Research Interests
atherosclerosis/thrombosis
,
metabolism
Recent Publications
Owens AP III, Passam RH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton J-A, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N.
Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest.
2012;
122(2):558-568.
Rayner KJ, Sheedy FJ, Esau CC, Hussain FN, Temel RE, Parathath S, van Gils JM, Rayner AJ, Chang AN, Suarez Y, et al.
Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J Clin Invest.
2011;
121(7):2921-2931.
Voruganti V, Jorgensen MJ, Kaplan JR, Kauanagh K [sic] [Kavanagh K], Rudel LL, Temel R, Fairbanks LA, Comuzzie AG.
Significant genotype by diet (GXD) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in Vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Am J Primatol.
2011;
73(Suppl 1):84.
Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, van Gils JM, Ray TD, Sheedy FJ, Lees CJ, Temel RE, et al.
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature.
2011;
478(7369):404-407.
Temel RE, Rayner KJ, Esau CC, McDaniel AL, Marshall SM, Lees CJ, van Gils JM, Fernandez-Hernando C, Fisher EA, Moore KJ.
Inhibition of miR-33a and b in non-human primates raises plasma HDL cholesterol and reduces VLDL triglycerides [abstract]. Circulation.
2011;
124(21 Suppl):A13280.
Temel RE, Sawyer JK, Yu L, Lord C, Degirolamo C, McDaniel A, Marshall S, Wang N, Shah R, Rudel LL, Brown JM.
Biliary sterol secretion is not required for macrophage reverse cholesterol transport. Cell Metab.
2010;
12(1):96-102.
Chung S, Rong S, Degirolamo C, Brown AW, Bi X, Forrest L, Temel R, Shelness GS, Parks JS.
Hepatocyte-specific knockout of ABCA1 alleviates liver lipid accumulation but exacerbates hepatic insulin resistance and inflammation [abstract]. Arterioscler Thromb Vasc Biol.
2010;
30(11):e187.
McDaniel AL, Lan T, Marshall SM, Boyd CA, Kelley KL, Wilson MD, Sawyer JK, Rudel LL, Temel RE.
Dietary n-3 fatty acids have minimal effects on intestinal Niemann-Pick C1 like 1 expression and cholesterol absorption [abstract]. Arterioscler Thromb Vasc Biol.
2009;
29(7):e30.
Alger HM, Temel RE, Kelley KL, Wilson MD, Sawyer JK, Shah R, Rudel LL.
ATP-binding cassette transporter G5/G8 prevents accumulation of toxic levels of phytosterols in dietary phytosterol-challenged mice [abstract]. Arterioscler Thromb Vasc Biol.
2008;
28(6):E58.
Temel RE, Alger HM, Marshall SM, Boyd CA, Kelley KL, Wilson MD, Sawyer JK, Gebre AK, Parks JS, Rudel LL.
Mice lacking ABCA1 and ACAT2 have surface-rich, core-depleted LDL due to LCAT deficiency [abstract]. Arterioscler Thromb Vasc Biol.
2008;
28(6):e-133.
All Publications
For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.
For a list of earlier publications, visit the Carpenter Library Publication Search.
Research Interests:
Effects of PPAR-delta agonists on HDL elevation in non-human primates; molecular and cellular mechanisms of intestinal cholesterol absorption; lipoprotein and hepatic cholesterol metabolism; mouse and non-human primate models of atherosclerosis.
Current Research:
- Mechanisms for PPAR∂ Agonist-Induced Elevation of High-Density Lipoprotein (HDL) cholesterol in Non-Human Primates
- Effects of dietary n-3 fatty acids on intestinal Niemann-Pick C1–like 1 expression and cholesterol absorption
- Mechanisms for cholesteryl ester depletion of low-density lipoprotein (LDL) in mice lacking ATP-binding cassette transporter A1 and acyl-CoA:cholesterol acyltransferase 2
Publications: