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Frank M.  Torti, M.D., M.P.H.

Frank M. Torti, M.D., M.P.H.

Vice President for Strategic Programs, Wake Forest Baptist Medical Center
Charles L. Spurr Professor of Medicine, Hematology & Oncology
Contact Information
Appointment:
336-713-5440
Office:
336-716-7971
Fax:
336-716-5687
Clinical Specialties
Genitourinary Oncology
Education & Training
  BAJohns Hopkins University1969
  MAJohns Hopkins University1969
  MPHHarvard School of Public Health1973
  MDHarvard Medical School1974
ResidencyMedicineBeth Israel Deaconess Med Ctr1976
InternshipMedicineBeth Israel Deaconess Med Ctr1975
FellowshipStanford University School of Medicine1979
Board Certifications
American Board of Internal Medicine , Medical Oncology
American Board of Internal Medicine , Internal Medicine
Memberships
American Association of Advancement of Science
American Association of Cancer Research
North Carolina Medical Society
Society for Free Radical Biology and Medicine
American Coll of Physicians
American Federation of Clinical Research
American Medical Association
American Urological Association
American Society of Cell Biology
American Society of Clinical Oncology
American Society of Hematology
International Bioiron Society
Int'L Society of Interferon Research
NPI Number
1134180698
Frank M.  Torti, M.D., M.P.H.

Frank M. Torti, M.D., M.P.H.

Vice President for Strategic Programs, Wake Forest Baptist Medical Center
Charles L. Spurr Professor of Medicine, Hematology & Oncology
Contact Information
Appointment:
336-713-5440
Office:
336-716-7971
Fax:
336-716-5687
Research Interests
anthropology/ethnography , cancer/oncogenesis , information sciences , transgenics
Recent Publications
Aklilu M, Hussain A, Evans CP, Hannon RA, Lipton A, Dimairo M, Yu J, Zobel P, Torti FM, Finkelman RD. A phase II, randomized, open-label, pilot study to evaluate the safety and the effects on bone resorption of saracatinib (AZD0530) in patients with prostate cancer or breast cancer with metastatic bone disease [abstract]. Bone. 2011; 48(1):S17.


Torti SV, Torti FM. Ironing out cancer. Cancer Res. 2011; 71(5):1511-1514.


Stacey RB, Kock ND, D'Agostino RB Jr, Torti FM, Eckman DM, Sane DC, Workman S, Lane KS, Hundley WG. Doxorubicin associated changes in coronary artery histology [abstract]. J Am Coll Cardiol. 2011; 57(14 Suppl 1):E1591.


Burke AR, Singh RN, Carroll DL, Owen JD, Kock ND, D'Agostino R Jr, Torti FM, Torti SV. Determinants of the thrombogenic potential of multiwalled carbon nanotubes. Biomaterials. 2011; 32(26):5970-5978.


Blekherman G, Laubenbacher R, Cortes DF, Mendes P, Torti FM, Akman S, Torti SV, Shulaev V. Bioinformatics tools for cancer metabolomics. Metabolomics. 2011; 7(3):329-343.


Han J, Seaman WE, Di X, Wang W, Willingham M, Torti FM, Torti SV. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. PLoS ONE. 2011; 6(8):e23800.


Clausen KA, Blish KR, Birse CE, Triplette MA, Kute TE, Russell GB, D'Agostino RB Jr, Miller LD, Torti FM, Torti SV. SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer. Breast Cancer Res Treat. 2011; 129(3):737-746.


Ding X, Singh R, Burke A, Hatcher H, Olson J, Kraft RA, Schmid M, Carroll D, Bourland JD, Akman S, Torti FM, Torti SV. Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy. Nanomedicine (Lond). 2011; 6(8):1341-1352.


Miller LD, Coffman LG, Chou JW, Black MA, Bergh J, D'Agostino R Jr, Torti SV, Torti FM. An iron regulatory gene signature predicts outcome in breast cancer. Cancer Res. 2011; 71(21):6728-6737.


Chaosuwannakit N, D'Agostino R Jr, Hamilton CA, Lane KS, Ntim WO, Lawrence J, Melin SA, Ellis LR, Torti FM, Little WC, Hundley WG. Aortic stiffness increases upon receipt of anthracycline chemotherapy. J Clin Oncol. 2010; 28(1):166-172.


Li L, Fang CJ, Ryan JC, Niemi EC, Lebron JA, Bjorkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, et al. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A. 2010; 107(8):3505-3510.


Burke A, Carroll D, Torti FM, Torti SV. Bi-functional nanomaterials for the imaging and treatment of cancer. In: Narlikar AV, Fu YY, eds. Oxford handbook of nanoscience and technology, vol 3:applications. Oxford (UK): Oxford University Press; 2010: 474-497.


Hamilton C, Hundley G, Morgan T, Lane K, Torti F. Non-invasive systems and methods for the determination of cardiac injury using a characterizing portion of a Voxel histogram. United States patent US 7,747,308. 2010 June 29. 2010; ():.


Wang W, Di X, Torti SV, Torti FM. Ferritin H induction by histone deacetylase inhibitors. Biochem Pharmacol. 2010; 80(3):316-324.


Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: past, present and future. Biochim Biophys Acta. 2010; 1800(8):760-769.


Lightfoot JC, D'Agostino RB Jr, Hamilton CA, Jordan J, Torti FM, Kock ND, Jordan J, Workman S, Hundley WG. Novel approach to early detection of doxorubicin cardiotoxicity by gadolinium-enhanced cardiovascular magnetic resonance imaging in an experimental model. Circ Cardiovasc Imaging. 2010; 3(5):550-558.


Pinnix ZK, Miller LD, Wang W, D'Agostino R Jr, Kute T, Willingham MC, Hatcher H, Tesfay L, Sui G, Di X, Torti SV, Torti FM. Ferroportin and iron regulation in breast cancer progression and prognosis. Sci Transl Med. 2010; 2(43):43ra56.


Blish KR, Clausen KA, Hawkins GA, Garvin AJ, Willingham MC, Turner JC, Torti FM, Torti SV. Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors. J Exp Clin Cancer Res. 2010; 29():147.


Twomley K, D'Agostino R Jr, Lawrence J, Melin S, Ellis LR, Stacey B, Hamilton CA, Torti F, Little W, Hundley W. Early and persistent evidence of subclinical cardiovascular injury after receipt of anthracycline chemotherapy [abstract]. Circulation. 2010; 122(21 Suppl):A12766.


Jiao Y, Wilkinson J IV, Di X, Wang W, Hatcher H, Kock ND, D'Agostino R Jr, Knovich MA, Torti FM, Torti SV. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood. 2009; 113(2):462-469.


Coffman LG, Parsonage D, D'Agostino RD Jr, Torti FM, Torti SV. Regulatory effects of ferritin on angiogenesis. Proc Natl Acad Sci U S A. 2009; 106(2):570-575.


Hower V, Mendes P, Torti FM, Laubenbacher R, Akman S, Shulaev V, Torti SV. A general map of iron metabolism and tissue-specific subnetworks. Mol Biosyst. 2009; 5(5):422-443.


Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM. Ferritin for the clinician. Blood Rev. 2009; 23(3):95-104.


Xu J, Kibel AS, Turner AR, Pruett K, Zheng SL, Sun J, Kim S-T, Hsu F-C, Torti FM, Chang B-L, et al. Prostate cancer risk associated loci in African Americans. Cancer Epidemiol Biomarkers Prev. 2009; 18(7):2145-2149.


Chaosuwannakit N, D'Agostino R Jr, Hamilton CA, Lane KS, Ntim WO, Lawrence J, Melin SA, Ellis LR, Torti FM, Little WC, Hundley WG. Subclinical cardiovascular toxicity of anthracyclines identified with cardiovascular magnetic resonance imaging [abstract]. Circulation. 2009; 120(18 Suppl):S299.


Laubenbacher R, Hower V, Jarrah A, Torti SV, Shulaev V, Mendes P, Torti FM, Akman S. A systems biology view of cancer. Biochim Biophys Acta. 2009; 1796(2):129-139.


Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Phase I and pharmacokinetic study of angiotensin-(1-7), an endogenous antiangiogenic hormone. Clin Cancer Res. 2009; 15(23):7398-7404.


Storey JA, Connor RF, Lewis ZT, Hurd D, Pomper G, Keung YK, Lovato J, Torti SV, Torti FM, Molnar I, et al. The transplant iron score as a predictor of stem cell transplant survival. J Hematol Oncol. 2009; 2():article 44.


Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Phase I study of angiotensin-(1-7), an endogenous antiangiogenic hormone: clinical, pharmacokinetic, and biomarker findings [abstract]. Mol Cancer Ther. 2009; 8(12 Suppl 1):B208.


Hatcher HC, Singh RN, Torti FM, Torti SV. Synthetic and natural iron chelators: therapeutic potential and clinical use. Future Med Chem. 2009; 1(9):1643-1670.


Burke A, Singh R, Kraft RA, Levi-Polyachenko N, Hatcher HC, D'Agostino R Jr, Kock ND, Carroll DL, Akman S, Torti FM, Torti SV, et al. Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. Proc Natl Acad Sci U S A. 2009; 106(31):12897-902.


Blish KR, Wang W, Willingham MC, Du W, Brown JC, Hawkins GA, Garvin AJ, D'Agostino RB Jr, Torti FM, Torti SV, et al. A human bone morphogenetic protein antagonist is down-regulated in renal cancer. Mol Biol Cell. 2008; 19(2):457-464.


Stadler WM, Desai AA, Quinn DI, Bukowski R, Poiesz B, Kardinal CG, Lewis N, Makalinao A, Murray P, Torti FM. A phase I/II study of GTI-2040 and capecitabine in patients with renal cell carcinoma. Cancer Chemother Pharmacol. 2008; 61(4):689-694.


Childers ML, Cho J, Regino CAS, Brechbiel MW, DiPasquale AG, Rheingold AL, Torti SV, Torti FM, Planalp RP. Influence of ligand structure on Fe(II) spin-state and redox rate in cytotoxic tripodal chelators. J Inorg Biochem. 2008; 102(1):150-156.


Coffman LG, Brown JC, Johnson DA, Parthasarathy N, D'Agostino RB Jr, Lively MO, Hua X, Willingham MC, Torti FM, Torti SV, et al. Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin. Am J Physiol Lung Cell Mol Physiol. 2008; 294(3):L505-L515.


Ryan CJ, Small EJ, Torti FM. Testicular cancer. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG, eds. Abeloff's clinical oncology. 4th ed. Philadelphia: Churchill Livingstone/Elsevier; 2008: 1713-1744.


Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci. 2008; 65(11):1631-1652.


Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Bi-directional translational research with angiotensin-(1-7) uncovers placental growth factor as a therapeutic target [abstract]. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research ; 2008 Apr 12-16; San Diego (CA). Philadelphia (PA): AACR. 2008; ():Abstr 4968.


Hundley G, Hamilton C, Lane K, Morgan T, Torti F, inventors; Wake Forest University Health Sciences, assignee. Non-invasive imaging for determination of global tissue characteristics. United States patent US 7,333,845. 2008 Feb 19. 2008; ():.


Zhang F, Wang W, Tsuji Y, Torti SV, Torti FM. Post-transcriptional modulation of iron homeostasis during P53-dependent growth arrest. J Biol Chem. 2008; 283(49):33911-18.


Anderson RT, Kimmick GG, Camacho F, Whitmire JT, Dickinson C, Levine EA, Torit FM, Balkrishnan R. Health system correlates of receipt of radiation therapy after breast-conserving surgery: a study of low-income Medicaid-enrolled women. Am J Manag Care. 2008; 14(10):644-652.


Torti FM, Altieri D, Broach J, Fan H, Lotze M, Manfredi J, Matrisian L, Yu D, Giaccia A. Ph.D. training in cancer biology. Cancer Res. 2008; 68(22):9122-9124.


Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Phase I trial of angiotensin-(1-7): an endogenous anti-angiogenic hormone [abstract]. J Clin Oncol. 2008; 26(15 Suppl):634s.


Storey JA, Torti FM. Bone metastases in prostate cancer: a targeted approach. Curr Opin Oncol. 2007; 19(3):254-258.


Huber WW, Haslinger E, Schachner D, Parzefall W, Grasl-Kraupp B, Hochreiter A, Lang H, Torti SV, Torti FM, Schulte-Hermann R. The carcinogen azonymethane causes necrosis and oxidative stress in rat liver within 48 hours after injection, a toxic effect that is however strongly mitigated by pretreatment with the coffee components kahweol and cafestol [abstract]. Naunyn Schmiedebergs Arch Pharmacol. 2007; 375(Suppl 1):94.


Jiao Y, Kennedy DP, Cho JH, Planalp R, Bou-Abdallah F, Chasteen ND, Wilkinson J, Wang W, Torti FM, Torti SV. Curcumin, a cancer chemopreventive agent, is a biologically relevant iron chelator [abstract]. Am J Hematol. 2007; 82(6):515.


Han J, Seaman WE, Torti FM, Torti SV. Ferritin-mediated iron transport via TIM-2 in mouse kidney cells [abstract]. Am J Hematol. 2007; 82(6):517.


Li L, Torti SV, Torti FM, Hayashi S, Seaman WE. Structural requirements for the endocytosis of H-ferritin by murine TIM-2 [abstract]. Am J Hematol. 2007; 82(6):586.


Torti FM, Coffman LG, Brown JC, Torti SV, Parthasarathy N, D'Agostino RB. Ferritin inhibits cleavage of high molecular weight kininogen by elastase and mast cell tryptase [abstract]. Am J Hematol. 2007; 82(6):508-509.


Torti FM, Wang W, Di X, Torti SV. Extensive excess capacity of the IRP system in cellular iron regulation [abstract]. Am J Hematol. 2007; 82(6):565.


Wang W, Di X, D'Agostino RB Jr, Torti SV, Torti FM. Excess capacity of the iron regulatory protein system. J Biol Chem. 2007; 282(34):24650-2465.


Torti SV, Byrne F, Whelan O, Levi N, Ucer B, Schmid M, Torti FM, Akman S, Liu J, Ajayan PM, et al. Thermal ablation therapeutics based on CN(x) multi-walled nanotubes. Int J Nanomedicine. 2007; 2(4):707-714.


Finkelman D, Torti FM, Lipton A, Hannon RA, Hussain A, Evans C, Akilu M, Iacona R, Swaisland A, Stuart M. A phase II pilot study of safety and effects on bone resorption of AZD0530 in prostate or breast cancer patients with bone metastases [abstract]. J Bone Miner Res. 2007; 22(Suppl 1):S409.


Storey JA, Connor R, Lewis ZT, Lovato J, Hurd D, Torti FM, Molnar I. The transfusion iron overload score is a potential predictor of survival in stem cell transplant patients [abstract]. Blood. 2007; 110(11 Pt 1):336A.


Borden LS Jr, Clark PE, Lovato J, Hall MC, Stindt D, Harmon M, Mohler RM, Torti FM. Vinorelbine, doxorubicin, and prednisone in androgen-independent prostate cancer. Cancer. 2006; 107(5):1093-1100.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Last Updated 1/20/2012
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