James K. Williams, D.V.M.Wake Forest School of Medicine

James K. Williams, D.V.M.


Contact Information

Academic: 336-713-1323 | Department: 336-716-2011


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Education & Training

  • B.S., Iowa State University, 1976
  • D.V.M., Iowa State University, 1983
  • Fellowship, University of Iowa, 1987


  • Am Assn Of Lab Animal Science
  • Am Assn Of Veterinary Medicine
  • Am Heart Association
  • Am Physiological Society
  • Aha - Council On Arteriosclero
  • Am Soc Of Primatologists
James K. Williams, D.V.M.

James K. Williams, D.V.M.

Professor, Institute for Regenerative Medicine
Center for Comparative Medicine Research

Research Interests

aging, cardiac function, degenerative disorders, diabetes, engineering/bioengineering, growth & development, prevention, women's health issues

Contact Information

Academic: 336-713-1323 | Department: 336-716-2011


Related Links

Recent Publications

Williams JK, Eckman D, Dean A, Moradi M, Allickson J, Cline JM, Yoo JJ, Atala A. The dose-effect safety profile of skeletal muscle precursor cell therapy in a dog model of intrinsic urinary sphincter deficiency. Stem Cells Transl Med. 2015;4(3):286-294.

Williams JK, Miller ES, Lane MR, Atala A, Yoo JJ, Jordan JE. Characterization of CD133 antibody-directed recellularized heart valves. J Cardiovasc Transl Res. 2015;8(7):411-420.

Vossler JD, Min Ju Y, Williams JK, Goldstein S, Hamlin J, Lee SJ, Yoo JJ, Atala A. CD133 antibody conjugation to decellularized human heart valves intended for circulating cell capture. Biomed Mater. 2015;10(5):055001.

Williams JK, Criswell T. Age and gender effects on regenerative medicine therapies [abstract]. Tissue Eng Part A. 2015;21(Suppl 1):S69.

Wang Z, Schuch G, Williams JK, Soker S. Peripheral blood stem cells In: Lanza R, Atala A. eds. Essentials of stem cell biology. 3rd ed. San Diego (CA): Academic Press;2014: 227-244.

Childers MK, Joubert R, Poulard K, Moal C, Grange RW, Doering JA, Lawlor MW, Rider BE, Jamet T, Daniele N, Martin S, Riviere C, Soker T, Hammer C, Van Wittenberghe L, Lockard M, Guan X, Goddard M, Mitchell E, Barber J, Williams JK,. Gene therapy prolongs survival and restores function in murine and canine models of myotubular myopathy. Sci Transl Med. 2014;6(220):220ra10.

Greven M, Laber P, Soker S, Walter KA, Williams JK, inventors; Wake Forest University Health Sciences, assignee. Corneal endothelial scaffolds and methods of use. United States patent US 8628572. 2014 Jan 14. 2014;():.

Williams JK, Andersson K. A comparison of cellular and acellular (chemokine) therapy in a primate model of urinary sphincter deficiency [abstract]. Neurourol Urodyn. 2014;33(6):835-836.

Williams J, Eckman D, Dean A, Allikson J, Cline J, Yoo J, Atala A. Safety of skeletal muscle precursor cell therapy in a dog model of urethral sphincter deficiency [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S18-S19.

Williams J, Jordan J, Lane M, Atala A, Yoo J. Expression of developmental proteins in valve leaflets during in vivo maturation of CD133-conjugated heart valves [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S62.

Badra S, Andersson KE, Dean A, Mourad S, Williams JK. A nonhuman primate model of stable urinary sphincter deficiency. J Urol. 2013;189(5):1967-1974.

Zhou Y, Mack DL, Williams JK, Mirmalek-Sani SH, Moorefield E, Chun SY, Wang J, Lorenzetti D, Furth M, Atala A, Soker S. Genetic modification of primate amniotic fluid-derived stem cells produces pancreatic progenitor cells in vitro. Cells Tissues Organs. 2013;197(4):269-282.

Lawlor M, Childers M, Jamet T, Joubert R, Furth M, Grange R, Doering J, Poulard K, Masurier C, Martin S, Riviere C, Hammer C, Vignaud A, Van Wittenberghe L, Messaddeq N, Guan X, Soker T, Holder M, Goddard M, Mitchell E,. Gene replacement therapy improves muscle function and pathology in murine and canine models of X-linked myotubular myopathy [abstract]. J Neuropathol Exp Neurol. 2013;72(6):546.

Badra S, Andersson KE, Dean A, Mourad S, Williams JK. Long-term structural and functional effects of autologous muscle precursor cell therapy in a nonhuman primate model of urinary sphincter deficiency. J Urol. 2013;190(5):1938-1945.

Atala AJ, Williams JK. Stem cell therapies in obstetrics and gynaecology: the female urogenital tract and the fetus as sources and targets for molecular and regenerative medicine. Royal College of Obstetricians and Gynaecologists. 2013;():.

Jordan JE, Williams JK, Lee S-J, Raghavan D, Atala A, Yoo JJ. Bioengineered self-seeding heart valves. J Thorac Cardiovasc Surg. 2012;143(1):201-208.

Williams JK, Andersson K-E, Christ G. Animal models of erectile dysfunction (ED): potential utility of non-human primates as a model of atherosclerosis-induced vascular ED. Int J Impot Res. 2012;24(3):91-100.

Stute P, Sielker S, Wood CE, Register TC, Lees CJ, Dewi FN, Williams JK, Wagner JD, Stefenelli U, Cline JM. Life stage differences in mammary gland gene expression profile in non-human primates. Breast Cancer Res Treat. 2012;133(2):617-634.

Williams J, Badra S, Yoo J. Cell therapy for the treatment of neurogenic urinary incontinence (UI) in female nonhuman primates [abstract]. J Tissue Eng Regen Med. 2012;6(Suppl 1):125-126.

Wang Z, Schuch G, Williams JK, Soker S. Peripheral blood stem cells In: Atala A, Lanza R, Thomson JA, Nerem R, eds. Principles of regenerative medicine. 2nd ed. San Diego (CA): Academic Press;2011: 383-401.

Williams JK. Endothelial FGF receptor signaling: angiogenic versus atherogenic effects [editorial]. Am J Physiol Heart Circ Physiol. 2011;300(1):H27-H28.

Soler R, Vianello A, Fullhase C, Wang Z, Atala A, Soker S, Yoo JJ, Williams JK. Vascular therapy for radiation cystitis. Neurourol Urodyn. 2011;30(3):428-434.

Wood CE, Kaplan JR, Fontenot MB, Williams JK, Cline JM. Endometrial profile of tamoxifen and low-dose estradiol combination therapy. Clin Cancer Res. 2010;16(3):946-956.

Choi JS, Williams JK, Greven M, Walter KA, Laber PW, Khang G, Soker S. Bioengineering endothelialized neo-corneas using donor-derived corneal endothelial cells and decellularized corneal stroma. Biomaterials. 2010;31(26):6738-6745.

Berry JL, Steen JA, Williams JK, Jordan JE, Atala A, Yoo JJ. Bioreactors for development of tissue engineered heart valves. Ann Biomed Eng. 2010;38(11):3272-3279.

Christ GJ, Andersson K-E, Williams K, Zhao W, D'Agostino R Jr, Kaplan J, Aboushwareb T, Yoo J, Calenda G, Davies KP, et al. Smooth-muscle-specific gene transfer with the human Maxi-K channel improves erectile function and enhances sexual behavior in atherosclerotic cynomolgus monkeys. Eur Urol. 2009;56(6):1055-1066.

Williams JK, Baptista PM, Daunais JB, Szeliga KT, Friedman DP, Soker S. The effects of ethanol consumption on vasculogenesis potential in nonhuman primates. Alcohol Clin Exp Res. 2008;32(1):155-161.

Soker S, Schuch G, Williams JK. Peripheral blood stem cells In: Atala A, Lanza R, Thomson JA, Nerem RM, eds. Principles of regenerative medicine. Boston (MA): Academic Press;2008: 438-455.

Suparto IH, Williams JK, Fox JL, Yusuf JTL, Sajuthi D. Effects of hormone therapy and dietary soy on myocardial ischemia/reperfusion injury in ovariectomized atherosclerotic monkeys. Menopause. 2008;15(2):256-263.

Gratzke C, Jarajapu YPR, Christ GJ, Kaplan JR, Williams JK, Andersson K-E, Badlani G. Effects of long-term dietary soy treatment on female urethral morphology and function in ovariectomized nonhuman primates. J Urol. 2008;180(5):2247-2253.

Cann JA, Register TC, Adams MR, St. Clair RW, Espeland MA, Williams JK. Timing of estrogen replacement influences atherosclerosis progression and plaque leukocyte populations in ApoE-/- mice. Atherosclerosis. 2008;201(1):43-52.

Delo DM, Eberli D, Williams JK, Andersson K-E, Atala A, Soker S. Angiogenic gene modification of skeletal muscle cells to compensate for ageing-induced decline in bioengineered functional muscle tissue. BJU Int. 2008;102(7):878-884.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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