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Barbara K. Yoza, Ph.D.Wake Forest School of Medicine

Barbara K. Yoza, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-716-9397 | Department: 336-716-9397

Email: byoza@wakehealth.edu

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Education & Training

  • A.B., Smith College, 1978
  • Ph.D., SUNY-Stony Brook, 1985
  • Fellowship, Rockefeller University, 1989
Barbara K. Yoza, Ph.D.

Barbara K. Yoza, Ph.D.

Assistant Professor, Surgery, General
Molecular Medicine

Research Interests

Transcription Factor RelB; Lipopolysaccharides; Immune Tolerance; Sepsis; Contusions
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Contact Information

Academic: 336-716-9397 | Department: 336-716-9397

Email: byoza@wakehealth.edu

Related Links

Recent Publications

GAPDH binding to TNF-alpha mRNA contributes to posttranscriptional repression in monocytes: a novel mechanism of communication between inflammation and metabolism. Millet P, Vachharajani V, McPhail L, Yoza B, McCall CE.. J Immunol. 2016;196(6):2541-2551.

Sirtuins link inflammation and metabolism. Vachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK, McCall CE.. J Immunol Res. 2016;2016():8167273.

Pulmonary contusion decreases SIRT1 and primes the lung for a second hit [abstract]. Hoth JJ, Furdui CM, Wells JD, Yoza B, McCall C.. Shock. 2016;45(6 Suppl 1):85.

Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-induced modulation of adhesion molecules in ob/ob mice. Wang X, Buechler NL, Yoza BK, McCall CE, Vachharajani VT.. Obesity (Silver Spring). 2015;23(6):1209-1217.

SIRT1 mediates a primed response to immune challenge after traumatic lung injury. Smith LM, Wells JD, Vachharajani VT, Yoza BK, McCall CE, Hoth JJ.. J Trauma Acute Care Surg. 2015;78(5):1034-1038.

Complement mediates a primed inflammatory response after traumatic lung injury. Hoth JJ, Wells JD, Jones SE, Yoza BK, McCall CE.. J Trauma Acute Care Surg. 2014;76(3):601-609.

SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome. Vachharajani VT, Liu T, Brown CM, Wang X, Buechler NL, Wells JD, Yoza BK, McCall CE.. J Leukoc Biol. 2014;96(5):785-796.

RelB: an outlier in leukocyte biology. Millet P, McCall C, Yoza B.. J Leukoc Biol. 2013;94(5):941-951.

Innate immune response to pulmonary contusion: identification of cell type-specific inflammatory responses. Hoth JJ, Wells JD, Yoza BK, McCall CE.. Shock. 2012;37(4):385-391.

Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. Vachharajani V, Cunningham C, Yoza B, Carson J Jr, Vachharajani TJ, McCall C.. Obesity (Silver Spring). 2012;20(3):498-504.

NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. Liu TF, Vachharajani VT, Yoza BK, McCall CE.. J Biol Chem. 2012;287(31):25758-69.

Fueling the flame: bioenergy couples metabolism and inflammation. Liu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, Vachharajani VT, Yoza BK, McCall CE.. J Leukoc Biol. 2012;92(3):499-507.

Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis. Yoza BK, McCall CE.. Cytokine. 2011;53(2):145-152.

NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. Liu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CE.. J Biol Chem. 2011;286(11):9856-9864.

Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Hoth JJ, Wells JD, Hiltbold EM, McCall CE, Yoza BK.. Shock. 2011;35(6):604-609.

Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. McCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza B.. J Leukoc Biol. 2011;90(3):439-446.

Dynamic and selective nucleosome repositioning during endotoxin tolerance. El Gazzar M, Liu T, Yoza BK, McCall CE.. J Biol Chem. 2010;285(2):1259-1271.

Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Vachharajani V, Wang SW, Mishra N, El Gazzar M, Yoza B, McCall C.. Microcirculation. 2010;17(6):407-416.

Gene-specific epigenetic regulation in serious infections with systemic inflammation. McCall CE, Yoza B, Liu T, El Gazzar M.. J Innate Immun. 2010;2(5):395-405.

Pulmonary parenchymal cells mediate toll-like receptor dependent responses after traumatic lung injury. Hoth JJ, Yoza BK, Wells JD, Meredith JW, McCall CE.. J Am Coll Surg. 2010;211(3 Suppl):S51.

RelB sustains IkappaBalpha expression during endotoxin tolerance. Chen X, Yoza BK, El Gazzar M, Hu JYQ, Cousart SL, McCall CE.. Clin Vaccine Immunol. 2009;16(1):104-110.

Chromatin-specific remodeling by HMGB1 and linker histone H1 silence proinflammatory genes during endotoxin tolerance. El Gazzar M, Yoza BK, Chen X, Garcia BA, Young NL, McCall CE.. Mol Cell Biol. 2009;29(7):1959-1971.

Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Hoth JJ, Wells JD, Brownlee NA, Hiltbold EM, Meredith JW, McCall CE, Yoza BK.. Shock. 2009;31(4):376-381.

The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance. Chen X, El Gazzar M, Yoza BK, McCall CE.. J Biol Chem. 2009;284(41):27857-65.

Pulmonary contusion primes systemic innate immunity responses. Hoth JJ, Martin RS, Yoza BK, Wells JD, Meredith JW, McCall CE.. J Trauma. 2009;67(1):14-21.

G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance. El Gazzar M, Yoza BK, Chen X, Hu J, Hawkins GA, McCall CE.. J Biol Chem. 2008;283(47):32198-208.

Gene silencing in severe systemic inflammation. McCall CE, Yoza BK.. Am J Respir Crit Care Med. 2007;175(8):763-767.

Epigenetic silencing of tumor necrosis factor alpha during endotoxin tolerance. El Gazzar M, Yoza BK, Hu JY-Q, Cousart SL, McCall CE.. J Biol Chem. 2007;282(37):26857-64.

Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Hoth JJ, Hudson WP, Brownlee NA, Yoza BK, Hiltbold EM, Meredith JW, McCall CE.. Shock. 2007;28(4):447-452.

The pathogenesis of pulmonary contusion: an open chest model in the rat. Hoth JJ, Stitzel JD, Gayzik FS, Brownlee NA, Miller PR, Yoza BK, McCall CE, Meredith JW, Payne RM.. J Trauma. 2006;61(1):32-45.

Induction of RelB participates in endotoxin tolerance. Yoza BK, Hu JY-Q, Cousart SL, Forrest LM, McCall CE.. J Immunol. 2006;177(6):4080-4085.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Surgery, General

Barbara K. Yoza, Ph.D.

Barbara K. Yoza, Ph.D.

Assistant Professor, Surgery, General
Molecular Medicine

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