Profile

Kounosuke Watabe, Ph.D.Wake Forest School of Medicine

Kounosuke Watabe, Ph.D.

Professor,

Contact Information

Academic: 336-716-0231 | Department: 336-716-0231

Email: kwatabe@wakehealth.edu

Additional Languages

Japanese

Related Links

Education & Training

  • B.S., Kyoto University, Japan, 1976
  • M.S., Kyoto University, Japan, 1978
  • Ph.D., Kyoto University, Japan, 1981

Memberships

  • Metastasis Research Society
  • Am Assn Of Advancement Of Scie
  • Am Assn Of Cancer Research
  • American Soc for Microbiology
Kounosuke Watabe, Ph.D.

Kounosuke Watabe, Ph.D.

Professor, Cancer Biology

Research Interests

Breast Neoplasms; Prostatic Neoplasms; Neoplasm Metastasis; Neoplastic Stem Cells; Neoplasms
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Contact Information

Academic: 336-716-0231 | Department: 336-716-0231

Email: kwatabe@wakehealth.edu

Related Links

Recent Publications

Biology and treatment of metastasis of sarcoma to the brain. Ahmad O, Chan M, Savage P, Watabe K, Lo HW, Qasem S.. Front Biosci (Elite Ed). 2016;8():233-244.

Regulation of breast tumorigenesis through acid sensors. Gupta SC, Singh R, Asters M, Liu J, Zhang X, Pabbidi MR, Watabe K, Mo YY.. Oncogene. 2016;35(31):4102-4111.

Treatment of brain metastases of lung cancer in the era of precision medicine. Haughton ME, Chan MD, Watabe K, Bonomi M, Debinski W, Lesser GJ, Ruiz J.. Front Biosci (Elite Ed). 2016;8():219-232.

Computational systems biology in cancer brain metastasis. Peng H, Tan H, Zhao W, Jin G, Sharma S, Xing F, Watabe K, Zhou X.. Front Biosci (Schol Ed). 2016;8():169-186.

Non-coding RNAs in cancer brain metastasis. Wu K, Sharma S, Venkat S, Liu K, Zhou X, Watabe K.. Front Biosci (Schol Ed). 2016;8():187-202.

Emerging indications for fractionated gamma knife radiosurgery. McTyre E, Helis CA, Farris M, Wilkins L, Sloan D, Hinson WH, Bourland JD, Dezarn WA, Munley MT, Watabe K, Xing F, Laxton AW, Tatter SB, Chan MD.. Neurosurgery. 2016;():.

Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis. Singh R, Gupta SC, Peng WX, Zhou N, Pochampally R, Atfi A, Watabe K, Lu Z, Mo YY.. Cell Death Dis. 2016;7(6):e2262.

Activation of the c-Met pathway mobilizes an inflammatory network in the brain microenvironment to promote brain metastasis of breast cancer. Xing F, Liu Y, Sharma S, Wu K, Chan MD, Lo HW, Carpenter RL, Metheny-Barlow LJ, Zhou X, Qasem SA, Pasche B, Watabe K.. Cancer Res. 2016;76(17):4970-4980.

Repeat stereotactic radiosurgery as salvage therapy for locally recurrent brain metastases previously treated with radiosurgery. McKay WH, McTyre ER, Okoukoni C, Alphonse-Sullivan NK, Ruiz J, Munley MT, Qasem S, Lo HW, Xing F, Laxton AW, Tatter SB, Watabe K, Chan MD.. J Neurosurg. 2016;():.

Predictors of neurologic and nonneurologic death in patients with brain metastasis initially treated with upfront stereotactic radiosurgery without whole-brain radiation therapy. McTyre ER, Johnson AG, Ruiz J, Isom S, Lucas JT Jr, Hinson WH, Watabe K, Laxton AW, Tatter SB, Chan MD.. Neuro Oncol. 2016;():.

Brain metastasis velocity: a novel prognostic metric predictive of overall survival and freedom from whole-brain radiation therapy after upfront radiosurgery alone for brain metastases [abstract]. Farris M, McTyre E, Hughes RT, Ayala-Peacock DN, Randolph DM II, Bourland JD, Tatter SB, Laxton AW, Watabe K, Ruiz J, Li W, Zhou X, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):S180.

Secreted protein acidic and rich in cysteine (SPARC) mediates metastatic dormancy of prostate cancer in bone. Sharma S, Xing F, Liu Y, Wu K, Said N, Pochampally R, Shiozawa Y, Lin HK, Balaji KC, Watabe K.. J Biol Chem. 2016;291(37):19351-63.

Roles of the cyclooxygenase 2-matrix metalloproteinase 1 pathway in brain metastasis of breast cancer. Wu K, Fukuda K, Xing F, Zhang Y, Sharma S, Liu Y, Chan M, Zhou X, Qasem S, Pochampally R, Mo YY, Watabe K.. J Biol Chem. 2015;290(15):9842-9854.

miR-509 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF-alpha. Xing F, Sharma S, Liu Y, Mo YY, Wu K, Zhang YY, Pochampally R, Martinez LA, Lo HW, Watabe K.. Oncogene. 2015;34(37):4890-4900.

Mechanisms regulating glioma invasion. Paw I, Carpenter RC [sic] [Carpenter RL], Watabe K, Debinski W, Lo HW.. Cancer Lett. 2015;362(1):1-7.

The gain-of-function truncated GLI1 (TGLI1) promotes glioblastoma angiogenesis by direct upregulation of VEGF-C and TEM7 expression [abstract]. Carpenter RL, Paw I, Sirkisoon S, Xing F, Gibo D, Watabe K, Debinski W, Lo HW.. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research (AACR); 2015 Apr 18-22; Philadelphia (PA). 2015;():A4165.

Impact of systemic targeted agents on the clinical outcomes of patients with brain metastases. Johnson AG, Ruiz J, Hughes R, Page BR, Isom S, Lucas JT, McTyre ER, Houseknecht KW, Ayala-Peacock DN, Bourland DJ, Hinson WH, Laxton AW, Tatter SB, Debinski W, Watabe K, Chan MD.. Oncotarget. 2015;6(22):18945-55.

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis. Carpenter RL, Paw I, Zhu H, Sirkisoon S, Xing F, Watabe K, Debinski W, Lo HW.. Oncotarget. 2015;6(26):22653-65.

Small molecule screening links metabolic plasticity with the target organ selectivity of triple-negative breast tumor metastases [abstract]. Zhou YD, Mahdi F, Li KP, Milasta S, Jekabsons MB, Wang YH, Khan IA, Gao J, Wu J, Chen T, Ouyang Y, Green DR, Watabe K, Nagle DG.. Planta Med. 2015;81(11):891.

SPARC in tumor microenvironment induces dormancy of prostate cancer in bone [abstract]. Sharma S, Xing F, Liu Y, Wu KR, Kobayashi A, Watabe K.. Cancer Res. 2015;75(15 Suppl):3206.

COX2-MMP1 pathway promotes brain metastasis by tampering with blood-brain barrier and supporting tumor initiating cells in the brain microenvironment [abstract]. Wu KR, Fukuda K, Xing F, Zhang YY, Sharma S, Liu Y, Watabe K.. Cancer Res. 2015;75(15 Suppl):2250.

A competing risks analysis assessing predictors of neurologic and non-neurologic death in patients with brain metastasis initially treated with upfront stereotactic radiosurgery without whole-brain radiation therapy [abstract]. McTyre E, Johnson A, Ruiz J, Isom S, Lucas JT Jr, Hinson W, Watabe K, Laxton AW, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2015;93(3 Suppl):S176.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cancer Biology

Kounosuke Watabe, Ph.D.

Kounosuke Watabe, Ph.D.

Professor, Cancer Biology

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