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James P. Vaughn, Ph.D.Wake Forest Baptist Health

James P. Vaughn, Ph.D.

Assistant Professor,

Clinical Specialties

Breast Cancer

Contact Information

Academic: 336-716-7122 | Department: 336-716-7122

Email: jvaughn@wakehealth.edu

Education & Training

  • Ph.D., University of Virginia , 1992
  • B.S., Duke University , 1983
  • Fellowship, Biophysical Chemistry, University of Virginia, 1984
  • Fellowship, Surgery, Duke University School of Medi, 1995
James P. Vaughn, Ph.D.Wake Forest Baptist Health

James P. Vaughn, Ph.D.

Assistant Professor, Cancer Biology
Comprehensive Cancer Center

Research Interests

biotechnology, cancer/oncogenesis, drugs/therapeutic agents pharm

Contact Information

Academic: 336-716-7122 | Department: 336-716-7122

Email: jvaughn@wakehealth.edu

Recent Publications

Nagalla S, Chou JW, Willingham MC, Ruiz J, Vaughn JP, Dubey P, Lash TL, Hamilton-Dutoit SJ, Bergh J, Sotiriou C, Black MA, Miller LD. Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis. Genome Biol. 2013;14(4):R34.

Huang W, Smaldino PJ, Zhang Q, Miller LD, Cao P, Stadelman K, Wan M, Giri B, Lei M, Nagamine Y, Vaughn JP, Akman SA, Sui G. Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1. Nucleic Acids Res. 2012;40(3):1033-1049.

Kute T, Stehle Jr JR, Ornelles D, Walker N, Delbono O, Vaughn JP. Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells. Oncoimmunology. 2012;1(6):810-821.

Giri B, Smaldino PJ, Thys RG, Creacy SD, Routh ED, Hantgan RR, Lattmann S, Nagamine Y, Akman SA, Vaughn JP. G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA. Nucleic Acids Res. 2011;39(16):7161-7178.

Lattmann S, Stadler MB, Vaughn JP, Akman SA, Nagamine Y. The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme. Nucleic Acids Res. 2011;39(21):9390-9404.

Lattmann S, Giri B, Vaughn JP, Akman SA, Nagamine Y. Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU. Nucleic Acids Res. 2010;38(18):6219-6233.

Kute TE, Savage L, Stehle JR Jr, Kim-Shapiro JW, Blanks MJ, Wood J, Vaughn JP. Breast tumor cells isolated from in vitro resistance to trastuzumab remain sensitive to trastuzumab anti-tumor effects in vivo and to ADCC killing. Cancer Immunol Immunother. 2009;58(11):1887-1896.


Kute TE, Savage L, Wood J, Vaughn J. Mechanism of action of herceptin killing of HER-2+breast cancer cells under 'in vitro' and 'in vivo' conditions [abstract]. Breast Cancer Res Treat. 2007;106(Suppl 1):S123.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Cancer Biology

Clinical Specialties

Breast Cancer

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