Profile

Jasmina Varagic, M.D., Ph.D.Wake Forest School of Medicine

Jasmina Varagic, M.D., Ph.D.

Associate Professor,


Contact Information

Academic: 336-716-2738 | Department: 336-716-2738

Email: jvaragic@wakehealth.edu

Additional Languages

Serbo-Croatian

Education & Training

  • M.D., Univesity Belgrade Faculty of Medicine-Yugoslavia , 1985
  • M.Sc., Univesity Belgrade Faculty of Medicine-Yugoslavia , 1991
  • Ph.D., Univesity Belgrade Faculty of Medicine-Yugoslavia , 1997
  • Fellowship, Nutrition and Epidemiology, Univesity Belgrade Faculty of, 1991
  • Fellowship, Cardiovascular Physiology, Univesity Belgrade Faculty of, 1997
  • Fellowship, Cardiovascular Physiology, Univesity Belgrade Faculty of, 2000

Memberships

  • Am Heart Association
  • Am Physiological Society
  • Council For High Blood Pressur
Jasmina Varagic, M.D., Ph.D.

Jasmina Varagic, M.D., Ph.D.

Associate Professor, Surgical Sciences-Hypertension
Hypertension and Vascular Research Center
Physiology & Pharmacology

Research Interests

diabetes, women's health issues

Contact Information

Academic: 336-716-2738 | Department: 336-716-2738

Email: jvaragic@wakehealth.edu

Recent Publications

Varagic J, Ahmad S, Nagata S, Ferrario CM. ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury. Curr Hypertens Rep. 2014;16(3):420.

Ahmad S, Varagic J, Groban L, Dell'italia LJ, Nagata S, Kon ND, Ferrario CM. Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate. Curr Hypertens Rep. 2014;16(5):429.

Ferrario CM, Ahmad S, Nagata S, Simington SW, Varagic J, Kon N, Dell'italia LJ. An evolving story of angiotensin-II-forming pathways in rodents and humans. Clin Sci. 2014;126(7-8):461-469.

Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB. Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. Hypertension. 2014;64(3):619-625.

Moniwa N, Varagic J, Ahmad S, Voncannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM. Hemodynamic and hormonal changes to dual Renin-Angiotensin system inhibition in experimental hypertension. Hypertension. 2013;61(2):417-424.

Varagic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM. Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats. Am J Hypertens. 2013;26(5):583-590.

Ahmad S, Wei CC, Tallaj J, Dell'Italia LJ, Moniwa N, Varagic J, Ferrario CM. Chymase mediates angiotensin-(1-12) metabolism in normal human hearts. J Am Soc Hypertens. 2013;7(2):128-136.

Varagic J, Gallagher PE. Tissue specific regulation of CB1/CB2 gene receptors in salt sensitive hypertension of SHR [abstract]. FASEB J. 2013;27():1108.8.


Moniwa N, Varagic J, Simington SW, Ahmad S, Nagata S, Voncannon JL, Ferrario CM. Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism. Am J Physiol Heart Circ Physiol. 2013;305(5):H644-H650.

Moniwa N, Varagic J, Nagata S, Ahmad S, Simington SW, VonCannon JL, Shimamura Y, Hasegawa K, Takizawa H, Ura N, Tanaka S, Furuhashi M, Yoshida H, Miura T, Ferrario CM. Renin independent Ang-(1-12) production in both the systemic and coronary circulation [abstract]. Hypertension. 2013;62(3 Suppl):604.

Pulgar VM, Yamaleyeva LM, Varagic J, Bader M, Dechend R, Brosnihan KB. Inhibition of metabolism of endogenous AEA and 2-AG reduces Ang II induced uterine artery contraction at early pregnancy in a transgenic model of preeclampsia [abstract]. Hypertension. 2013;62(3 Suppl):416.

Nagata S, Varagic J, Simington SW, Ahmad S, VonCannon JL, Wang H, Groban L, Kon ND, Dell'Italia LJ, Ferrario CM. Differential expression of angiotensin-(1-12)/chymase in human atrial tissue [abstract]. Hypertension. 2013;62(3 Suppl):629.

Varagic J, Gallagher PE, Grabenauer M, Thomas BF. Renal endocannabinoids in salt-sensitive hypertension of SHR [abstract]. Hypertension. 2013;62(3 Suppl):499.

Nagata S, Varagic J, Simington SW, Ahmad S, VonCannon JL, Wang H, Kon ND, Dell'Italia LJ, Ferrario CM, Groban L. Does cardiac ang-(1-12) have a role in sex-specific heart disease? [abstract]. Hypertension. 2013;62(3 Suppl):632.

Varagic J, Gallagher PE, Grabenauer M, Thomas BF. Cardiac and renal endocannabinoids in salt-loaded SHR [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Moniwa N, Varagic J, Ahmad S, VonCannon JL, Ferrario CM. Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats. Ther Adv Cardiovasc Dis. 2012;6(1):15-29.

Yamaleyeva LM, Lindsey SH, Varagic J, Zhang LL, Gallagher PE, Chen AF, Chappell MC. Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. J Cardiovasc Pharmacol. 2012;59(6):529-538.

Moniwa N, Varagic J, Ahmad S, Ferrario CM. Effects of combination therapy with valsartan and aliskiren on arterial pressure, cardiac hypertrophy and urinary protein excretion in hypertensive rats [abstract]. FASEB J. 2012;26(Meeting Abstracts):1105.4.

Moniwa N, Wei C-C, Dell'Italia LJ, Ferrario CM, Ahmad S, Varagic J. Chymase-mediated angiotensin II generation from angiotensin-(1-12) in left ventricular tissue of normal and diseased human subjects [abstract]. J Clin Hypertens (Greenwich). 2012;14(Suppl 1):149.

Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW Jr, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. J Hypertens. 2012;30(9):1766-1774.

Moniwa N, Varagic J, Ahmad S, Ferrario CM. Differential effects of ACE and chymase in the metabolism of exogenous angiotensin-(1-12) in Wistar-Kyoto rats [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):1105.3.

Santiago N, Melo MB, Chappell M, Varagic J, Santos RAS, Campagnole-Santos MJ. Diabetes abolishes the cardioprotective effect of estrogen on systolic cardiac function [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):1057.23.

Moniwa N, Ahmad S, VonCannon JL, Simington SW, Varagic J, Ferrario CM. Role of angiotensin converting enzyme on the production of angiotensins from angiotensin-(1-12) in normotensive Winstar-kyoto rats and spontaneously hypertensive rats [abstract]. Hypertension. 2012;60(3 Suppl):235.

Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM. Predominance of angiotensin II type 1 receptor blockade over antiotensin-(1-7) mechanisms in the regulation of blood pressure and renin angiotensin system in mRen.Lewis rats [abstract]. Hypertension. 2012;60(Suppl 3):283.

Simington SW, Moniwa N, Ahmad S, VonCannon JL, Dell'Italia LJ, Varagic J, Ferrario CM. Renin does not participate in the production of plasma ang-(1-12) from angiotensinogen [abstract]. Hypertension. 2012;60(3 Suppl):628.

Santiago NM, Figueiredo GZ, Souza M, Campagnole-Santos MJ, Varagic J. Activation of GPR30 attenuates cardiac injury in the ovariectomized diabetic mRen2.Lewis rat [abstract]. Hypertension. 2012;60(3 Suppl):312.

Ahmad S, Varagic J, Westwood BM, Chappell MC, Ferrario CM. Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes. PLoS ONE. 2011;6(1):e15759.

Varagic J, Ahmad S, Habibi J, Sowers JR, Ferrario CM. Differential regulation of NOS in kidney and heart of SHR fed high salt diet [abstract]. FASEB J. 2011;25(Meeting Abstracts):643.7.

Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Ferrario CM. Olmesartan reduces angiotensin II without affecting ACE activity in kidneys of mRen2.Lewis rats [abstract]. FASEB J. 2011;25(Meeting Abstracts):1b358.

Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Lively M, Ferrario CM. Localization and metabolism of angiotensin-(1-12) in human atrial tissue [abstract]. Hypertension. 2011;58(5):e50.

Moniwa N, Varagic J, Ahmad S, Ferrario CM. RAS blockade restores circadian rhythm of arterial pressure in a renin-dependent model of experimental hypertension [abstract]. Hypertension. 2011;58(5):e151.

Santiago NM, Yamaleyeva LM, Campagnole-Santos MJ, Chappell M, Varagic J. Early diabetes is associated with lower cardiac ACE2 activity but not altered blood pressure in female hypertensive mRen2.Lewis rats [abstract]. Hypertension. 2011;58(5):e126-e127.

Varagic J, Ahmad S, Gallagher PE, Habibi J, Sowers J, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded SHR [abstract]. Hypertension. 2011;58(5):e80.

Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Ferrario CM. Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue. PLoS ONE. 2011;6(12):e28501.

Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010;4(1):17-25.

Trask AJ, Groban L, Westwood BM, Varagic J, Ganten D, Gallagher PE, Chappell MC, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens. 2010;23(6):687-693.

Ferrario CM, Varagic J. The ANG-(1-7)/ACE2/mas axis in the regulation of nephron function. Am J Physiol Renal Physiol. 2010;298(6):F1297-305.

Susic D, Varagic J, Frohlich ED. Cardiovascular effects of inhibition of renin-angiotensin-aldosterone system components in hypertensive rats given salt excess. Am J Physiol Heart Circ Physiol. 2010;298(4):H1177-81.

Ahmad S, Varagic J, Westwood B, Chappell MC, Strawn WB, Simmons T, Ferrario CM. Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):605.4.

Ferrario CM, Ahmad S, Joyner J, Varagic J. Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7). Adv Pharmacol. 2010;59():197-233.

Santiago NM, Yamaleyeva LM, Campagnole-Santos MJ, Chappell M, Varagic J. Cardiac remodeling is associated with altered cardiac AT(1) receptor/eNOS pathway in ovariectomized mRen2 Lewis diabetic rats [abstract]. Hypertension. 2010;56(5):e81.

Varagic J, Ahmad S, Brosnihan KB, Habibi J, Sowers JR, Ferrario CM. The effects of nebivolol on salt-induced renal injury [abstract]. Hypertension. 2010;56(5):e155.

Varagic J, Ahmad S, Brosnihan KB, Habibi J, Tilmon RD, Sowers JR, Ferrario CM. Salt-induced renal injury in spontaneously hypertensive rats: effects of nebivolol. Am J Nephrol. 2010;32(6):557-566.

Ferrario CM, Varagic J, Habibi J, Nagata S, Kato J, Chappell MC, Trask AJ, Kitamura K, Whaley-Connell A, Sowers JR. Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy. Am J Physiol Heart Circ Physiol. 2009;296(4):H1184-1192.

Ahmad S, Varagic J, Westwood B, Chappell MC, Ferrario CM. Uptake of novel peptide angiotensin-(1-12) by cardiac myocytes [abstract]. Hypertension. 2009;54(4):e111.

Varagic J, Ahmad S, Brosnihan KB, Ferrario CM. Spironolactone and angiotensin-(1-7) in salt-induced cardiac injury [abstract]. Hypertension. 2009;54(4):e26.

Varagic J, Frohlich ED, Susic D, Ahn J, Matavelli L, Lopez B, Diez J. AT1 receptor antagonism attenuates target organ effects of salt excess in SHRs without affecting pressure. Am J Physiol Heart Circ Physiol. 2008;294(2):H853-858.

Varagic J, Trask AJ, Jessup JA, Chappell MC, Ferrario CM. New angiotensins. J Mol Med. 2008;86(6):663-671.

Diz DI, Varagic J, Groban L. Aging and the brain renin-angiotensin system: relevance to age-related decline in cardiac function. Future Cardiol. 2008;4(3):237-245.

Ferrario CM, Varagic J, Chappell MC, Trask AJ, Nagata S, Kato J. Bilateral nephrectomy augments the cardiac content of angiotensin-(1-12) and angiotensin I in Wistar Kyoto rats [abstract]. Hypertension. 2008;52(4):e126.

Trask AJ, Groban L, Varagic J, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 aggravates cardiac hypertrophy in Ren-2 hypertensive rats [abstract]. Hypertension. 2008;52(4):e126.

Varagic J, Brosnihan KB, Groban L, Gallagher PE, Ferrario CM. Decreased expression of cardiac ACE2 is associated with salt-induced cardiac remodeling and dysfunction [abstract]. Hypertension. 2007;50(4):e150.

Matavelli LC, Zhou X, Varagic J, Susic D, Frohlich ED. Salt loading produces severe renal hemodynamic dysfunction independent of arterial pressure in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2007;292(2):H814-H819.

Susic D, Varagic J, Ahn J, Matavelli L, Frohlich ED. Long-term mineralocorticoid receptor blockade reduces fibrosis and improves cardiac performance and coronary hemodynamics in elderly SHR. Am J Physiol Heart Circ Physiol. 2007;292(1):H175-H179.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Surgical Sciences-Hypertension

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