Profile

Jeffrey L. Weiner, Ph.D.Wake Forest School of Medicine

Jeffrey L. Weiner, Ph.D.

Professor,

Contact Information

Academic: 336-716-8692 | Department: 336-716-8692

Email: jweiner@wakehealth.edu

Additional Languages

French

Related Links

Education & Training

  • B.S., University Toronto Med-Canada, 1988
  • M.Sc., University Toronto Med-Canada, 1990
  • Ph.D., University Toronto Med-Canada, 1994
  • Fellowship, U Colorado Hlth Sci Ctr, 1998

Memberships

  • Research Society On Alcoholism
  • Int Soc for Biomed Res on Alco
  • Society for Neuroscience
Jeffrey L. Weiner, Ph.D.

Jeffrey L. Weiner, Ph.D.

Professor, Physiology & Pharmacology
Institute for Regenerative Medicine

Research Interests

cognition/learning, mental disorders/psychiatry/ps, neurosciences/behavior, substance abuse

Contact Information

Academic: 336-716-8692 | Department: 336-716-8692

Email: jweiner@wakehealth.edu

Related Links

Recent Publications

Skelly MJ, Chappell AM, Ariwodola OJ, Weiner JL. Behavioral and neurophysiological evidence that lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the acquisition and extinction of fear learning. Neurobiol Learn Mem. 2016;127():10-16.

Karkhanis AN, Rose JH, Weiner JL, Jones SR. Early-Life social isolation stress increases kappa opioid receptor responsiveness and downregulates the dopamine system. Neuropsychopharmacology. 2016;():.

Butler TR, Karkhanis AN, Jones SR, Weiner JL. Adolescent social isolation as a model of heightened vulnerability to comorbid alcoholism and anxiety disorders. Alcohol Clin Exp Res. 2016;40(6):1202-1214.

Rau AR, Ariwodola OJ, Weiner JL. Postsynaptic adenosine A2A receptors modulate intrinsic excitability of pyramidal cells in the rat basolateral amygdala. Int J Neuropsychopharmacol. 2015;18(6):.

Karkhanis AN, Alexander NJ, McCool BA, Weiner JL, Jones SR. Chronic social isolation during adolescence augments catecholamine response to acute ethanol in the basolateral amygdala. Synapse. 2015;69(8):385-395.

Skelly MJ, Chappell AE, Carter E, Weiner JL. Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: possible role of disrupted noradrenergic signaling. Neuropharmacology. 2015;97():149-159.

Rau AR, Chappell AM, Butler TR, Ariwodola OJ, Weiner JL. Increased basolateral amygdala pyramidal cell excitability may contribute to the anxiogenic phenotype induced by chronic early-life stress. J Neurosci. 2015;35(26):9730-9740.

Adamah-Biassi EB, Almonte AG, Blagovechtchenski E, Grinevich VP, Weiner JL, Bonin KD, Budygin EA. Real time adenosine fluctuations detected with fast-scan cyclic voltammetry in the rat striatum and motor cortex. J Neurosci Methods. 2015;256():56-62.

Adamah-Biassi EB, Almonte AG, Bonin KD, Weiner JL, Budygin EA. Effects of ethanol on real-time adenosine dynamics in the rat striatum [abstract]. Alcohol Clin Exp Res. 2015;39(Suppl 1):182A.

Fetzer JA, Ariwodola OJ, Weiner JL. Impact of early life stress on alcohol addiction vulnerability and the developmental trajectory of basolateral amygdala circuitry [abstract]. Alcohol Clin Exp Res. 2015;39(Suppl 1):116A.

Rau AR, Ariwodola OJ, Butler TR, McCool BA, Weiner JL. Increased excitability of Bla pyramidal cells may contribute to the phenotype associated with a rodent model of alcohol addiction vulnerability [abstract]. Alcohol Clin Exp Res. 2015;39(Suppl 1):297A.

Skelly MJ, Ariwodola O, Chappell AM, Weiner JL. A novel role of Bla lateral paracapsular synapses in fear learning: implications for comorbid Ptsd and alcohol use disorder [abstract]. Alcohol Clin Exp Res. 2015;39(Suppl 1):114A.

Karkhanis AN, Rose JH, Weiner JL, Jones SR. Social isolation stress increases K-opioid receptor activity in the nucleus accumbens shell and core [abstract]. Alcohol Clin Exp Res. 2015;39(Suppl 1):121A.

Weiner JL, Karkhanis AN, Rau A, Skelly MJ, Jones SR. Adolescent social isolation as a model of alcohol addiction vulnerability [abstract]. Alcohol Alcohol. 2015;50(Suppl 1):SY17-2.

Yorgason JT, Calipari ES, Ferris MJ, Karkhanis AN, Fordahl SC, Weiner JL, Jones SR. Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. Neuropharmacology. 2015;101():471-479.

Budygin EA, Weiner JL. Exploring the neurochemical basis of alcohol addiction-related behaviors: translational research. Transl Biomed. 2015;6(Suppl Spec):.

Butler TR, Chappell AM, Weiner JL. Effect of beta3 adrenoceptor activation in the basolateral amygdala on ethanol seeking behaviors. Psychopharmacology (Berl). 2014;231(1):293-303.

Butler TR, Ariwodola OJ, Weiner JL. The impact of social isolation on HPA axis function, anxiety-like behaviors, and ethanol drinking. Front Integr Neurosci. 2014;7():102.

Rau AR, Ariwodola OJ, Weiner JL. Presynaptic adenosine A(1) receptors modulate excitatory transmission in the rat basolateral amygdala. Neuropharmacology. 2014;77():465-474.

Karkhanis A, Skelly MJ, Rau A, Yorgason J, Chappell A, Carter E, Jones S, McCool B, Weiner J. Early life stress increases behavioral and neurobiological risk factors of alcohol addiction in male Long Evans rats [abstract]. Alcohol. 2014;48(2):161.

Skelly MJ, Ariwodola OJ, Chappell AM, Weiner JL. Activation of basolateral amygdala beta 3 adrenoreceptors blocks fear conditioning, extinction learning, and the induction of synaptic plasticity [abstract]. Alcohol. 2014;48(2):192-193.

Budygin EA, Grinevich VP, Carr A, Chappell AM, Bass CE, Bonin KD, Weiner JL. Modulation of ethanol and sucrose drinking behaviors by optogenetic stimulation of the mesolimbic dopamine system [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):169A.

Butler TR, Chappell AM, Carter E, Weiner JL. Social isolation and ethanol self-administration: disparate behavioral phenotypes in male and female rats [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):14A.

Carter E, Weiner JL. Adolescent social isolation increases sensitivity to ethanol's acute anxiolytic effects [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):15A.

Karkhanis AN, McCool BA, Weiner JL, Jones SR. Social isolation stress augments dopamine and norepinephrine responses to ethanol in the nucleus accumbens and the basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):81A.

Rau AR, Ariwodola OJ, Carter E, Weiner JL. Juvenile social isolation increases anxiety-like behavior, ethanol consumption, and modifies intrinsic excitability of BLA pyramidal neurons [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):91A.

Skelly MJ, Ariwodola OJ, Chappell AM, Weiner JL. Disrupted noradrenergic facilitation of amygdala gabaergic inhibition following fear conditioning: implications for comorbid alcoholism and PTSD [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):162A.

Skelly MJ, Butler TR, Carter E, Chappell AM, Ariwodola OJ, Weiner JL. beta 3-adrenoceptors in the basolateral amygdala regulate fear learning and appetitive ethanol drinking behaviors [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):346A.

Butler TR, Carter E, Weiner JL. Adolescent social isolation does not lead to persistent increases in anxiety- like behavior or ethanol intake in female long-evans rats. Alcohol Clin Exp Res. 2014;38(8):2199-2207.

Gill KE, Chappell AM, Beveridge TJ, Porrino LJ, Weiner JL. Chronic methylphenidate treatment during early life is associated with greater ethanol intake in socially isolated rats. Alcohol Clin Exp Res. 2014;38(8):2260-2268.

Skelly MJ, Weiner JL. Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. Brain Behav. 2014;4(4):468-483.

Karkhanis AN, Locke JL, McCool BA, Weiner JL, Jones SR. Social isolation rearing increases nucleus accumbens dopamine and norepinephrine responses to acute ethanol in adulthood. Alcohol Clin Exp Res. 2014;38(11):2770-2779.

Masicampo ML, Riegle MA, Carter E, Weiner JL, Godwin DW. A role for T-type calcium channels in alcohol withdrawal-induced anxiety [abstract]. Soc Neurosci Abstr. 2014;40(Neuroscience Meeting Planner):.

Chappell AM, Carter E, McCool BA, Weiner JL. Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats. Alcohol Clin Exp Res. 2013;37(Suppl 1):E394-E403.

Abrahao KP, Ariwodola OJ, Butler TR, Rau AR, Skelly MJ, Carter E, Alexander NP, McCool BA, Souza-Formigoni ML, Weiner JL. Locomotor sensitization to ethanol impairs NMDA receptor-dependent synaptic plasticity in the nucleus accumbens and increases ethanol self-administration. J Neurosci. 2013;33(11):4834-4842.

Yorgason JT, Espana RA, Konstantopoulos JK, Weiner JL, Jones SR. Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats. Eur J Neurosci. 2013;37(6):1022-1031.

Grinevich VP, Bass CE, Gioia D, Chappell AM, Bonin KD, Weiner JL, Budygin EA. Preliminary evidence that optogenetic activation of VTA dopamine cells inhibits alcohol self-administration in male Long Evans rats [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):229A.

Abrahao KP, Souza-Formigoni MLO, McCool BA, Camirini R, Weiner JL. Behavioral sensitization to ethanol has bidirectional effects on MGLUR1/5 dependent long-term depression in the nucleus accumbens core and shell [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):120A.

Butler TR, Carter E, Weiner JL. Developmental corticosterone levels and anxiety-like behavior in high and low drinking rats [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):234A.

Karkhanis AN, Konstantopoulos J, Locke J, Weiner JL, Jones SR. Social isolation rearing increases dopamine and norepinephrine responses to ethanol and K-opioid receptor activity in nucleus accumbens [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):240A.

Rau AR, Ariwodola OJ, Chappell AM, Carter E, Weiner JL. Adenosinergic signaling modulates basolateral amygdala glutamatergic synaptic transmission and reduces ethanol drinking [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):181A.

Skelly MJ, Carter ES, Ariwodola OJ, Weiner JL. Preliminary evidence that adolescent social isolation disrupts inhibitory signaling at lateral paracapsular synapses in the rat basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):180A.

Weiner JL, Chappell AM, Carter E, Yorgason J, Jones SR, McCool BA. Adolescent social isolation increases behavioral and neurobiological risk factors of alcoholism in male Long Evans rats [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):299A.

Molina DP, Ariwodola OJ, Weiner JL, Brunso-Bechtold JK, Adams MM. Growth hormone and insulin-like growth factor-I alter hippocampal excitatory synaptic transmission in young and old rats. Age (Dordr). 2013;35(5):1575-1587.

Bass CE, Grinevich VP, Gioia D, Day-Brown JD, Bonin KD, Stuber GD, Weiner JL, Budygin EA. Optogenetic stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self-administration. Front Behav Neurosci. 2013;7():173.

Riegle M, Carter E, Weiner J, Godwin D. Ethosuximide, a T-type calcium channel antagonist, as a potential treatment for alcohol dependence and withdrawal [abstract]. Soc Neurosci Abstr. 2013;2013(Neuroscience Meeting Planner):.

Molina DP, Ariwodola OJ, Linville C, Sonntag WE, Weiner JL, Brunso-Bechtold JK, Adams MM. Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats. Neurobiol Aging. 2012;33(9):1938-1949.

Butler TR, Chappell AM, Weiner JL. Activation of beta 3 adrenoceptors in the basolateral amygdala reduces ethanol drinking behaviors in male Long Evans rats [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 1):17A.

Rau AR, Ariwodola OJ, Carter E, Chappell AM, Weiner JL. Adenosine signaling modulates excitibility in the amygdala and is altered in a rodent model of early life stress that increases ethanol drinking [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 1):104A.

Skelly MJ, Chappell AM, Weiner JL. Social isolation disrupts extinction of fear learning and enhances adrenoceptor antagonist-mediated inhibition of ethanol drinking in Long Evans rats [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 1):115A.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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