Ryan E. Temel, Ph.D., Assistant Professor Pathology-Lipid Sciences

Ryan E. Temel, Ph.D.

Assistant Professor, Pathology-Lipid Sciences
WFU Primate Center

Contact Information

Academic: 336-713-1163 | Department: 336-713-1163

Email: rtemel@wakehealth.edu

Education & Training

Ph.D., SUNY-Stony Brook , 2001
Fellowship, Molecular Biology, WFU School of Medicine, 2006

Ryan E. Temel, Ph.D.

Assistant Professor, Pathology-Lipid Sciences WFU Primate Center

Research Interests

atherosclerosis/thrombosis, metabolism

Contact Information

Academic: 336-713-1163 | Department: 336-713-1163

Email: rtemel@wakehealth.edu

Recent Publications

Saddar S, Carriere V, Lee WR, Tanigaki K, Yuhanna IS, Parathath S, Morel E, Warrier M, Sawyer JK, Gerard RD, Temel RE, Brown JM, Connelly M, Mineo C, Shaul PW. Scavenger receptor class B type I is a plasma membrane cholesterol sensor. Circ Res. 2013;112(1):140-151.

Bura KS, Lord C, Marshall S, McDaniel A, Thomas G, Warrier M, Zhang J, Davis MA, Sawyer JK, Shah R, Wilson MD, Dikkers A, Tietge UJ, Collet X, Rudel LL, Temel RE, Brown JM. Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice. J Lipid Res. 2013;54(6):1567-1577.

Owens AP III, Passam RH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton J-A, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest. 2012;122(2):558-568.

Temel RE, Brown JM. Biliary and nonbiliary contributions to reverse cholesterol transport. Curr Opin Lipidol. 2012;23(2):85-90.

Ha JH, Gourineni V, Lee MA, Temel R, Chung S. Transcriptional attributes of constitutively active brown adipose tissue in nonhuman primates [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):819.31.

Medina MW, Gao F, Naidoo D, Rudel LL, Temel RE, McDaniel AL, Marshall SM, Krauss RM. Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake. PLoS ONE. 2011;6(4):e19420.

Rayner KJ, Sheedy FJ, Esau CC, Hussain FN, Temel RE, Parathath S, van Gils JM, Rayner AJ, Chang AN, Suarez Y, et al. Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J Clin Invest. 2011;121(7):2921-2931.

Voruganti V, Jorgensen MJ, Kaplan JR, Kauanagh K [sic] [Kavanagh K], Rudel LL, Temel R, Fairbanks LA, Comuzzie AG. Significant genotype by diet (GXD) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in Vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Am J Primatol. 2011;73(Suppl 1):84.

Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, van Gils JM, Ray TD, Sheedy FJ, Lees CJ, Temel RE, et al. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature. 2011;478(7369):404-407.

Temel RE, Rayner KJ, Esau CC, McDaniel AL, Marshall SM, Lees CJ, van Gils JM, Fernandez-Hernando C, Fisher EA, Moore KJ. Inhibition of miR-33a and b in non-human primates raises plasma HDL cholesterol and reduces VLDL triglycerides [abstract]. Circulation. 2011;124(21 Suppl):A13280.

Temel RE, Sawyer JK, Yu L, Lord C, Degirolamo C, McDaniel A, Marshall S, Wang N, Shah R, Rudel LL, Brown JM. Biliary sterol secretion is not required for macrophage reverse cholesterol transport. Cell Metab. 2010;12(1):96-102.

Chung S, Rong S, Degirolamo C, Brown AW, Bi X, Forrest L, Temel R, Shelness GS, Parks JS. Hepatocyte-specific knockout of ABCA1 alleviates liver lipid accumulation but exacerbates hepatic insulin resistance and inflammation [abstract]. Arterioscler Thromb Vasc Biol. 2010;30(11):e187.

Temel RE, Brown JM. A new framework for reverse cholesterol transport: non-biliary contributions to reverse cholesterol transport. World J Gastroenterol. 2010;16(47):5946-5952.

Temel RE, Brown JM, Ma Y, Tang W, Rudel LL, Ioannou YA, Davies JP, Yu L. Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent. J Lipid Res. 2009;50(5):915-923.

McDaniel AL, Lan T, Marshall SM, Boyd CA, Kelley KL, Wilson MD, Sawyer JK, Rudel LL, Temel RE. Dietary n-3 fatty acids have minimal effects on intestinal Niemann-Pick C1 like 1 expression and cholesterol absorption [abstract]. Arterioscler Thromb Vasc Biol. 2009;29(7):e30.

Alger HM, Temel RE, Kelley KL, Wilson MD, Sawyer JK, Shah R, Rudel LL. ATP-binding cassette transporter G5/G8 prevents accumulation of toxic levels of phytosterols in dietary phytosterol-challenged mice [abstract]. Arterioscler Thromb Vasc Biol. 2008;28(6):E58.

Temel RE, Alger HM, Marshall SM, Boyd CA, Kelley KL, Wilson MD, Sawyer JK, Gebre AK, Parks JS, Rudel LL. Mice lacking ABCA1 and ACAT2 have surface-rich, core-depleted LDL due to LCAT deficiency [abstract]. Arterioscler Thromb Vasc Biol. 2008;28(6):e-133.

Temel RE, Tang W, Ma Y, Rudel LL, Willingham MC, Ioannou YA, Davies JP, Nilsson L-M, Yu L. Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J Clin Invest. 2007;117(7):1968-1978.

Temel RE, Hou L, Rudel LL, Shelness GS. ACAT2 stimulates cholesteryl ester secretion in apoB-containing lipoproteins. J Lipid Res. 2007;48(7):1618-1627.

Temel RE, Rudel LL. Diet effects on atherosclerosis in mice. Curr Drug Targets. 2007;8(11):1150-1160.