Research Interests
genetics/genome
Recent Publications
Lu Y, Sun J, Kader AK, Kim S-T, Kim J-W, Liu W, Sun J, Lu D, Feng J, Zhu Y, Jin T, Zhang Z, Dimitrov L, Lowey J, Campbell K, Suh E, Duggan D, Carpten J, Trent JM, Gronberg H, Zheng SL, Isaacs WB, Xu J.
Association of prostate cancer risk with SNPs in regions containing androgen receptor binding sites captured by ChIP-On-chip analyses. Prostate.
2012;
72(4):376-385.
Wang M, Liu F, Hsing AW, Wang X, Shao Q, Zhang Y, Jin G, Sun J, Zheng SL, Xu J, et al.
Replication and cumulative effects of GWAS-identified genetic variations for prostate cancer in Asians: a case-control study in the ChinaPCa consortium. Carcinogenesis.
2012;
33(2):356-360.
Qin Y, Sun M, You L, Wei D, Sun J, Liang X, Zhang B, Jiang H, Xu J, Chen Z-J.
ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure. Orphanet J Rare Dis.
2012;
7():5.
Tao S, Wang Z, Feng J, Hsu F-C, Jin G, Kim S-T, Zhang Z, Gronberg H, Zheng LS [sic] [Zheng SL], Isaacs WB, Xu J, Sun J.
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. Carcinogenesis.
2012;
33(3):598-603.
Zheng J, Liu F, Lin X, Wang X, Ding Q, Jiang H, Chen H, Lu D, Jin G, Hsing AW, Shao Q, Qi J, Ye Y, Wang Z, Gao X, Wang G, Chu LW, OuYang J, Huang Y, Chen Y, Gao Y, Shi R, Wu Q, Wang M, Zhang Z, Hu Y, Sun J, Zheng SL, Gao X, Xu C.
Predictive performance of prostate cancer risk in Chinese men using 33 reported prostate cancer risk-associated SNPs. Prostate.
2012;
72(5):577-583.
Sun J, Kader AK, Hsu F-C, Kim S-T, Zhu Y, Turner AR, Jin T, Zhang Z, Zheng SL, Xu J, et al.
Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer. Prostate.
2011;
71(4):421-430.
Jin G, Sun J, Liu W, Zhang Z, Chu LW, Kim S-T, Sun J, Feng J, Zheng SL, Xu J, et al.
Genome-wide copy-number variation analysis identifies common genetic variants at 20p13 associated with aggressiveness of prostate cancer. Carcinogenesis.
2011;
32(7):1057-1062.
Berndt SI, Sampson J, Yeager M, Jacobs KB, Wang Z, Hutchinson A, Chung C, Xu J, Zheng SL, Sun J, et al.
Large-scale fine mapping of the HNF1B locus and prostate cancer risk. Hum Mol Genet.
2011;
20(16):3322-3329.
Liu F, Hsing AW, Wang X, Shao Q, Qi J, Ye Y, Jin G, Sun J, Zheng SL, Xu J, et al.
Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men. Cancer Sci.
2011;
102(10):1916-1920.
Jin G, Sun J, Isaacs SD, Wiley KE, Kim S-T, Chu LW, Zhang Z, Zhao H, Zheng SL, Isaacs WB, Xu J.
Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk. Carcinogenesis.
2011;
32(11):1655-1659.
Tong N, Fang Y, Li J, Wang M, Lu Q, Wang S, Tian Y, Rong L, Sun J, Xu J, et al.
Methylenetetrahydrofolate reductase polymorphisms, serum methylenetetrahydrofolate reductase levels, and risk of childhood acute lymphoblastic leukemia in a Chinese population. Cancer Sci.
2010;
101(3):782-786.
Xu J, Zheng SL, Isaacs SD, Wiley KE, Sun J, Kader AK, Li G, Purcell LD, Kim S-T, Hsu F-C, et al.
Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. Proc Natl Acad Sci U S A.
2010;
107(5):2136-2140.
Zheng SL, Hsing AW, Sun J, Chu LW, Yu K, Li G, Gao Z, Kim S-T, Isaacs WB, Xu J, et al.
Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men. Prostate.
2010;
70(4):425-432.
Hsu F-C, Sun J, Zhu Y, Kim S-T, Jin T, Zhang Z, Wiklund F, Kader AK, Zheng SL, Xu J, et al.
Comparison of two methods for estimating absolute risk of prostate cancer based on single nucleotide polymorphisms and family history. Cancer Epidemiol Biomarkers Prev.
2010;
19(4):1083-1088.
Sun J, Zheng SL, Li G, Kim S-T, Zhu Y, Zhang Z, Hsu F-C, Turner AR, Liu W, Kim JW, Xu J, Chang B-L, et al.
Sequence variants at 22q13 are associated with prostate cancer risk. Cancer Res.
2009;
69(1):10-15.
Zheng SL, Sun J, Gao Z, Purcell LD, Hsu F-C, Zhu Y, Turner AR, Adams TS, Liu W, Chang B-L, Xu J, et al.
Genetic variants and family history predict prostate cancer similar to prostate-specific antigen. Clin Cancer Res.
2009;
15(3):1105-1111.
Liu W, Sun J, Li G, Zhu Y, Zhang S, Kim S-T, Sun J, Xu J, Zheng SL, Chang B-L, et al.
Association of a germ-line copy number variation at 2p24.3 and risk for aggressive prostate cancer. Cancer Res.
2009;
69(6):2176-2179.
Wiklund F, Zheng SL, Sun J, Adami H-O, Lilja H, Hsu F-C, Stattin P, Cramer SD, Chang B-L, Xu J, et al.
Association of reported prostate cancer risk alleles with PSA levels among men without a diagnosis of prostate cancer. Prostate.
2009;
69(4):419-427.
Chang B-L, Cramer SD, Sun J, Smith S, Pruett K, Romero LM, Zhu Y, Zhang Z, Hsu F-C, Turner AR, Liu W, Kim JW, Zheng SL, Xu J, et al.
Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk. Hum Mol Genet.
2009;
18(7):1368-1375.
Hsu F-C, Sun J, Purcell LD, Gao Z, Zhu Y, Kim S-T, Zhang Z, Liu W, Chang B-L, Xu J, Zheng SL, et al.
A novel prostate cancer susceptibility locus at 19q13. Cancer Res.
2009;
69(7):2720-2723.
Butler JE, Lager KM, Splichal I, Francis D, Kacskovics I, Sinkora M, Wertz N, Sun J, Zhao Y, Brown WR, et al.
The piglet as a model for B cell and immune system development. Vet Immunol Immunopathol.
2009;
128(Special Issue 1-3):147-170.
Zheng SL, Sun J, Smith S, Pruett K, Kim S-T, Zhu Y, Zhang Z, Hsu F-C, Turner AR, Liu W, Kim JW, Chang B-L, Xu J, et al.
Two independent prostate cancer risk-associated Loci at 11q13. Cancer Epidemiol Biomarkers Prev.
2009;
18(6):1815-1820.
Xu J, Sun J, Kader AK, Lindstrom S, Wiklund F, Hsu F-C, Kim S-T, Johansson J-E, Zheng SL, Platz EA, et al.
Estimation of absolute risk for prostate cancer from blood DNA [abstract]. J Urol.
2009;
181(4 Suppl):643.
Kader AK, Sun J, Isaacs SD, Wiley KE, Yan G, Kim S-T, Fedor H, DeMarzo AM, Zheng SL, Xu J, et al.
Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients. Prostate.
2009;
69(11):1195-1205.
Lu L, Sun J, Isaacs SD, Smith S, Pruett K, Zhu Y, Zhang Z, Chang B-L, Zheng SL, Xu J, et al.
Fine-mapping and family-based association analyses of prostate cancer risk variants at Xp11. Cancer Epidemiol Biomarkers Prev.
2009;
18(7):2132-2136.
Xu J, Kibel AS, Turner AR, Pruett K, Zheng SL, Sun J, Kim S-T, Hsu F-C, Torti FM, Chang B-L, et al.
Prostate cancer risk associated loci in African Americans. Cancer Epidemiol Biomarkers Prev.
2009;
18(7):2145-2149.
Xu J, Sun J, Kader AK, Lindstrom S, Wiklund F, Hsu F-C, Johansson J-E, Zheng SL, Thomas G, Hayes RB, et al.
Estimation of absolute risk for prostate cancer using genetic markers and family history. Prostate.
2009;
69(14):1565-1572.
Yeager M, Chatterjee N, Ciampa J, Jacobs KB, Gonzalez-Bosquet J, Hayes RB, Kraft P, Xu J, Zheng SL, Sun J, et al.
Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nat Genet.
2009;
41(10):1055-1057.
Sun J, Lange EM, Isaacs SD, Liu W, Wiley KE, Lange L, Gronberg H, Xu J, Chang B-L, Zheng SL, et al.
Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients. Prostate.
2008;
68(5):489-497.
Zheng SL, Sun J, Smith S, Li G, Hsu F-C, Zhu Y, Kader AK, Turner AR, Liu W, Bleecker ER, Meyers DA, Chang B-L, Xu J, et al.
Cumulative association of five genetic variants with prostate cancer. N Engl J Med.
2008;
358(9):910-919.
Chen S-H, Sun J, Dimitrov L, Turner AR, Adams TS, Meyers DA, Chang B-L, Zheng SL, Xu J, Hsu F-C, et al.
A support vector machine approach for detecting gene-gene interaction. Genet Epidemiol.
2008;
32(2):152-167.
Gudmundsson J, Sulem P, Rafnar T, Bergthorsson JT, Manolescu A, Gudbjartsson D, Zheng SL, Sun J, Chang B-L, Xu J, et al.
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat Genet.
2008;
40(3):281-283.
Sun J, Purcell L, Gao Z, Isaacs SD, Wiley KE, Hsu F-C, Liu W, Xu J, Chang B-L, Zheng SL, et al.
Association between sequence variants at 17q12 and 17q24.3 and prostate cancer risk in European and African Americans. Prostate.
2008;
68(7):691-697.
Hsu F-C, Lindstrom S, Sun J, Wiklund F, Turner AR, Liu W, Kim JW, Chang B-l, Xu J, Zheng SL, et al.
A multigenic approach to evaluating prostate cancer risk in a systematic replication study. Cancer Genet Cytogenet.
2008;
183(2):94-98.
Kader AK, Sun J, Yang G, Zheng L, Xu J, Liu W, Issacs WB.
Loss of chromosome 17p13.1 significantly correlates with Gleason score at the time of radical prostatectomy [abstract]. J Urol.
2008;
179(4 Suppl):227-228.
Sun J, Chang B-L, Isaacs SD, Wiley KE, Wiklund F, Stattin P, Duggan D, Carpten JD, Xu J, Zheng SL, et al.
Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations. Prostate.
2008;
68(12):1257-1262.
Sun J, Zheng SL, Purcell LD, Gao Z, Hsu F-C, Kim S-T, Liu W, Zhu Y, Dimitrov L, Sun J, Li T, Turner AR, Adams TS, Chang B-L, Xu J, et al.
Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nat Genet.
2008;
40(10):1153-1155.
Xu J, Sun J, Li G, Zhu Y, Hsu F-C, Turner AR, Adams TS, Liu W, Chang B, Zheng S, et al.
Association of prostate cancer risk variants with clinicopathologic characteristics of the disease. Clin Cancer Res.
2008;
14(18):5819-5824.
Liu W, Xie CC, Zhu Y, Li T, Sun J, Cheng Y, Turner AR, Sun J, Chang B-L, Zheng SL, Xu J, et al.
Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer. Neoplasia.
2008;
10(8):897-907.
Sun J, Liu W, Adams TS, Sun J, Li X, Turner AR, Chang B, Kim JW, Zheng SL, Xu J, et al.
DNA copy number alterations in prostate cancers: a combined analysis of published CGH studies. Prostate.
2007;
67(7):692-700.
Liu W, Chang B-L, Li T, Sun J, Turner AR, Dimitrov L, Zhu Y, Sun J, Kim JW, Zheng SL, Xu J, et al.
Multiple genomic alterations on 21q22 predict various TMPRSS2/ERG fusion transcripts in human prostate cancers. Genes Chromosomes Cancer.
2007;
46(11):972-980.
Zheng SL, Sun J, Cheng Y, Li G, Hsu F-C, Zhu Y, Chang B-L, Liu W, Kim JW, Turner AR, Xu J, et al.
Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans. J Natl Cancer Inst.
2007;
99(20):1525-1533.
Duggan D, Zheng SL, Dimitrov L, Cheng Y, Li G, Sun J, Chang B-L, Liu W, Kim JW, Bleecker ER, Meyers DA, Xu J, et al.
Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB21P. J Natl Cancer Inst.
2007;
99(24):1836-1844.
Shahedi K, Lindstrom S, Zheng SL, Wiklund F, Adolfsson J, Sun J, Augustsson-Balter K, Chang B-L, Liu W, Xu J, et al.
Genetic variation in the COX-2 gene and the association with prostate cancer risk. Int J Cancer.
2006;
119(3):668-672.
Liu W, Chang B, Sauvageot J, Dimitrov L, Gielzak M, Li T, Yan G, Sun J, Sun J, Adams TS, Turner AR, Kim JW, Meyers DA, Zheng SL, Isaacs WB, Xu J.
Comprehensive assessment of DNA copy number alterations in human prostate cancers using Affymetrix 100K SNP mapping array. Genes Chromosomes Cancer.
2006;
45(11):1018-1032.
Zheng SL, Liu W, Dimitrov L, Sun J, Sun J, Chang B, Loza M, Turner AR, Bleecker ER, Meyers DA, Xu J, et al.
A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS Study. Prostate.
2006;
66(14):1556-1564.
Lindstrom S, Zheng SL, Wiklund F, Jonsson B-A, Adami H-O, Balter KA, Brookes AJ, Sun J, Chang B-L, Liu W, Li G, Xu J, et al.
Systematic replication study of reported genetic associations in prostate cancer: strong support for genetic variation in the androgen pathway. Prostate.
2006;
66(16):1729-1743.
All Publications
For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.
For a list of earlier publications, visit the Carpenter Library Publication Search.