Profile

Janice D. Wagner, D.V.M., Ph.D.

Education & Training

  • B.A., Hiram College , 1978
  • Ph.D., Wake Forest University , 1991
  • D.V.M., Ohio State University , 1985
  • M.S., University of Virginia School of Medicine , 1981
  • Fellowship, WFU School of Medicine, 1989

Memberships

  • Am Assn for Lab Animal Science
  • NC Acad Of Lab Animal Med
  • North Carolina Assn Of Biomedi
  • Am Diabetes Assn
  • Aha - Council On Arteriosclero
  • Am Veterinary Medical Assn

Related Links

Janice D. Wagner, D.V.M., Ph.D.

Janice D. Wagner, D.V.M., Ph.D.

Professor, Pathology-Comparative Medicine Translational Science Institute
Center for Diabetes Research
WFU Primate Center
Institute for Regenerative Medicine
Translational Science Institute

Research Interests

cancer/oncogenesis, diabetes, genetics/genome, information sciences

Contact Information

Academic: 336-716-4548 | Department: 336-716-1630

Email: jwagner@wakehealth.edu

Recent Publications

Wagner JD, Cann JA, Zhang L, Harwood HJ Jr.Diabetes and obesity research using nonhuman primates

Stute P, Sielker S, Wood CE, Register TC, Lees CJ, Dewi FN, Williams JK, Wagner JD, Stefenelli U, Cline JM. Life stage differences in mammary gland gene expression profile in non-human primates. Breast Cancer Res Treat. 2012;133(2):617-634.

O'Grady SP, Valenzuela LO, Remien CH, Enright LE, Jorgensen MJ, Kaplan JR, Wagner JD, Cerling TE, Ehleringer JR. Hydrogen and oxygen isotope ratios in body water and hair: modeling isotope dynamics in nonhuman primates. Am J Primatol. 2012;74(7):651-660.

Harwood HJ Jr, Listrani P, Wagner JD. Nonhuman primates and other animal models in diabetes research. J Diabetes Sci Technol. 2012;6(3):503-514.

Saisho Y, Manesso E, Butler AE, Galasso R, Kavanagh K, Flynn M, Zhang L, Clark P, Gurlo T, Wagner JD, et al. Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes. Diabetes. 2011;60(3):848-856.

Kavanagh K, Flynn DM, Nelson C, Zhang L, Wagner JD. Characterization and validation of a streptozotocin-induced diabetes model in the vervet monkey. J Pharmacol Toxicol Methods. 2011;63(3):296-303.

Kavanagh K, Flynn DM, Jenkins KA, Zhang L, Wagner JD. Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys. Am J Physiol Endocrinol Metab. 2011;300(5):E894-E901.

Wang Y, Song Z, Wagner JD, Pachuk C, Subramanian RR. Development of a sensitive ELISA to quantify apolipoprotein CIII in nonhuman primate serum. J Lipid Res. 2011;52(6):1265-1271.

Gray SB, Langefeld CD, Ziegler JT, Hawkins GA, Wagner JD, Howard TD. Single-nucleotide polymorphisms in the TNF gene are associated with obesity-related phenotypes in vervet monkeys. Obesity (Silver Spring). 2011;19(7):1427-1432.

Rowe PA, Kavanagh K, Zhang L, Harwood HJ Jr, Wagner JD. Short-term hyperglycemia increases arterial superoxide production and iron dysregulation in atherosclerotic monkeys. Metabolism. 2011;60(8):1070-1080.

Cheng H-J, Shao Q, Zhang L, Callahan MF, Wagner JD, Cheng CP. Upregulation and adverse effects of cardiac beta3-adrenoreceptor-mediated inducible nitric oxide synthase (iNOS)-coupled pathway in monkeys with naturally occurring type 2 diabetes [abstract]. Circulation. 2011;124(21 Suppl):A10649.

Adusumilli S, Aycock T, Wock J, Zhang L, Wagner J. Decreased inflammation following dental prophylaxis in diabetic cynomolgus macaques [abstract]. J Am Assoc Lab Anim Sci. 2011;50(5):811-812.

Howard TD, Ho S-M, Zhang L, Chen J, Cui W, Slager R, Gray S, Hawkins GA, Medvedovic M, Wagner JD. Epigenetic changes with dietary soy in cynomolgus monkeys. PLoS ONE. 2011;6(10):e26791.

Saisho Y, Butler AE, Manesso E, Galasso R, Zhang L, Gurlo T, Toffolo GM, Cobelli C, Kavanagh K, Wagner JD, et al. Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys. Diabetologia. 2010;53(1):111-114.


Wagner JD, Shadoan MK, Zhang L, Ward GM, Royer LJ, Kavanagh K, Francone OL, Auerbach BJ, Harwood HJ Jr. A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys. J Pharmacol Exp Ther. 2010;333(3):844-853.

Kavanagh K, Sajadian S, Jenkins KA, Wilson MD, Carr JJ, Wagner JD, Rudel LL. Neonatal and fetal exposure to trans-fatty acids retards early growth and adiposity while adversely affecting glucose in mice. Nutr Res. 2010;30(6):418-426.

Cann JA, Kavanagh K, Jorgensen MJ, Mohanan S, Howard TD, Gray SB, Hawkins GA, Fairbanks LA, Wagner JD. Clinicopathologic characterization of naturally occurring diabetes mellitus in vervet monkeys. Vet Pathol. 2010;47(4):713-718.

Wagner JD, Zhang L, Kavanagh K, Ward GM, Chin JE, Hadcock JR, Auerbach BJ, Harwood HJ Jr. A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys. J Pharmacol Exp Ther. 2010;335(1):103-113.

Saisho Y, Manesso E, Butler AE, Galasso R, Flynn M, Zhang L, Clark P, gurlo T, Toffolo GM, Wagner JD, et al. Sustained beta cell turnover in adult non human primates is predominantly derived from beta cell neogenesis, but this is not adaptively increased in streptozotocin-induced diabetes [abstract]. Endocr J. 2010;57(Suppl 2):S323.

Appt SE, Ethun KF, Jorgensen MJ, Wagner JD. Do diet and ovarian reserve predict risk for development of the metabolic syndrome? [abstract]. Menopause. 2010;17(6):1218.

Clark PB, Plaza MJ, Kraas J, Burbank N, Elster AW, Garg P, Garg S, Gage HD, Calles-Escandon J, Wagner JD, et al. Dual radiotracer analysis of cholinergic neuronal changes in prediabetic mouse pancreas. Diabetes Technol Ther. 2009;11(2):107-111.

Kavanagh K, Zhang L, Wagner JD. Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys. Cell Stress Chaperones. 2009;14(3):291-299.

Wagner JD, Jorgensen MJ, Cline JM, Lees CJ, Franke AA, Zhang L, Ayers MR, Schultz C, Kaplan JR. Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring. Am J Primatol. 2009;71(9):802-811.

Mohanan S, Wagner JD, Kock ND, Kavanagh K, Cline JM. Hepatic Mallory-Denk body formation in a streptozotocin-treated vervet monkey (Chlorocebus aethiops) [abstract]. Toxicol Pathol. 2009;37(1):135-136.

Wang ZQ, Floyd ZE, Qin J, Liu X, Yu Y, Zhang XH, Wagner JD, Cefalu WT. Modulation of skeletal muscle insulin signaling with chronic caloric restriction in cynomolgus monkeys. Diabetes. 2009;58(7):1488-1498.

Kavanagh K, Davis MA, Zhang L, Wilson MD, Register TC, Adams MR, Rudel LL, Wagner JD. Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA: cholesterol acyltransferase 2 (ACAT2) in monkeys. Arterioscler Thromb Vasc Biol. 2009;29(10):1471-1477.

Chen Z, van Doorslaer K, DeSalle R, Wood CE, Kaplan JR, Wagner JD, Burk RD. Genomic diversity and interspecies host infection of alpha 12 Macaca fascicularis papillomaviruses (MfPVs). Virology. 2009;393(2):304-310.

Cohen JA, Zhang L, Sajuthi A, Wagner JD. Iron metabolism and oxidative stress in insulin resistant and diabetic monkeys [abstract]. J Am Assoc Lab Anim Sci. 2009;48(5):552-553.

Gray SB, Howard TD, Langefeld CD, Hawkins GA, Diallo AF, Wagner JD. Comparative analyses of single-nucleotide polymorphisms in the TNF promoter region provide further validation for the vervet monkey model of obesity. Comp Med. 2009;59(6):580-588.

Clark PB, Kavanagh K, Gage HD, Garg P, Garg S, Calles-Escandon J, Wagner JD, Morton K. Enhanced cholinergic response in pancreata of nonhuman primates with impaired glucose tolerance shown on [18F]fluorobenzyltrozamicol positron emission tomography. Diabetes Technol Ther. 2009;11(7):451-455.

Wagner JD, Zhang L, Shadoan MK, Kavanagh K, Chen H, Tresnasari K, Kaplan JR, Adams MR. Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys. Metabolism. 2008;57(Suppl 1):S24-S31.

Kavanagh K, Jones KL, Zhang L, Flynn DM, Shadoan MK, Wagner JD. High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates. Nutr Res. 2008;28(6):368-376.

Shadoan MK, Kavanagh K, Zhang L, Anthony MS, Wagner JD. Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissue. Metabolism. 2007;56(6):830-837.

Kavanagh K, Berquist M, Brown KK, Zhang L, Wagner JD. Evaluation of pioglitazone induced fluid retention in primates [abstract]. Am J Primatol. 2007;69(Suppl 1):49.

Gray SB, Howard TD, Hawkins GA, Diallo AF, Wagner JD. Single nucleotide polymorphisms of the TNF-alpha gene in captive vervet monkeys (Chlorocebus aethiops) [abstract]. Am J Primatol. 2007;69(Suppl 1):61-62.

Wagner JD, Zhang L, Kavanagh K, Gray SB, Adams MR, Kaplan JR. Effects of sex hormones and soy isoflavones on obesity and insulin resistance in cynomolgus monkeys [abstract]. Am J Primatol. 2007;69(Suppl 1):71.

Kavanagh K, Jones KL, Sawyer J, Kelley K, Carr JJ, Wagner JD, Rudel LL. Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys. Obesity. 2007;15(7):1675-1684.

Kavanagh K, Fairbanks LA, Bailey JN, Jorgensen MJ, Wilson M, Zhang L, Rudel LL, Wagner JD. Characterization and heritability of obesity and associated risk factors in vervet monkeys. Obesity. 2007;15(7):1666-1674.

Flynn M, Kavanagh K, Zhang L, Collins J, Rankin S, Sajuthi A, Butler PC, Wagner JD. Development of a nonhuman primate model of type 1 diabetes in African green monkeys [abstract]. J Am Assoc Lab Anim Sci. 2007;46(4):126.

Gray SB, Cann JA, Trybus JA, Kavanagh K, Wagner JD. Characterization of clinical and pancreatic islet pathology in captive, spontaneously diabetic Vervet monkeys (Chlorocebus aethiops) [abstract]. J Am Assoc Lab Anim Sci. 2007;46(4):107.

Gray SB, Howard T, Hawkins G, Diallo A, Wagner J. Amylin gene sequence of the amyloidogenic region in the vervet monkey (Chlorocebus aethiops) [abstract]. Diabetes. 2007;56(Suppl 1):A691.

Kavanagh K, Zhang L, Wagner JD. Differential regulation of heat shock proteins in liver and pancreas of diabetic monkeys [abstract]. Diabetes. 2007;56(Suppl 1):A516.

Flynn M, Shadoan MK, Kavanagh K, Zhang L, Auerbach BJ, Harwood HJ, Wagner JD. A novel selective PPAR-alpha agonist, CP900691, improves plasma lipids, lipoproteins, glycemic control and reduces body weight in diabetic monkeys [abstract]. Diabetes. 2007;56(Suppl 1):A138.

Hayward CM, Bagley SW, Hada WA, Hamanaka ES, Aldinger C, Auerbach B, Francone OL, Haghpassand M, Kane CD, Wagner JD, et al. Synthesis and structure activity relationship of potent, selective piperidine-based PPARa agonists [abstract]. Abstr Pap Am Chem Soc. 2006;231():180-MEDI.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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