Profile

Jeffrey L. Weiner, Ph.D.Wake Forest School of Medicine

Jeffrey L. Weiner, Ph.D.

Professor,

Contact Information

Academic: 336-716-8692 | Department: 336-716-8692

Email: jweiner@wakehealth.edu

Additional Languages

French

Related Links

Education & Training

  • B.S., University Toronto Med-Canada, 1988
  • M.Sc., University Toronto Med-Canada, 1990
  • Ph.D., University Toronto Med-Canada, 1994
  • Fellowship, U Colorado Hlth Sci Ctr, 1998

Memberships

  • Research Society On Alcoholism
  • Int Soc for Biomed Res on Alco
  • Society for Neuroscience
Jeffrey L. Weiner, Ph.D.

Jeffrey L. Weiner, Ph.D.

Professor, Physiology & Pharmacology
Institute for Regenerative Medicine

Research Interests

Ethanol; Amygdala; Synapses; Synaptic Transmission; gamma-Aminobutyric Acid
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Contact Information

Academic: 336-716-8692 | Department: 336-716-8692

Email: jweiner@wakehealth.edu

Related Links

Recent Publications

Behavioral and neurophysiological evidence that lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the acquisition and extinction of fear learning. Skelly MJ, Chappell AM, Ariwodola OJ, Weiner JL.. Neurobiol Learn Mem. 2016;127():10-16.

Early-life social isolation stress increases kappa opioid receptor responsiveness and downregulates the dopamine system. Karkhanis AN, Rose JH, Weiner JL, Jones SR.. Neuropsychopharmacology. 2016;41(9):2263-2274.

Adolescent social isolation as a model of heightened vulnerability to comorbid alcoholism and anxiety disorders. Butler TR, Karkhanis AN, Jones SR, Weiner JL.. Alcohol Clin Exp Res. 2016;40(6):1202-1214.

Postsynaptic adenosine A2A receptors modulate intrinsic excitability of pyramidal cells in the rat basolateral amygdala. Rau AR, Ariwodola OJ, Weiner JL.. Int J Neuropsychopharmacol. 2015;18(6):.

Chronic social isolation during adolescence augments catecholamine response to acute ethanol in the basolateral amygdala. Karkhanis AN, Alexander NJ, McCool BA, Weiner JL, Jones SR.. Synapse. 2015;69(8):385-395.

Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: possible role of disrupted noradrenergic signaling. Skelly MJ, Chappell AE, Carter E, Weiner JL.. Neuropharmacology. 2015;97():149-159.

Increased basolateral amygdala pyramidal cell excitability may contribute to the anxiogenic phenotype induced by chronic early-life stress. Rau AR, Chappell AM, Butler TR, Ariwodola OJ, Weiner JL.. J Neurosci. 2015;35(26):9730-9740.

Real time adenosine fluctuations detected with fast-scan cyclic voltammetry in the rat striatum and motor cortex. Adamah-Biassi EB, Almonte AG, Blagovechtchenski E, Grinevich VP, Weiner JL, Bonin KD, Budygin EA.. J Neurosci Methods. 2015;256():56-62.

Effects of ethanol on real-time adenosine dynamics in the rat striatum [abstract]. Adamah-Biassi EB, Almonte AG, Bonin KD, Weiner JL, Budygin EA.. Alcohol Clin Exp Res. 2015;39(Suppl 1):182A.

Impact of early life stress on alcohol addiction vulnerability and the developmental trajectory of basolateral amygdala circuitry [abstract]. Fetzer JA, Ariwodola OJ, Weiner JL.. Alcohol Clin Exp Res. 2015;39(Suppl 1):116A.

Increased excitability of Bla pyramidal cells may contribute to the phenotype associated with a rodent model of alcohol addiction vulnerability [abstract]. Rau AR, Ariwodola OJ, Butler TR, McCool BA, Weiner JL.. Alcohol Clin Exp Res. 2015;39(Suppl 1):297A.

A novel role of Bla lateral paracapsular synapses in fear learning: implications for comorbid Ptsd and alcohol use disorder [abstract]. Skelly MJ, Ariwodola O, Chappell AM, Weiner JL.. Alcohol Clin Exp Res. 2015;39(Suppl 1):114A.

Social isolation stress increases K-opioid receptor activity in the nucleus accumbens shell and core [abstract]. Karkhanis AN, Rose JH, Weiner JL, Jones SR.. Alcohol Clin Exp Res. 2015;39(Suppl 1):121A.

Adolescent social isolation as a model of alcohol addiction vulnerability [abstract]. Weiner JL, Karkhanis AN, Rau A, Skelly MJ, Jones SR.. Alcohol Alcohol. 2015;50(Suppl 1):SY17-2.

Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. Yorgason JT, Calipari ES, Ferris MJ, Karkhanis AN, Fordahl SC, Weiner JL, Jones SR.. Neuropharmacology. 2015;101():471-479.

Exploring the neurochemical basis of alcohol addiction-related behaviors: translational research. Budygin EA, Weiner JL.. Transl Biomed. 2015;6(Suppl Spec):.

Effect of beta3 adrenoceptor activation in the basolateral amygdala on ethanol seeking behaviors. Butler TR, Chappell AM, Weiner JL.. Psychopharmacology (Berl). 2014;231(1):293-303.

The impact of social isolation on HPA axis function, anxiety-like behaviors, and ethanol drinking. Butler TR, Ariwodola OJ, Weiner JL.. Front Integr Neurosci. 2014;7():102.

Presynaptic adenosine A(1) receptors modulate excitatory transmission in the rat basolateral amygdala. Rau AR, Ariwodola OJ, Weiner JL.. Neuropharmacology. 2014;77():465-474.

Early life stress increases behavioral and neurobiological risk factors of alcohol addiction in male Long Evans rats [abstract]. Karkhanis A, Skelly MJ, Rau A, Yorgason J, Chappell A, Carter E, Jones S, McCool B, Weiner J.. Alcohol. 2014;48(2):161.

Activation of basolateral amygdala beta 3 adrenoreceptors blocks fear conditioning, extinction learning, and the induction of synaptic plasticity [abstract]. Skelly MJ, Ariwodola OJ, Chappell AM, Weiner JL.. Alcohol. 2014;48(2):192-193.

Modulation of ethanol and sucrose drinking behaviors by optogenetic stimulation of the mesolimbic dopamine system [abstract]. Budygin EA, Grinevich VP, Carr A, Chappell AM, Bass CE, Bonin KD, Weiner JL.. Alcohol Clin Exp Res. 2014;38(Suppl 1):169A.

Social isolation and ethanol self-administration: disparate behavioral phenotypes in male and female rats [abstract]. Butler TR, Chappell AM, Carter E, Weiner JL.. Alcohol Clin Exp Res. 2014;38(Suppl 1):14A.

Adolescent social isolation increases sensitivity to ethanol's acute anxiolytic effects [abstract]. Carter E, Weiner JL.. Alcohol Clin Exp Res. 2014;38(Suppl 1):15A.

Social isolation stress augments dopamine and norepinephrine responses to ethanol in the nucleus accumbens and the basolateral amygdala [abstract]. Karkhanis AN, McCool BA, Weiner JL, Jones SR.. Alcohol Clin Exp Res. 2014;38(Suppl 1):81A.

Juvenile social isolation increases anxiety-like behavior, ethanol consumption, and modifies intrinsic excitability of BLA pyramidal neurons [abstract]. Rau AR, Ariwodola OJ, Carter E, Weiner JL.. Alcohol Clin Exp Res. 2014;38(Suppl 1):91A.

Disrupted noradrenergic facilitation of amygdala gabaergic inhibition following fear conditioning: implications for comorbid alcoholism and PTSD [abstract]. Skelly MJ, Ariwodola OJ, Chappell AM, Weiner JL.. Alcohol Clin Exp Res. 2014;38(Suppl 1):162A.

beta 3-adrenoceptors in the basolateral amygdala regulate fear learning and appetitive ethanol drinking behaviors [abstract]. Skelly MJ, Butler TR, Carter E, Chappell AM, Ariwodola OJ, Weiner JL.. Alcohol Clin Exp Res. 2014;38(Suppl 1):346A.

Adolescent social isolation does not lead to persistent increases in anxiety- like behavior or ethanol intake in female long-evans rats. Butler TR, Carter E, Weiner JL.. Alcohol Clin Exp Res. 2014;38(8):2199-2207.

Chronic methylphenidate treatment during early life is associated with greater ethanol intake in socially isolated rats. Gill KE, Chappell AM, Beveridge TJ, Porrino LJ, Weiner JL.. Alcohol Clin Exp Res. 2014;38(8):2260-2268.

Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. Skelly MJ, Weiner JL.. Brain Behav. 2014;4(4):468-483.

Social isolation rearing increases nucleus accumbens dopamine and norepinephrine responses to acute ethanol in adulthood. Karkhanis AN, Locke JL, McCool BA, Weiner JL, Jones SR.. Alcohol Clin Exp Res. 2014;38(11):2770-2779.

A role for T-type calcium channels in alcohol withdrawal-induced anxiety [abstract]. Masicampo ML, Riegle MA, Carter E, Weiner JL, Godwin DW.. Soc Neurosci Abstr. 2014;40(Neuroscience Meeting Planner):.

Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats. Chappell AM, Carter E, McCool BA, Weiner JL.. Alcohol Clin Exp Res. 2013;37(Suppl 1):E394-E403.

Locomotor sensitization to ethanol impairs NMDA receptor-dependent synaptic plasticity in the nucleus accumbens and increases ethanol self-administration. Abrahao KP, Ariwodola OJ, Butler TR, Rau AR, Skelly MJ, Carter E, Alexander NP, McCool BA, Souza-Formigoni ML, Weiner JL.. J Neurosci. 2013;33(11):4834-4842.

Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats. Yorgason JT, Espana RA, Konstantopoulos JK, Weiner JL, Jones SR.. Eur J Neurosci. 2013;37(6):1022-1031.

Preliminary evidence that optogenetic activation of VTA dopamine cells inhibits alcohol self-administration in male Long Evans rats [abstract]. Grinevich VP, Bass CE, Gioia D, Chappell AM, Bonin KD, Weiner JL, Budygin EA.. Alcohol Clin Exp Res. 2013;37(Suppl 2):229A.

Behavioral sensitization to ethanol has bidirectional effects on MGLUR1/5 dependent long-term depression in the nucleus accumbens core and shell [abstract]. Abrahao KP, Souza-Formigoni MLO, McCool BA, Camirini R, Weiner JL.. Alcohol Clin Exp Res. 2013;37(Suppl 2):120A.

Developmental corticosterone levels and anxiety-like behavior in high and low drinking rats [abstract]. Butler TR, Carter E, Weiner JL.. Alcohol Clin Exp Res. 2013;37(Suppl 2):234A.

Social isolation rearing increases dopamine and norepinephrine responses to ethanol and K-opioid receptor activity in nucleus accumbens [abstract]. Karkhanis AN, Konstantopoulos J, Locke J, Weiner JL, Jones SR.. Alcohol Clin Exp Res. 2013;37(Suppl 2):240A.

Adenosinergic signaling modulates basolateral amygdala glutamatergic synaptic transmission and reduces ethanol drinking [abstract]. Rau AR, Ariwodola OJ, Chappell AM, Carter E, Weiner JL.. Alcohol Clin Exp Res. 2013;37(Suppl 2):181A.

Preliminary evidence that adolescent social isolation disrupts inhibitory signaling at lateral paracapsular synapses in the rat basolateral amygdala [abstract]. Skelly MJ, Carter ES, Ariwodola OJ, Weiner JL.. Alcohol Clin Exp Res. 2013;37(Suppl 2):180A.

Adolescent social isolation increases behavioral and neurobiological risk factors of alcoholism in male Long Evans rats [abstract]. Weiner JL, Chappell AM, Carter E, Yorgason J, Jones SR, McCool BA.. Alcohol Clin Exp Res. 2013;37(Suppl 2):299A.

Growth hormone and insulin-like growth factor-I alter hippocampal excitatory synaptic transmission in young and old rats. Molina DP, Ariwodola OJ, Weiner JL, Brunso-Bechtold JK, Adams MM.. Age (Dordr). 2013;35(5):1575-1587.

Optogenetic stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self-administration. Bass CE, Grinevich VP, Gioia D, Day-Brown JD, Bonin KD, Stuber GD, Weiner JL, Budygin EA.. Front Behav Neurosci. 2013;7():173.

Ethosuximide, a T-type calcium channel antagonist, as a potential treatment for alcohol dependence and withdrawal [abstract]. Riegle M, Carter E, Weiner J, Godwin D.. Soc Neurosci Abstr. 2013;2013(Neuroscience Meeting Planner):.

Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats. Molina DP, Ariwodola OJ, Linville C, Sonntag WE, Weiner JL, Brunso-Bechtold JK, Adams MM.. Neurobiol Aging. 2012;33(9):1938-1949.

Activation of beta 3 adrenoceptors in the basolateral amygdala reduces ethanol drinking behaviors in male Long Evans rats [abstract]. Butler TR, Chappell AM, Weiner JL.. Alcohol Clin Exp Res. 2012;36(Suppl 1):17A.

Adenosine signaling modulates excitibility in the amygdala and is altered in a rodent model of early life stress that increases ethanol drinking [abstract]. Rau AR, Ariwodola OJ, Carter E, Chappell AM, Weiner JL.. Alcohol Clin Exp Res. 2012;36(Suppl 1):104A.

Social isolation disrupts extinction of fear learning and enhances adrenoceptor antagonist-mediated inhibition of ethanol drinking in Long Evans rats [abstract]. Skelly MJ, Chappell AM, Weiner JL.. Alcohol Clin Exp Res. 2012;36(Suppl 1):115A.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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