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Jeff D. Williamson, M.D.Wake Forest School of Medicine

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Jeff D. Williamson, M.D.

Interim Chair,
Program Director,
Professor,






Clinical Interests

Clinical Geriatrics, Dementia, Geriatric Continuity Care, Geriatric Medicine and Assessment, Geriatrics

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-713-8250
Department: 336-713-8964

Insurance Accepted »

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Education & Training

  • B.S., Emory University, 1982
  • M.D., Medical College of Georgia, 1986
  • M.H.S., Sch Hyg & PH;Johns Hopkins U, 1995
  • Internship, Internal Medicine, U Maryland Medical System, 1987
  • Residency, Internal Medicine, U Maryland Medical System, 1989
  • Fellowship, Johns Hopkins University Schoo, 1992
  • Fellowship, Johns Hopkins University Schoo, 1994

Board Certifications

  • American Board of Internal Medicine, Internal Medicine, Geriatric Medicine

NPI Number

  • 1508842089
Jeff D. Williamson, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Jeff D. Williamson, M.D.

Interim Chair, Internal Medicine
Program Director, Sticht Center on Aging
Professor, Gerontology and Geriatric Medicine
Center for Comparative Medicine Research
Center for Diabetes Research
Sticht Center on Aging
Neurology
Epidemiology & Prevention
Translational Science Institute

Research Interests

aging, cognition/learning, fitness/physical, cardiac function, epidemiology

Contact Information

Department: 336-713-8964

Media Medical Expert »

Recent Publications

Raffield LM, Brenes GA, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Xu J, Wagner BC, Williamson JD, Maldjian JA, Bowden DW. Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes. J Diabetes Complications. 2016;30(1):143-149.

Barzilay JI, Morgan TM, Murray AM, Bryan RN, Williamson JD, Schnall A, Launer LJ. Brain MRI volume findings in diabetic adults with albuminuria: the ACCORD-MIND study. J Gerontol A Biol Sci Med Sci. 2016;71(6):803-810.

Pajewski NM, Williamson JD, Applegate WB, Berlowitz DR, Bolin LP, Chertow GM, Krousel-Wood MA, Lopez-Barrera N, Powell JR, Roumie CL, Still C, Sink KM, Tang R, Wright CB, Supiano MA. Characterizing frailty status in the systolic blood pressure intervention trial. J Gerontol A Biol Sci Med Sci. 2016;71(5):649-655.

Adams JN, Martelle SE, Raffield LM, Freedman BI, Langefeld CD, Hsu FC, Maldjian JA, Williamson JD, Hugenschmidt CE, Carr JJ, Cox AJ, Bowden DW. Analysis of advanced glycation end products in the DHS Mind Study. J Diabetes Complications. 2016;30(2):262-268.

Martelle SE, Raffield LM, Palmer ND, Cox AJ, Freedman BI, Hugenschmidt CE, Williamson JD, Bowden DW. Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study. Brain Behav. 2016;6(4):e00446.

Williamson JD, Supiano MA, Applegate WB, Berlowitz DR, Campbell RC, Chertow GM, Fine LJ, Haley WE, Hawfield AT, Ix JH, Kitzman DW, Kostis JB, Krousel-Wood MA, Launer LJ, Oparil S, Rodriguez CJ, Roumie CL, Shorr RI, Sink KM, Wadley VG,. Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged greater than or equal to 75 years: a randomized clinical trial. JAMA. 2016;():.

Sink KM, Divers J, Whitlow CT, Palmer ND, Smith SC, Xu J, Hugenschmidt CE, Wagner BC, Williamson JD, Bowden DW, Maldjian JA, Freedman BI. Cerebral structural changes in diabetic kidney disease: African American-Diabetes Heart Study MIND. Diabetes Care. 2015;38(2):206-212.

Erus G, Battapady H, Zhang T, Lovato J, Miller ME, Williamson JD, Launer LJ, Bryan RN, Davatzikos C. Spatial patterns of structural brain changes in type 2 diabetic patients and their longitudinal progression with intensive control of blood glucose. Diabetes Care. 2015;38(1):97-104.

Raffield LM, Cox AJ, Hugenschmidt CE, Freedman BI, Langefeld CD, Williamson JD, Hsu F, Maldjian JA, Bowden DW. Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study. Neurobiol Aging. 2015;36(3):1602.e7-15.

Wrights AP, Fain CW, Miller ME, Rejeski WJ, Williamson JD, Marsh AP. Assessing physical and cognitive function of older adults in continuing care retirement communities: who are we recruiting?. Contemp Clin Trials. 2015;40():159-165.

Williamson JD, Launer LJ, Miller ME. Faster brain shrinkage in the ACCORD MIND study [reply to letter]. JAMA Intern Med. 2015;175(1):144-145.

Corbett T, Callahan K, Russell G, Atkinson H, Williamson J. Pilot of a teleGeriatrics interprofessional curriculum in long-term care [abstract]. J Pain Symptom Manage. 2015;49(2):417-418.

Hunter DJ, Beavers DP, Eckstein F, Guermazi A, Loeser RF, Nicklas BJ, Mihalko SL, Miller GD, Lyles M, DeVita P, Legault C, Carr JJ, Williamson JD, Messier SP. The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes. Osteoarthritis Cartilage. 2015;23(7):1090-1098.

Kumar NR, Pajewski N, Watkins F, Zimmer R, Callahan KE, Williamson JD. The impact of post-hospital discharge home visit timing by nurse practitioners and physicians on all-cause readmissions [abstract]. J Am Geriatr Soc. 2015;63(Suppl 1):S270.

Willard SL, Uberseder B, Clark A, Daunais JB, Johnston WD, Neely D, Massey A, Williamson JD, Kraft RA, Bourland JD, Jones SR, Shively CA. Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates. Neuropharmacology. 2015;99():369-378.

Applegate WB, Sink KM, Williamson JD. Managing high blood pressure in older persons with decline in function [editorial]. Am J Kidney Dis. 2015;66(5):745-747.

Hsu FC, Raffield LM, Hugenschmidt CE, Cox A, Xu J, Carr JJ, Freedman BI, Maldjian JA, Williamson JD, Bowden DW. Relationships between cognitive performance, neuroimaging and vascular disease: the DHS-MIND study. Neuroepidemiology. 2015;45(1):1-11.

Whitlow CT, Sink KM, Divers J, Smith SC, Xu J, Palmer ND, Hugenschmidt CE, Williamson JD, Bowden DW, Freedman BI, Maldjian JA. Effects of type 2 diabetes on brain structure and cognitive function: African American-Diabetes Heart Study MIND. AJNR Am J Neuroradiol. 2015;36(9):1648-1653.

Callahan KE, Lovato JF, Miller ME, Easterling D, Snitz B, Williamson JD. Associations between mild cognitive impairment and hospitalization and readmission. J Am Geriatr Soc. 2015;63(9):1880-1885.

Houston DK, Tooze JA, Demons JL, Davis BL, Shertzer-Skinner R, Kearsley LB, Kritchevsky SB, Williamson JD. Delivery of a vitamin D intervention in homebound older adults using a Meals-on-Wheels program: a pilot study. J Am Geriatr Soc. 2015;63(9):1861-1867.

Schwartz AV, Chen H, Ambrosius WT, Sood A, Josse RG, Bonds DE, Schnall AM, Vittinghoff E, Bauer DC, Banerji MA, Cohen RM, Hamilton BP, Isakova T, Sellmeyer DE, Simmons DL, Shibli-Rahhal A, Williamson JD, Margolis KL. Effects of TZD use and discontinuation on fracture rates in ACCORD bone study. J Clin Endocrinol Metab. 2015;100(11):4059-4066.

Gifford A, Lawrence J, Case D, Rapp S, Baker L, Craft S, Groteluschen DL, Klepin H, Lesser G, Naughton MJ, Sachs B, Samuel TA, Sink K, Williamson, J, Shaw EG. Mild cognitive impairment (MCI) in chemotherapy-treated breast cancer survivors [abstract]. J Clin Oncol. 2015;33(15 Suppl):9560.

Sink KM, Espeland MA, Castro CM, Church T, Cohen R, Dodson JA, Guralnik J, Hendrie HC, Jennings J, Katula J, Lopez OL, McDermott MM, Pahor M, Reid KF, Rushing J, Verghese J, Rapp S, Williamson JD. Effect of a 24-month physical activity intervention vs health education on cognitive outcomes in sedentary older adults: the LIFE randomized trial. JAMA. 2015;314(8):781-790.

Freedman BI, Divers J, Whitlow CT, Bowden DW, Palmer ND, Smith SC, Xu J, Register TC, Carr JJ, Wagner BC, Williamson JD, Sink KM, Maldjian JA. Subclinical atherosclerosis is inversely associated with gray matter volume in African Americans with type 2 diabetes. Diabetes Care. 2015;38(11):2158-2165.

Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103-2116.

Williamson JD, Launer LJ, Bryan RN, Coker LH, Lazar RM, Gerstein HC, Murray AM, Sullivan MD, Horowitz KR, Ding J, Marcovina S, Lovato L, Lovato J, Margolis KL, Davatzikos C, Barzilay J, Ginsberg HN, Linz PE, Miller ME. Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial. JAMA Intern Med. 2014;174(3):324-333.

Coker LH, Espeland MA, Hogan PE, Resnick SM, Bryan RN, Robinson JG, Goveas JS, Davatzikos C, Kuller LH, Williamson JD, Bushnell CD, Shumaker SA. Change in brain and lesion volumes after CEE therapies: the WHIMS-MRI studies. Neurology. 2014;82(5):427-434.

Hugenschmidt C, Williamson JD. Solving the mystery of the diabetes-dementia connection: new clues--but far from 'case closed' [editorial]. J Diabetes Complications. 2014;28(1):8-9.

Hughes TM, Lopez OL, Evans RW, Kamboh MI, Williamson JD, Klunk WE, Mathis CA, Price JC, Cohen AD, Snitz BE, Dekosky ST, Kuller LH. Markers of cholesterol transport are associated with amyloid deposition in the brain. Neurobiol Aging. 2014;35(4):802-807.

Miller ME, Williamson JD, Gerstein HC, Byington RP, Cushman WC, Ginsberg HN, Ambrosius WT, Lovato L, Applegate WB. Effects of randomization to intensive glucose control on adverse events, cardiovascular disease, and mortality in older versus younger adults in the ACCORD trial. Diabetes Care. 2014;37(3):634-643.

Tate JA, Snitz BE, Alvarez KA, Nahin RL, Weissfeld LA, Lopez O, Angus DC, Shah F, Ives DG, Fitzpatrick AL, Williamson JD, Arnold AM, Dekosky ST, Yende S. Infection hospitalization increases risk of dementia in the elderly. Crit Care Med. 2014;42(5):1037-1046.

Callahan K, Wilson L, Pavon J, Atkinson H, Busby-Whitehead J, Heflin M, Iverson P, Lovato J, Marsden J, Moran W, Roberts E, Williamson J. Age distribution and core geriatric conditions in Internal Medicine resident continuity clinics [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S206.

Corbett TM, Callahan KE, Phillips KC, Russell GB, Williamson JD, Atkinson HH. Pilot of a telegeriatrics interprofessional curriculum in long-term care [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S52.

Fitzgerald HM, Williamson JD, Lovato JF, Callahan KE. Alcohol use and hospitalization events in a population of community-dwelling older adults [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S271.

Sink KM, Chelune G, Coker L, Gaussoin S, Lerner A, Nichols L, Pajewski NM, Rapp S, Wadley V, Williamson J. The Montreal Cognitive Assessment (MoCA) in 8,724 SPRINT participants [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S9-S10.

Watkins FS, Williamson J, Craver K, Smith S, Duncan P. Initial readmissions data from a joint venture between an academic medical center and a national home health company [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S225-S226.

Ambrosius WT, Sink KM, Foy CG, Berlowitz DR, Cheung AK, Cushman WC, Fine LJ, Goff DC Jr, Johnson KC, Killeen AA, Lewis CE, Oparil S, Reboussin DM, Rocco MV, Williamson JD, Wright JT Jr, Whelton PK. The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT). Clin Trials. 2014;11(5):532-546.

Hugenschmidt CE, Burdette JH, Morgan AR, Williamson JD, Kritchevsky SB, Laurienti PJ. Graph theory analysis of functional brain networks and mobility disability in older adults. J Gerontol A Biol Sci Med Sci. 2014;69(11):1399-1406.

Espeland MA, Rapp SR, Bray GA, Houston DK, Johnson KC, Kitabchi AE, Hergenroeder AL, Williamson J, Jakicic JM, van Dorsten B, Kritchevsky SB. Long-term impact of behavioral weight loss intervention on cognitive function. J Gerontol A Biol Sci Med Sci. 2014;69(9):1101-1108.

Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD. Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA. 2014;311(23):2387-2396.

Demons JL, Chenna S, Callahan KE, Davis BR, Kearsley L, Sink KM, Watkins FS, Williamson JD, Atkinson HH. Utilizing a Meals on Wheels program to teach falls risk assessment to medical students. Gerontol Geriatr Educ. 2014;35(4):409-420.

Kritchevsky SB, Williamson J. Putting function first [commentary]. J Nutr Health Aging. 2014;18(5):467-468.

Cox AJ, Hugenschmidt CE, Raffield LM, Langefeld CD, Freedman BI, Williamson JD, Hsu FC, Bowden DW. Heritability and genetic association analysis of cognition in the Diabetes Heart Study. Neurobiol Aging. 2014;35(8):1958e3-e12.

Bryan RN, Bilello M, Davatzikos C, Lazar RM, Murray A, Horowitz K, Lovato J, Miller ME, Williamson J, Launer LJ. Effect of diabetes on brain structure: the action to control cardiovascular risk in diabetes MR imaging baseline data. Radiology. 2014;272(1):210-216.

Hugenschmidt CE, Lovato JF, Ambrosius WT, Bryan RN, Gerstein HC, Horowitz KR, Launer LJ, Lazar RM, Murray AM, Chew EY, Danis RP, Williamson JD, Miller ME, Ding J. The cross-sectional and longitudinal associations of diabetic retinopathy with cognitive function and brain MRI findings: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Diabetes Care. 2014;37(12):3244-3252.

Sink KM, Espeland MA, Rushing J, Castro CM, Church TS, Cohen R, Gill TM, Henkin L, Jennings JM, Kerwin DR, Manini TM, Myers V, Pahor M, Reid KF, Woolard N, Rapp SR, Williamson JD. The LIFE Cognition Study: design and baseline characteristics. Clin Interv Aging. 2014;9():1425-1436.

Zhang Z, Lovato J, Battapady H, Davatzikos C, Gerstein HC, Ismail-Beigi F, Launer LJ, Murray A, Punthakee Z, Tirado AA, Williamson J, Bryan RN, Miller ME. Effect of hypoglycemia on brain structure in people with type 2 diabetes: epidemiological analysis of the ACCORD-MIND MRI trial. Diabetes Care. 2014;37(12):3279-3285.

Palmer ND, Sink KM, Smith SC, Xu J, Bowden DW, Hugenschmidt CE, Whitlow CT, Williamson JD, Maldjian JA, Divers J, Freedman BI. Kidney disease and cognitive function: African American-Diabetes Heart Study MIND. Am J Nephrol. 2014;40(3):200-207.

Sink K, Chmelo E, Nicklas B, Katula J, Cofman C, Williamson J, Baker L. Pilot trial of buddy-assisted exercise in people with mild cognitive impairment [abstract]. Alzheimers Dement. 2013;9(4 Suppl):P494.

Baker L, Craft S, Cholerton B, Wilkinson C, Foster-Schubert K, McTiernan A, Williamson J, Sink K, Duncan G. Aerobic exercise effects on cognition in at-risk adults: role of insulin sensitivity and APOE-epsilon 4 [abstract]. Alzheimers Dement. 2013;9(4 Suppl):P690.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Gerontology and Geriatric Medicine

Clinical Interests

Clinical Geriatrics, Dementia, Geriatric Continuity Care, Geriatric Medicine and Assessment, Geriatrics
Jeff D. Williamson, M.D.
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