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Lynne E. Wagenknecht, Dr.P.H.Wake Forest School of Medicine

Lynne E. Wagenknecht, Dr.P.H.

Associate Dean,
Associate Director,
Professor,


Clinical Interests

Epidemiology

Contact Information

Academic: 336-716-7652 | Department: 336-716-7652

Email: lwgnkcht@wakehealth.edu

Education & Training

  • B.S., Lenoir Rhyne College, 1982
  • M.P.H., University of Alabama School of Public Health, 1984
  • Dr.P.H., University of Alabama School of Public Health, 1989

Memberships

  • Am Diabetes Assn
  • Am Heart Association
Lynne E. Wagenknecht, Dr.P.H.

Lynne E. Wagenknecht, Dr.P.H.

Associate Dean, Dean's Office
Associate Director, Public Health Sciences
Professor, Public Health Sciences
Office of Women in Medicine and Science
Center on Diabetes, Obesity, and Metabolism

Research Interests

Diabetes Mellitus, Type 2; Insulin Resistance; Atherosclerosis; African Americans; Hispanic Americans
More »

Contact Information

Academic: 336-716-7652 | Department: 336-716-7652

Email: lwgnkcht@wakehealth.edu

Recent Publications

FGF23 concentration and APOL1 genotype are novel predictors of mortality in African Americans with type 2 diabetes. Chan GC, Divers J, Russell GB, Langefeld CD, Wagenknecht LE, Hsu FC, Xu J, Smith SC, Palmer ND, Hicks PJ, Bowden DW, Register TC, Ma L, Carr JJ, Freedman BI.. Diabetes Care. 2018;41(1):178-186.

Genome-wide study of subcutaneous and visceral adipose tissue reveals novel sex-specific adiposity loci in Mexican Americans. Gao C, Langefeld CD, Ziegler JT, Taylor KD, Norris JM, Chen YI, Hellwege JN, Guo X, Allison MA, Speliotes EK, Rotter JI, Bowden DW, Wagenknecht LE, Palmer ND.. Obesity (Silver Spring). 2018;26(1):202-212.

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF,.. Nat Genet. 2018;50(1):26-41.

Silent myocardial infarction and long-term risk of heart failure: the ARIC study. Qureshi WT, Zhang ZM, Chang PP, Rosamond WD, Kitzman DW, Wagenknecht LE, Soliman EZ.. J Am Coll Cardiol. 2018;71(1):1-8.

Trans-ethnic evaluation identifies novel low frequency loci associated with 25-hydroxyvitamin D concentrations. Hong J, Hatchell KE, Bradfield JP, Andrew B, Alessandra C, Chao-Qiang L, Langefeld CD, Lu L, Lu Y, Lutsey PL, Musani SK, Nalls MA, Robinson-Cohen C, Roizen JD, Saxena R, Tucker KL, Ziegler JT, Arking DE, Bis JC, Boerwinkle E, Bottinger EP,.. J Clin Endocrinol Metab. 2018;():.

Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans. Hellwege JN, Palmer ND, Dimitrov L, Keaton JM, Tabb KL, Sajuthi S, Taylor KD, Ng MC, Speliotes EK, Hawkins GA, Long J, Ida Chen YD, Lorenzo C, Norris JM, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW.. J Hum Genet. 2017;62(2):175-184.

Cardiovascular dysfunction and frailty among older adults in the community: the ARIC Study. Nadruz W Jr, Kitzman D, Windham BG, Kucharska-Newton A, Butler K, Palta P, Griswold ME, Wagenknecht LE, Heiss G, Solomon SD, Skali H, Shah AM.. J Gerontol A Biol Sci Med Sci. 2017;72(7):958-964.

The importance of mid-to-late-life body mass index trajectories on late-life gait speed. Windham BG, Griswold ME, Wang W, Kucharska-Newton A, Demerath EW, Gabriel KP, Pompeii LA, Butler K, Wagenknecht L, Kritchevsky S, Mosley TH Jr.. J Gerontol A Biol Sci Med Sci. 2017;72(8):1130-1136.

Baseline blood pressure control in Hispanics: characteristics of Hispanics in the Systolic Blood Pressure Intervention Trial. Rodriguez CJ, Still CH, Garcia KR, Wagenknecht L, White S, Bates JT, Del Cid MV, Lioudis M, Lopez Barrera N, Moreyra A, Punzi H, Ringer RJ, Cushman WC, Contreras G, Servilla K, Rocco M.. J Clin Hypertens (Greenwich). 2017;19(2):116-125.

Repeatability of ectopic beats from 48-hr ambulatory electrocardiography: the Atherosclerosis Risk in Communities (ARIC) Study. Meyer ML, Soliman EZ, Wruck LM, Mosley TH, Wagenknecht LE, Poon AK, Whitsel EA, Alonso A, Heiss G, Loehr LR.. Ann Noninvasive Electrocardiol. 2017;22(4):e12426.

Analysis of whole exome sequencing with cardiometabolic traits using family-based linkage and association in the IRAS Family Study. Tabb KL, Hellwege JN, Palmer ND, Dimitrov L, Sajuthi S, Taylor KD, Ng MC, Hawkins GA, Chen YI, Brown WM, McWilliams D, Williams A, Lorenzo C, Norris JM, Long J, Rotter JI, Curran JE, Blangero J, Wagenknecht LE, Langefeld CD, Bowden DW.. Ann Hum Genet. 2017;81(2):49-58.

Sex differences in the association between insulin resistance and incident coronary heart disease and stroke among blacks without diabetes mellitus: the Jackson Heart Study. Effoe VS, Wagenknecht LE, Echouffo Tcheugui JB, Chen H, Joseph JJ, Kalyani RR, Bell RA, Wu WH, Casanova R, Bertoni AG.. J Am Heart Assoc. 2017;6(2):e004229.

Cardiovascular disease and patterns of change in functional status over 15 years: findings from the Atherosclerosis Risk in Communities (ARIC) study. Kucharska-Newton A, Griswold M, Yao ZH, Foraker R, Rose K, Rosamond W, Wagenknecht L, Koton S, Pompeii L, Windham BG.. J Am Heart Assoc. 2017;6(3):e004144.

Association between midlife vascular risk factors and estimated brain amyloid deposition. Gottesman RF, Schneider AL, Zhou Y, Coresh J, Green E, Gupta N, Knopman DS, Mintz A, Rahmim A, Sharrett AR, Wagenknecht LE, Wong DF, Mosley TH.. JAMA. 2017;317(14):1443-1450.

Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012. Mayer-Davis EJ, Lawrence JM, Dabelea D, Divers J, Isom S, Dolan L, Imperatore G, Linder B, Marcovina S, Pettitt DJ, Pihoker C, Saydah S, Wagenknecht L.. N Engl J Med. 2017;376(15):1419-1429.

Diabetes status modifies the association between carotid intima-media thickness and incident heart failure: the Atherosclerosis Risk in Communities Study. Effoe VS, McClendon EE, Rodriguez CJ, Wagenknecht LE, Evans GW, Chang PP, Bertoni AG.. Diabetes Res Clin Pract. 2017;128():58-66.

A genome-wide association study of IVGTT-based measures of first phase insulin secretion refines the underlying physiology of type 2 diabetes variants. Wood AR, Jonsson A, Jackson AU, Wang N, van Leewen N, Palmer ND, Kobes S, Deelen J, Boquete-Vilarino L, Paananen J, Stancakova A, Boomsma DI, de Geus EJ, Eekhoff EM, Fritsche A, Kramer M, Nijpels G, Simonis-Bik A, van Haeften TW,.. Diabetes. 2017;66(8):2296-2309.

Urinary F2-isoprostanes and the risk of hypertension. Melton CD, Luo R, Wong BJ, Spasojevic I, Wagenknecht LE, D'Agostino RB Jr, Il'yasova D.. Ann Epidemiol. 2017;27(6):391-396.

The effect of intentional weight loss on fracture risk in persons with diabetes: results from the Look AHEAD randomized clinical trial. Johnson KC, Bray GA, Cheskin LJ, Clark JM, Egan CM, Foreyt JP, Garcia KR, Glasser S, Greenway FL, Gregg EW, Hazuda HP, Hergenroeder A, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Kahn SE, Knowler WC, Lewis CE, Miller M, Montez MG, Nathan DM,.. J Bone Miner Res. 2017;32(11):2278-2287.

Association of directly measured plasma free 25(OH)D with insulin sensitivity and secretion: the IRAS Family Study. Lee CC, Young KA, Norris JM, Rotter JI, Liu Y, Lorenzo C, Wagenknecht LE, Cole DE, Haffner SM, Chen YI, Hanley AJ.. J Clin Endocrinol Metab. 2017;102(8):2781-2788.

Type 2 diabetes variants disrupt function of SLC16A11 through two distinct mechanisms. Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH, Centeno-Cruz F, Zerrweck C,.. Cell. 2017;170(1):.

Comparison of relationships between four common anthropometric measures and incident diabetes. Lee CMY, Woodward M, Pandeya N, Adams R, Barrett-Connor E, Boyko EJ, Eliasson M, Franco LJ, Fujimoto WY, Gonzalez C, Howard BV, Jacobs DR Jr, Keinanen-Kiukaanniemi S, Magliano D, Schreiner P, Shaw JE, Stevens J, Taylor A, Tuomilehto J,.. Diabetes Res Clin Pract. 2017;132():36-44.

Effect of intensive blood-pressure treatment on patient-reported outcomes. Berlowitz DR, Foy CG, Kazis LE, Bolin LP, Conroy MB, Fitzpatrick P, Gure TR, Kimmel PL, Kirchner K, Morisky DE, Newman J, Olney C, Oparil S, Pajewski NM, Powell J, Ramsey T, Simmons DL, Snyder J, Supiano MA, Weiner DE, Whittle J, Rocco M,.. N Engl J Med. 2017;377(8):733-744.

Long-term impact of weight loss intervention on changes in cognitive function: exploratory analyses from the Action for Health in Diabetes randomized controlled clinical trial. Espeland MA, Carmichael O, Hayden K, Neiberg RH, Newman AB, Keller JN, Wadden TA, Rapp SR, Hill JO, Horton ES, Johnson KC, Wagenknecht L, Wing RR.. J Gerontol A Biol Sci Med Sci. 2017;():.

Individual serum saturated fatty acids and markers of chronic subclinical inflammation: the Insulin Resistance Atherosclerosis Study. Santaren ID, Watkins SM, Liese AD, Wagenknecht LE, Rewers MJ, Haffner SM, Lorenzo C, Festa A, Bazinet RP, Hanley AJ.. J Lipid Res. 2017;58(11):2171-2179.

The paperless paradigm: transitioning to direct participant data entry in the search for diabetes in youth study [abstract]. Robertson J, Henkin L, Wilson K, Barnes J, Hepler J, Pihoker C, Loots B, Mottle AK, Wagenknecht L, D'Agostino R.. Trials. 2017;18(Suppl 1):P274.

Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies. Wu JHY, Marklund M, Imamura F, Tintle N, Ardisson Korat AV, de Goede J, Zhou X, Yang WS, de Oliveira Otto MC, Kroger J, Qureshi W, Virtanen JK, Bassett JK, Frazier-Wood AC, Lankinen M, Murphy RA, Rajaobelina K, Del Gobbo LC, Forouhi NG,.. Lancet Diabetes Endocrinol. 2017;5(12):965-974.

Incidence of components of metabolic syndrome in the metabolically healthy obese over 9 years follow-up: the Atherosclerosis Risk In Communities study. Bradshaw PT, Reynolds KR, Wagenknecht LE, Ndumele CE, Stevens J.. Int J Obes (Lond). 2017;():.

Genetic architecture of lipid traits in the Hispanic Community Health Study/Study of Latinos. Graff M, Emery LS, Justice AE, Parra E, Below JE, Palmer ND, Gao C, Duan Q, Valladares-Salgado A, Cruz M, Morrison AC, Boerwinkle E, Whitsel EA, Kooperberg C, Reiner A, Li Y, Rodriguez CJ, Talavera GA, Langefeld CD, Wagenknecht LE, Norris JM,.. Lipids Health Dis. 2017;16(1):200.

Diabetes-related factors and abdominal aortic aneurysm events: the Atherosclerotic Risk in Communities Study. Kubota Y, Folsom AR, Pankow JS, Wagenknecht LE, Tang W.. Ann Epidemiol. 2017;():.

Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes. Divers J, Palmer ND, Langefeld CD, Brown WM, Lu L, Hicks PJ, Smith SC, Xu J, Terry JG, Register TC, Wagenknecht LE, Parks JS, Ma L, Chan GC, Buxbaum SG, Correa A, Musani S, Wilson JG, Taylor HA, Bowden DW, Carr JJ, Freedman BI.. BMC Genet. 2017;18(1):105.

From neighborhood to genome: three decades of nutrition-related research from the Atherosclerosis Risk in Communities Study [commentary]. Savoca MR, Steffen LM, Bertoni AG, Wagenknecht LE.. J Acad Nutr Diet. 2017;117(12):.

Prospective association of GLUL rs10911021 with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD Study. Huggins GS, Berkowitz RI, Blackburn GL, Bray GA, Cheskin L, Clark JM, Coday M, Espeland MA, Evans M, Foreyt JP, Glasser S, Greenway FL, Gregg EW, Hanson RL, Hazuda HP, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Kitzman DW,.. Diabetes. 2016;65(1):297-302.

Branched-chain amino acids and insulin metabolism: the Insulin Resistance Atherosclerosis Study (IRAS). Lee CC, Watkins SM, Lorenzo C, Wagenknecht LE, Il'yasova D, Chen YI, Haffner SM, Hanley AJ.. Diabetes Care. 2016;39(4):582-588.

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C, Tayo B, Nalls M, Feitosa MF, Isaacs A, Dehghan A, d'Adamo P, Adeyemo A,.. Nat Commun. 2016;7():10023.

Prediabetes and diabetes are associated with arterial stiffness in older adults: the ARIC study. Loehr LR, Meyer ML, Poon AK, Selvin E, Palta P, Tanaka H, Pankow JS, Wright JD, Griswold ME, Wagenknecht LE, Heiss G.. Am J Hypertens. 2016;29(9):1038-1045.

Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American-Diabetes Heart Study. Palmer ND, Divers J, Lu L, Register TC, Carr JJ, Hicks PJ, Smith SC, Xu J, Judd SE, Irvin MR, Gutierrez OM, Bowden DW, Wagenknecht LE, Langefeld CD, Freedman BI.. Bone. 2016;87():71-77.

Risk prediction of major complications in individuals with diabetes: the Atherosclerosis Risk in Communities Study. Parrinello CM, Matsushita K, Woodward M, Wagenknecht LE, Coresh J, Selvin E.. Diabetes Obes Metab. 2016;18(9):899-906.

Relationships between measures of adiposity with subclinical atherosclerosis in patients with type 2 diabetes. Yuan M, Hsu FC, Bowden DW, Xu J, Carrie Smith S, Wagenknecht LE, Comeau ME, Divers J, Register TC, Jeffrey Carr J, Langefeld CD, Freedman BI.. Obesity (Silver Spring). 2016;24(8):1810-1818.

Triglyceride levels and its relationship with hemoglobin A1C in patients with diabetes [abstract]. Pitts R, Garcia K, Ribisl P, Vitolins M, Cheskin L, Glasser S, Balasubramanyam A, Pownall HJ, Wagenknecht L, Eckel R.. J Am Coll Cardiol. 2016;67(13 Suppl):2020.

Improved performance of dynamic measures of insulin response over surrogate indices to identify genetic contributors of type 2 diabetes: the GUARDIAN Consortium. Palmer ND, Wagenknecht LE, Langefeld CD, Wang N, Buchanan TA, Xiang AH, Allayee H, Bergman RN, Raffel LJ, Chen YD, Haritunians T, Fingerlin T, Goodarzi MO, Taylor KD, Rotter JI, Watanabe RM, Bowden DW.. Diabetes. 2016;65(7):2072-2080.

The ARIC-PET amyloid imaging study: brain amyloid differences by age, race, sex, and APOE. Gottesman RF, Schneider AL, Zhou Y, Chen X, Green E, Gupta N, Knopman DS, Mintz A, Rahmim A, Sharrett AR, Wagenknecht LE, Wong DF, Mosley TH Jr.. Neurology. 2016;87(5):473-480.

Genome-wide interaction with insulin secretion loci reveals novel loci for type 2 diabetes in African Americans. Keaton JM, Hellwege JN, Ng MC, Palmer ND, Pankow JS, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Chen YD, Taylor KD, Rich SS, Wagenknecht LE, Freedman B, Bowden DW.. PLoS One. 2016;11(7):e0159977.

Bone mineral density and progression of subclinical atherosclerosis in African Americans with type 2 diabetes. Wagenknecht LE, Divers J, Register TC, Russell GB, Bowden DW, Xu J, Langefeld CD, Lenchik L, Hruska KA, Carr JJ, Freedman BI.. J Clin Endocrinol Metab. 2016;101(11):4135-4141.

Association of weight loss maintenance and weight regain on 4-year changes in CVD risk factors: the Action for Health in Diabetes (Look AHEAD) Clinical Trial. Wing RR, Espeland MA, Clark JM, Hazuda HP, Knowler WC, Pownall HJ, Unick J, Wadden T, Wagenknecht L.. Diabetes Care. 2016;39(8):1345-1355.

Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes. Hsu FC, Yuan M, Bowden DW, Xu J, Smith SC, Wagenknecht LE, Langefeld CD, Divers J, Register TC, Carr JJ, Williamson JD, Sink KM, Maldjian JA, Freedman BI.. J Diabetes Complications. 2016;30(8):1506-1512.

Prediction of incident diabetes in the Jackson Heart Study using high-dimensional machine learning. Casanova R, Saldana S, Simpson SL, Lacy ME, Subauste AR, Blackshear C, Wagenknecht L, Bertoni AG.. PLoS One. 2016;11(10):e0163942.

Genome-wide interaction with selected type 2 diabetes loci reveals novel loci for type 2 diabetes in African Americans. Keaton JM, Hellwege JN, Ng MC, Palmer ND, Pankow JS, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Chen YI, Taylor KD, Rich SS, Wagenknecht LE, Freedman BI, Bowden DW.. Pac Symp Biocomput. 2016;22():242-253.

Whole genome sequence analysis of serum amino acid levels. Yu B, de Vries PS, Metcalf GA, Wang Z, Feofanova EV, Liu X, Muzny DM, Wagenknecht LE, Gibbs RA, Morrison AC, Boerwinkle E.. Genome Biol. 2016;17(1):237.

APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes. Freedman BI, Langefeld CD, Lu L, Palmer ND, Carrie Smith S, Bagwell BM, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Jeffrey Carr J, Bowden DW, Divers J.. Kidney Int. 2015;87(1):176-181.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Public Health Sciences

Clinical Interests

Epidemiology

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