Charles H. Tegeler IV, M.D.Wake Forest School of Medicine

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Charles H. Tegeler IV, M.D.


Clinical Interests

Cerebrovascular Disease (Stroke), Neurology (general), Neurosonology, Prevention and Treatment of Stroke and other Cerebrovascular Disease

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New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-4101
Department: 336-716-4101

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Education & Training

  • B.A., University of Missouri-Kansas City, 1979
  • M.D., University of Missouri School of Medicine-Kansas, 1979
  • Residency, Internal Medicine, University of Missouri School, 1982
  • Residency, Neurology, University of Texas Health Sci, 1985

Board Certifications

  • American Board of Internal Medicine, Internal Medicine
  • American Board of Psychiatry & Neurology, Neurology
  • American Board of Psychiatry & Neurology, Neurology, Vascular Neurology

NPI Number

  • 1720064819
Charles H. Tegeler IV, M.D.

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Charles H. Tegeler IV, M.D.

Professor, Neurology
Center for Integrative Medicine
Hypertension and Vascular Research Center
Institute for Regenerative Medicine

Research Interests


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Academic: 336-716-9482 | Department: 336-716-4101

Recent Publications

Fortunato JE, Tegeler CL, Gerdes L, Lee SW, Pajewski NM, Franco ME, Cook JF, Shaltout HA, Tegeler CH. Use of an allostatic neurotechnology by adolescents with postural orthostatic tachycardia syndrome (POTS) is associated with improvements in heart rate variability and changes in temporal lobe electrical activity. Exp Brain Res. 2016;234(3):791-798.

Bots ML, Evans GW, Tegeler CH, Meijer R. Carotid intima-media thickness measurements: relations with atherosclerosis, risk of cardiovascular disease and application in randomized controlled trials. Chin Med J (Engl). 2016;129(2):215-226.

Strowd RE, Wise SM, Umesi UN, Bishop L, Craig J, Lefkowitz D, Reynolds PS, Tegeler C, Arnan M, Duncan PW, Bushnell CD. Predictors of 30-day hospital readmission following ischemic and hemorrhagic stroke. Am J Med Qual. 2015;30(5):441-446.

Suwatcharangkoon S, Meads DB, Tegeler CH, Reynolds PS. Transcranial doppler sonography: atypical dicrotic pulse waveforms in a man with HIV infection and severe cardiomyopathy. J Neuroimaging. 2015;25(4):680-682.

Tegeler CH, Tegeler CL, Cook JF, Lee SW, Pajewski NM. Reduction in menopause-related symptoms associated with use of a noninvasive neurotechnology for autocalibration of neural oscillations. Menopause. 2015;22(6):650-655.

Tegeler CH, Shaltout HA, Tegeler CL, Gerdes L, Lee SW. Rightward dominance in temporal high-frequency electrical asymmetry corresponds to higher resting heart rate and lower baroreflex sensitivity in a heterogeneous population. Brain Behav. 2015;5(6):e00343.

Gerdes L, Tegeler CH, Lee SW. A groundwork for allostatic neuro-education. Front Psychol. 2015;6():1224.

Houle T, Turner DP, Golding AG, Tegeler CH, Porter JAH, Martin VT, Penzien DB. Forecasting individual headache attacks: longitudinal study [abstract]. Cephalalgia. 2015;35(13):1228.

Tegeler CH, Lee SW, Shaltout HA. Significance of right anterior insula activity for mental health intervention [letter]. JAMA Psychiatry. 2014;71(3):336.

Strowd RE, Wabnitz A, Balakrishnan N, Craig J, Tegeler CH. Clinical reasoning: acute-onset homonymous hemianopia with hyperglycemia: seeing is believing. Neurology. 2014;82(15):e129-e133.

Tegeler C, Tegeler C, Cook J, Lee S, Franco M, Gerdes L, Shaltout H. Use of HIRREM, a noninvasive neurotechnology, is associated with symptom reduction and increased heart rate variability among individuals with traumatic brain injury [abstract]. Brain Inj. 2014;28(5-6):818-819.

Tegeler CH, Tegeler CL, Cook JF, Lee SW, Franco ME, Gerdes L, Shaltout HA. Use of a non-invasive neurotechnology, HIRREM, is associated with improved sleep, mood, and baroreflex sensitivity in athletes with persisting post-concussion symptoms [abstract]. Neurology. 2014;82(10 Suppl):P5.313.

Tegeler CL, Fortunato JE, Cook JF, Lee SW, Franco ME, Tegeler CH. A noninvasive neurotechnology, HIRREM, is associated with symptom reduction and improved cardiovacular autonomic measures in adolescents with POTS. Neurology. 2014;82(10):P7.320.

Cook JF, Tegeler CL, Lee SW, Shaltout HA, Franco ME, Tegeler CH. Use of a non-invasive neurotechnology, HIRREM, is associated with improved sleep and mood in a heterogeneous cohort [abstract]. Neurology. 2014;82(10 Suppl):P5.287.

Tegeler CH, Cook JF, Tegeler CL, Lee SW, Nicholas JN, Shaltout HA. Use of HIRREM, a non-invasive neurotechnology, is associated with improved autonomic function and decreased temporal hemispheric asymmetry in a 67 year old male with a recent stroke [abstract]. Neurology. 2014;82(10 Suppl):P1.138.

Tegeler CH, Tegeler CL, Cook JF, Lee SW, Franco ME, Nicholas JN, Ray CE, Howard LJ, Shaltout HA. A noninvasive approach to improve insomnia in a military cohort [abstract]. Sleep. 2014;37(Abstract Suppl):A192.0551.

Lee SW, Gerdes L, Tegeler CL, Shaltout HA, Tegeler CH. A bihemispheric autonomic model for traumatic stress effects on health and behavior. Front Psychol. 2014;5():843.

Rundek T, Brown SC, Wang K, Dong C, Farrell MB, Heller GV, Gornik HL, Hutchisson M, Needleman L, Benenati JF, Jaff MR, Meier GH, Perese S, Bendick P, Hamburg NM, Lohr JM, LaPerna L, Leers SA, Lilly MP, Tegeler C, Alexandrov AV, Katanick SL. Accreditation status and geographic location of outpatient vascular testing facilities among Medicare beneficiaries: the VALUE (Vascular Accreditation, Location & Utilization Evaluation) Study. Vasc Med. 2014;19(5):376-384.

Kanaya A, Ewing S, Vittinghoff E, Herrington D, Tegeler C, Mills C, Kandula N. Acculturation and subclinical atherosclerosis among U.S. South Asians: findings from the MASALA study. J Clin Exp Res Cardiol. 2014;1(1):.

Tegeler CH, Tegeler CL, Cook JF, Lee SW, Shaltout HA. Use of a closed-loop neurotechnology, HIR-REM, is associated with symptom reduction and improved autonomic regulation in migraineurs [abstract]. Ann Neurol. 2014;76(Suppl 18):S104.

Yang JP, Wu TC, Tegeler C, Xian Y, Olson DM, Kolls BJ. Targeting telestroke: benchmarking time performance in telestroke consultations. J Stroke Cerebrovasc Dis. 2013;22(4):470-475.

Ratanakorn D, Kongsakorn N, Keandoungchun J, Tegeler CH. Prevalence and predictors of carotid stenosis in Thai patients with ocular disorders. J Clin Neurosci. 2013;20(6):862-866.

Tegeler CH, Crutchfield K, Katsnelson M, Kim J, Tang R, Passmore Griffin L, Rundek T, Evans G. Transcranial Doppler velocities in a large, healthy population. J Neuroimaging. 2013;23(3):466-472.

Tegeler, CH, Tegeler CL, Kumar SR, Turner DP, Gerdes L, Lee SW, Houle TT. Randomized, placebo-controlled pilot trial of a novel, noninvasive EEG-based intervention, HIRREM, for alleviation of episodic migraine [abstract]. Cephalalgia. 2013;33(8 Suppl):99-100.

Tegeler CL, Cook JF, Lee SW, Pajewski NM, Nicholas JN, Tegeler CH. Pilot study of menopause-related symptom reduction through a noninvasive EEG-based technology for auto-calibration of neural oscillations (HIRREM) [abstract]. Menopause. 2013;20(12):1356.

Tegeler C, Lee SW, Tegeler CL, Shaltout HA. Correlation between temporal lobe EEG asymmetry and heart rate variability [abstract]. Neurology. 2013;80(Suppl):P03031.

Tegeler CH, Tegeler CL, Lee SW, Shaltout HA, Pejewski NM. Neural-oscillatory intervention for auto-calibration improves EEG asymmetry and HRV [abstract]. Ann Neurol. 2013;74(Suppl 17):S77.

Tegeler CH, Tegeler CL, Lee SW, Cook JF, Shaltout HA. High-resolution, relational, resonance-based electroencephalic mirroring (HIRREM) reduces symptoms and EEG asymmetry in an individual with PTSD [abstract]. Ann Neurol. 2013;74(Suppl 17):S77.

Fortunato JE, Tegeler CL, Lee SW, Pajewski NM, Franco M, Cook JF, Tegeler CH. Case series using high-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM) for POTS [abstract]. Clin Auton Res. 2013;23(5):269-270.

Ratanakorn D, Keandoungchun J, Sittichanbuncha Y, Laothamatas J, Tegeler CH. Stroke fast track reduces time delay to neuroimaging and increases use of thrombolysis in an academic medical center in Thailand. J Neuroimaging. 2012;22(1):53-57.

Tegeler CH, Kumar S, Conklin D, Turner D, Tegeler C, McCall V, Houle T. A new method of dynamic, relational, electroencephalic auditory feedback for primary insomnia [abstract]. Sleep. 2012;35(Abstract Suppl):A220.

Alexandrov AV, Sloan MA, Tegeler CH, Newell DN, Lumsden A, Garami Z, Levy CR, Wong LK, Douville C, Kaps M, Tsivgoulis G. Practice standards for transcranial doppler (TCD) ultrasound. Part II. Clinical indications and expected outcomes. J Neuroimaging. 2012;22(3):215-224.

Bots ML, Taylor AJ, Kastelein JJ, Peters SAE, den Ruijter HM, Tegeler CH, Baldassarre D, Stein JH, O'Leary DH, Revkin JH, Grobbee DE. Rate of change in carotid intima-media thickness and vascular events: meta-analyses can not solve all the issues. A point of view [editorial]. J Hypertens. 2012;30(9):1690-1696.

Ratanakorn D, Keandoungchun J, Tegeler CH. Prevalence and association between risk factors, stroke subtypes, and abnormal ankle brachial index in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2012;21(6):498-503.

Tegeler CH, Kumar SR, Conklin D, Lee SW, Gerdes L, Turner DP, Tegeler CL, C Fidali B, Houle TT. Open label, randomized, crossover pilot trial of high-resolution, relational, resonance-based, electroencephalic mirroring to relieve insomnia. Brain Behav. 2012;2(6):814-824.

Ratanakorn D, Keandoungchun J, Tegeler CH. Coexistent extra- and intracranial stenosis, cervical atherosclerosis, and abnormal ankle brachial index in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2012;21(8):782-789.

Tegeler CH, Suwatcharangkoon S, Bradbury E. Telestroke to improve acute stroke care in North Carolina [invited commentary]. N C Med J. 2012;73(6):481-484.

Curtis AR, Tegeler C, Burdette J, Yosipovitch G. Holistic approach to treatment of intractable central neuropathic itch. J Am Acad Dermatol. 2011;64(5):955-959.

Turner DP, Tegeler CH, Kumar S, Penzien DB, Rains JC, Smitherman TA, Houle TT. Rounding MIDAS scores is reduced with a decreased recall interval [abstract]. Headache. 2011;51(Suppl 1):26.

Anderson RT, Camacho F, Iaconi AI, Tegeler CH, Balkrishnan R. Enhancing the effectiveness of community stroke risk screening: a randomized controlled trial. J Stroke Cerebrovasc Dis. 2011;20(4):330-335.

Asimos AW, Johnson AM, Rosamond WD, Price MF, Rose KM, Catellier D, Murphy CV, Singh S, Tegeler CH, Felix A. A multicenter evaluation of the ABCD2 score's accuracy for predicting early ischemic stroke in admitted patients with transient ischemic attack. Ann Emerg Med. 2010;55(2):201-210.

Tang R, Tegeler C, Larrimore D, Cowgill S, Kemper KJ. Improving the well-being of nursing leaders through healing touch training. J Altern Complement Med. 2010;16(8):837-841.

Anderson R, Tegeler C, Camacho F, Parks ME, Toole J. A trial to enhance the effectiveness of community stroke risk screening in North Carolina [abstract]. Stroke. 2009;40(4):e265.

Rudisill M, Parks ME, Tegeler C, Bushnell C. Education for stroke survivors: extending quality improvement 'Beyond the Hospital' [abstract]. Stroke. 2009;40(4):e138.

Asimos AW, Rosamond WD, Johnson AM, Price MF, Rose KM, Murphy CV, Tegeler CH, Felix A. Early diffusion weighted MRI as a negative predictor for disabling stroke after ABCD2 score risk categorization in transient ischemic attack patients. Stroke. 2009;40(10):3252-3257.

Asimos AW, Rosamond WD, Rose KM, Howard AG, Murphy CV, Tegeler CH, Coleman SW. MRI use in TIA patients: variations by Joint Commission Stroke Center certification status and implications for a revised tissue-based definition of TIA [abstract]. Stroke. 2008;39(2):584.

Kim YJ, Tegeler CH. Indications for carotid artery surgery and stent: the role of carotid ultrasound. Curr Cardiol Rep. 2008;10(1):17-24.

Tegeler CH, Babikian VL. Ultrasound imaging of the cerebral vasculature In: Bradley WG, Daroff R, Fenichel G, Jankovic J, eds. Neurology in clinical practice, vol 1. 5th ed. Philadelphia: Butterworth-Heinemann/Elsevier;2008: 659-679.

Rose KM, Rosamond WD, Huston SL, Murphy CV, Tegeler CH. Predictors of time from hospital arrival to initial brain-imaging among suspected stroke patients: the North Carolina Collaborative Stroke Registry. Stroke. 2008;39(12):3262-3267.

Asimos AW, Rosamond WD, Price MF, Johnson A, Felix AC, Tegeler CH, Rose KM, Murphy CV. Ability of the ABCD2 score to predict early stroke and DWI positive MRI in admitted transient ischemic attack patients without a history of prior stroke [abstract]. Ann Emerg Med. 2008;52(4 Suppl):S98.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Neurology

Clinical Interests

Cerebrovascular Disease (Stroke), Neurology (general), Neurosonology, Prevention and Treatment of Stroke and other Cerebrovascular Disease

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