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Jeff D. Williamson, M.D.Wake Forest School of Medicine

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Jeff D. Williamson, M.D.

Interim Chair,
Program Director,

Office of Research

Clinical Interests

Geriatrics, Clinical Geriatrics, Geriatric Continuity Care, Dementia, Geriatric Medicine and Assessment

Contact Information

Returning Patient Appointments: 336-713-8250
Department: 336-713-8964

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Education & Training

  • B.S., Emory University, 1982
  • M.D., Medical College of Georgia, 1986
  • M.H.S., Sch Hyg & PH;Johns Hopkins U, 1995
  • Internship, Internal Medicine, U Maryland Medical System, 1987
  • Residency, Internal Medicine, U Maryland Medical System, 1989
  • Fellowship, Johns Hopkins University Schoo, 1992
  • Fellowship, Johns Hopkins University Schoo, 1994

Board Certifications

  • American Board of Internal Medicine, Geriatric Medicine
  • American Board of Internal Medicine, Internal Medicine

NPI Number

  • 1508842089
Jeff D. Williamson, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Jeff D. Williamson, M.D.

Interim Chair, Internal Medicine
Program Director, Sticht Center on Aging
Professor, Gerontology and Geriatric Medicine
Office of Women in Medicine and Science
Epidemiology & Prevention
Office of Research

Research Interests

Hypertension; Antihypertensive Agents; Diabetes Mellitus, Type 2; Cognition; Brain
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Contact Information

Department: 336-713-8964

Media Medical Expert »

Recent Publications

ACCORDION MIND: results of the observational extension of the ACCORD MIND randomised trial. Murray AM, Hsu FC, Williamson JD, Bryan RN, Gerstein HC, Sullivan MD, Miller ME, Leng I, Lovato LL, Launer LJ.. Diabetologia. 2017;60(1):69-80.

Association of 3 different antihypertensive medications with hip and pelvic fracture risk in older adults: secondary analysis of a randomized clinical trial. Puttnam R, Davis BR, Pressel SL, Whelton PK, Cushman WC, Louis GT, Margolis KL, Oparil S, Williamson J, Ghosh A, Einhorn PT, Barzilay JI.. JAMA Intern Med. 2017;177(1):67-76.

Association of brain amyloid-beta with slow gait in elderly individuals without dementia: influence of cognition and apolipoprotein E epsilon4 genotype. Nadkarni NK, Perera S, Snitz BE, Mathis CA, Price J, Williamson JD, DeKosky ST, Klunk WE, Lopez OL.. JAMA Neurol. 2017;74(1):82-90.

Applying the systolic blood pressure intervention trial results to older adults. Supiano MA, Williamson JD.. J Am Geriatr Soc. 2017;65(1):16-21.

Effect of intensive blood pressure control on gait speed and mobility limitation in adults 75 years or older: a randomized clinical trial. Odden MC, Peralta CA, Berlowitz DR, Johnson KC, Whittle J, Kitzman DW, Beddhu S, Nord JW, Papademetriou V, Williamson JD, Pajewski NM.. JAMA Intern Med. 2017;177(4):500-507.

Baseline characteristics of participants in the ASPREE (ASPirin in Reducing Events in the Elderly) study. McNeil JJ, Woods RL, Nelson MR, Murray AM, Reid CM, Kirpach B, Storey E, Shah RC, Wolfe RS, Tonkin AM, Newman AB, Williamson JD, Lockery JE, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Trevaks RE, Orchard SG,.. J Gerontol A Biol Sci Med Sci. 2017;():.

Adding recognition discriminability index to the delayed recall is useful to predict conversion from mild cognitive impairment to Alzheimer's disease in the Alzheimer's disease Neuroimaging Initiative. Russo MJ, Campos J, Vazquez S, Sevlever G, Allegri RF, Sink KM, Williamson JD, Garg P.. Front Aging Neurosci. 2017;9():46.

Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes. Raffield LM, Brenes GA, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Xu J, Wagner BC, Williamson JD, Maldjian JA, Bowden DW.. J Diabetes Complications. 2016;30(1):143-149.

Brain MRI volume findings in diabetic adults with albuminuria: the ACCORD-MIND study. Barzilay JI, Morgan TM, Murray AM, Bryan RN, Williamson JD, Schnall A, Launer LJ.. J Gerontol A Biol Sci Med Sci. 2016;71(6):803-810.

Characterizing frailty status in the systolic blood pressure intervention trial. Pajewski NM, Williamson JD, Applegate WB, Berlowitz DR, Bolin LP, Chertow GM, Krousel-Wood MA, Lopez-Barrera N, Powell JR, Roumie CL, Still C, Sink KM, Tang R, Wright CB, Supiano MA.. J Gerontol A Biol Sci Med Sci. 2016;71(5):649-655.

Analysis of advanced glycation end products in the DHS Mind Study. Adams JN, Martelle SE, Raffield LM, Freedman BI, Langefeld CD, Hsu FC, Maldjian JA, Williamson JD, Hugenschmidt CE, Carr JJ, Cox AJ, Bowden DW.. J Diabetes Complications. 2016;30(2):262-268.

Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study. Martelle SE, Raffield LM, Palmer ND, Cox AJ, Freedman BI, Hugenschmidt CE, Williamson JD, Bowden DW.. Brain Behav. 2016;6(4):e00446.

Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged greater than or equal to 75 years: a randomized clinical trial. Williamson JD, Supiano MA, Applegate WB, Berlowitz DR, Campbell RC, Chertow GM, Fine LJ, Haley WE, Hawfield AT, Ix JH, Kitzman DW, Kostis JB, Krousel-Wood MA, Launer LJ, Oparil S, Rodriguez CJ, Roumie CL, Shorr RI, Sink KM, Wadley VG,.. JAMA. 2016;315(24):2673-2682.

Are statins beneficial when used for primary prevention in older patients? [abstract]. Sutin D, Han BH, Williamson J, Davis B, Piller L, Pervin H, Blaum C.. J Am Geriatr Soc. 2016;64(Suppl 1):S7-S8.

A potential neuroprotective association between smoking and dementia in MCI patients [abstract]. Wirth SH, Williamson J, Lovato J.. J Am Geriatr Soc. 2016;64(Suppl 1):S261-S262.

APOL1 renal-risk variants associate with reduced cerebral white matter lesion volume and increased gray matter volume. Freedman BI, Gadegbeku CA, Bryan RN, Palmer ND, Hicks PJ, Ma L, Rocco MV, Smith SC, Xu J, Whitlow CT, Wagner BC, Langefeld CD, Hawfield AT, Bates JT, Lerner AJ, Raj DS, Sadaghiani MS, Toto RD, Wright JT Jr, Bowden DW, Williamson JD, Sink KM,.. Kidney Int. 2016;90(2):440-449.

Clinical and demographic correlates of medication and visit adherence in a large randomized controlled trial. Whittle J, Yamal JM, Williamson JD, Ford CE, Probstfield JL, Beard BL, Marginean H, Hamilton BP, Suhan PS, Davis BR.. BMC Health Serv Res. 2016;16(1):236.

A call for comparative effectiveness research to learn whether routine clinical care decisions can protect from dementia and cognitive decline. Dacks PA, Armstrong JJ, Brannan SK, Carman AJ, Green AM, Kirkman MS, Krakoff LR, Kuller LH, Launer LJ, Lovestone S, Merikle E, Neumann PJ, Rockwood K, Shineman DW, Stefanacci RG, Velentgas P, Viswanathan A, Whitmer RA, Williamson JD, Fillit HM.. Alzheimers Res Ther. 2016;8():33.

Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes. Hsu FC, Yuan M, Bowden DW, Xu J, Smith SC, Wagenknecht LE, Langefeld CD, Divers J, Register TC, Carr JJ, Williamson JD, Sink KM, Maldjian JA, Freedman BI.. J Diabetes Complications. 2016;30(8):1506-1512.

Effect of intensive chemotherapy on physical, cognitive, and emotional health of older adults with acute myeloid leukemia. Klepin HD, Tooze JA, Pardee TS, Ellis LR, Berenzon D, Mihalko SL, Danhauer SC, Rao AV, Wildes TM, Williamson JD, Powell BL, Kritchevsky SB.. J Am Geriatr Soc. 2016;64(10):1988-1995.

APOE genotypes associate with cognitive performance but not cerebral structure: Diabetes Heart Study MIND. Palmer Allred ND, Raffield LM, Hardy JC, Hsu FC, Divers J, Xu J, Smith SC, Hugenschmidt CE, Wagner BC, Whitlow CT, Sink KM, Maldjian JA, Williamson JD, Bowden DW, Freedman BI.. Diabetes Care. 2016;39(12):2225-2231.

Intensive vs standard blood pressure control for older adults [reply to letter]. Williamson JD, Supiano MA, Pajewski NM.. JAMA. 2016;316(18):1923.

Cortical amyloid-beta and slow gait in older adults without dementia [abstract]. Nadkarni NK, Perera S, Snitz B, Price J, Williamson J, DeKosky S, Klunk WE, Lopez OL.. Gerontologist. 2016;56(Suppl 3):335.

Cerebral structural changes in diabetic kidney disease: African American-Diabetes Heart Study MIND. Sink KM, Divers J, Whitlow CT, Palmer ND, Smith SC, Xu J, Hugenschmidt CE, Wagner BC, Williamson JD, Bowden DW, Maldjian JA, Freedman BI.. Diabetes Care. 2015;38(2):206-212.

Spatial patterns of structural brain changes in type 2 diabetic patients and their longitudinal progression with intensive control of blood glucose. Erus G, Battapady H, Zhang T, Lovato J, Miller ME, Williamson JD, Launer LJ, Bryan RN, Davatzikos C.. Diabetes Care. 2015;38(1):97-104.

Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study. Raffield LM, Cox AJ, Hugenschmidt CE, Freedman BI, Langefeld CD, Williamson JD, Hsu F, Maldjian JA, Bowden DW.. Neurobiol Aging. 2015;36(3):1602.e7-15.

Assessing physical and cognitive function of older adults in continuing care retirement communities: who are we recruiting?. Wrights AP, Fain CW, Miller ME, Rejeski WJ, Williamson JD, Marsh AP.. Contemp Clin Trials. 2015;40():159-165.

Faster brain shrinkage in the ACCORD MIND study [reply to letter]. Williamson JD, Launer LJ, Miller ME.. JAMA Intern Med. 2015;175(1):144-145.

Pilot of a teleGeriatrics interprofessional curriculum in long-term care [abstract]. Corbett T, Callahan K, Russell G, Atkinson H, Williamson J.. J Pain Symptom Manage. 2015;49(2):417-418.

The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes. Hunter DJ, Beavers DP, Eckstein F, Guermazi A, Loeser RF, Nicklas BJ, Mihalko SL, Miller GD, Lyles M, DeVita P, Legault C, Carr JJ, Williamson JD, Messier SP.. Osteoarthritis Cartilage. 2015;23(7):1090-1098.

The impact of post-hospital discharge home visit timing by nurse practitioners and physicians on all-cause readmissions [abstract]. Kumar NR, Pajewski N, Watkins F, Zimmer R, Callahan KE, Williamson JD.. J Am Geriatr Soc. 2015;63(Suppl 1):S270.

Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates. Willard SL, Uberseder B, Clark A, Daunais JB, Johnston WD, Neely D, Massey A, Williamson JD, Kraft RA, Bourland JD, Jones SR, Shively CA.. Neuropharmacology. 2015;99():369-378.

Managing high blood pressure in older persons with decline in function [editorial]. Applegate WB, Sink KM, Williamson JD.. Am J Kidney Dis. 2015;66(5):745-747.

Relationships between cognitive performance, neuroimaging and vascular disease: the DHS-MIND study. Hsu FC, Raffield LM, Hugenschmidt CE, Cox A, Xu J, Carr JJ, Freedman BI, Maldjian JA, Williamson JD, Bowden DW.. Neuroepidemiology. 2015;45(1):1-11.

Effects of type 2 diabetes on brain structure and cognitive function: African American-Diabetes Heart Study MIND. Whitlow CT, Sink KM, Divers J, Smith SC, Xu J, Palmer ND, Hugenschmidt CE, Williamson JD, Bowden DW, Freedman BI, Maldjian JA.. AJNR Am J Neuroradiol. 2015;36(9):1648-1653.

Associations between mild cognitive impairment and hospitalization and readmission. Callahan KE, Lovato JF, Miller ME, Easterling D, Snitz B, Williamson JD.. J Am Geriatr Soc. 2015;63(9):1880-1885.

Delivery of a vitamin D intervention in homebound older adults using a Meals-on-Wheels program: a pilot study. Houston DK, Tooze JA, Demons JL, Davis BL, Shertzer-Skinner R, Kearsley LB, Kritchevsky SB, Williamson JD.. J Am Geriatr Soc. 2015;63(9):1861-1867.

Effects of TZD use and discontinuation on fracture rates in ACCORD bone study. Schwartz AV, Chen H, Ambrosius WT, Sood A, Josse RG, Bonds DE, Schnall AM, Vittinghoff E, Bauer DC, Banerji MA, Cohen RM, Hamilton BP, Isakova T, Sellmeyer DE, Simmons DL, Shibli-Rahhal A, Williamson JD, Margolis KL.. J Clin Endocrinol Metab. 2015;100(11):4059-4066.

Mild cognitive impairment (MCI) in chemotherapy-treated breast cancer survivors [abstract]. Gifford A, Lawrence J, Case D, Rapp S, Baker L, Craft S, Groteluschen DL, Klepin H, Lesser G, Naughton MJ, Sachs B, Samuel TA, Sink K, Williamson, J, Shaw EG.. J Clin Oncol. 2015;33(15 Suppl):9560.

Effect of a 24-month physical activity intervention vs health education on cognitive outcomes in sedentary older adults: the LIFE randomized trial. Sink KM, Espeland MA, Castro CM, Church T, Cohen R, Dodson JA, Guralnik J, Hendrie HC, Jennings J, Katula J, Lopez OL, McDermott MM, Pahor M, Reid KF, Rushing J, Verghese J, Rapp S, Williamson JD.. JAMA. 2015;314(8):781-790.

Subclinical atherosclerosis is inversely associated with gray matter volume in African Americans with type 2 diabetes. Freedman BI, Divers J, Whitlow CT, Bowden DW, Palmer ND, Smith SC, Xu J, Register TC, Carr JJ, Wagner BC, Williamson JD, Sink KM, Maldjian JA.. Diabetes Care. 2015;38(11):2158-2165.

A randomized trial of intensive versus standard blood-pressure control. Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT, Kitzman DW, et al.. N Engl J Med. 2015;373(22):2103-2116.

Associations of mild cognitive impairment with hospital utilization and readmission [abstract]. Callahan K, Lovato JF, Miller ME, Easterling D, Williamson JD.. Gerontologist. 2015;55(Suppl 2):318.

Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial. Williamson JD, Launer LJ, Bryan RN, Coker LH, Lazar RM, Gerstein HC, Murray AM, Sullivan MD, Horowitz KR, Ding J, Marcovina S, Lovato L, Lovato J, Margolis KL, Davatzikos C, Barzilay J, Ginsberg HN, Linz PE, Miller ME.. JAMA Intern Med. 2014;174(3):324-333.

Change in brain and lesion volumes after CEE therapies: the WHIMS-MRI studies. Coker LH, Espeland MA, Hogan PE, Resnick SM, Bryan RN, Robinson JG, Goveas JS, Davatzikos C, Kuller LH, Williamson JD, Bushnell CD, Shumaker SA.. Neurology. 2014;82(5):427-434.

Solving the mystery of the diabetes-dementia connection: new clues--but far from 'case closed' [editorial]. Hugenschmidt C, Williamson JD.. J Diabetes Complications. 2014;28(1):8-9.

Markers of cholesterol transport are associated with amyloid deposition in the brain. Hughes TM, Lopez OL, Evans RW, Kamboh MI, Williamson JD, Klunk WE, Mathis CA, Price JC, Cohen AD, Snitz BE, Dekosky ST, Kuller LH.. Neurobiol Aging. 2014;35(4):802-807.

Effects of randomization to intensive glucose control on adverse events, cardiovascular disease, and mortality in older versus younger adults in the ACCORD trial. Miller ME, Williamson JD, Gerstein HC, Byington RP, Cushman WC, Ginsberg HN, Ambrosius WT, Lovato L, Applegate WB.. Diabetes Care. 2014;37(3):634-643.

Infection hospitalization increases risk of dementia in the elderly. Tate JA, Snitz BE, Alvarez KA, Nahin RL, Weissfeld LA, Lopez O, Angus DC, Shah F, Ives DG, Fitzpatrick AL, Williamson JD, Arnold AM, Dekosky ST, Yende S.. Crit Care Med. 2014;42(5):1037-1046.

Age distribution and core geriatric conditions in Internal Medicine resident continuity clinics [abstract]. Callahan K, Wilson L, Pavon J, Atkinson H, Busby-Whitehead J, Heflin M, Iverson P, Lovato J, Marsden J, Moran W, Roberts E, Williamson J.. J Am Geriatr Soc. 2014;62(Suppl 1):S206.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Gerontology and Geriatric Medicine

Clinical Interests

Geriatrics, Clinical Geriatrics, Geriatric Continuity Care, Dementia, Geriatric Medicine and Assessment
Jeff D. Williamson, M.D.
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