Profile

William E. Swords, Ph.D.Wake Forest School of Medicine

William E. Swords, Ph.D.

Professor,

Contact Information

Academic: 336-713-5049 | Department: 336-716-2011

Email: wswords@wakehealth.edu

Education & Training

  • B.S., Auburn University-Auburn , 1988
  • M.S., Mississippi State University , 1990
  • Ph.D., University of Alabama-Birmingham , 1996
  • Fellowship, Bacteriology, University of Iowa, 2001

Memberships

  • Am Soc Of Microbiology
William E. Swords, Ph.D.

William E. Swords, Ph.D.

Professor, Microbiology & Immunology
Center for Comparative Medicine Research

Research Interests

cancer/oncogenesis, health services, research/outc, immunology/allergy/inflammatio, infectious diseases

Contact Information

Academic: 336-713-5049 | Department: 336-716-2011

Email: wswords@wakehealth.edu

Recent Publications


Perez AC, Pang B, King LB, Tan L, Murrah KA, Reimche JL, Wren JT, Richardson SH, Ghandi U, Swords WE. Residence of Streptococcus pneumoniae and Moraxella catarrhalis within polymicrobial biofilm promotes antibiotic resistance and bacterial persistence in vivo. Pathog Dis. 2014;70(3):280-288.

Rosch JW, Iverson AR, Humann J, Mann B, Gao G, Vogel P, Mina M, Murrah KA, Perez AC, Edward Swords W, Tuomanen EI, McCullers JA. A live-attenuated pneumococcal vaccine elicits CD4+ T-cell dependent class switching and provides serotype independent protection against acute otitis media. EMBO Mol Med. 2014;6(1):141-154.

Wren JT, Blevins LK, Pang B, King LB, Perez AC, Murrah KA, Reimche JL, Alexander-Miller MA, Swords WE. Influenza a virus alters pneumococcal nasal colonization and middle ear infection independently of phase variation. Infect Immun. 2014;82(11):4802-4812.

Murrah KA, Turner RL, Pang B, Perez AC, Reimche JL, King LB, Wren J, Gandhi U, Swords WE, Ornelles DA. Replication of type 5 adenovirus promotes middle ear infection by Streptococcus pneumoniae in the chinchilla model of otitis media. Pathog Dis. 2014;():.

Blevins LK, Wren JT, Holbrook BC, Hayward SL, Swords WE, Parks GD, Alexander-Miller MA. Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8+ T cell response. J Immunol. 2014;193(10):5076-5087.


Murphy TF, Chonmaitree T, Barenkamp S, Kyd J, Nokso-Koivisto J, Patel JA, Heikkinen T, Yamanaka N, Ogra P, Swords WE, Sih T, Pettigrew MM. Panel 5: Microbiology and immunology panel. Otolaryngol Head Neck Surg. 2013;148(Suppl 4):E64-E89.

Jen FE, Warren MJ, Schulz BL, Power PM, Swords WE, Weiser JN, Apicella MA, Edwards JL, Jennings MP. Dual pili post-translational modifications synergize to mediate meningococcal adherence to platelet activating factor receptor on human airway cells. PLoS Pathog. 2013;9(5):e1003377.

King LB, Pang B, Perez AC, Reimche JL, Kirse DJ, Whigham AS, Evans AK, Swords EW [sic] [Swords WE]. Observation of viable nontypeable haemophilus influenzae bacteria within neutrophil extracellular traps in clinical samples from chronic otitis media. Otolaryngology. 2013;3(4):.

Castro-Garza J, Swords WE, Karls RK, Quinn FD. Dual mechanism for Mycobacterium tuberculosis cytotoxicity on lung epithelial cells. Can J Microbiol. 2012;58(7):909-916.


Swords WE. Quorum signaling and sensing by nontypeable Haemophilus influenzae. Front Cell Infect Microbiol. 2012;2():100.

Swords WE. Nontypeable Haemophilus influenzae biofilms: role in chronic airway infections. Front Cell Infect Microbiol. 2012;2():97.

Holder RC, Kirse DJ, Evans AK, Peters TR, Poehling KA, Swords WE, Reid SD. One third of middle ear effusions from children undergoing tympanostomy tube placement had multiple bacterial pathogens. BMC Pediatr. 2012;12():87.

Juneau RA, Pang B, Weimer KED, Armbruster CE, Swords WE. Nontypeable Haemophilus influenzae initiates formation of neutrophil extracellular traps. Infect Immun. 2011;79(1):431-438.

Weimer KED, Juneau RA, Murrah KA, Pang B, Armbruster CE, Richardson SH, Swords WE. Divergent mechanisms for passive pneumococcal resistance to beta-lactam antibiotics in the presence of Haemophilus influenzae. J Infect Dis. 2011;203(4):549-555.

Byrd MS, Pang B, Hong W, Waligora EA, Juneau RA, Armbruster CE, Weimer KED, Murrah K, Lu H, Sprinkle A, Kock ND, Swords WE, et al. Direct evaluation of Pseudomonas aeruginosa biofilm mediators in a chronic infection model. Infect Immun. 2011;79(8):3087-3095.

Armbruster CE, Pang B, Murrah K, Juneau RA, Perez AC, Weimer KED, Swords WE. RbsB (NTHI_0632) mediates quorum signal uptake in nontypeable Haemophilus influenzae strain 86-028NP. Mol Microbiol. 2011;82(4):836-850.

Byrd MS, Pang B, Mishra M, Swords WE, Wozniak DJ. The Pseudomonas aeruginosa exopolysaccharide Psl facilitates surface adherence and NF-kappaB activation in A549 cells. MBio. 2010;1(3):e00140-10.

Armbruster CE, Hong W, Pang B, Weimer KED, Juneau RA, Turner J, Swords WE. Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling. MBio. 2010;1(3):e00102-10.


Armbruster CE, Swords WE. Interspecies bacterial communication as a target for therapy in otitis media [editorial]. Expert Rev Anti Infect Ther. 2010;8(10):1067-1070.

Doern CD, Roberts AL, Hong W, Nelson J, Lukomski S, Swords WE, Reid SD. Biofilm formation by group A Streptococcus: a role for the streptococcal regulator of virulence (Srv) and streptococcal cysteine protease (SpeB). Microbiology. 2009;155(Pt 1):46-52.

Reid SD, Hong W, Dew KE, Winn DR, Pang B, Watt J, Glover DT, Hollingshead SK, Swords WE. Streptococcus pneumoniae forms surface-attached communities in the middle ear of experimentally infected chinchillas. J Infect Dis. 2009;199(6):786-794.


Armbruster CE, Hong W, Pang B, Dew KE, Juneau RA, Byrd MS, Love CF, Kock ND, Swords WE. LuxS promotes biofilm maturation and persistence of nontypeable haemophilus influenzae in vivo via modulation of lipooligosaccharides on the bacterial surface. Infect Immun. 2009;77(9):4081-4091.

Pang B, Winn D, Johnson R, Hong W, West-Barnette S, Kock N, Swords WE. Lipooligosaccharides containing phosphorylcholine delay pulmonary clearance of nontypeable Haemophilus influenzae. Infect Immun. 2008;76(5):2037-2043.




Sandal I, Hong W, Swords WE, Inzana TJ. Characterization and comparison of biofilm development by pathogenic and commensal isolates of Histophilus somni. J Bacteriol. 2007;189(22):8179-8185.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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