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Vidula Tushar Vachharajani, M.D.Wake Forest School of Medicine

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Vidula Tushar Vachharajani, M.D.

Associate Professor,

CIIRRC

Clinical Interests

Critical Care, Sepsis

Contact Information

Email: vvachhar@wakehealth.edu

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Education & Training

  • M.B.,B.S., Bombay Univ Grant Medical College-India, 1986
  • Residency, Lsu-Shreveport Affil Hsps, 2000
  • Fellowship, LSU School of Medicine-Shrevep, 2004

Board Certifications

  • American Board of Internal Medicine, Internal Medicine, Critical Care Medicine

Memberships

  • Amer Coll Of Chest Physicians
  • Shock Society
  • Soc Of Critical Care Medicine

NPI Number

  • 1952323040
Vidula Tushar Vachharajani, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Vidula Tushar Vachharajani, M.D.

Associate Professor, Anesthesiology
Hypertension and Vascular Research Center
CIIRRC

Research Interests

critical/intensive care medici, immunology/allergy/inflammatio, infectious diseases, metabolism, obesity, minority health issues

Contact Information

Academic: 336-716-4498

Email: vvachhar@wakehealth.edu

Recent Publications

Millet P, Vachharajani V, McPhail L, Yoza B, McCall CE. GAPDH binding to TNF-alpha mRNA contributes to posttranscriptional repression in monocytes: a novel mechanism of communication between inflammation and metabolism. J Immunol. 2016;196(6):2541-2551.

Vachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK, McCall CE. Sirtuins link inflammation and metabolism. J Immunol Res. 2016;2016():8167273.

Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE. Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. J Biol Chem. 2015;290(1):396-408.

Wang X, Buechler NL, Yoza BK, McCall CE, Vachharajani VT. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015;23(6):1209-1217.

Smith LM, Wells JD, Vachharajani VT, Yoza BK, McCall CE, Hoth JJ. SIRT1 mediates a primed response to immune challenge after traumatic lung injury. J Trauma Acute Care Surg. 2015;78(5):1034-1038.

Vachharajani VT, Liu T, Brown CM, Wang X, Buechler NL, Wells JD, Yoza BK, McCall CE. SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome. J Leukoc Biol. 2014;96(5):785-796.

Vachharajani V, Liu T, McCall CE. Epigenetic coordination of acute systemic inflammation: potential therapeutic targets. Expert Rev Clin Immunol. 2014;10(9):1141-1150.

Vachharajani V, Cunningham C, Yoza B, Carson J Jr, Vachharajani TJ, McCall C. Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. Obesity (Silver Spring). 2012;20(3):498-504.

Liu TF, Vachharajani VT, Yoza BK, McCall CE. NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. J Biol Chem. 2012;287(31):25758-69.

Liu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, Vachharajani VT, Yoza BK, McCall CE. Fueling the flame: bioenergy couples metabolism and inflammation. J Leukoc Biol. 2012;92(3):499-507.

Liu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CE. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem. 2011;286(11):9856-9864.

Vachharajani TJ, Vachharajani V. A circuitous detour. Kidney Int. 2011;79(12):1383.

Vachharajani TJ, Moossavi S, Jordan JR, Vachharajani V, Freedman BI, Burkart JM. Re-evaluating the Fistula First Initiative in octogenarians on hemodialysis. Clin J Am Soc Nephrol. 2011;6(7):1663-1667.

McCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza B. Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. J Leukoc Biol. 2011;90(3):439-446.

Vachharajani V, Vital S, Russell J. Modulation of circulating cell-endothelial cell interaction by erythropoietin in lean and obese mice with cecal ligation and puncture. Pathophysiology. 2010;17(1):9-18.

Vachharajani TJ, Vachharajani V. Obstacles for clinical monitoring in hemodialysis patients because of multiple vascular accesses. Semin Dial. 2010;23(1):114-116.

Vachharajani V, Wang SW, Mishra N, El Gazzar M, Yoza B, McCall C. Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Microcirculation. 2010;17(6):407-416.

Vachharajani V, Granger DN. Adipose tissue: a motor for the inflammation associated with obesity. IUBMB Life. 2009;61(4):424-430.

Vachharajani V. Diet-induced obesity exacerbates cell adhesion in sepsis [abstract]. Shock. 2009;31(Suppl 1):72.

Vachharajani V. Influence of obesity on sepsis. Pathophysiology. 2008;15(2):123-134.

Vachharajani V, Vital S, Russell J, Granger DN. Hypertonic saline and the cerebral microcirculation in obese septic mice. Microcirculation. 2007;14(3):223-231.

Vachharajani T, Vachharajani V. Vasopressin-receptor antagonist therapy in patients with hyponatraemia. Br J Hosp Med. 2007;68(7):367-372.

Vachharajani V, Vital S. Obesity and sepsis. J Intensive Care Med. 2006;21(5):287-295.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Anesthesiology

Clinical Interests

Critical Care, Sepsis
Vidula Tushar Vachharajani, M.D.

Vidula Tushar Vachharajani, M.D.

Associate Professor, Anesthesiology
Hypertension and Vascular Research Center
CIIRRC

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