Profile

Lynne E. Wagenknecht, Dr.P.H.Wake Forest School of Medicine

Lynne E. Wagenknecht, Dr.P.H.

Associate Director,
Associate Dean,
Professor,




Clinical Interests

Epidemiology

Contact Information

Academic: 336-716-7652 | Department: 336-716-7652

Email: lwgnkcht@wakehealth.edu

Education & Training

  • B.S., Lenoir Rhyne College, 1982
  • M.P.H., University of Alabama School of Public Health, 1984
  • Dr.P.H., University of Alabama School of Public Health, 1989

Memberships

  • Am Diabetes Assn
  • Am Heart Association
Lynne E. Wagenknecht, Dr.P.H.

Lynne E. Wagenknecht, Dr.P.H.

Associate Director, Public Health Sciences
Associate Dean, Dean's Office
Professor, Public Health Sciences
Sticht Center on Aging
Center for Diabetes Research
Center for Public Health Genomics
Translational Science Institute

Research Interests

aging, alzheimer's disease, atherosclerosis/thrombosis, cardiac function, cognition/learning, degenerative disorders, diabetes, epidemiology, fitness/physical, genetics/genome, genomics and proteomics, health services, research/outc, maternal & child health, metabolism, minority health issues, neurosciences/behavior, obesity, prevention, radiology imaging/nuclear medi, statistics/mathematics, vascular diseases

Contact Information

Academic: 336-716-7652 | Department: 336-716-7652

Email: lwgnkcht@wakehealth.edu

Recent Publications

Freedman BI, Langefeld CD, Lu L, Palmer ND, Carrie Smith S, Bagwell BM, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Jeffrey Carr J, Bowden DW, Divers J. APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes. Kidney Int. 2015;87(1):176-181.

Hellwege JN, Palmer ND, Brown MW, Ziegler JT, An SS, Guo X, Chen IY, Taylor K, Hawkins GA, Ng MC, Speliotes EK, Lorenzo C, Norris JM, Rotter JI, Wagenknecht LE, Langefeld CD, Bowden DW. Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels. Hum Genet. 2015;134(2):203-213.

Palmer ND, Goodarzi MO, Langefeld CD, Wang N, Guo X, Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH , Haritunians T, Ziegler JT, Williams AH, Stefansovski D, Cui J, Mackay AW, Henkin LF, Bergman RN, Gao X, Gauderman J, Varma R, Hanis CL,. Genetic variants associated with quantitative glucose homeostasis traits translate to type 2 diabetes in Mexican Americans: the GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Diabetes. 2015;64(5):1853-1866.

Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert MF, Raghavan S, Lipovich L, Hidalgo B, Fox K, Huffman JE, An P, Lu Y, Rasmussen-Torvik LJ, Grarup N, Ehm MG, Li L, Baldridge AS, Stancakova A, Abrol R, Besse C,. Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nat Commun. 2015;6():5897.

Il'yasova D, Wagenknecht LE, Spasojevic I, Watkins S, Bowden D, Wang F, D'Agostino RB Jr. Urinary F2-isoprostanes and metabolic markers of fat oxidation. Oxid Med Cell Longev. 2015;2015():729191.

Pownall HJ, Bray GA, Wagenknecht LE, Walkup MP, Heshka S, Hubbard VS, Hill J, Kahn SE, Nathan DM, Schwartz AV, Johnson KC. Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: the Look AHEAD study. Obesity (Silver Spring). 2015;23(3):565-572.

Palmer ND, Stevens RD, Antinozzi PA, Anderson A, Bergman RN, Wagenknecht LE, Newgard CB, Bowden DW. Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study. J Clin Endocrinol Metab. 2015;100(3):E463-E468.

Keaton JM, Ng MC, Palmer N, Pankow J, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Rich SS, Wagenknecht LE, Freedman BI, Bowden DW. Genome-wide gene-gene interaction with insulin secretion loci reveals novel loci contributing to type 2 diabetes etiology in African Americans [abstract]. Diabetes. 2015;64(Suppl 1):A465.

Sharma PR, Mackey AJ, Dejene EA, Ramadan JW, Langefeld CD, Palmer ND, Taylor KD, Wagenknecht LE, Watanabe RM, Rich SS, Nunemaker CS. An islet-targeted genome-wide association scan identifies novel genes implicated in cytokine-mediated islet stress in type 2 diabetes. Endocrinology. 2015;():.

Shah AS, Dolan LM, Dabelea D, Stafford JM, D'Agostino RB Jr, Mayer-Davis EJ, Marcovina S, Imperatore G, Wadwa RP, Daniels SR, Reynolds K, Hamman RF, Bowlby DA, Maahs DM, Wagenknecht LE. Change in adiposity minimally affects the lipid profile in youth with recent onset type 1 diabetes. Pediatr Diabetes. 2015;16(4):280-286.

Peter I, Papandonatos GD, Belalcazar LM, Yang Y, Erar B, Jakicic JM, Unick JL, Balasubramanyam A, Lipkin EW, Delahanty LM, Wagenknecht LE, Wing RR, McCaffery JM, Huggins GS, Espeland MA, Reboussin D, et al. Genetic modifiers of cardiorespiratory fitness response to lifestyle intervention. Med Sci Sports Exerc. 2014;46(2):302-311.

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2014;99(1):315-321.

Fitzpatrick SL, Jeffery R, Johnson KC, Roche CC, Van Dorsten B, Gee M, Dotson K, Walkup MP, Espeland MA, Bahnson JL, Wagenknecht LE, Reboussin D, Rejeski WJ, Bertoni AG, Lang W, Lawlor MS, Lefkowitz D, Miller GD, Reynolds PS, Ribisl PM,. Baseline predictors of missed visits in the Look AHEAD study. Obesity (Silver Spring). 2014;22(1):131-140.

Chang PP, Chambless LE, Shahar E, Bertoni AG, Russell SD, Ni H, He M, Mosley TH, Wagenknecht LE, Samdarshi TE, Wruck LM, Rosamond WD. Incidence and survival of hospitalized acute decompensated heart failure in four US communities (from the Atherosclerosis Risk in Communities Study). Am J Cardiol. 2014;113(3):504-510.

Hellwege JN, Palmer ND, Raffield LM, Ng MC, Hawkins GA, Long J, Lorenzo C, Norris JM, Ida Chen YD, Speliotes EK, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW. Genome-wide family-based linkage analysis of exome chip variants and cardiometabolic risk. Genet Epidemiol. 2014;38(4):345-352.

Goodarzi MO, Langefeld CD, Xiang AH, Chen YD, Guo X, Hanley AJ, Raffel LJ, Kandeel F, Nadler JL, Buchanan TA, Norris JM, Fingerlin TE, Lorenzo C, Rewers MJ, Haffner SM, Bowden DW, Rich SS, Bergman RN, Rotter JI, Watanabe RM, Wagenknecht LE. Insulin sensitivity and insulin clearance are heritable and have strong genetic correlation in Mexican Americans. Obesity (Silver Spring). 2014;22(4):1157-1164.

Gottesman RF, Rawlings AM, Sharrett AR, Albert M, Alonso A, Bandeen-Roche K, Coker LH, Coresh J, Couper DJ, Griswold ME, Heiss G, Knopman DS, Patel MD, Penman AD, Power MC, Selnes OA, Schneider AL, Wagenknecht LE, Windham BG, Wruck LM, Mosley TH. Impact of differential attrition on the association of education with cognitive change over 20 years of follow-up: the ARIC Neurocognitive Study. Am J Epidemiol. 2014;179(8):956-966.

Effoe VS, Rodriguez CJ, Wagenknecht LE, Evans GW, Chang PP, Mirabelli MC, Bertoni AG. Carotid intima-media thickness is associated with incident heart failure among middle-aged whites and backs: the Atherosclerosis Risk in Communities study. J Am Heart Assoc. 2014;3(3):e000797.

Howard G, Wagenknecht LE, Kernan WN, Cushman M, Thacker EL, Judd SE, Howard VJ, Kissela BM. Racial differences in the association of insulin resistance with stroke risk: the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Stroke. 2014;45(8):2257-2262.

Liu CT, Young KL, Brody JA, Olden M, Wojczynski MK, Heard-Costa N, Li G, Morrison AC, Muzny D, Gibbs RA, Reid JG, Shao Y, Zhou Y, Boerwinkle E, Heiss G, Wagenknecht L, McKnight B, Borecki IB, Fox CS, North KE, Cupples LA. Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet. 2014;7(3):344-349.

Ng MC, Shriner D, Chen BH, Li J, Chen WM, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, An P, Patel SR, Lu Y, Long J, Armstrong LL, Wagenknecht L, Yang L, Snively BM, Palmer ND, Mudgal P,. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet. 2014;18(8):e1004517.

Lee CT, Liese AD, Lorenzo C, Wagenknecht LE, Haffner SM, Rewers MJ, Hanley AJ. Egg consumption and insulin metabolism in the Insulin Resistance Atherosclerosis Study (IRAS). Public Health Nutr. 2014;17(7):1595-1602.

Qureshi W, Soliman EZ, Solomon SD, Alonso A, Arking DE, Shah A, Gupta DK, Wagenknecht LE, Herrington D. Risk factors for atrial fibrillation in patients with normal versus dilated left atrium (from the Atherosclerosis Risk in Communities study). Am J Cardiol. 2014;114(9):1368-1372.

Dearborn JL, Knopman D, Sharrett AR, Schneider AL, Jack CR Jr, Coker LH, Alonso A, Selvin E, Mosley TH, Wagenknecht LE, Windham BG, Gottesman RF. The metabolic syndrome and cognitive decline in the Atherosclerosis Risk in Communities study (ARIC).. Dement Geriatr Cogn Disord. 2014;38(5-6):337-346.

Santaren ID, Watkins SM, Liese AD, Wagenknecht LE, Rewers MJ, Haffner SM, Lorenzo C, Hanley AJ. Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders. Am J Clin Nutr. 2014;100(6):1532-1540.

Freedman BI, Langefeld CD, Lu L, Palmer ND, Smith SC, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Bowden DW, Divers J. Apolipoprotein L1 gene associations with atherosclerosis, nephropathy, and mortality in African Americans with type 2 diabetes [abstract]. J Am Soc Nephrol. 2014;25(Abstract Suppl):231A.

Knowler WC, Bahnson JL, Bantle JP, Bertoni AG, Bray GA, Chen H, Cheskin L, Clark JM, Egan C, Evans M, Foreyt JP, Glasser SP, Greenway FL, Gregg EW, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE,. Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol. 2014;2(10):801-809.

Rawlings AM, Sharrett AR, Schneider AL, Coresh J, Albert M, Couper D, Griswold M, Gottesman RF, Wagenknecht LE, Windham BG, Selvin E. Diabetes in midlife and cognitive change over 20 years: a cohort study. Ann Intern Med. 2014;161(11):785-793.

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 2013;98(1):E60-E65.

An SS, Palmer ND, Hanley AJ, Ziegler JT, Brown WM, Haffner SM, Norris JM, Rotter JI, Guo X, Chen YD, Wagenknecht LE, Langefeld CD, Bowden DW. Estimating the contributions of rare and common genetic variations and clinical measures to a model trait: adiponectin. Genet Epidemiol. 2013;37(1):13-24.

Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni AG,. Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2013;6(1):97-105.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Smith SC, Xu J, Langefeld CD, Freedman BI. Albuminuria associates with calcified atherosclerotic plaque in African Americans with diabetes [letter]. Diabetes Care. 2013;36(3):e34-e35.

Lee CC, Lorenzo C, Haffner SM, Wagenknecht LE, Festa A, Goodarzi MO, Stefanovski D, Olson NC, Norris JM, Rewers MJ, Hanley AJ. The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS). Diabetologia. 2013;56(1):112-120.

Lorenzo C, Hartnett S, Hanley AJ, Rewers MJ, Wagenknecht LE, Karter AJ, Haffner SM. Impaired fasting glucose and impaired glucose tolerance have distinct lipoprotein and apolipoprotein changes: the Insulin Resistance Atherosclerosis Study. J Clin Endocrinol Metab. 2013;98(4):1622-1630.

Lorenzo C, Hanley AJ, Wagenknecht LE, Rewers MJ, Stefanovski D, Goodarzi MO, Haffner SM. Relationship of insulin sensitivity, insulin secretion, and adiposity with insulin clearance in a multiethnic population: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 2013;36(1):101-103.

Unick JL, Beavers D, Bond DS, Clark JM, Jakicic JM, Kitabchi AE, Knowler WC, Wadden TA, Wagenknecht LE, Wing RR. The long-term effectiveness of a lifestyle intervention in severely obese individuals. Am J Med. 2013;126(3):236-242.

Register TC, Divers J, Bowden DW, Carr JJ, Lenchik L, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2013;98(5):1916-1922.

Lee CC, Haffner SM, Wagenknecht LE, Lorenzo C, Norris JM, Bergman RN, Stefanovski D, Anderson AM, Rotter JI, Goodarzi MO, Hanley AJ. Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study. Diabetes Care. 2013;36(4):901-907.

Lee CC, Lorenzo C, Haffner SM, Wagenknecht LE, Goodarzi MO, Stefanovski D, Norris JM, Rewers MJ, Hanley AJ. Components of metabolic syndrome and 5-year change in insulin clearance--the Insulin Resistance Atherosclerosis Study. Diabetes Obes Metab. 2013;15(5):441-447.

Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, Coday M, Crow RS, Curtis JM, Egan CM, Espeland MA, Evans M, Foreyt JP, Ghazarian S, Gregg EW, Harrison B, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Jakicic JM,. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369(2):145-154.

Huggins GS, Papandonatos GD, Erar B, Belalcazar LM, Brautbar A, Ballantyne C, Kitabchi AE, Wagenknecht LE, Knowler WC, Pownall HJ, Wing RR, Peter I, McCaffery JM. Do genetic modifiers of high-density lipoprotein cholesterol and triglyceride levels also modify their response to a lifestyle intervention in the setting of obesity and type-2 diabetes mellitus?: The Action for Health in Diabetes (Look AHEAD) study. Circ Cardiovasc Genet. 2013;6(4):391-399.

Festa A, Haffner SM, Wagenknecht LE, Lorenzo C, Hanley AJ. Longitudinal decline of beta-cell function: comparison of a direct method vs a fasting surrogate measure: the Insulin Resistance Atherosclerosis Study. J Clin Endocrinol Metab. 2013;98(10):4152-4159.

Lee C, Liese A, Wagenknecht L, Lorenzo C, Haffner S, Hanley A. Fish consumption, insulin sensitivity and beta-cell function in the Insulin Resistance Atherosclerosis Study (IRAS). Nutr Metab Cardiovasc Dis. 2013;23(9):829-835.

McCaffery JM, Papandonatos GD, Huggins GS, Peter I, Erar B, Kahn SE, Knowler WC, Lipkin EW, Kitabchi AE, Wagenknecht LE, Wing RR. Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the LOOK AHEAD trial. Hum Hered. 2013;75(2-4):160-174.

Samaropoulos XF, Hairston KG, Anderson A, Haffner SM, Lorenzo C, Montez M, Norris JM, Scherzinger AL, Chen YD, Wagenknecht LE. A metabolically healthy obese phenotype in Hispanic participants in the IRAS family study. Obesity (Silver Spring). 2013;21(11):2303-2309.

Sandy An S, Palmer ND, Hanley AJ, Ziegler JT, Mark Brown W, Freedman BI, Register TC, Rotter JI, Guo X, Ida Chen YD, Wagenknecht LE, Langefeld CD, Bowden DW. Genetic analysis of adiponectin variation and its association with type 2 diabetes in African Americans. Obesity (Silver Spring). 2013;21(12):E721-E729.

Johnson KC, Wagenknecht L, Bray GA, Walkup MP, Wing R. The effect of intentional weight loss on changes in body composition over eight years in the Look AHEAD clinical trial [abstract]. Gerontologist. 2013;53(Suppl 1):388-389.

Palmer ND, Musani SK, Yerges-Armstrong LM, Feitosa MF, Bielak LF, Hernaez R, Kahali B, Carr JJ, Harris TB, Jhun MA, Kardia SL, Langefeld CD, Mosley TH Jr, Norris JM, Smith AV, Taylor HA, Wagenknecht LE, Liu J, Borecki IB, Peyser PA, Speliotes EK. Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent. Hepatology. 2013;58(3):966-975.

McCaffery JM, Papandonatos GD, Huggins GS, Peter I, Kahn SE, Knowler WC, Hudnall GE, Lipkin EW, Kitabchi AE, Wagenknecht LE, Espeland MA, Bahnson JL, Reboussin D, Rejeski WJ, Bertoni A,. FTO predicts weight regain in the Look AHEAD clinical trial. Int J Obes (Lond). 2013;37(12):1545-1552.

Howard G, Wagenknecht LE, Cushman M, Thacker EL, Judd SE, Howard VJ, Kissela BM. Could there be an offsetting impact of insulin resistance on ischemic stroke and intracerebral hemorrhage? The REasons for geographic and racial differences in Stroke (REGARDS) Study [abstract]. Circulation. 2013;127(12 Suppl):AP216.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Public Health Sciences

Clinical Interests

Epidemiology

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