, Thomas MJ, Zannis VI, Duka A, Sorci-Thomas MG. ApoA-I FIN partially prevents cholesterol deposition and inflammation in skin and lymph nodes of diet-fed LDLr-/-, ApoA-I-/- mice [abstract]. Arterioscler Thromb Vasc Biol. 2007;27(6):e-124.

Zabalawi M, Bharadwaj MS, Tang LJ, Sorci-Thomas MG. Reduced plasma corticosterone levels in LDLr-/-, ApoA-I-/- mice: a model to study the role of HPA axis in the metabolic syndrome [abstract]. Arterioscler Thromb Vasc Biol. 2007;27(6):e-94.

Bhat S, Sorci-Thomas MG, Tuladhar R, Samuel MP, Thomas MJ. Conformational adaptation of apolipoprotein A-I to discretely sized phospholipid complexes. Biochemistry. 2007;46(26):7811-7821.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

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For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Pathology-Lipid Sciences

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