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Suzy V.  Torti, Ph.D.

Suzy V. Torti, Ph.D.

Professor, Biochemistry
Contact Information
Office:
336-716-9357
Education & Training
  BA Reed College 1970
  PhD Tufts University 1977
Fellowship University of California-Berkeley 1980
Memberships
American Association of Cancer Research
Society for Free Radical Biology and Medicine
American Society of Biochem & Molecular Biology
American Society of Microbiology
Genotoxicity Environment.Mutagenesis Soc
International Bioiron Society
Suzy V.  Torti, Ph.D.

Suzy V. Torti, Ph.D.

Professor, Biochemistry
Contact Information
Office:
336-716-9357
Research Interests
cancer/oncogenesis , hormones/cytokines/signalling , molecular biology/molecular me
Recent Publications
Burke AR, Singh RN, Carroll DL, Wood JCS, D'Agostino RB Jr, Ajayan PM, Torti FM, Torti SV. The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy. Biomaterials. 2012; 33(10):2961-2970.

Wan M, Huang W, Kute TE, Miller LD, Zhang Q, Hatcher H, Wang J, Stovall DB, Russell GB, Cao PD, Deng Z, Wang W, Zhang Q, Lei M, Torti SV, Akman SA, Sui G. Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27. Am J Pathol. 2012; 180(5):2120-2133.

Torti SV, Torti FM. Ironing out cancer. Cancer Res. 2011; 71(5):1511-1514.

Cortes DF, Sha W, Hower V, Blekherman G, Laubenbacher R, Akman S, Torti SV, Shulaev V. Differential gene expression in normal and transformed human mammary epithelial cells in response to oxidative stress. Free Radic Biol Med. 2011; 50(11):1565-1574.

Burke AR, Singh RN, Carroll DL, Owen JD, Kock ND, D'Agostino R Jr, Torti FM, Torti SV. Determinants of the thrombogenic potential of multiwalled carbon nanotubes. Biomaterials. 2011; 32(26):5970-5978.

Blekherman G, Laubenbacher R, Cortes DF, Mendes P, Torti FM, Akman S, Torti SV, Shulaev V. Bioinformatics tools for cancer metabolomics. Metabolomics. 2011; 7(3):329-343.

Han J, Seaman WE, Di X, Wang W, Willingham M, Torti FM, Torti SV. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. PLoS ONE. 2011; 6(8):e23800.

Clausen KA, Blish KR, Birse CE, Triplette MA, Kute TE, Russell GB, D'Agostino RB Jr, Miller LD, Torti FM, Torti SV. SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer. Breast Cancer Res Treat. 2011; 129(3):737-746.

Ding X, Singh R, Burke A, Hatcher H, Olson J, Kraft RA, Schmid M, Carroll D, Bourland JD, Akman S, Torti FM, Torti SV. Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy. Nanomedicine (Lond). 2011; 6(8):1341-1352.

Miller LD, Coffman LG, Chou JW, Black MA, Bergh J, D'Agostino R Jr, Torti SV, Torti FM. An iron regulatory gene signature predicts outcome in breast cancer. Cancer Res. 2011; 71(21):6728-6737.

Li L, Fang CJ, Ryan JC, Niemi EC, Lebron JA, Bjorkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, et al. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A. 2010; 107(8):3505-3510.

Burke A, Carroll D, Torti FM, Torti SV. Bi-functional nanomaterials for the imaging and treatment of cancer. In: Narlikar AV, Fu YY, eds. Oxford handbook of nanoscience and technology, vol 3:applications. Oxford (UK): Oxford University Press; 2010: 474-497.

Neal RE II, Singh R, Hatcher HC, Kock ND, Torti SV, Davalos RV. Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode. Breast Cancer Res Treat. 2010; 123(1):295-301.

Wang W, Di X, Torti SV, Torti FM. Ferritin H induction by histone deacetylase inhibitors. Biochem Pharmacol. 2010; 80(3):316-324.

Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: past, present and future. Biochim Biophys Acta. 2010; 1800(8):760-769.

Pinnix ZK, Miller LD, Wang W, D'Agostino R Jr, Kute T, Willingham MC, Hatcher H, Tesfay L, Sui G, Di X, Torti SV, Torti FM. Ferroportin and iron regulation in breast cancer progression and prognosis. Sci Transl Med. 2010; 2(43):43ra56.

Fisher JW, Sarkar S, Buchanan CF, Szot CS, Whitney J, Hatcher HC, Torti SV, Rylander CG, Rylander MN. Photothermal response of human and murine cancer cells to multiwalled carbon nanotubes after laser irradiation. Cancer Res. 2010; 70(23):9855-9864.

Blish KR, Clausen KA, Hawkins GA, Garvin AJ, Willingham MC, Turner JC, Torti FM, Torti SV. Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors. J Exp Clin Cancer Res. 2010; 29():147.

Jiao Y, Wilkinson J IV, Di X, Wang W, Hatcher H, Kock ND, D'Agostino R Jr, Knovich MA, Torti FM, Torti SV. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood. 2009; 113(2):462-469.

Coffman LG, Parsonage D, D'Agostino RD Jr, Torti FM, Torti SV. Regulatory effects of ferritin on angiogenesis. Proc Natl Acad Sci U S A. 2009; 106(2):570-575.

Hower V, Mendes P, Torti FM, Laubenbacher R, Akman S, Shulaev V, Torti SV. A general map of iron metabolism and tissue-specific subnetworks. Mol Biosyst. 2009; 5(5):422-443.

Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM. Ferritin for the clinician. Blood Rev. 2009; 23(3):95-104.

Turk T, Leeuwis JW, Gray J, Torti SV, Lyons KM, Nguyen TQ, Goldschmeding R. BMP signaling and podocyte markers are decreased in human diabetic nephropathy in association with CTGF overexpression. J Histochem Cytochem. 2009; 57(7):623-631.

Rylander MN, Fisher J, Buchanan C, Szot C, Whitney J, Kraft R, Torti S, Burke A, Ding X. Controlling heat shock protein expression in laser cancer therapy using multi-walled carbon nanotubes [abstract]. Lasers Surg Med. 2009; (Suppl 21):5-6.

Laubenbacher R, Hower V, Jarrah A, Torti SV, Shulaev V, Mendes P, Torti FM, Akman S. A systems biology view of cancer. Biochim Biophys Acta. 2009; 1796(2):129-139.

Storey JA, Connor RF, Lewis ZT, Hurd D, Pomper G, Keung YK, Lovato J, Torti SV, Torti FM, Molnar I, et al. The transplant iron score as a predictor of stem cell transplant survival. J Hematol Oncol. 2009; 2():article 44.

Hatcher HC, Singh RN, Torti FM, Torti SV. Synthetic and natural iron chelators: therapeutic potential and clinical use. Future Med Chem. 2009; 1(9):1643-1670.

Burke A, Singh R, Kraft RA, Levi-Polyachenko N, Hatcher HC, D'Agostino R Jr, Kock ND, Carroll DL, Akman S, Torti FM, Torti SV, et al. Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. Proc Natl Acad Sci U S A. 2009; 106(31):12897-902.

Blish KR, Wang W, Willingham MC, Du W, Brown JC, Hawkins GA, Garvin AJ, D'Agostino RB Jr, Torti FM, Torti SV, et al. A human bone morphogenetic protein antagonist is down-regulated in renal cancer. Mol Biol Cell. 2008; 19(2):457-464.

Childers ML, Cho J, Regino CAS, Brechbiel MW, DiPasquale AG, Rheingold AL, Torti SV, Torti FM, Planalp RP. Influence of ligand structure on Fe(II) spin-state and redox rate in cytotoxic tripodal chelators. J Inorg Biochem. 2008; 102(1):150-156.

Coffman LG, Brown JC, Johnson DA, Parthasarathy N, D'Agostino RB Jr, Lively MO, Hua X, Willingham MC, Torti FM, Torti SV, et al. Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin. Am J Physiol Lung Cell Mol Physiol. 2008; 294(3):L505-L515.

Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci. 2008; 65(11):1631-1652.

Zhang F, Wang W, Tsuji Y, Torti SV, Torti FM. Post-transcriptional modulation of iron homeostasis during P53-dependent growth arrest. J Biol Chem. 2008; 283(49):33911-18.

Hatcher HC, Kock ND, Pettus J, Richard JR, Torti SV. Cytoprotective effect of ferritin following oxidative stress in renal ischemia-reperfusion injury [abstract]. Free Radic Biol Med. 2008; 45(Suppl 1):S83.

Huber WW, Haslinger E, Schachner D, Parzefall W, Grasl-Kraupp B, Hochreiter A, Lang H, Torti SV, Torti FM, Schulte-Hermann R. The carcinogen azonymethane causes necrosis and oxidative stress in rat liver within 48 hours after injection, a toxic effect that is however strongly mitigated by pretreatment with the coffee components kahweol and cafestol [abstract]. Naunyn Schmiedebergs Arch Pharmacol. 2007; 375(Suppl 1):94.

Jiao Y, Kennedy DP, Cho JH, Planalp R, Bou-Abdallah F, Chasteen ND, Wilkinson J, Wang W, Torti FM, Torti SV. Curcumin, a cancer chemopreventive agent, is a biologically relevant iron chelator [abstract]. Am J Hematol. 2007; 82(6):515.

Han J, Seaman WE, Torti FM, Torti SV. Ferritin-mediated iron transport via TIM-2 in mouse kidney cells [abstract]. Am J Hematol. 2007; 82(6):517.

Li L, Torti SV, Torti FM, Hayashi S, Seaman WE. Structural requirements for the endocytosis of H-ferritin by murine TIM-2 [abstract]. Am J Hematol. 2007; 82(6):586.

Torti FM, Coffman LG, Brown JC, Torti SV, Parthasarathy N, D'Agostino RB. Ferritin inhibits cleavage of high molecular weight kininogen by elastase and mast cell tryptase [abstract]. Am J Hematol. 2007; 82(6):508-509.

Torti FM, Wang W, Di X, Torti SV. Extensive excess capacity of the IRP system in cellular iron regulation [abstract]. Am J Hematol. 2007; 82(6):565.

Wang W, Di X, D'Agostino RB Jr, Torti SV, Torti FM. Excess capacity of the iron regulatory protein system. J Biol Chem. 2007; 282(34):24650-2465.

Torti SV, Byrne F, Whelan O, Levi N, Ucer B, Schmid M, Torti FM, Akman S, Liu J, Ajayan PM, et al. Thermal ablation therapeutics based on CN(x) multi-walled nanotubes. Int J Nanomedicine. 2007; 2(4):707-714.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Last Updated 5/1/2012
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