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Kounosuke Watabe, Ph.D.Wake Forest School of Medicine

Kounosuke Watabe, Ph.D.

Professor,

Contact Information

Academic: 336-716-0231 | Department: 336-716-0231

Email: kwatabe@wakehealth.edu

Additional Languages

Japanese

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Education & Training

  • B.S., Kyoto University, Japan, 1976
  • M.S., Kyoto University, Japan, 1978
  • Ph.D., Kyoto University, Japan, 1981

Memberships

  • Metastasis Research Society
  • Am Assn Of Advancement Of Scie
  • Am Assn Of Cancer Research
  • American Soc for Microbiology
Kounosuke Watabe, Ph.D.

Kounosuke Watabe, Ph.D.

Professor, Cancer Biology

Research Interests

Breast Neoplasms; Brain Neoplasms; Neoplastic Stem Cells; Neoplasm Metastasis; Prostatic Neoplasms
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Contact Information

Academic: 336-716-0231 | Department: 336-716-0231

Email: kwatabe@wakehealth.edu

Related Links

Recent Publications

Use of non-ionizing electromagnetic fields for the treatment of cancer. Jimenez H, Blackman C, Lesser G, Debinski W, Chan M, Sharma S, Watabe K, Lo HW, Thomas A, Godwin D, Blackstock W, Mudry A, Posey J, O'Connor R, Brezovich I, Bonin K, Kim-Shapiro D, Barbault A, Pasche B.. Front Biosci (Landmark Ed). 2018;23():284-297.

Emerging indications for fractionated gamma knife radiosurgery. McTyre E, Helis CA, Farris M, Wilkins L, Sloan D, Hinson WH, Bourland JD, Dezarn WA, Munley MT, Watabe K, Xing F, Laxton AW, Tatter SB, Chan MD.. Neurosurgery. 2017;80(2):210-216.

Repeat stereotactic radiosurgery as salvage therapy for locally recurrent brain metastases previously treated with radiosurgery. McKay WH, McTyre ER, Okoukoni C, Alphonse-Sullivan NK, Ruiz J, Munley MT, Qasem S, Lo HW, Xing F, Laxton AW, Tatter SB, Watabe K, Chan MD.. J Neurosurg. 2017;127(1):148-156.

Predictors of neurologic and nonneurologic death in patients with brain metastasis initially treated with upfront stereotactic radiosurgery without whole-brain radiation therapy. McTyre ER, Johnson AG, Ruiz J, Isom S, Lucas JT Jr, Hinson WH, Watabe K, Laxton AW, Tatter SB, Chan MD.. Neuro Oncol. 2017;19(4):558-566.

The roles of microglia/macrophages in tumor progression of brain cancer and metastatic disease. Wu SY, Watabe K.. Front Biosci (Landmark Ed). 2017;22():1805-1829.

The effects of smoking status and smoking history on patients with brain metastases from lung cancer. Shenker RF, McTyre ER, Ruiz J, Weaver KE, Cramer C, Alphonse-Sullivan NK, Farris M, Petty WJ, Bonomi MR, Watabe K, Laxton AW, Tatter SB, Warren GW, Chan MD.. Cancer Med. 2017;6(5):944-952.

Leptomeningeal failure in patients with breast cancer receiving stereotactic radiosurgery for brain metastases. Wang EC, Huang AJ, Huang KE, McTyre ER, Lo HW, Watabe K, Metheny-Barlow L, Laxton AW, Tatter SB, Strowd RE, Chan MD, Page BR.. J Clin Neurosci. 2017;43():6-10.

Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Carpenter RL, Sirkisoon S, Zhu D, Rimkus T, Harrison A, Anderson A, Paw I, Qasem S, Xing F, Liu Y, Chan M, Metheny-Barlow L, Pasche BC, Debinski W, Watabe K, Lo HW.. Oncotarget. 2017;8(43):73947-63.

Prediction of new brain metastases after radiosurgery: validation and analysis of performance of a multi-institutional nomogram. Ayala-Peacock DN, Attia A, Braunstein SE, Ahluwalia MS, Hepel J, Chung C, Contessa J, McTyre E, Peiffer AM, Lucas JT Jr, Isom S, Pajewski NM, Kotecha R, Stavas MJ, Page BR, Kleinberg L, Shen C, Taylor RB, Onyeuku NE, Hyde AT, Gorovets D,.. J Neurooncol. 2017;135(2):403-411.

Stereotactic radiosurgery in the treatment of brain metastases from gynecologic primary cancer. Johnston H, McTyre ER, Cramer CK, Lesser GJ, Ruiz J, Bourland JD, Watabe K, Lo HW, Qasem S, Laxton AW, Tatter SB, Chan MD.. J Radiosurg SBRT. 2017;5(1):55-61.

Extracellular vesicles as emerging targets in cancer: recent development from bench to bedside. Wu K, Xing F, Wu SY, Watabe K.. Biochim Biophys Acta. 2017;1868(2):538-563.

Staged stereotactic radiosurgery for large brain metastases: local control and clinical outcomes of a one-two punch technique. Dohm A, McTyre ER, Okoukoni C, Henson A, Cramer CK, LeCompte MC, Ruiz J, Munley MT, Qasem S, Lo HW, Xing F, Watabe K, Laxton AW, Tatter SB, Chan MD.. Neurosurgery. 2017;():.

DBF 2.0: A web-based predictive model for distant brain failure, brain metastasis velocity, and early death after radiosurgery for brain metastases [abstract]. Henson A, Ayala-Peacock DN, Chung C, Hepel JT, Chao ST, Contessa JN, Fiveash JB, Attia A, McTyre E, Braunstein SE, Page BR, Shen C, Kleinberg LR, Watabe K, Pasche B, D'Agostino R Jr, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E78-E79.

Clinical outcomes of upfront stereotactic radiosurgery alone for patients with greater than 4 brain metastases [abstract]. Hughes RT, McTyre E, LeCompte MC, Cramer CK, Munley MT, Laxton A, Tatter SB, Ruiz J, Pasche B, Watabe K, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E80-E81.

Survival and failure outcomes predicted by brain metastasis kinetics following initial distant brain failure in melanoma patients treated upfront with stereotactic radiosurgery alone [abstract]. LeCompte MC, McTyre E, Henson A, Farris M, Okoukoni C, Cramer CK, Triozzi P, Munley MT, Qasem S, Xing F, Watabe K, Laxton A, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E86-E87.

Multi-institutional validation of brain metastasis velocity, a recently defined predictor of outcomes following stereotactic radiosurgery [abstract]. McTyre E, Farris M, Ayala-Peacock DN, Page BR, Shen C, Kleinberg LR, Contessa JN, Chung C, Ruiz J, Pasche B, Watabe K, Fiveash JB, Hepel JT, Chao ST, Braunstein SE, Attia A, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E93.

Drivers of the cost of management in patients treated with radiosurgery without whole brain radiation therapy for brain metastases [abstract]. Shenker RF, McTyre E, Cramer CK, Munley MT, Ruiz J, Watabe K, Pasche B, Laxton A, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E414-E415.

Determination of tumor gene expression in non-small cell lung cancer patients who develop brain metastasis diagnosis: analysis of a prospective trial [abstract]. Dohm AE, Su J, McTyre E, Soike M, Miller LD, Petty WJ, Xing F, Lo HW, Metheny-Barlow L, Watabe K, Chan MD, Ruiz J, Pasche B.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E453.

Sociodemographic predictors of patients with brain metastases treated with stereotactic radiosurgery. Alphonse-Sullivan N, Taksler GB, Lycan T, Weaver KE, McTyre ER, Shenker RF, Page BR, Isom S, Johnson A, Munley MT, Laxton AW, Tatter SB, Watabe K, Chan MD, Ruiz J.. Oncotarget. 2017;8(60):101055-11.

Stromal cell extracellular vesicular cargo mediated regulation of breast cancer cell metastasis via ubiquitin conjugating enzyme E2 N pathway. Vallabhaneni KC, Penfornis P, Xing F, Hassler Y, Adams KV, Mo YY, Watabe K, Pochampally R.. Oncotarget. 2017;8(66):109861-76.

The number of prior lines of systemic therapy as a prognostic factor for patients with brain metastases treated with stereotactic radiosurgery: results of a large single institution retrospective analysis. Lanier CM, McTyre E, LeCompte M, Cramer CK, Hughes R, Watabe K, Lo HW, O'Neill S, Munley MT, Laxton AW, Tatter SB, Ruiz J, Chan MD.. Clin Neurol Neurosurg. 2017;165():24-28.

Survival and failure outcomes predicted by brain metastasis volumetric kinetics in melanoma patients following upfront treatment with stereotactic radiosurgery alone. LeCompte MC, McTyre E, Henson A, Farris M, Okoukoni C, Cramer CK, Triozzi P, Ruiz J, Watabe K, Lo HW, Munley MT, Laxton AW, Tatter SB, Zhou X, Chan M.. Cureus. 2017;9(12):1-12.

Biology and treatment of metastasis of sarcoma to the brain. Ahmad O, Chan M, Savage P, Watabe K, Lo HW, Qasem S.. Front Biosci (Elite Ed). 2016;8():233-244.

Regulation of breast tumorigenesis through acid sensors. Gupta SC, Singh R, Asters M, Liu J, Zhang X, Pabbidi MR, Watabe K, Mo YY.. Oncogene. 2016;35(31):4102-4111.

Treatment of brain metastases of lung cancer in the era of precision medicine. Haughton ME, Chan MD, Watabe K, Bonomi M, Debinski W, Lesser GJ, Ruiz J.. Front Biosci (Elite Ed). 2016;8():219-232.

Computational systems biology in cancer brain metastasis. Peng H, Tan H, Zhao W, Jin G, Sharma S, Xing F, Watabe K, Zhou X.. Front Biosci (Schol Ed). 2016;8():169-186.

Non-coding RNAs in cancer brain metastasis. Wu K, Sharma S, Venkat S, Liu K, Zhou X, Watabe K.. Front Biosci (Schol Ed). 2016;8():187-202.

Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis. Singh R, Gupta SC, Peng WX, Zhou N, Pochampally R, Atfi A, Watabe K, Lu Z, Mo YY.. Cell Death Dis. 2016;7(6):e2262.

Activation of the c-Met pathway mobilizes an inflammatory network in the brain microenvironment to promote brain metastasis of breast cancer. Xing F, Liu Y, Sharma S, Wu K, Chan MD, Lo HW, Carpenter RL, Metheny-Barlow LJ, Zhou X, Qasem SA, Pasche B, Watabe K.. Cancer Res. 2016;76(17):4970-4980.

Brain metastasis velocity: a novel prognostic metric predictive of overall survival and freedom from whole-brain radiation therapy after upfront radiosurgery alone for brain metastases [abstract]. Farris M, McTyre E, Hughes RT, Ayala-Peacock DN, Randolph DM II, Bourland JD, Tatter SB, Laxton AW, Watabe K, Ruiz J, Li W, Zhou X, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):S180.

Secreted protein acidic and rich in cysteine (SPARC) mediates metastatic dormancy of prostate cancer in bone. Sharma S, Xing F, Liu Y, Wu K, Said N, Pochampally R, Shiozawa Y, Lin HK, Balaji KC, Watabe K.. J Biol Chem. 2016;291(37):19351-63.

Local control of brain metastases after stereotactic radiosurgery: the impact of whole brain radiotherapy and treatment paradigm. Hughes RT, Black PJ, Page BR, Lucas JT, Qasem SA, Watabe K, Ruiz J, Laxton AW, Tatter SB, Debinski W, Chan MD.. J Radiosurg SBRT. 2016;4(2):89-96.

TRAF6 restricts p53 mitochondrial translocation, apoptosis, and tumor suppression. Zhang X, Li CF, Zhang L, Wu CY, Han L, Jin G, Rezaeian AH, Han F, Liu C, Xu C, Xu X, Huang CY, Tsai FJ, Tsai CH, Watabe K, Lin HK.. Mol Cell. 2016;64(4):803-814.

Roles of the cyclooxygenase 2-matrix metalloproteinase 1 pathway in brain metastasis of breast cancer. Wu K, Fukuda K, Xing F, Zhang Y, Sharma S, Liu Y, Chan M, Zhou X, Qasem S, Pochampally R, Mo YY, Watabe K.. J Biol Chem. 2015;290(15):9842-9854.

miR-509 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF-alpha. Xing F, Sharma S, Liu Y, Mo YY, Wu K, Zhang YY, Pochampally R, Martinez LA, Lo HW, Watabe K.. Oncogene. 2015;34(37):4890-4900.

Mechanisms regulating glioma invasion. Paw I, Carpenter RC [sic] [Carpenter RL], Watabe K, Debinski W, Lo HW.. Cancer Lett. 2015;362(1):1-7.

The gain-of-function truncated GLI1 (TGLI1) promotes glioblastoma angiogenesis by direct upregulation of VEGF-C and TEM7 expression [abstract]. Carpenter RL, Paw I, Sirkisoon S, Xing F, Gibo D, Watabe K, Debinski W, Lo HW.. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research (AACR); 2015 Apr 18-22; Philadelphia (PA). 2015;():A4165.

Impact of systemic targeted agents on the clinical outcomes of patients with brain metastases. Johnson AG, Ruiz J, Hughes R, Page BR, Isom S, Lucas JT, McTyre ER, Houseknecht KW, Ayala-Peacock DN, Bourland DJ, Hinson WH, Laxton AW, Tatter SB, Debinski W, Watabe K, Chan MD.. Oncotarget. 2015;6(22):18945-55.

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis. Carpenter RL, Paw I, Zhu H, Sirkisoon S, Xing F, Watabe K, Debinski W, Lo HW.. Oncotarget. 2015;6(26):22653-65.

Small molecule screening links metabolic plasticity with the target organ selectivity of triple-negative breast tumor metastases [abstract]. Zhou YD, Mahdi F, Li KP, Milasta S, Jekabsons MB, Wang YH, Khan IA, Gao J, Wu J, Chen T, Ouyang Y, Green DR, Watabe K, Nagle DG.. Planta Med. 2015;81(11):891.

SPARC in tumor microenvironment induces dormancy of prostate cancer in bone [abstract]. Sharma S, Xing F, Liu Y, Wu KR, Kobayashi A, Watabe K.. Cancer Res. 2015;75(15 Suppl):3206.

COX2-MMP1 pathway promotes brain metastasis by tampering with blood-brain barrier and supporting tumor initiating cells in the brain microenvironment [abstract]. Wu KR, Fukuda K, Xing F, Zhang YY, Sharma S, Liu Y, Watabe K.. Cancer Res. 2015;75(15 Suppl):2250.

A competing risks analysis assessing predictors of neurologic and non-neurologic death in patients with brain metastasis initially treated with upfront stereotactic radiosurgery without whole-brain radiation therapy [abstract]. McTyre E, Johnson A, Ruiz J, Isom S, Lucas JT Jr, Hinson W, Watabe K, Laxton AW, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2015;93(3 Suppl):S176.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cancer Biology

Kounosuke Watabe, Ph.D.

Kounosuke Watabe, Ph.D.

Professor, Cancer Biology

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