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David Soto Pantoja, Ph.D.Wake Forest School of Medicine

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Education & Training

  • Ph.D., Wake Forest University, 2008
  • Fellowship, Cardiovascular Disease, WFU School of Medicine, 2004
  • Fellowship, Oncology/Pathology, National Institutes of Health, 2015
David Soto Pantoja, Ph.D.

David Soto Pantoja, Ph.D.

Assistant Professor, Hypertension
Comprehensive Cancer Center
Maya Angelou Center for Health Equity
Hypertension and Vascular Research Center
Cancer Biology
Radiation Oncology

Research Interests

Thrombospondin 1; Burns; Wound Healing; Skin; Signal Transduction
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Contact Information

Department: 336-716-0792


Recent Publications

Mitochondrial autophagosomes as a mechanism of drug resistance in breast carcinoma. Abunimer AN, Mohammed H, Cook KL, Soto-Pantoja DR, Campos MM, Abu-Asab MS.. Ultrastruct Pathol. 2018;42(2):170-180.

Targeting of the unfolded protein response signaling arms differentially regulates macrophage proliferation, plasticity, and breast cancer cell clearance [abstract]. Cook KL, Wilson A, Westwood B, Soto-Pantoja DR.. Cancer Res. 2017;77(Suppl 4):P2-04-06.

"UPRegulation" of CD47 by the endoplasmic reticulum stress pathway controls anti-tumor immune responses. Cook KL, Soto-Pantoja DR.. Biomark Res. 2017;5():26.

Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness. Soto-Pantoja DR, Wilson AS, Clear KY, Westwood B, Triozzi PL, Cook KL.. Oncotarget. 2017;8(46):80545-59.

Thrombospondin-1 regulates intestinal microbiota and bile acid metabolism in a murine model of colorectal cancer [abstract]. Soto-Pantoja DR, Sipes JM, Westwood B, Morris N, Emenaker NJ, Roberts DD.. Cancer Res. 2017;77(13 Suppl):LB-213.

Targeting CD47 expression on macrophages regulates immunometabolism enhancing tumoricidal activity against cancer cells [abstract]. Smith AA, Wilson AS, Soto-Pantoja DR.. Cancer Res. 2017;77(13 Suppl):5661.

UPR signaling promotes T-cell dysfunction to prevent immune-mediated cancer cell killing and immune checkpoint therapy resistance [abstract]. Feliz-Mosquea YR, Soto-Pantoja DR, Wilson A, Triozzi PL, Cook KL.. Cancer Res. 2017;77(13 Suppl):1704.

Dietary fat overcomes the protective activity of thrombospondin-1 signaling in the Apc(Min/+) model of colon cancer. Soto-Pantoja DR, Sipes JM, Martin-Manso G, Westwood B, Morris NL, Ghosh A, Emenaker NJ, Roberts DD.. Oncogenesis. 2016;5(5):e230.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S,.. Autophagy. 2016;12(1):1-222.

Targeting thrombospondin-1 and its receptor CD47 to improve cell and tissue responses to stress [abstract]. Roberts D, Miller TW, Soto-Pantoja DR.. Shock. 2016;45(6 Suppl 1):35.

Endoplasmic reticulum stress protein GRP78 modulates lipid metabolism to control drug sensitivity and antitumor immunity in breast cancer. Cook KL, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Warri A, Hilakivi-Clarke L, Roberts DD, Clarke R.. Cancer Res. 2016;76(19):5657-5670.

High-throughput matrix screening reveals synergistic chemotherapeutic combinations with blockade of CD47 to enhance cytotoxicity in breast cancer [abstract]. Roberts DD, Smith A, Sipes JM, Wilson A, Mathews-Griner L, Guha R, Thomas CJ, Ferrer M, Soto-Pantoja DR.. Cancer Res. 2016;76(14 Suppl):1352.

CD47. Roberts DD, Isenberg JS, Soto-Pantoja DR. In: Choi S, ed. Encyclopedia of signaling molecules. New York (NY): Springer Science;2016: 1-12.

Thrombospondin-1. Roberts DD, Kaur S, Soto-Pantoja DR. In: Choi S, ed. Encyclopedia of signaling molecules. New York (NY): Springer Science;2016: 1-10.

CD47 receptor globally regulates metabolic pathways that control resistance to ionizing radiation. Miller TW, Soto-Pantoja DR, Schwartz AL, Sipes JM, DeGraff WG, Ridnour LA, Wink DA, Roberts DD.. J Biol Chem. 2015;290(41):24858-74.

Therapeutic applications of morpholino oligonucleotides. Soto-Pantoja DR, Isenberg JS, Roberts DD. In: Templeton NS, ed. Gene and cell therapy: therapeutic mechanisms and strategies. 4th ed. Boca Raton: CRC Press, Taylor & Francis Group;2015: 521-542.

Angiotensin peptides and lung cancer. Gallagher PE, Cook K, Soto-Pantoja D, Menon J, Tallant EA.. Curr Cancer Drug Targets. 2011;11(4):394-404.

Angiotensin-(1-7) inhibition of human breast tumors with distinct hormone receptor expression results in a differential regulation of AKT [abstract]. Cook KL, Soto PD, Gallagher P, Tallant EA.. Cancer Res. 2009;69(2 Suppl):240S.

Angiotensin-(1-7) inhibits triple negative tumor growth through the inhibition of angiogenesis and a reduction in placental growth factor PIGF [abstract]. Soto-Pantoja DR, Petty WJ, Gallagher PE, Tallant EA.. Cancer Res. 2009;69(2 Suppl):103S.

Angiotensin-(1-7) inhibits tumor angiogenesis in human lung cancer xenografts with a reduction in vascular endothelial growth factor. Soto-Pantoja DR, Menon J, Gallagher PE, Tallant EA.. Mol Cancer Ther. 2009;8(6):1676-1683.

Angiotensin-(1-7) reduces lung tumor incidence in a novel bitransgenic Ki-ras G12C mouse model of lung tumorigenesis through a reduction in cyclooxygenase-2 [abstract]. Menon J, Miller MS, Soto-Pantoja DR, Callahan MF, Tallant EA, Gallagher PE.. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research; 2008 Apr 12-16; San Diego, CA. Philadelphia (PA): AACR. 2008;():Abstr 4654.

Angiotensin-(1-7) inhibits the growth of human triple negative breast tumors in an orthotopic model [abstract]. Soto-Pantoja DR, Menon J, Gallagher PE, Tallant EA.. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research ; 2008 Apr 12-16; San Diego (CA). Philadelphia (PA): AACR. 2008;():Abstr 2416.

Angiotensin-(1-7) reduces endothelial cell growth and migration and increases VEGI to inhibit angiogenesis [abstract]. Gallagher PE, Soto-Pantoja DR, Tallant EA.. Hypertension. 2008;52(4):e72.

Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. Menon J, Soto-Pantoja DR, Callahan MF, Cline JM, Ferrario CM, Tallant EA, Gallagher PE.. Cancer Res. 2007;67(6):2809-2815.

Angiotensin-(1-7) inhibits angiogenesis by reducing endothelial cell growth [abstract]. Gallagher PE, Soto-Pantoja DR, Tallant EA.. Hypertension. 2007;50(4):e91.

Angiotensin peptides and cancer. Tallant EA, Menon J, Soto-Pantoja DR, Gallagher PE. In: Kastin AJ, ed. Handbook of biologically active peptides. Boston: Academic Press;2006: 459-465.

Inhibition of angiogenesis by angiotensin-(1-7) [abstract]. Soto-Pantoja DR, Gallagher PE, Tallant EA.. In: Proceedings of the 97th Annual Meeting of the American Association for Cancer Research ; 2006 Apr 1-5; Washington, DC. Philadelphia (PA): AACR. 2006;():Abstr 950.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Hypertension

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