Profile

Jasmina Varagic, M.D., Ph.D.Wake Forest School of Medicine

Jasmina Varagic, M.D., Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-2738 | Department: 336-716-2738

Email: jvaragic@wakehealth.edu

Additional Languages

Serbo-Croatian

Education & Training

  • M.D., Univesity Belgrade Faculty of Medicine-Yugoslavia, 1985
  • M.Sc., Univesity Belgrade Faculty of Medicine-Yugoslavia, 1991
  • Ph.D., Univesity Belgrade Faculty of Medicine-Yugoslavia, 1997
  • Fellowship, Nutrition and Epidemiology, Univesity Belgrade Faculty of, 1991
  • Fellowship, Cardiovascular Physiology, Univesity Belgrade Faculty of, 1997
  • Fellowship, Cardiovascular Physiology, Univesity Belgrade Faculty of, 2000

Memberships

  • Am Heart Association
  • Am Physiological Society
  • Council For High Blood Pressur
Jasmina Varagic, M.D., Ph.D.

Jasmina Varagic, M.D., Ph.D.

Associate Professor, Hypertension
Physiology & Pharmacology

Research Interests

Hypertension; Peptide Fragments; Angiotensin I; Blood Pressure; Angiotensin II
More »

Contact Information

Academic: 336-716-2738 | Department: 336-716-2738

Email: jvaragic@wakehealth.edu

Recent Publications

Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene. Ferrario CM, VonCannon JL, Jiao Y, Ahmad S, Bader M, Dell'Italia LJ, Groban L, Varagic J.. Am J Physiol Heart Circ Physiol. 2016;310(8):H995-H1002.

Hemodynamic and renoprotective actions of (Pyr1)-Apelin-13 in preeclampsia [abstract]. Yamaleyeva LM, Brosnihan KB, Mcgee C, Shi S, Varagic J, Bader M, Dechend R, Shaltout H.. Reprod Sci. 2016;23(Suppl 1):62A.

Photoacoustic imaging for the detection of hypoxia in the rat femoral artery and skeletal muscle microcirculation. Smith L, Varagic J, Yamaleyeva L.. Shock. 2016;():.

Apelin-13 in blood pressure regulation and cardiovascular disease. Yamaleyeva LM, Shaltout HA, Varagic J.. Curr Opin Nephrol Hypertens. 2016;25(5):396-403.

Intracrine angiotensin II functions originate from noncanonical pathways in the human heart. Ferrario CM, Ahmad S, Varagic J, Cheng CP, Groban L, Wang H, Collawn JF, Dell'Italia LJ.. Am J Physiol Heart Circ Physiol. 2016;311(2):H404-H414.

Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme. Ahmad S, Varagic J, VonCannon JL, Groban L, Collawn JF, Dell'Italia LJ, Ferrario CM.. Biochem Biophys Res Commun. 2016;478(2):559-564.

Intracellular angiotensin-(1-12) changes the electrical properties of intact cardiac muscle. De Mello WC, Dell'Itallia LJ, Varagic J, Ferrario CM.. Mol Cell Biochem. 2016;():.

Vasoactive lipid mediators control uterine vascular reactivity at early pregnancy in the transgenic hAGNxhREN rat [abstract]. Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB.. Pregnancy Hypertens. 2015;5(1):8.

Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity. Yamaleyeva LM, Pulgar VM, Lindsey SH, Yamane L, Varagic J, McGee C, daSilva M, Bonfa PL, Gurley SB, Brosnihan KB.. Am J Physiol Endocrinol Metab. 2015;309(1):E84-E94.

Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue. Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CM.. Ther Adv Cardiovasc Dis. 2015;9(4):168-180.

Functional changes in the uterine artery precede the hypertensive phenotype in a transgenic model of hypertensive pregnancy. Pulgar VM, Yamaleyeva LM, Varagic J, McGee C, Bader M, Dechend R, Brosnihan KB.. Am J Physiol Endocrinol Metab. 2015;309(9):E811-E817.

Functional significance of the chymase/ang-(1-12) pathway on cardiomyocytes [abstract]. Zhang X, Li T, Ahmad S, Varagic J, Groban L, Dell'Italia LJ, Cheng C-P, Ferrario CM.. Hypertension. 2015;66(Suppl 1):A078.

Systemic administration of (Pyr1)-apelin-13 at late pregnancy reduces blood pressure, proteinuria, and improves autonomic function in preeclamptic rats [abstract]. Yamaleyeva LM, Brosnihan KB, McGee C, Shi S, Varagic J, Bader M, Dechend R, Shaltout HA.. Hypertension. 2015;66(Suppl 1):A126.

Cardiac and skeletal muscle dysfunction in an aging mouse model of acute lung injury [abstract]. Sanchez MA, Liu C, Varagic J, Morris PE, Files DC.. Am J Respir Crit Care Med. 2015;191():A2054.

ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury. Varagic J, Ahmad S, Nagata S, Ferrario CM.. Curr Hypertens Rep. 2014;16(3):420.

Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate. Ahmad S, Varagic J, Groban L, Dell'italia LJ, Nagata S, Kon ND, Ferrario CM.. Curr Hypertens Rep. 2014;16(5):429.

An evolving story of angiotensin-II-forming pathways in rodents and humans. Ferrario CM, Ahmad S, Nagata S, Simington SW, Varagic J, Kon N, Dell'italia LJ.. Clin Sci. 2014;126(7-8):461-469.

Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB.. Hypertension. 2014;64(3):619-625.

Clinical utility of fixed-dose combinations in hypertension: evidence for the potential of nebivolol/valsartan. Varagic J, Punzi H, Ferrario CM.. Integr Blood Press Control. 2014;7():61-70.

Increased role of COX-derived prostanoids in regulating Ang II induced uterine artery contraction at early pregnancy in a transgenic model of preeclampsia [abstract]. Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Delbruck M, Dechend R, Brosnihan KB.. Hypertension. 2014;64(Suppl 1):A579.

Uterine artery dysfunction in ACE2 deficient mice is associated with placental hypoxia and reduced umbilical flow [abstract]. Yamaleyeva LM, Pulgar VM, Lindsey SH, Varagic J, McGee CM, Yamane L, Brosnihan KB.. Hypertension. 2014;64(Suppl 1):A092.

Human Ang-(1-12) and hemodynamic and cardiac biometrics in rats overexpressing human angiotensinogen [abstract]. Varagic J, VonCannon JL, Nagata S, Ahmad S, Ferrario CM.. Hypertension. 2014;64(Suppl 1):A477.

Increased uterine interimplantation levels of Ang II, AT1R, and CB1R are associated with reduced uterine permeability at early pregnancy in a transgenic model of preeclampsia [abstract]. Brosnihan KB, Pulgar VM, Varagic J, Oliva K, Bader M, Delbruck M, Dechend R, Gallagher P, Thomas BF, Grabenauer M, Yamaleyeva LM.. Hypertension. 2014;64(Suppl 1):A577.

Chymase-mediated angiotensin II formation in the heart of rats overexpressing the human angiotensinogen gene [abstract]. Ahmad S, VonCannon JL, Bader M, Delbruck M, Varagic J, Ferrario CM.. Hypertension. 2014;64(Suppl 1):A621.

Angiotensin-(1-12) is a better substrate compared to angiotensin I to generate angiotensin Ii by rat chymase [abstract]. Ahmad S, Varagic J, VonCannon JL, Dell'Italia LJ, Groban L, Ferrario CM.. Hypertension. 2014;64(Suppl 1):A622.

Curcumin ameliorates cardiac dysfunction in the ovariectomized diabetic mRen2.Lewis rat by inhibiting renin angiotensin system [abstract]. VonCannon JL, Jiao Y, Kim-Shapiro D, Varagic J.. Hypertension. 2014;64(Suppl 1):A659.

Hemodynamic and hormonal changes to dual Renin-Angiotensin system inhibition in experimental hypertension. Moniwa N, Varagic J, Ahmad S, Voncannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM.. Hypertension. 2013;61(2):417-424.

Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats. Varagic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM.. Am J Hypertens. 2013;26(5):583-590.

Chymase mediates angiotensin-(1-12) metabolism in normal human hearts. Ahmad S, Wei CC, Tallaj J, Dell'Italia LJ, Moniwa N, Varagic J, Ferrario CM.. J Am Soc Hypertens. 2013;7(2):128-136.

Tissue specific regulation of CB1/CB2 gene receptors in salt sensitive hypertension of SHR [abstract]. Varagic J, Gallagher PE.. FASEB J. 2013;27():1108.8.

Response to 'Angiotensin-(1-7) in the central regulation of blood pressure and renin-angiotensin system' [response to letter]. Varagic J, Ferrario CM.. Am J Hypertens. 2013;26(9):1175.

Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism. Moniwa N, Varagic J, Simington SW, Ahmad S, Nagata S, Voncannon JL, Ferrario CM.. Am J Physiol Heart Circ Physiol. 2013;305(5):H644-H650.

Renin independent Ang-(1-12) production in both the systemic and coronary circulation [abstract]. Moniwa N, Varagic J, Nagata S, Ahmad S, Simington SW, VonCannon JL, Shimamura Y, Hasegawa K, Takizawa H, Ura N, Tanaka S, Furuhashi M, Yoshida H, Miura T, Ferrario CM.. Hypertension. 2013;62(3 Suppl):604.

Inhibition of metabolism of endogenous AEA and 2-AG reduces Ang II induced uterine artery contraction at early pregnancy in a transgenic model of preeclampsia [abstract]. Pulgar VM, Yamaleyeva LM, Varagic J, Bader M, Dechend R, Brosnihan KB.. Hypertension. 2013;62(3 Suppl):416.

Differential expression of angiotensin-(1-12)/chymase in human atrial tissue [abstract]. Nagata S, Varagic J, Simington SW, Ahmad S, VonCannon JL, Wang H, Groban L, Kon ND, Dell'Italia LJ, Ferrario CM.. Hypertension. 2013;62(3 Suppl):629.

Renal endocannabinoids in salt-sensitive hypertension of SHR [abstract]. Varagic J, Gallagher PE, Grabenauer M, Thomas BF.. Hypertension. 2013;62(3 Suppl):499.

Does cardiac ang-(1-12) have a role in sex-specific heart disease? [abstract]. Nagata S, Varagic J, Simington SW, Ahmad S, VonCannon JL, Wang H, Kon ND, Dell'Italia LJ, Ferrario CM, Groban L.. Hypertension. 2013;62(3 Suppl):632.

Cardiac and renal endocannabinoids in salt-loaded SHR [abstract]. Varagic J, Gallagher PE, Grabenauer M, Thomas BF.. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats. Moniwa N, Varagic J, Ahmad S, VonCannon JL, Ferrario CM.. Ther Adv Cardiovasc Dis. 2012;6(1):15-29.

Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. Yamaleyeva LM, Lindsey SH, Varagic J, Zhang LL, Gallagher PE, Chen AF, Chappell MC.. J Cardiovasc Pharmacol. 2012;59(6):529-538.

Effects of combination therapy with valsartan and aliskiren on arterial pressure, cardiac hypertrophy and urinary protein excretion in hypertensive rats [abstract]. Moniwa N, Varagic J, Ahmad S, Ferrario CM.. FASEB J. 2012;26(Meeting Abstracts):1105.4.

Chymase-mediated angiotensin II generation from angiotensin-(1-12) in left ventricular tissue of normal and diseased human subjects [abstract]. Moniwa N, Wei C-C, Dell'Italia LJ, Ferrario CM, Ahmad S, Varagic J.. J Clin Hypertens (Greenwich). 2012;14(Suppl 1):149.

Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW Jr, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM.. J Hypertens. 2012;30(9):1766-1774.

Differential effects of ACE and chymase in the metabolism of exogenous angiotensin-(1-12) in Wistar-Kyoto rats [abstract]. Moniwa N, Varagic J, Ahmad S, Ferrario CM.. FASEB J. 2012;26(Meeting Abstracts Suppl):1105.3.

Diabetes abolishes the cardioprotective effect of estrogen on systolic cardiac function [abstract]. Santiago N, Melo MB, Chappell M, Varagic J, Santos RAS, Campagnole-Santos MJ.. FASEB J. 2012;26(Meeting Abstracts Suppl):1057.23.

Role of angiotensin converting enzyme on the production of angiotensins from angiotensin-(1-12) in normotensive Winstar-kyoto rats and spontaneously hypertensive rats [abstract]. Moniwa N, Ahmad S, VonCannon JL, Simington SW, Varagic J, Ferrario CM.. Hypertension. 2012;60(3 Suppl):235.

Predominance of angiotensin II type 1 receptor blockade over antiotensin-(1-7) mechanisms in the regulation of blood pressure and renin angiotensin system in mRen.Lewis rats [abstract]. Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM.. Hypertension. 2012;60(Suppl 3):283.

Renin does not participate in the production of plasma ang-(1-12) from angiotensinogen [abstract]. Simington SW, Moniwa N, Ahmad S, VonCannon JL, Dell'Italia LJ, Varagic J, Ferrario CM.. Hypertension. 2012;60(3 Suppl):628.

Activation of GPR30 attenuates cardiac injury in the ovariectomized diabetic mRen2.Lewis rat [abstract]. Santiago NM, Figueiredo GZ, Souza M, Campagnole-Santos MJ, Varagic J.. Hypertension. 2012;60(3 Suppl):312.

Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes. Ahmad S, Varagic J, Westwood BM, Chappell MC, Ferrario CM.. PLoS ONE. 2011;6(1):e15759.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Hypertension

Jasmina Varagic, M.D., Ph.D.

Jasmina Varagic, M.D., Ph.D.

Associate Professor, Hypertension
Physiology & Pharmacology

Quick Reference

Request an Appointment
New Patients

336-716-WAKE
888-716-WAKE

Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
Comprehensive Cancer Centers National Designation is RenewedMagnet Hospital RecognitionConsumer Choice2015 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.