Profile

James P. Vaughn, Ph.D.

James P. Vaughn, Ph.D.

Assistant Professor, Cancer Biology
Comprehensive Cancer Center
Contact Information
Office:
336-716-7122
Email: jvaughn@wakehealth.edu
Clinical Specialties
Breast Cancer
Languages
English
Education & Training
  BSDuke University1983
  PhDUniversity of Virginia1992
FellowshipBiophysical ChemistryUniversity of Virginia1984
  SurgeryDuke University School of Medicine1995
James P. Vaughn, Ph.D.

James P. Vaughn, Ph.D.

Assistant Professor, Cancer Biology
Comprehensive Cancer Center
Contact Information
Office:
336-716-7122
Email: jvaughn@wakehealth.edu
Research Interests
biotechnology , cancer/oncogenesis , drugs/therapeutic agents pharm
Recent Publications
Huang W, Smaldino PJ, Zhang Q, Miller LD, Cao P, Stadelman K, Wan M, Giri B, Lei M, Nagamine Y, Vaughn JP, Akman SA, Sui G. Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1. Nucleic Acids Res. 2012; 40(3):1033-1049.

Giri B, Smaldino PJ, Thys RG, Creacy SD, Routh ED, Hantgan RR, Lattmann S, Nagamine Y, Akman SA, Vaughn JP. G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA. Nucleic Acids Res. 2011; 39(16):7161-7178.

Lattmann S, Stadler MB, Vaughn JP, Akman SA, Nagamine Y. The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme. Nucleic Acids Res. 2011; 39(21):9390-9404.

Lattmann S, Giri B, Vaughn JP, Akman SA, Nagamine Y. Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU. Nucleic Acids Res. 2010; 38(18):6219-6233.

Kute TE, Savage L, Stehle JR Jr, Kim-Shapiro JW, Blanks MJ, Wood J, Vaughn JP. Breast tumor cells isolated from in vitro resistance to trastuzumab remain sensitive to trastuzumab anti-tumor effects in vivo and to ADCC killing. Cancer Immunol Immunother. 2009; 58(11):1887-1896.

Creacy SD, Routh ED, Iwamoto F, Nagamine Y, Akman SA, Vaughn JP. G4 resolvase-1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates. J Biol Chem. 2008; 283(50):34626-34.

Kute TE, Savage L, Wood J, Vaughn J. Mechanism of action of herceptin killing of HER-2+breast cancer cells under 'in vitro' and 'in vivo' conditions [abstract]. Breast Cancer Res Treat. 2007; 106(Suppl 1):S123.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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Last Updated 3/19/2012
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