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Lynne E. Wagenknecht, Dr.P.H.Wake Forest School of Medicine

Lynne E. Wagenknecht, Dr.P.H.

Associate Dean,
Associate Director,
Professor,


Clinical Interests

Epidemiology

Contact Information

Academic: 336-716-7652 | Department: 336-716-7652

Email: lwgnkcht@wakehealth.edu

Education & Training

  • B.S., Lenoir Rhyne College, 1982
  • M.P.H., University of Alabama School of Public Health, 1984
  • Dr.P.H., University of Alabama School of Public Health, 1989

Memberships

  • Am Diabetes Assn
  • Am Heart Association
Lynne E. Wagenknecht, Dr.P.H.

Lynne E. Wagenknecht, Dr.P.H.

Associate Dean, Dean's Office
Associate Director, Public Health Sciences
Professor, Public Health Sciences
Office of Women in Medicine and Science
Center on Diabetes, Obesity, and Metabolism

Research Interests

Diabetes Mellitus, Type 2; Insulin Resistance; Atherosclerosis; Obesity; Hispanic Americans
More »

Contact Information

Academic: 336-716-7652 | Department: 336-716-7652

Email: lwgnkcht@wakehealth.edu

Recent Publications

Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans. Hellwege JN, Palmer ND, Dimitrov L, Keaton JM, Tabb KL, Sajuthi S, Taylor KD, Ng MC, Speliotes EK, Hawkins GA, Long J, Ida Chen YD, Lorenzo C, Norris JM, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW.. J Hum Genet. 2017;62(2):175-184.

Baseline blood pressure control in Hispanics: characteristics of Hispanics in the Systolic Blood Pressure Intervention Trial. Rodriguez CJ, Still CH, Garcia KR, Wagenknecht L, White S, Bates JT, Del Cid MV, Lioudis M, Lopez Barrera N, Moreyra A, Punzi H, Ringer RJ, Cushman WC, Contreras G, Servilla K, Rocco M.. J Clin Hypertens (Greenwich). 2017;19(2):116-125.

Repeatability of ectopic beats from 48-hr ambulatory electrocardiography: the Atherosclerosis Risk in Communities (ARIC) Study. Meyer ML, Soliman EZ, Wruck LM, Mosley TH, Wagenknecht LE, Poon AK, Whitsel EA, Alonso A, Heiss G, Loehr LR.. Ann Noninvasive Electrocardiol. 2017;():.

Analysis of whole exome sequencing with cardiometabolic traits using family-based linkage and association in the IRAS Family Study. Tabb KL, Hellwege JN, Palmer ND, Dimitrov L, Sajuthi S, Taylor KD, Ng MC, Hawkins GA, Chen YI, Brown WM, McWilliams D, Williams A, Lorenzo C, Norris JM, Long J, Rotter JI, Curran JE, Blangero J, Wagenknecht LE, Langefeld CD, Bowden DW.. Ann Hum Genet. 2017;81(2):49-58.

Sex differences in the association between insulin resistance and incident coronary heart disease and stroke among blacks without diabetes mellitus: the Jackson Heart Study. Effoe VS, Wagenknecht LE, Echouffo Tcheugui JB, Chen H, Joseph JJ, Kalyani RR, Bell RA, Wu WH, Casanova R, Bertoni AG.. J Am Heart Assoc. 2017;6(2):e004229.

Cardiovascular disease and patterns of change in functional status over 15 years: findings from the Atherosclerosis Risk in Communities (ARIC) study. Kucharska-Newton A, Griswold M, Yao ZH, Foraker R, Rose K, Rosamond W, Wagenknecht L, Koton S, Pompeii L, Windham BG.. J Am Heart Assoc. 2017;6(3):e004144.

Association between midlife vascular risk factors and estimated brain amyloid deposition. Gottesman RF, Schneider AL, Zhou Y, Coresh J, Green E, Gupta N, Knopman DS, Mintz A, Rahmim A, Sharrett AR, Wagenknecht LE, Wong DF, Mosley TH.. JAMA. 2017;317(14):1443-1450.

Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012. Mayer-Davis EJ, Lawrence JM, Dabelea D, Divers J, Isom S, Dolan L, Imperatore G, Linder B, Marcovina S, Pettitt DJ, Pihoker C, Saydah S, Wagenknecht L.. N Engl J Med. 2017;376(15):1419-1429.

Prospective association of GLUL rs10911021 with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD Study. Huggins GS, Berkowitz RI, Blackburn GL, Bray GA, Cheskin L, Clark JM, Coday M, Espeland MA, Evans M, Foreyt JP, Glasser S, Greenway FL, Gregg EW, Hanson RL, Hazuda HP, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Kitzman DW,.. Diabetes. 2016;65(1):297-302.

Branched-chain amino acids and insulin metabolism: the Insulin Resistance Atherosclerosis Study (IRAS). Lee CC, Watkins SM, Lorenzo C, Wagenknecht LE, Il'yasova D, Chen YI, Haffner SM, Hanley AJ.. Diabetes Care. 2016;39(4):582-588.

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C, Tayo B, Nalls M, Feitosa MF, Isaacs A, Dehghan A, d'Adamo P, Adeyemo A,.. Nat Commun. 2016;7():10023.

Prediabetes and diabetes are associated with arterial stiffness in older adults: the ARIC study. Loehr LR, Meyer ML, Poon AK, Selvin E, Palta P, Tanaka H, Pankow JS, Wright JD, Griswold ME, Wagenknecht LE, Heiss G.. Am J Hypertens. 2016;29(9):1038-1045.

Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American-Diabetes Heart Study. Palmer ND, Divers J, Lu L, Register TC, Carr JJ, Hicks PJ, Smith SC, Xu J, Judd SE, Irvin MR, Gutierrez OM, Bowden DW, Wagenknecht LE, Langefeld CD, Freedman BI.. Bone. 2016;87():71-77.

Risk prediction of major complications in individuals with diabetes: the Atherosclerosis Risk in Communities Study. Parrinello CM, Matsushita K, Woodward M, Wagenknecht LE, Coresh J, Selvin E.. Diabetes Obes Metab. 2016;18(9):899-906.

Relationships between measures of adiposity with subclinical atherosclerosis in patients with type 2 diabetes. Yuan M, Hsu FC, Bowden DW, Xu J, Carrie Smith S, Wagenknecht LE, Comeau ME, Divers J, Register TC, Jeffrey Carr J, Langefeld CD, Freedman BI.. Obesity (Silver Spring). 2016;24(8):1810-1818.

Triglyceride levels and its relationship with hemoglobin A1C in patients with diabetes [abstract]. Pitts R, Garcia K, Ribisl P, Vitolins M, Cheskin L, Glasser S, Balasubramanyam A, Pownall HJ, Wagenknecht L, Eckel R.. J Am Coll Cardiol. 2016;67(13 Suppl):2020.

Improved performance of dynamic measures of insulin response over surrogate indices to identify genetic contributors of type 2 diabetes: the GUARDIAN Consortium. Palmer ND, Wagenknecht LE, Langefeld CD, Wang N, Buchanan TA, Xiang AH, Allayee H, Bergman RN, Raffel LJ, Chen YD, Haritunians T, Fingerlin T, Goodarzi MO, Taylor KD, Rotter JI, Watanabe RM, Bowden DW.. Diabetes. 2016;65(7):2072-2080.

The ARIC-PET amyloid imaging study: brain amyloid differences by age, race, sex, and APOE. Gottesman RF, Schneider AL, Zhou Y, Chen X, Green E, Gupta N, Knopman DS, Mintz A, Rahmim A, Sharrett AR, Wagenknecht LE, Wong DF, Mosley TH Jr.. Neurology. 2016;87(5):473-480.

Genome-wide interaction with insulin secretion loci reveals novel loci for type 2 diabetes in African Americans. Keaton JM, Hellwege JN, Ng MC, Palmer ND, Pankow JS, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Chen YD, Taylor KD, Rich SS, Wagenknecht LE, Freedman B, Bowden DW.. PLoS One. 2016;11(7):e0159977.

Bone mineral density and progression of subclinical atherosclerosis in African Americans with type 2 diabetes. Wagenknecht LE, Divers J, Register TC, Russell GB, Bowden DW, Xu J, Langefeld CD, Lenchik L, Hruska KA, Carr JJ, Freedman BI.. J Clin Endocrinol Metab. 2016;101(11):4135-4141.

Association of weight loss maintenance and weight regain on 4-year changes in CVD risk factors: the Action for Health in Diabetes (Look AHEAD) Clinical Trial. Wing RR, Espeland MA, Clark JM, Hazuda HP, Knowler WC, Pownall HJ, Unick J, Wadden T, Wagenknecht L.. Diabetes Care. 2016;39(8):1345-1355.

Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes. Hsu FC, Yuan M, Bowden DW, Xu J, Smith SC, Wagenknecht LE, Langefeld CD, Divers J, Register TC, Carr JJ, Williamson JD, Sink KM, Maldjian JA, Freedman BI.. J Diabetes Complications. 2016;30(8):1506-1512.

Cardiovascular dysfunction and frailty among older adults in the community: the ARIC Study. Nadruz W Jr, Kitzman D, Windham BG, Kucharska-Newton A, Butler K, Palta P, Griswold ME, Wagenknecht LE, Heiss G, Solomon SD, Skali H, Shah AM.. J Gerontol A Biol Sci Med Sci. 2016;():.

Prediction of incident diabetes in the Jackson Heart Study using high-dimensional machine learning. Casanova R, Saldana S, Simpson SL, Lacy ME, Subauste AR, Blackshear C, Wagenknecht L, Bertoni AG.. PLoS One. 2016;11(10):e0163942.

Genome-wide interaction with selected type 2 diabetes loci reveals novel loci for type 2 diabetes in African Americans. Keaton JM, Hellwege JN, Ng MC, Palmer ND, Pankow JS, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Chen YI, Taylor KD, Rich SS, Wagenknecht LE, Freedman BI, Bowden DW.. Pac Symp Biocomput. 2016;22():242-253.

The importance of mid-to-late-life body mass index trajectories on late-life gait speed. Windham BG, Griswold ME, Wang W, Kucharska-Newton A, Demerath EW, Gabriel KP, Pompeii LA, Butler K, Wagenknecht L, Kritchevsky S, Mosley TH Jr.. J Gerontol A Biol Sci Med Sci. 2016;():.

Whole genome sequence analysis of serum amino acid levels. Yu B, de Vries PS, Metcalf GA, Wang Z, Feofanova EV, Liu X, Muzny DM, Wagenknecht LE, Gibbs RA, Morrison AC, Boerwinkle E.. Genome Biol. 2016;17(1):237.

APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes. Freedman BI, Langefeld CD, Lu L, Palmer ND, Carrie Smith S, Bagwell BM, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Jeffrey Carr J, Bowden DW, Divers J.. Kidney Int. 2015;87(1):176-181.

Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels. Hellwege JN, Palmer ND, Brown MW, Ziegler JT, An SS, Guo X, Chen IY, Taylor K, Hawkins GA, Ng MC, Speliotes EK, Lorenzo C, Norris JM, Rotter JI, Wagenknecht LE, Langefeld CD, Bowden DW.. Hum Genet. 2015;134(2):203-213.

Genetic variants associated with quantitative glucose homeostasis traits translate to type 2 diabetes in Mexican Americans: the GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Palmer ND, Goodarzi MO, Langefeld CD, Wang N, Guo X, Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH , Haritunians T, Ziegler JT, Williams AH, Stefansovski D, Cui J, Mackay AW, Henkin LF, Bergman RN, Gao X, Gauderman J, Varma R, Hanis CL,.. Diabetes. 2015;64(5):1853-1866.

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert MF, Raghavan S, Lipovich L, Hidalgo B, Fox K, Huffman JE, An P, Lu Y, Rasmussen-Torvik LJ, Grarup N, Ehm MG, Li L, Baldridge AS, Stancakova A, Abrol R, Besse C,.. Nat Commun. 2015;6():5897.

Urinary F2-isoprostanes and metabolic markers of fat oxidation. Il'yasova D, Wagenknecht LE, Spasojevic I, Watkins S, Bowden D, Wang F, D'Agostino RB Jr.. Oxid Med Cell Longev. 2015;2015():729191.

Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: the Look AHEAD study. Pownall HJ, Bray GA, Wagenknecht LE, Walkup MP, Heshka S, Hubbard VS, Hill J, Kahn SE, Nathan DM, Schwartz AV, Johnson KC.. Obesity (Silver Spring). 2015;23(3):565-572.

Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study. Palmer ND, Stevens RD, Antinozzi PA, Anderson A, Bergman RN, Wagenknecht LE, Newgard CB, Bowden DW.. J Clin Endocrinol Metab. 2015;100(3):E463-E468.

Genome-wide gene-gene interaction with insulin secretion loci reveals novel loci contributing to type 2 diabetes etiology in African Americans [abstract]. Keaton JM, Ng MC, Palmer N, Pankow J, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Rich SS, Wagenknecht LE, Freedman BI, Bowden DW.. Diabetes. 2015;64(Suppl 1):A465.

An islet-targeted genome-wide association scan identifies novel genes implicated in cytokine-mediated islet stress in type 2 diabetes. Sharma PR, Mackey AJ, Dejene EA, Ramadan JW, Langefeld CD, Palmer ND, Taylor KD, Wagenknecht LE, Watanabe RM, Rich SS, Nunemaker CS.. Endocrinology. 2015;156(9):3147-3156.

Change in adiposity minimally affects the lipid profile in youth with recent onset type 1 diabetes. Shah AS, Dolan LM, Dabelea D, Stafford JM, D'Agostino RB Jr, Mayer-Davis EJ, Marcovina S, Imperatore G, Wadwa RP, Daniels SR, Reynolds K, Hamman RF, Bowlby DA, Maahs DM, Wagenknecht LE.. Pediatr Diabetes. 2015;16(4):280-286.

Associations of coffee consumption with markers of liver injury in the Insulin Resistance Atherosclerosis Study. Dickson JC, Liese AD, Lorenzo C, Haffner SM, Watkins SM, Hamren SJ, Stiles JK, Wagenknecht LE, Hanley AJ.. BMC Gastroenterol. 2015;15(1):88.

Genetic predisposition to weight loss and regain with lifestyle intervention: analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials. Papandonatos GD, Pan Q, Pajewski NM, Delahanty LM, Peter I, Erar B, Ahmad S, Harden M, Chen L, Fontanillas P, Wagenknecht LE, Kahn SE, Wing RR, Jablonski KA, Huggins GS, Knowler WC, Florez JC, McCaffery JM, Franks PW, Espeland MA, et al.. Diabetes. 2015;64(12):4312-4321.

Vitamin D associations with renal, bone, and cardiovascular phenotypes: African American-Diabetes Heart Study. Freedman BI, Divers J, Russell GB, Palmer ND, Wagenknecht LE, Smith SC, Xu J, Carr JJ, Bowden DW, Register T.. J Clin Endocrinol Metab. 2015;100(10):3693-3701.

Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial. McCaffery JM, Anderson A, Bantle JP, Berkowitz RI, Bray GA, Cheskin L, Clark JM, Curtis JM, Delahanty LM, Evans M, Foreyt JP, Glasser S, Gregg EW, Hanson RL, Hazuda HP, Hill JO, Horton ES, Huggins GS, Jakicic JM, Jeffery RW, Johnson KC,.. Diabetologia. 2015;58(8):1803-1813.

Obesity, insulin resistance, and incident small vessel disease on magnetic resonance imaging: Atherosclerosis Risk in Communities study. Dearborn JL, Schneider AL, Sharrett AR, Mosley TH, Bezerra DC, Knopman DS, Selvin E, Jack CR, Coker LH, Alonso A, Wagenknecht LE, Windham BG, Gottesman RF.. Stroke. 2015;46(11):3131-3136.

Genetic predictors of depressive symptoms in the Look AHEAD trial. McCaffery JM, Papandonatos GD, Faulconbridge LF, Erar B, Peter I, Wagenknecht LE, Pajewski NM, Anderson A, Wadden TA, Wing RR, Espeland M.. Psychosom Med. 2015;77(9):982-992.

Plasma FGF23 and calcified atherosclerotic plaque in African Americans with type 2 diabetes mellitus. Freedman BI, Divers J, Russell GB, Palmer ND, Bowden DW, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Langefeld CD, Hruska KA, Register TC.. Am J Nephrol. 2015;42(6):391-401.

A comprehensive analysis of common and rare variants to identify adiposity loci in Hispanic Americans: the IRAS Family Study (IRASFS). Gao C, Wang N, Guo X, Ziegler JT, Taylor KD, Xiang AH, Hai Y, Kridel SJ, Nadler JL, Kandeel F, Raffel LJ, Chen YD, Norris JM, Rotter JI, Watanabe RM, Wagenknecht LE, Bowden DW, Speliotes EK, Goodarzi MO, Langefeld CD, Palmer ND.. PLoS One. 2015;10(11):e0134649.

Bone resorption assessed by serum type I collagen C-terminal telopeptide (crosslaps) is inversely associated with bone mineral density and change in BMD but not with change in calcified atherosclerotic plaque in African Americans. Register T, Carr JJ, Lenchik L, Divers J, Russell GB, Palmer ND, Wagenknecht LE, Smith SC, Xu J, Bowden DW, Freedman BI.. J Bone Miner Res. 2015;30(Suppl 1):.

Genetic modifiers of cardiorespiratory fitness response to lifestyle intervention. Peter I, Papandonatos GD, Belalcazar LM, Yang Y, Erar B, Jakicic JM, Unick JL, Balasubramanyam A, Lipkin EW, Delahanty LM, Wagenknecht LE, Wing RR, McCaffery JM, Huggins GS, Espeland MA, Reboussin D, et al.. Med Sci Sports Exerc. 2014;46(2):302-311.

Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI.. J Clin Endocrinol Metab. 2014;99(1):315-321.

Baseline predictors of missed visits in the Look AHEAD study. Fitzpatrick SL, Jeffery R, Johnson KC, Roche CC, Van Dorsten B, Gee M, Dotson K, Walkup MP, Espeland MA, Bahnson JL, Wagenknecht LE, Reboussin D, Rejeski WJ, Bertoni AG, Lang W, Lawlor MS, Lefkowitz D, Miller GD, Reynolds PS, Ribisl PM,.. Obesity (Silver Spring). 2014;22(1):131-140.

Incidence and survival of hospitalized acute decompensated heart failure in four US communities (from the Atherosclerosis Risk in Communities Study). Chang PP, Chambless LE, Shahar E, Bertoni AG, Russell SD, Ni H, He M, Mosley TH, Wagenknecht LE, Samdarshi TE, Wruck LM, Rosamond WD.. Am J Cardiol. 2014;113(3):504-510.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Public Health Sciences

Clinical Interests

Epidemiology

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