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James K. Williams, D.V.M.Wake Forest School of Medicine

James K. Williams, D.V.M.


Contact Information

Academic: 336-713-1323


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Education & Training

  • B.S., Iowa State University, 1976
  • D.V.M., Iowa State University, 1983
  • Fellowship, University of Iowa, 1987


  • Am Assn Of Lab Animal Science
  • Am Assn Of Veterinary Medicine
  • Am Heart Association
  • Am Physiological Society
  • Aha - Council On Arteriosclero
  • Am Soc Of Primatologists
James K. Williams, D.V.M.

James K. Williams, D.V.M.

Professor, Institute for Regenerative Medicine
Center for Comparative Medicine Research
Pathology-Comparative Medicine

Research Interests

Estrogen Replacement Therapy; Apolipoproteins E; Estradiol; Estrogens; Atherosclerosis
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Contact Information

Academic: 336-713-1323


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Recent Publications

Determinates of muscle precursor cell therapy efficacy in a nonhuman primate model of intrinsic urinary sphincter deficiency. Williams JK, Dean A, Lankford S, Criswell T, Badlani G, Andersson KE.. Stem Cell Res Ther. 2017;8(1):1.

Regenerative pharmacology in urology [editorial]. Andersson KE, Williams JK.. Investig Clin Urol. 2017;58(2):79-81.

Efficacy and initial safety profile of CXCL12 treatment in a rodent model of urinary sphincter deficiency. Koudy Williams J, Dean A, Lankford S, Andersson KE.. Stem Cells Transl Med. 2017;6(8):1740-1746.

Animal models in tissue engineering. Part I. Piedrahita JA, Williams JK.. Tissue Eng Part C Methods. 2017;23(11):641-642.

Cell versus chemokine therapy in a nonhuman primate model of chronic intrinsic urinary sphincter deficiency. Williams JK, Dean A, Badra S, Lankford S, Poppante K, Badlani G, Andersson KE.. J Urol. 2016;196(6):1809-1815.

Regenerative medicine therapies for stress urinary incontinence. Williams JK, Dean A, Badlani G, Andersson KE.. J Urol. 2016;196(6):1619-1626.

Local versus intravenous injections of skeletal muscle precursor cells in nonhuman primates with acute or chronic intrinsic urinary sphincter deficiency. Williams JK, Badlani G, Dean A, Lankford S, Poppante K, Criswell T, Andersson KE.. Stem Cell Res Ther. 2016;7(1):147.

Engineering of corporal tissue constructs using non-human primate and human corpus cavernosal smooth muscle and endothelial cells for clinical applications [abstract]. Ju Y, Somara S, Baume A, Dean A, Zambon J, Williams J, Allickson J, Yoo J, Terlecki R, Atala A, Jackson J.. J Sex Med. 2016;13(5 Suppl 1):S1-S2.

Regenerative pharmacology: recent developments and future perspectives. Williams JK, Andersson KE.. Regen Med. 2016;11(8):859-870.

The dose-effect safety profile of skeletal muscle precursor cell therapy in a dog model of intrinsic urinary sphincter deficiency. Williams JK, Eckman D, Dean A, Moradi M, Allickson J, Cline JM, Yoo JJ, Atala A.. Stem Cells Transl Med. 2015;4(3):286-294.

Characterization of CD133 antibody-directed recellularized heart valves. Williams JK, Miller ES, Lane MR, Atala A, Yoo JJ, Jordan JE.. J Cardiovasc Transl Res. 2015;8(7):411-420.

CD133 antibody conjugation to decellularized human heart valves intended for circulating cell capture. Vossler JD, Min Ju Y, Williams JK, Goldstein S, Hamlin J, Lee SJ, Yoo JJ, Atala A.. Biomed Mater. 2015;10(5):055001.

Age and gender effects on regenerative medicine therapies [abstract]. Williams JK, Criswell T.. Tissue Eng Part A. 2015;21(Suppl 1):S69.

Peripheral blood stem cells. Wang Z, Schuch G, Williams JK, Soker S. In: Lanza R, Atala A. eds. Essentials of stem cell biology. 3rd ed. San Diego (CA): Academic Press;2014: 227-244.

Gene therapy prolongs survival and restores function in murine and canine models of myotubular myopathy. Childers MK, Joubert R, Poulard K, Moal C, Grange RW, Doering JA, Lawlor MW, Rider BE, Jamet T, Daniele N, Martin S, Riviere C, Soker T, Hammer C, Van Wittenberghe L, Lockard M, Guan X, Goddard M, Mitchell E, Barber J, Williams JK,.. Sci Transl Med. 2014;6(220):220ra10.

Corneal endothelial scaffolds and methods of use. Greven M, Laber P, Soker S, Walter KA, Williams JK, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 8628572. 2014 Jan 14. 2014;():.

A comparison of cellular and acellular (chemokine) therapy in a primate model of urinary sphincter deficiency [abstract]. Williams JK, Andersson K.. Neurourol Urodyn. 2014;33(6):835-836.

Safety of skeletal muscle precursor cell therapy in a dog model of urethral sphincter deficiency [abstract]. Williams J, Eckman D, Dean A, Allikson J, Cline J, Yoo J, Atala A.. Tissue Eng Part A. 2014;20(Suppl 1):S18-S19.

Expression of developmental proteins in valve leaflets during in vivo maturation of CD133-conjugated heart valves [abstract]. Williams J, Jordan J, Lane M, Atala A, Yoo J.. Tissue Eng Part A. 2014;20(Suppl 1):S62.

A nonhuman primate model of stable urinary sphincter deficiency. Badra S, Andersson KE, Dean A, Mourad S, Williams JK.. J Urol. 2013;189(5):1967-1974.

Genetic modification of primate amniotic fluid-derived stem cells produces pancreatic progenitor cells in vitro. Zhou Y, Mack DL, Williams JK, Mirmalek-Sani SH, Moorefield E, Chun SY, Wang J, Lorenzetti D, Furth M, Atala A, Soker S.. Cells Tissues Organs. 2013;197(4):269-282.

Gene replacement therapy improves muscle function and pathology in murine and canine models of X-linked myotubular myopathy [abstract]. Lawlor M, Childers M, Jamet T, Joubert R, Furth M, Grange R, Doering J, Poulard K, Masurier C, Martin S, Riviere C, Hammer C, Vignaud A, Van Wittenberghe L, Messaddeq N, Guan X, Soker T, Holder M, Goddard M, Mitchell E,.. J Neuropathol Exp Neurol. 2013;72(6):546.

Long-term structural and functional effects of autologous muscle precursor cell therapy in a nonhuman primate model of urinary sphincter deficiency. Badra S, Andersson KE, Dean A, Mourad S, Williams JK.. J Urol. 2013;190(5):1938-1945.

Stem cell therapies in obstetrics and gynaecology: the female urogenital tract and the fetus as sources and targets for molecular and regenerative medicine. Atala AJ, Williams JK.. Royal College of Obstetricians and Gynaecologists. 2013;():.

Bioengineered self-seeding heart valves. Jordan JE, Williams JK, Lee S-J, Raghavan D, Atala A, Yoo JJ.. J Thorac Cardiovasc Surg. 2012;143(1):201-208.

Animal models of erectile dysfunction (ED): potential utility of non-human primates as a model of atherosclerosis-induced vascular ED. Williams JK, Andersson K-E, Christ G.. Int J Impot Res. 2012;24(3):91-100.

Life stage differences in mammary gland gene expression profile in non-human primates. Stute P, Sielker S, Wood CE, Register TC, Lees CJ, Dewi FN, Williams JK, Wagner JD, Stefenelli U, Cline JM.. Breast Cancer Res Treat. 2012;133(2):617-634.

Cell therapy for the treatment of neurogenic urinary incontinence (UI) in female nonhuman primates [abstract]. Williams J, Badra S, Yoo J.. J Tissue Eng Regen Med. 2012;6(Suppl 1):125-126.

Peripheral blood stem cells. Wang Z, Schuch G, Williams JK, Soker S. In: Atala A, Lanza R, Thomson JA, Nerem R, eds. Principles of regenerative medicine. 2nd ed. San Diego (CA): Academic Press;2011: 383-401.

Endothelial FGF receptor signaling: angiogenic versus atherogenic effects [editorial]. Williams JK.. Am J Physiol Heart Circ Physiol. 2011;300(1):H27-H28.

Vascular therapy for radiation cystitis. Soler R, Vianello A, Fullhase C, Wang Z, Atala A, Soker S, Yoo JJ, Williams JK.. Neurourol Urodyn. 2011;30(3):428-434.

Endometrial profile of tamoxifen and low-dose estradiol combination therapy. Wood CE, Kaplan JR, Fontenot MB, Williams JK, Cline JM.. Clin Cancer Res. 2010;16(3):946-956.

Bioengineering endothelialized neo-corneas using donor-derived corneal endothelial cells and decellularized corneal stroma. Choi JS, Williams JK, Greven M, Walter KA, Laber PW, Khang G, Soker S.. Biomaterials. 2010;31(26):6738-6745.

Bioreactors for development of tissue engineered heart valves. Berry JL, Steen JA, Williams JK, Jordan JE, Atala A, Yoo JJ.. Ann Biomed Eng. 2010;38(11):3272-3279.

Smooth-muscle-specific gene transfer with the human Maxi-K channel improves erectile function and enhances sexual behavior in atherosclerotic cynomolgus monkeys. Christ GJ, Andersson K-E, Williams K, Zhao W, D'Agostino R Jr, Kaplan J, Aboushwareb T, Yoo J, Calenda G, Davies KP, et al.. Eur Urol. 2009;56(6):1055-1066.

The effects of ethanol consumption on vasculogenesis potential in nonhuman primates. Williams JK, Baptista PM, Daunais JB, Szeliga KT, Friedman DP, Soker S.. Alcohol Clin Exp Res. 2008;32(1):155-161.

Peripheral blood stem cells. Soker S, Schuch G, Williams JK. In: Atala A, Lanza R, Thomson JA, Nerem RM, eds. Principles of regenerative medicine. Boston (MA): Academic Press;2008: 438-455.

Effects of hormone therapy and dietary soy on myocardial ischemia/reperfusion injury in ovariectomized atherosclerotic monkeys. Suparto IH, Williams JK, Fox JL, Yusuf JTL, Sajuthi D.. Menopause. 2008;15(2):256-263.

Effects of long-term dietary soy treatment on female urethral morphology and function in ovariectomized nonhuman primates. Gratzke C, Jarajapu YPR, Christ GJ, Kaplan JR, Williams JK, Andersson K-E, Badlani G.. J Urol. 2008;180(5):2247-2253.

Timing of estrogen replacement influences atherosclerosis progression and plaque leukocyte populations in ApoE-/- mice. Cann JA, Register TC, Adams MR, St. Clair RW, Espeland MA, Williams JK.. Atherosclerosis. 2008;201(1):43-52.

Angiogenic gene modification of skeletal muscle cells to compensate for ageing-induced decline in bioengineered functional muscle tissue. Delo DM, Eberli D, Williams JK, Andersson K-E, Atala A, Soker S.. BJU Int. 2008;102(7):878-884.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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