Profile

Mark E. Van Dyke, Ph.D.

Mark E. Van Dyke, Ph.D.

Assistant Professor, Orthopaedics
Translational Science Institute
Sticht Center on Aging
Translational Science Institute

Contact Information

Academic: 336-713-7266 | Department: 336-716-8200

Email: mavandyk@wakehealth.edu

Education & Training

  • Ph.D., University of Cincinnati , 1998
  • B.S., Central Michigan University , 1988
Mark E. Van Dyke, Ph.D.

Mark E. Van Dyke, Ph.D.

Assistant Professor, Orthopaedics Translational Science Institute
Sticht Center on Aging
Translational Science Institute

Research Interests

biotechnology, cell growth, differentiation,d, engineering/bioengineering, immunology/allergy/inflammatio, osteoporosis, surgery/trauma/burns/trauma

Contact Information

Academic: 336-713-7266 | Department: 336-716-8200

Email: mavandyk@wakehealth.edu

Recent Publications

de Guzman RC, Saul JM, Ellenburg MD, Merrill MR, Coan HB, Smith TL, Van Dyke ME. Bone regeneration with BMP-2 delivered from keratose scaffolds. Biomaterials. 2013;34(6):1644-1656.

Gaines C, Poranki D, Du W, Clark RA, Van Dyke M. Development of a porcine deep partial thickness burn model. Burns. 2013;39(2):311-319.

Rahmany MB, Hantgan RR, Van Dyke M. A mechanistic investigation of the effect of keratin-based hemostatic agents on coagulation. Biomaterials. 2013;34(10):2492-2500.

Rahmany MB, Van Dyke M. Biomimetic approaches to modulate cellular adhesion in biomaterials: a review. Acta Biomater. 2013;9(3):5431-5437.

Lin Y-C, Ramadan M, Van Dyke M, Kokai LE, Philips BJ, Rubin JP, Marra KG. Keratin gel filler for peripheral nerve repair in a rodent sciatic nerve injury model. Plast Reconstr Surg. 2012;129(1):67-78.

Richter JR, de Guzman RC, Greengauz-Roberts OK, Van Dyke M. Structure-property relationships of meta-kerateine biomaterials derived from human hair. Acta Biomater. 2012;8(1):274-281.


Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN, Breuer C, Burnett L, Christ G, Farney A, Figliuzzi M, Holmes JH IV, Koch K, Macchiarini P, Mirmalek Sani S-H, Opara E, Remuzzi A, Rogers J, Saul JM, Seliktar D,. Regenerative medicine as applied to general surgery. Ann Surg. 2012;255(5):867-880.

Stern AR, Stern MM, Van Dyke ME, Jahn K, Prideaux M, Bonewald LF. Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice. Biotechniques. 2012;52(6):361-373.

Van Dyke M. How much risk are you prepared to take?. Nat Biotechnol. 2012;30(9):821-824.

Whitlock PW, Seyler TM, Parks GD, Ornelles DA, Smith TL, Van Dyke ME, Poehling GG. A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructural properties, and cell infiltration. J Bone Joint Surg Am. 2012;94(16):1458-1467.

Bertram TA, Tentoff E, Johnson PC, Tawil B, Van Dyke M, Hellman KB. Hurdles in tissue engineering/regenerative medicine product commercialization: a pilot survey of governmental funding agencies and the financial industry. Tissue Eng Part A. 2012;18(21-22):2187-2194.

Nunez FA, Kislukin V, Smith TL, Callahan MF, Burnett L, VanDyke ME. Hemodynamic response after hypovolemic shock and resuscitation with low-volume 6% hetastarch (HS) and high-volume lactated Ringer's (LR) solution [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):1132.8.

Hill PS, Apel PJ, Barnwell J, Smith T, Koman LA, Atala A, Van Dyke M. Repair of peripheral nerve defects in rabbits using keratin hydrogel scaffolds. Tissue Eng Part A. 2011;17(11-12):1499-1505.

Saul JM, Ellenburg MD, de Guzman RC, Van Dyke M. Keratin hydrogels support the sustained release of bioactive ciprofloxacin. J Biomed Mater Res A. 2011;98(4):544-553.

Richter JR, de Guzman RC, Van Dyke ME. Mechanisms of hepatocyte attachment to keratin biomaterials. Biomaterials. 2011;32(30):7555-7561.

de Guzman RC, Merrill MR, Richter JR, Hamzi RI, Greengauz-Roberts OK [sic] [Gringauz Roberts OK], Van Dyke ME. Mechanical and biological properties of keratose biomaterials. Biomaterials. 2011;32(32):8205-8217.

Nunez F, Trach S, Burnett L, Handa R, Van Dyke M, Callahan M, Smith T. Vasoactive properties of keratin-derived compounds. Microcirculation. 2011;18(8):663-669.

Hill P, Brantley H, Van Dyke M. Some properties of keratin biomaterials: kerateines. Biomaterials. 2010;31(4):585-593.

Lim GJ, Zare S, Van Dyke M, Atala A. Cell microencapsulation. Adv Exp Med Biol. 2010;670():126-136.

Rath AL, Bonewald LF, Ling J, Jiang JX, Van Dyke ME, Nicolella DP. Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow. J Biomech. 2010;43(8):1560-1564.

Stabile KJ, Odom D, Smith TL, Northam C, Whitlock PW, Smith BP, Van Dyke ME, Ferguson CM. An acellular, allograft-derived meniscus scaffold in an ovine model. Arthroscopy. 2010;26(7):936-948.

Nunez F, Trach S, Kislukin V, Van Dyke M, Callahan M, Smith T, Koman LA. Comparison of hemodynamic changes after hemorrhage and treatment with hyperviscous fluids [abstract]. Shock. 2010;33(Suppl 1):16.

Stern MM, Myers RL, Hammam N, Stern KA, Eberli D, Kritchevsky SB, Soker S, Van Dyke M. The influence of extracellular matrix derived from skeletal muscle tissue on the proliferation and differentiation of myogenic progenitor cells ex vivo. Biomaterials. 2009;30(12):2393-2399.

Jung SH, Kim SH, Yang JC, Hong HH, Kim HL, Kim W, Son Y, Lee SJ, van Dyke M, Yoo JJ, et al. [Effect of keratin/PLGA scaffold on the articular cartilage tissue engineering: in vivo test] [Korean]. Tissue Eng Regen Med. 2009;6(1-3):192-198.

Oh AY, Kim SH, Kim CM, Jung SH, Jeon NR, Hong HH, Lee SJ, van Dyke M, Yoo JJ, Lee DW, et al. [The effect of keratin/PLGA scaffold on neural differentiation of rat BMSCs] [Korean]. Tissue Eng Regen Med. 2009;6(1-3):112-118.


Oh AY, Kim SH, Kim YT, Jeon NR, Yang JC, Lee SJ, Yoo JJ, van Dyke M, Shin HS, Rhee JM, et al. [A study on proliferation and phenotypical stability of Schwann cell on keratin/PLGA film] [Korean]. Polymer [Korea]. 2009;33(2):118-123.

Aboushwareb T, Eberli D, Ward C, Broda C, Holcomb J, Atala A, Van Dyke M. A keratin biomaterial gel hemostat derived from human hair: evaluation in a rabbit model of lethal liver injury. J Biomed Mater Res B Appl Biomater. 2009;90(1):45-54.

Zhang Y, He Y, Bharadwaj S, Hammam N, Carnagey K, Myers R, Atala A, Van Dyke M. Tissue-specific extracellular matrix coatings for the promotion of cell proliferation and maintenance of cell phenotype. Biomaterials. 2009;30(23-24):4021-4028.

Jeon NR, Jo EH, Park HJ, Choi JS, Lee SJ, Van Dyke M, Lee JJ, Lee D, Rhee JM, Khang G. Effects of keratin/PLGA scaffolds on proliferation and phenotype of olafactory ensheathing cells. Tissue Eng Regen Med. 2009;6(4-11 Special Issue):819-824.

Sierpinski P, Garrett J, Ma J, Apel P, Klorig D, Smith T, Koman LA, Atala A, Van Dyke M. The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves. Biomaterials. 2008;29(1):118-128.

Tsai A, Intaglietta M, Van Dyke M. Blood substitutes: reverse evolution from oxygen carrying to non-oxygen carrying plasma expanders In: Atala A, Lanza R, Thomson JA, Nerem RM, eds. Principles of regenerative medicine. Boston (MA): Academic Press;2008: 756-765.

Sierpinski P, Garrett J, Ma J, Apel P, Smith T, Atala A. Koman A [sic] [Koman L], Van Dyke M. Human hair derived keratins mediate Schwann cell behavior in vitro and facilitate rapid regeneration of peripheral nerves in vivo [abstract]. Tissue Eng Part A. 2008;14(5):859.

Van Dyke M. Enabling technologies for tissue engineering and regenerative medicine [abstract]. Tissue Eng Part A. 2008;14(5):727.

Whitlock PW, Smith TL, Shilt JS, Poehling GG, Van Dyke ME. A tissue-engineered tendon scaffold [abstract]. Tissue Eng Part A. 2008;14(5):698.

Xu T, Hipp J, Atala A, Yoo JJ, Van Dyke ME. Genomic guided ECM biomaterials development for regenerative medicine applications [abstract]. Tissue Eng Part A. 2008;14(5):739.

Yazdani SK, Watts B, Machingal M, Jarajapu YPR, Van Dyke ME, Christ GJ. Smooth muscle cell seeding of decellularized scaffolds: further development toward a more native architecture for tissue engineered blood vessels [abstract]. Tissue Eng Part A. 2008;14(5):778.

Lee SJ, Van Dyke M, Atala A, Yoo JJ. Host cell mobilization for in situ tissue regeneration. Rejuvenation Res. 2008;11(4):747-756.

Apel PJ, Garrett JP, Sierpinski P, Ma J, Atala A, Smith TL, Koman LA, Van Dyke ME. Peripheral nerve regeneration using a keratin-based scaffold: long-term functional and histological outcomes in a mouse model. J Hand Surg [Am]. 2008;33(9):1541-1547.

Oh AY, Kim SH, Lee SJ, Yoo JJ, Van Dyke M, Rhee JM, Khang G. [Preparation and characterization of PLGA scaffold impregnated keratin for tissue engineering application] [Korean]. Polymer [Korea]. 2008;32(5):403-408.

Hong HH, Kim SH, Oh AY, Jeon NR, Jung SH, Lee SJ, Van Dyke M, Yoo JJ, Son Y, Rhee JM, et al. [Effect of keratin/PLGA hybrid scaffold for chondrogenesis: in vitro test] [Korean]. Tissue Eng Regen Med. 2008;5(4-6):861-868.

Oh AY, Kim SH, Jung SH, Hong HH, Jeon NR, Lee SJ, Van Dyke M, Yoo JJ, Rhee JM, Khang G. [Effect of keratin/PLGA scaffold on proliferation and phenotype of Schwann cell] [Korean]. Tissue Eng Regen Med. 2008;5(4-6):855-860.

Van Dyke M, inventor; Wake Forest University Health Sciences, assignee. Ambient stored blood plasma expanders. United States patent US 7,436,012. 2008 Oct 21. 2008;():.

Whitlock P, Poehling G, Smith T, VanDyke M, Shilt J. Development, characterization, and cell-seeding of a naturally-derived scaffold for tendon and ligament resconstruction [abstract]. In: Program Book of the 54th Annual Meeting of the Orthopaedic Research Society; 2008 Mar 2-5; San Francisco (CA). 2008;():1481.

Myers RL, Carnagey KM, Soker S, Van Dyke M, Kritchevsky S. Impact of age on characteristics of muscle progenitor cells and adipose derived stem cells [abstract]. J Am Geriatr Soc. 2007;55(4 Suppl):S66.

Yazdani SK, Machingal M, Watts B, Jarajapu YPR, Van Dyke ME, Christ GJ. Smooth muscle seeded natural collagen scaffolds for tissue engineered blood vessels [abstract]. FASEB J. 2007;21(5):A81.

Sierpinski P, Garrett J, Ma J, Apel P, Smith T, Atala A, Koman LA, Van Dyke M. Human hair derived keratins mediate Schwann cell behavior in vitro and facilitate rapid peripheral nerve regeneration in vivo [abstract]. FASEB J. 2007;21(6):A1273.

Van Dyke M, Oberpenning F, Meng J, Soker S, Yoo JJ, Atala A. Total organ replacement using tissue engineering [abstract]. FASEB J. 2007;21(5):A140.

Whitlock PW, Smith TL, Shilt JS, Poehling GG, Van Dyke ME. Development, characterization and cell-seeding of a novel biocompatible scaffold for tendon and ligament reconstruction [abstract]. FASEB J. 2007;21(5):A268.

Whitlock PW, Smith TL, Poehling GG, Shilt JS, Van Dyke M. A naturally derived, cytocompatible, and architecturally optimized scaffold for tendon and ligament regeneration. Biomaterials. 2007;28(29):4321-4329.

Furth ME, Atala A, Van Dyke ME. Smart biomaterials design for tissue engineering and regenerative medicine. Biomaterials. 2007;28(34):5068-5073.

Lee SJ, Van Dyke M, Atala A, Yoo JJ. Stem/progenitor cell mobilization for tissue regeneration [abstract]. Tissue Eng. 2007;13(7):1757.

Sierpinski P, Garrett J, Ma J, Apel P, Smith T, Atala A, Koman LA, Van Dyke M. Human hair derived keratins facilitate regeneration of peripheral nerves in vivo [abstract]. Tissue Eng. 2007;13(7):1706-1707.

Whitener W, Mesen T, Howse S, Nanney L, Molnar J, Van Dyke M. Biologically active wound dressings derived from human hair [abstract]. Tissue Eng. 2007;13(7):1644.

Yazdani SK, Jarajapu YPR, Machinga M [sic] [Machingal M], Watts B, Van Dyke ME, Christ GJ. Bioreactor protocols for improved cellular penetration of decellularized scaffolds [abstract]. Tissue Eng. 2007;13(7):1645.

Yazdani SK, Jarajapu YPR, Machingal M, Watts B, Van Dyke ME, Christ GJ. Development of tissue engineered blood vessels with a functional medial muscle layer [abstract]. Tissue Eng. 2007;13(7):1673.

Stabile KJ, Whitlock PW, Smith TL, VanDyke ME, Ferguson CM. A tissue engineered meniscus scaffold [abstract]. In: Transactions Online of the 6th Combined Meeting of the Orthopaedic Research Societies; 2007 Oct 20-24; Honolulu (HI). 2007;():222.

Whitlock PW, Knutson J, Smith TL, Van Dyke ME, Shilt JS, Koman LA, Poehling GG. Effects of mechanical stimulation on a cell-seeded scaffold developed for tendon and ligament regeneration [abstract]. In: Transactions Online of the 6th Combined Meeting of the Orthopaedic Research Societies; 2007 Oct 20-24; Honolulu (HI). 2007;():391.

Apel PJ, Garrett J, Sierpinski P, Ma J, Hick J, Smith TL, Koman LA, Van Dyke ME. Peripheral nerve regeneration using a keratin gel-based scaffold: long-term functional and histological outcomes in a mouse model [abstract]. In: Transactions Online of the 6th Combined Meeting of the Orthopaedic Research Societies; 2007 Oct 20-24; Honolulu (HI). 2007;():364.

Whitlock PW, Smith TL, Shilt JS, Van Dyke ME, Poehling GG. A novel scaffold for tendon and ligament regeneration derived from human allograft tissue [abstract]. In: Transactions Online of the 6th Combined Meeting of the Orthopaedic Research Societies; 2007 Oct 20-24; Honolulu (HI). 2007;():188.

Sierpinski PL, Garrett J, Ma J, Apel PJ, Smith T, Koman LA, Atala A, Van Dyke M. A biomaterial derived from human hair keratins can serve as a scaffold for tissue engineering in orthopaedic applications [abstract]. In: Transactions Online of the 6th Combined Meeting of the Orthopaedic Research Societies; 2007 Oct 20-24; Honolulu (HI). 2007;():61.

Sierpinski PL, Apel PJ, Burnell JM, Klorig D, Smith T, Koman LA, Atala A, Van Dyke M. Keratin biomaterials made from human hair mediate Schwann and endothelial cell activity in vitro [abstract]. In: Transactions Online of the 6th Combined Meeting of the Orthopaedic Research Societies; 2007 Oct 20-24; Honolulu (HI). 2007;():417.

Whitlock PW, Smith TL, Shilt JS, Poehling GG, Van Dyke ME. Development of a biocompatible scaffold for tendon and ligament regeneration [abstract]. In: Transactions Online of the 53rd Annual Meeting of the Orthopaedic Research Societies; 2007 Feb 11-14; San Diego (CA). 2007;32():0333.

Mikos AG, Herring SW, Ochareon P, Elisseeff J, Lu HH, Kandel R, Schoen FJ, Toner M, Atala A, Van Dyke ME, et al. Engineering complex tissues. Tissue Eng. 2006;12(12):3307-3339.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Orthopaedics

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