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Raghunatha Yammani, Ph.D.Wake Forest School of Medicine

Raghunatha Yammani, Ph.D.

Associate Professor,


Assistant Professor,

Contact Information

Academic: 336-716-1578 | Department: 336-716-2011

Education & Training

  • B.S., Osmania University-India, 1990
  • M.S., Free Standing Institute-India, 1993
  • Ph.D., Osmania University-India, 1999
  • Fellowship, Indian Institute Of Science-In, 1999
  • Fellowship, Medical College of Wisconsin, 2004
  • Fellowship, Rush Medical College, 2004
Raghunatha Yammani, Ph.D.

Raghunatha Yammani, Ph.D.

Associate Professor, Molecular Medicine
Sticht Center on Aging
Center for Comparative Medicine Research
Assistant Professor, Translational Science Institute

Research Interests

arthritis, degenerative disorders, metabolism, model development, obesity

Contact Information

Academic: 336-716-1578 | Department: 336-716-2011

Recent Publications

Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med. 2015;7(278):278ra32.

Wood ST, Long D, Reisz J, Yammani R, Burke E, Klomsiri C, Poole L, Furdui C, Loeser R. Cysteine-mediated redox regulation of cell signaling in chondrocytes stimulated with fibronectin fragments [abstract]. Osteoarthritis Cartilage. 2015;23(Suppl 2):A65-A66.

Yammani R. Palmitate induces endoplasmic reticulum (ER) stress and activates unfolded protein response (UPR) signaling in meniscus cells [abstract]. Osteoarthritis Cartilage. 2015;23(Suppl 2):A273.

Yammani RR, Loeser RF. Brief report: stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes. Arthritis Rheum. 2014;66(5):1266-1271.

Yammani RR, Loeser RF. Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes. Arthritis Res Ther. 2012;14(1):R23.

Yammani RR. S100 proteins in cartilage: role in arthritis. Biochim Biophys Acta. 2012;1822(4):600-606.

Miranda KJ, Loeser RF, Yammani RR. Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13. J Biol Chem. 2010;285(41):31517-24.

Miranda KJ, Loeser RF, Yammani RR. Response to Berge et al.: comment on the importance of S100A4 in regulation of MMP-13 [letter]. J Biol Chem. 2010;285(53):Ie24.

Cravero JD, Carlson CS, Im H-J, Yammani RR, Long D, Loeser RF. Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum. 2009;60(2):492-500.

Yammani RR, Long D, Loeser RF. Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes. Arthritis Rheum. 2009;60(3):792-800.

Ahuja R, Yammani R, Bauer JA, Kaira S, Seetharam S, Seetharam B. Interactions of cubillin with megalin and the product of the amnionless gene (AMN): effect on its stability. Biochem J. 2008;410(2):301-308.

Bose S, Kalra S, Yammani RR, Ahuja R, Seetharam B. Plasma membrane delivery, endocytosis and turnover of transcobalamin receptor in polarized human intestinal epithelial cells. J Physiol. 2007;581(Pt 2):457-466.

Yammani RR, Carlson CS, Bresnick AR, Loeser RF. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: role of the receptor for advanced glycation end products. Arthritis Rheum. 2006;54(9):2901-2911.

Loeser RF, Yammani R, Erickson E, King B, Poole L. Chondrocyte MMP-13 expression in response to alpha 5 beta 1 integrin stimulation requires protein sulfenic acids as signaling intermediates [abstract]. Arthritis Rheum. 2006;54(9 Suppl):S318.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Molecular Medicine

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