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Yuanyuan Zhang, M.D., Ph.D.Wake Forest School of Medicine

Yuanyuan Zhang, M.D., Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-1189 | Department: 336-716-2011

Email: yzhang@wakehealth.edu

Education & Training

  • M.D., China-Jiangxi Medical College, 1982
  • M.S., China-Jiangxi Medical College, 1989
  • Ph.D., Univ Lausanne Faculty of Medicine-Switzerland, 2001
  • Fellowship, Urology, Hospital-New Zealand, 1995
  • Fellowship, Pediatrics, Univ Lausanne Faculty of Medic, 1997
Yuanyuan Zhang, M.D., Ph.D.

Yuanyuan Zhang, M.D., Ph.D.

Assistant Professor, Institute for Regenerative Medicine
Hypertension and Vascular Research Center

Research Interests

cell growth, differentiation,d, diabetes, engineering/bioengineering

Contact Information

Academic: 336-713-1189 | Department: 336-716-2011

Email: yzhang@wakehealth.edu

Recent Publications

Li L, Zhang D, Li P, Damaser M, Zhang Y. Virus integration and genome influence in approaches to stem cell based therapy for andro-urology. Adv Drug Deliv Rev. 2015;82-83():12-21.

Li M, Tang Z, Zhang D, Sun H, Liu H, Zhang Y, Zhang Y, Chen X. Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in rodent models. Biomaterials. 2015;51():161-172.

Li W, Kidiyoor A, Hu Y, Guo C, Liu M, Yao X, Zhang Y, Peng B, Zheng J. Evaluation of transforming growth factor-beta1 suppress Pokemon/epithelial-mesenchymal transition expression in human bladder cancer cells. Tumour Biol. 2015;36(2):1155-1162.

Lei B, Lv D, Zhou X, Zhang S, Shu F, Ding Y, Zhang Y, Mao X. Biochemical hormone parameters in seminal and blood plasma samples correlate with histopathologic properties of testicular biopsy in azoospermic patients. Urology. 2015;85(5):1074-1078.

Wu Y, Feng G, Song J, Zhang Y, Yu Y, Huang L, Zheng L, Deng F. TrAmplification of human dental follicle cells by piggyBac transposon - mediated reversible immortalization system. PLoS One. 2015;10(7):e0130937.

Xu H, Xu B, Yang Q, Li X, Ma X, Xia Q, Zhang Y, Zhang C, Wu Y, Zhang Y. Comparison of decellularization protocols for preparing a decellularized porcine annulus fibrosus scaffold. PLoS One. 2014;9(1):e86723.

Liu X, Liu J, Kang N, Yan L, Wang Q, Fu X, Zhang Y, Xiao R, Cao Y. Role of insulin-transferrin-selenium in auricular chondrocyte proliferation and engineered cartilage formation in vitro. Int J Mol Sci. 2014;15(1):1525-1537.

Cui Y, Cao W, Shen H, Xie J, Adams TS, Zhang Y, Shao Q. Comparison of ESWL and ureteroscopic holmium laser lithotripsy in management of ureteral stones. PLoS One. 2014;9(2):e87634.

Li M, Tang Z, Lv S, Song W, Hong H, Jing X, Zhang Y, Chen X. Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery of doxorubicin. Biomaterials. 2014;35(12):3851-3864.

Song L, Murphy SV, Yang B, Xu Y, Zhang Y, Atala A. Bladder acellular matrix and its application in bladder augmentation. Tissue Eng Part B Rev. 2014;20(2):163-172.

Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF, Childers MK. Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery. Stem Cell Res. 2014;12(2):467-480.

Ouyang B, Sun X, Han D, Chen S, Yao B, Gao Y, Bian J, Huang Y, Zhang Y, Wan Z, Yang B, Xiao H, Songyang Z, Liu G, Zhang Y, Deng C. Human urine-derived stem cells alone or genetically-modified with FGF2 improve type 2 diabetic erectile dysfunction in a rat model. PLoS One. 2014;9(3):e92825.

Hu B, Zhang Y, Zhou J, Li J, Deng F, Wang Z, Song J. Low-intensity pulsed ultrasound stimulation facilitates osteogenic differentiation of human periodontal ligament cells. PLoS One. 2014;9(4):e95168.

Lv S, Tang Z, Li M, Lin J, Song W, Liu H, Huang Y, Zhang Y, Chen X. Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer. Biomaterials. 2014;35(23):6118-6129.

Chen W, Xie M, Yang B, Bharadwaj S, Song L, Liu G, Yi S, Ye G, Atala A, Zhang Y. Skeletal myogenic differentiation of human urine-derived cells as a potential source for skeletal muscle regeneration. J Tissue Eng Regen Med. 2014;():.

Pei M, Li J, Zhang Y, Liu G, Wei L, Zhang Y. Expansion on a matrix deposited by nonchondrogenic urine stem cells strengthens the chondrogenic capacity of repeated-passage bone marrow stromal cells. Cell Tissue Res. 2014;356(2):391-403.

Wang Y, Chai Z, Zhang Y, Deng F, Wang Z, Song J. Influence of low-intensity pulsed ultrasound on osteogenic tissue regeneration in a periodontal injury model: X-ray image alterations assessed by micro-computed tomography. Ultrasonics. 2014;54(6):1581-1584.

Qin D, Long T, Deng J, Zhang Y. Urine-derived stem cells for potential use in bladder repair. Stem Cell Res Ther. 2014;5(3):69.

Wang W, Wang L, Xu J, Shi S, Tian Y, Zhang Y. Combination of CT imaging and endoscopy in diagnosis of appendicovesical fistula caused by appendiceal adenocarcinoma. J Xray Sci Technol. 2014;22(4):493-501.

Zhang D, Liu X, Peng J, He D, Lin T, Zhu J, Li X, Zhang Y, Wei G. Potential spermatogenesis recovery with bone marrow mesenchymal stem cells in an azoospermic rat model. Int J Mol Sci. 2014;15(8):13151-65.

Huang JW, Xie MK, Zhang Y, Wei GJ, Li X, Li HB, Wang JH, Zhu WD, Li C, Xu YM, Song LJ. Reconstruction of penile urethra with the 3-dimensional porous bladder acellular matrix in a rabbit model. Urology. 2014;84(6):1499-1505.

Liu G, Li T, Zhang J, Yang X, Liang X, Zhang Y. The potential application of urine derived stem cells in male infertility [abstract]. Fertil Steril. 2014;102(3 Suppl):e192.

Zhang D, Wei G, Li P, Zhou X, Zhang Y. Urine-derived stem cells: A novel and versatile progenitor source for cell-based therapy and regenerative medicine. Genes Dis. 2014;1(1):8-17.

Zhang Y, Atala A. Urothelial cell culture: stratified urothelial sheet and three-dimensional growth of urothelial structure. Methods Mol Biol. 2013;945():383-399.

Orabi H, AbouShwareb T, Zhang Y, Yoo JJ, Atala A. Cell-seeded tubularized scaffolds for reconstruction of long urethral defects: a preclinical study. Eur Urol. 2013;63(3):531-538.

Lang R, Liu G, Shi Y, Bharadwaj S, Leng X, Zhou X, Liu H, Atala A, Zhang Y. Self-renewal and differentiation capacity of urine-derived stem cells after urine preservation for 24 hours. PLoS One. 2013;8(1):e53980.

Zhou L, Yang B, Sun C, Qiu X, Sun Z, Chen Y, Zhang Y, Dai Y. Coadministration of platelet-derived growth factor-BB and vascular endothelial growth factor with bladder acellular matrix enhances smooth muscle regeneration and vascularization for bladder augmentation in a rabbit model. Tissue Eng Part A. 2013;19(1 & 2):264-276.

Liu G, Pareta RA, Wu R, Shi Y, Zhou X, Liu H, Deng C, Sun X, Atala A, Opara EC, Zhang Y. Skeletal myogenic differentiation of urine-derived stem cells and angiogenesis using microbeads loaded with growth factors. Biomaterials. 2013;34(4):1311-1326.

Song L, Xie M, Zhang Y, Xu Y. Imaging techniques for the diagnosis of male traumatic urethral strictures. J Xray Sci Technol. 2013;21(1):111-123.

Wu R, Liu G, Bharadwaj S, Zhang Y. Isolation and myogenic differentiation of mesenchymal stem cells for urologic tissue engineering. Methods Mol Biol. 2013;1001():65-80.

Guo Y, Liu G, Yang D, Sun X, Wang H, Deng C, Zhang Y, Feng ST. Role of MRI in assessment of ejaculatory duct obstruction. J Xray Sci Technol. 2013;21(1):141-146.

Li H, Sun X, Liu G, Zhang Y, Chu J, Deng C, Zhou B, Chen W, Yang J. Endovascular stent placement for nutcracker phenomenon. J Xray Sci Technol. 2013;21(1):95-102.

Xue BX, Zang YC, Zhang YY, Yang DR, Gao J, Sun CY, Cui Y, Zhu J, Liu XL, Shan YX. GreenLight HPS 120-W laser vaporization versus transurethral resection of the prostate for treatment of benign prostatic hyperplasia: a prospective randomized trial. J Xray Sci Technol. 2013;21(1):125-132.

Dai W, Gerczuk P, Zhang Y, Smith L, Kopyov O, Kay GL, Jyrala AJ, Kloner RA. Intramyocardial injection of heart tissue-derived extracellular matrix improves postinfarction cardiac function in rats. J Cardiovasc Pharmacol Ther. 2013;18(3):270-279.

Guan X, Mack D, Shi YA, Markert C, Liu GH, Lawlor M, Moorefield E, Jones T, Furth M, Zhang YY, Childers MK. iPSC-derived cardiomyocytes from the urine of a patient with Duchenne muscular dystrophy [abstract]. Mol Ther. 2013;21(Suppl 1):S182.

Markert CD, Guo X, Skardal A, Bharadwaj S, Zhang Y, Bonin K, Guthold M. How stiff is it? Characterizing the micro-scale elastic modulus of hydrogels for use in regenerative medicine [abstract]. FASEB J. 2013;27():1217.21.

Tao W, Yang D, Shan Y, Xue B, Sun C, Zang Y, Zhang Y. Safety and efficacy of 120W high performance system greenlight laser vaporization for non-muscle-invasive bladder cancer. J Xray Sci Technol. 2013;21(2):309-316.

Tu XA, Zhuang JT, Zhao L, Zhao LY, Zhao JQ, Lu KL, Sun XZ, Qiu SP, Zhang Y, Deng CH. Transurethral bipolar plasma kinetic resection of ejaculatory duct for treatment of ejaculatory duct obstruction. J Xray Sci Technol. 2013;21(2):293-302.

Zhang Y, Tong Z, Zhang Y. X-ray computed tomography and sonography features of continuous splenogonadal fusion. J Xray Sci Technol. 2013;21(2):303-308.

Liu G, Wang X, Sun X, Deng C, Atala A, Zhang Y. The effect of urine-derived stem cells expressing VEGF loaded in collagen hydrogels on myogenesis and innervation following after subcutaneous implantation in nude mice. Biomaterials. 2013;34(34):8617-8629.

Tao W, Xue B, Zang Y, Sun C, Yang D, Zhang Y, Shan Y. The application of 120-W high-performance system GreenLight laser vaporization of the prostate in high-risk patients. Lasers Med Sci. 2013;28(4):1151-1157.

Wu Y, Xu B, Yang Q, Li X, Zhang Y, Ma X, Xia Q, Zeng C, Zhang Y. A novel natural ECM-derived biphasic scaffold for intervertebral disc tissue engineering. Mater Lett. 2013;105():102-105.

Yang B, Zheng JH, Zhang YY. Myogenic differentiation of mesenchymal stem cells for muscle regeneration in urinary tract. Chin Med J (Engl). 2013;126(15):2952-2959.

Zhang Y, Atala A. Urothelial cell culture. Methods Mol Biol. 2013;1037():27-43.

Liu G, Sun X, Bian J, Wu R, Guan X, Ouyang B, Huang Y, Xiao H, Luo D, Atala A, Zhang Y, Deng C. Correction of diabetic erectile dysfunction with adipose derived stem cells modified with the vascular endothelial growth factor gene in a rodent diabetic model. PLoS One. 2013;8(8):e72790.

Shao Q, Xu J, Adams T, Tao S, Cui Y, Shen H, Cao W, Xie J, Fan Y, Zhang Y, Huang M. Comparison of aspiration-sclerotherapy versus laparoscopic decortication in management of symptomatic simple renal cysts. J Xray Sci Technol. 2013;21(3):419-428.

Ji Q, Liu G, Sun X, Liu G, Lu M, Xie X, Xu M, Zhang Y, Zheng S. Liver specific phase of perflubutane microbubbles contrast-enhanced ultrasound for potential use in the diagnosis of focal liver lesions. J Xray Sci Technol. 2013;21(3):409-418.

Luo D, Liu G, Mo J, Xiao L, Xie Q, Li M, Zhang Z, Lu J, Liang Z, Meng X, Zhang Y, Deng C, Mi Q. Suprapubic-assisted umbilical laparoendoscopic mini-dual-site surgery in the treatment of simple kidney cyst: report of 26 cases. J Xray Sci Technol. 2013;21(3):441-447.

Xu C, Zhang Z, Ye H, Wu C, Zhang C, Zhang Y, Wang Y, Cao Z, Wang H, Xu W, Pan A, Wei R, Zeng S, Sun Y. Imaging diagnosis and endoscopic treatment for ureteral fibroepithelial polyp prolapsing into the bladder. J Xray Sci Technol. 2013;21(3):393-399.

Zeng D, Liu G, Sun X, Zhuang W, Zhang Y, Guo W, Yang J, Chen W. Transarterial embolization for serious renal hemorrhage following renal biopsy. J Xray Sci Technol. 2013;21(3):401-407.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Yuanyuan Zhang, M.D., Ph.D.

Yuanyuan Zhang, M.D., Ph.D.

Assistant Professor, Institute for Regenerative Medicine
Hypertension and Vascular Research Center

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