Profile

Jeffrey L. Weiner, Ph.D.Wake Forest School of Medicine

Jeffrey L. Weiner, Ph.D.

Professor,

Contact Information

Academic: 336-716-8692 | Department: 336-716-8692

Email: jweiner@wakehealth.edu

Additional Languages

French

Education & Training

  • B.S., University Toronto Med-Canada , 1988
  • M.Sc., University Toronto Med-Canada , 1990
  • Ph.D., University Toronto Med-Canada , 1994
  • Fellowship, U Colorado Hlth Sci Ctr, 1998

Memberships

  • Research Society On Alcoholism
  • Int Soc for Biomed Res on Alco
  • Society for Neuroscience
Jeffrey L. Weiner, Ph.D.

Jeffrey L. Weiner, Ph.D.

Professor, Physiology & Pharmacology
Institute for Regenerative Medicine

Research Interests

mental disorders/psychiatry/ps, neurosciences/behavior

Contact Information

Academic: 336-716-8692 | Department: 336-716-8692

Email: jweiner@wakehealth.edu

Recent Publications

Butler TR, Chappell AM, Weiner JL. Effect of beta3 adrenoceptor activation in the basolateral amygdala on ethanol seeking behaviors. Psychopharmacology (Berl). 2014;231(1):293-303.

Butler TR, Ariwodola OJ, Weiner JL. The impact of social isolation on HPA axis function, anxiety-like behaviors, and ethanol drinking. Front Integr Neurosci. 2014;7():102.

Rau AR, Ariwodola OJ, Weiner JL. Presynaptic adenosine A(1) receptors modulate excitatory transmission in the rat basolateral amygdala. Neuropharmacology. 2014;77():465-474.

Karkhanis A, Skelly MJ, Rau A, Yorgason J, Chappell A, Carter E, Jones S, McCool B, Weiner J. Early life stress increases behavioral and neurobiological risk factors of alcohol addiction in male Long Evans rats [abstract]. Alcohol. 2014;48(2):161.

Skelly MJ, Ariwodola OJ, Chappell AM, Weiner JL. Activation of basolateral amygdala beta 3 adrenoreceptors blocks fear conditioning, extinction learning, and the induction of synaptic plasticity [abstract]. Alcohol. 2014;48(2):192-193.

Chappell AM, Carter E, McCool BA, Weiner JL. Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats. Alcohol Clin Exp Res. 2013;37(Suppl 1):E394-E403.

Abrahao KP, Ariwodola OJ, Butler TR, Rau AR, Skelly MJ, Carter E, Alexander NP, McCool BA, Souza-Formigoni ML, Weiner JL. Locomotor sensitization to ethanol impairs NMDA receptor-dependent synaptic plasticity in the nucleus accumbens and increases ethanol self-administration. J Neurosci. 2013;33(11):4834-4842.

Yorgason JT, Espana RA, Konstantopoulos JK, Weiner JL, Jones SR. Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats. Eur J Neurosci. 2013;37(6):1022-1031.

Grinevich VP, Bass CE, Gioia D, Chappell AM, Bonin KD, Weiner JL, Budygin EA. Preliminary evidence that optogenetic activation of VTA dopamine cells inhibits alcohol self-administration in male Long Evans rats [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):229A.

Abrahao KP, Souza-Formigoni MLO, McCool BA, Camirini R, Weiner JL. Behavioral sensitization to ethanol has bidirectional effects on MGLUR1/5 dependent long-term depression in the nucleus accumbens core and shell [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):120A.

Butler TR, Carter E, Weiner JL. Developmental corticosterone levels and anxiety-like behavior in high and low drinking rats [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):234A.

Karkhanis AN, Konstantopoulos J, Locke J, Weiner JL, Jones SR. Social isolation rearing increases dopamine and norepinephrine responses to ethanol and K-opioid receptor activity in nucleus accumbens [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):240A.

Rau AR, Ariwodola OJ, Chappell AM, Carter E, Weiner JL. Adenosinergic signaling modulates basolateral amygdala glutamatergic synaptic transmission and reduces ethanol drinking [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):181A.

Skelly MJ, Carter ES, Ariwodola OJ, Weiner JL. Preliminary evidence that adolescent social isolation disrupts inhibitory signaling at lateral paracapsular synapses in the rat basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):180A.

Weiner JL, Chappell AM, Carter E, Yorgason J, Jones SR, McCool BA. Adolescent social isolation increases behavioral and neurobiological risk factors of alcoholism in male Long Evans rats [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):299A.

Molina DP, Ariwodola OJ, Weiner JL, Brunso-Bechtold JK, Adams MM. Growth hormone and insulin-like growth factor-I alter hippocampal excitatory synaptic transmission in young and old rats. Age (Dordr). 2013;35(5):1575-1587.

Bass CE, Grinevich VP, Gioia D, Day-Brown JD, Bonin KD, Stuber GD, Weiner JL, Budygin EA. Optogenetic stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self-administration. Front Behav Neurosci. 2013;7():173.

Riegle M, Carter E, Weiner J, Godwin D. Ethosuximide, a T-type calcium channel antagonist, as a potential treatment for alcohol dependence and withdrawal [abstract]. Soc Neurosci Abstr. 2013;2013(Neuroscience Meeting Planner):.

Molina DP, Ariwodola OJ, Linville C, Sonntag WE, Weiner JL, Brunso-Bechtold JK, Adams MM. Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats. Neurobiol Aging. 2012;33(9):1938-1949.

Butler TR, Chappell AM, Weiner JL. Activation of beta 3 adrenoceptors in the basolateral amygdala reduces ethanol drinking behaviors in male Long Evans rats [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 1):17A.

Rau AR, Ariwodola OJ, Carter E, Chappell AM, Weiner JL. Adenosine signaling modulates excitibility in the amygdala and is altered in a rodent model of early life stress that increases ethanol drinking [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 1):104A.

Skelly MJ, Chappell AM, Weiner JL. Social isolation disrupts extinction of fear learning and enhances adrenoceptor antagonist-mediated inhibition of ethanol drinking in Long Evans rats [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 1):115A.

Chappell AM, Carter E, Yorgason JT, Jones SR, McCool BA, Weiner JL. Juvenile social isolation in rats increases behavioral and neurobiological risk factors of alcoholism [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 2):51A.


Weiner J. Identification of a novel GABAergic circuit in the basolateral amygdala that may contribute to alcohol's anxiolytic effects [abstract]. Alcohol. 2011;45(3):269.

Abrahao KP, Souza-Formigoni MLO, Weiner JL. Decrease in accumbal NMDA receptor-mediated excitatory transmission is associated with high levels of behavioral sensitization to ethanol [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):57A.

Carter E, Chappell AM, Weiner JL. Effect of housing conditions on anxiety-like behaviors and ethanol drinking in adolescent and adult Long-Evans rats [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):54A.

Rau AR, Ariwodola OJ, Weiner JL. Effect of stimulation frequency on ethanol enhancement of hippocampal gabaergic synaptic inhibition [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):62A.

Weiner JL, Silberman Y, Ariwodola OJ, Chappell AM, Carter E. Treatment of alcohol use disorders? [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):305A.

Silberman Y, Ariwodola OJ, Chappell AM, Yorgason JT, Weiner JL. Lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the anxiolytic effects of beta 3 adrenoceptor activation. Neuropsychopharmacology. 2010;35(9):1886-1896.

Weiner JL, Royal R, Chappell AM, Carter E. Effect of juvenile social isolation on anxiety-like behaviors and intermittent ethanol self-administration in male Long-Evans rats [abstract]. Alcohol Clin Exp Res. 2010;34(8 Suppl):99A.

Silberman Y, Ariwodola OJ, Weiner JL. Analysis of unitary IPSCS confirms distinct mechanisms of ethanol action at local and paracapsular GABAergic synapses in the rat basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2010;34(6 Suppl 2):196A.

Silberman Y, Ariwodola OJ, Chappell AM, Weiner JL. Identification of a novel GABAergic circuit in the basolateral amygdala that may contribute to alcohol's anti-anxiety effects [abstract]. Alcohol Clin Exp Res. 2010;34(6 Suppl 2):279A.


Carter ES, Chappell AM, Jones SR, Weiner JL. Effect of oral adolescent methylphenidate treatment and withdrawal on ethanol drinking and locomotor response to psychostimulants [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):98A.

Chappell AM, Weiner JL. Relationship between intermittent and operant ethanol self-administration in male Long-Evans rats [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):221A.

Silberman Y, Ariwodola OJ, Yorgason JT, Chappell AM, Weiner JL. Basolateral amygdala paracapsular cells may contribute to the anti-anxiety effects of B3-adrenoceptor agonists: implications for ethanol actions [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):83A.

Silberman Y, Ariwodola OJ, Yorgason JT, Weiner JL. Beta 1-adrenoceptors are required for ethanol potentiation of lateral paracapsular gabaergic synapses in the rat basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):150A.

Molina DP, Weiner JL, Ariwodola OJ, Adams MM, Brunso-Bechtold JK. Age-related alterations in GH and IGF-I signaling cascade elements in Fisher 344 x Brown Norway rats [abstract]. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Silberman Y, Bajo M, Chappell AM, Christian DT, Cruz M, Diaz MR, Kash T, Lack AK, McCool BA, Weiner JL, et al. Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions. Alcohol. 2009;43(7):509-519.

Silberman Y, Shi L, Brunso-Bechtold JK, Weiner JL. Distinct mechanisms of ethanol potentiation of local and paracapsular GABAergic synapses in the rat basolateral amygdala. J Pharmacol Exp Ther. 2008;324(1):251-260.

Chappell AM, Jones SR, Weiner JL. Effect of adolescent methylphenidate treatment on ethanol self-administration in male Long-Evans rats [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):220A.

Silberman Y, Weiner JL. Acute effects of ethanol on local and paracapsular GABAergic synapses in the rat basolateral amygdala [abstract]. Alcohol. 2008;42(4):314.

Silberman Y, Weiner JL. Distinct mechanisms underlying ethanol potentiation of two inhibitory pathways in the rat basolateral amygdala [abstract]. Alcohol. 2008;42(4):330.

Silberman Y, Weiner JL. Local and paracapsular GABAergic synapses in the rat basolateral amygdala display different GABAb autoreceptor properties [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):27A.

Weiner JL, Ariwodola OJ, Jones KM, Chappell AM, Werner DF, Homanics GE. Paradoxical increases in behavioral and synaptic sensitivity to ethanol in genetically-engineered mice with ethanol-insensitive alphal GABAa receptors [abstract]. Alcohol. 2008;42(4):330.

Molina DP, Weiner JL, Ariwodola SJ, Sonntag WE, Adams MM, Brunso-Bechtold JK. Effect of growth hormone (GH) supplementation on age-related changes in excitatory synaptic transmission in CA1 [abstract]. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

Lack AK, Ariwodola OJ, Chappell AM, Weiner JL, McCool BA. Ethanol inhibition of kainate receptor-mediated excitatory neurotransmission in the rat basolateral nucleus of the amygdala. Neuropharmacology. 2008;55(5):661-668.


Ariwodola OJ, Jones KM, Chappell AM, Werner DF, Homanics GE, Weiner JL. Paradoxical increases in behavioral and synaptic sensitivity to ethanol in knockin mice with ethanol-insensitive alpha1 GABA receptors [abstract]. Alcohol Clin Exp Res. 2007;31(6 Suppl):10A.

Jones KM, Chappell AM, Weiner JL. A comparison of umami (MSG) vs. sweet (sucrose) fading in the initiation of operant ethanol self-administration [abstract]. Alcohol Clin Exp Res. 2007;31(6 Suppl):91A.

Molina DP, Ariwodola OJ, Weiner JL, Brunso-Bechtold JK, Adams MM. AMPA- and NMDA-dependent synaptic transmission is enhanced by growth hormone (GH) and insulin-like growth factor 1 (IGF-1) similarly in young and old Fisher 344 x Brown Norway (F344xBN) [abstract]. Soc Neurosci Abstr. 2007;2007(Abstr Viewer):.

Weiner JL, Valenzuela CF. Ethanol modulation of GABAergic transmission: the view from the slice. Pharmacol Ther. 2006;111(3):533-554.

DuBois DW, Perlegas A, Floyd DW, Weiner JL, McCool BA. Distinct functional characteristics of the lateral/basolateral amygdala GABAergic system in C57BL/6J and DBA/2J mice. J Pharmacol Exp Ther. 2006;318(2):629-640.

Crowder TL, Ariwodola OJ, Weiner JL. Kainate receptor activation potentiates GABAergic synaptic transmission in the nucleus accumbens core. Brain Res. 2006;1088(1):73-82.

Werner DF, Blednov YA, Ariwodola OJ, Silberman Y, Logan E, Berry RB, Borghese CM, Matthews DB, Weiner JL, Harrison NL, et al. Knockin mice with ethanol-insensitive alpha 1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol. J Pharmacol Exp Ther. 2006;319(1):219-227.

Ariwodola OJ, Silberman Y, Chappell AM, Weiner JL. Identification of possible synaptic correlates of an ethanol drinking-related behavior [abstract]. Alcohol Clin Exp Res. 2006;30(6 Suppl):135A.

Chappell AM, Weiner JL. Relationship between initial sensitivity to the acute locomotor effects of ethanol and ethanol self-administration [abstract]. Alcohol Clin Exp Res. 2006;30(6 Suppl):188A.

Silberman Y, Weiner JL. Ethanol potentiation of GABAergic neurotransmission in the basolaterla [sic] amygdala: a role for norepinephrine? [abstract]. Alcohol Clin Exp Res. 2006;30(6 Suppl):18A.

John CE, Budygin EA, Weiner JL, Jones SR. NMDA receptor deficient mice display altered synaptic function and reward related behaviors [abstract]. Neuropsychopharmacology. 2006;31(Suppl):S76.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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