Yuanyuan Zhang, M.D., Ph.D.Wake Forest School of Medicine

Yuanyuan Zhang, M.D., Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-1189 | Department: 336-716-2011


Education & Training

  • M.D., China-Jiangxi Medical College, 1982
  • M.S., China-Jiangxi Medical College, 1989
  • Ph.D., Univ Lausanne Faculty of Medicine-Switzerland, 2001
  • Fellowship, Urology, Hospital-New Zealand, 1995
  • Fellowship, Pediatrics, Univ Lausanne Faculty of Medic, 1997
Yuanyuan Zhang, M.D., Ph.D.

Yuanyuan Zhang, M.D., Ph.D.

Assistant Professor, Institute for Regenerative Medicine
Hypertension and Vascular Research Center

Research Interests

cell growth, differentiation,d, diabetes, engineering/bioengineering

Contact Information

Academic: 336-713-1189 | Department: 336-716-2011


Recent Publications

Li L, Zhang D, Li P, Damaser M, Zhang Y. Virus integration and genome influence in approaches to stem cell based therapy for andro-urology. Adv Drug Deliv Rev. 2015;82-83():12-21.

Li W, Kidiyoor A, Hu Y, Guo C, Liu M, Yao X, Zhang Y, Peng B, Zheng J. Evaluation of transforming growth factor-beta1 suppress Pokemon/epithelial-mesenchymal transition expression in human bladder cancer cells. Tumour Biol. 2015;36(2):1155-1162.

Xu H, Xu B, Yang Q, Li X, Ma X, Xia Q, Zhang Y, Zhang C, Wu Y, Zhang Y. Comparison of decellularization protocols for preparing a decellularized porcine annulus fibrosus scaffold. PLoS One. 2014;9(1):e86723.

Liu X, Liu J, Kang N, Yan L, Wang Q, Fu X, Zhang Y, Xiao R, Cao Y. Role of insulin-transferrin-selenium in auricular chondrocyte proliferation and engineered cartilage formation in vitro. Int J Mol Sci. 2014;15(1):1525-1537.

Cui Y, Cao W, Shen H, Xie J, Adams TS, Zhang Y, Shao Q. Comparison of ESWL and ureteroscopic holmium laser lithotripsy in management of ureteral stones. PLoS One. 2014;9(2):e87634.

Li M, Tang Z, Lv S, Song W, Hong H, Jing X, Zhang Y, Chen X. Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery of doxorubicin. Biomaterials. 2014;35(12):3851-3864.

Song L, Murphy SV, Yang B, Xu Y, Zhang Y, Atala A. Bladder acellular matrix and its application in bladder augmentation. Tissue Eng Part B Rev. 2014;20(2):163-172.

Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF, Childers MK. Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery. Stem Cell Res. 2014;12(2):467-480.

Ouyang B, Sun X, Han D, Chen S, Yao B, Gao Y, Bian J, Huang Y, Zhang Y, Wan Z, Yang B, Xiao H, Songyang Z, Liu G, Zhang Y, Deng C. Human urine-derived stem cells alone or genetically-modified with FGF2 improve type 2 diabetic erectile dysfunction in a rat model. PLoS One. 2014;9(3):e92825.

Hu B, Zhang Y, Zhou J, Li J, Deng F, Wang Z, Song J. Low-intensity pulsed ultrasound stimulation facilitates osteogenic differentiation of human periodontal ligament cells. PLoS One. 2014;9(4):e95168.

Lv S, Tang Z, Li M, Lin J, Song W, Liu H, Huang Y, Zhang Y, Chen X. Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer. Biomaterials. 2014;35(23):6118-6129.

Chen W, Xie M, Yang B, Bharadwaj S, Song L, Liu G, Yi S, Ye G, Atala A, Zhang Y. Skeletal myogenic differentiation of human urine-derived cells as a potential source for skeletal muscle regeneration. J Tissue Eng Regen Med. 2014;():.

Qin D, Long T, Deng J, Zhang Y. Urine-derived stem cells for potential use in bladder repair. Stem Cell Res Ther. 2014;5(3):69.

Wang W, Wang L, Xu J, Shi S, Tian Y, Zhang Y. Combination of CT imaging and endoscopy in diagnosis of appendicovesical fistula caused by appendiceal adenocarcinoma. J Xray Sci Technol. 2014;22(4):493-501.

Zhang D, Liu X, Peng J, He D, Lin T, Zhu J, Li X, Zhang Y, Wei G. Potential spermatogenesis recovery with bone marrow mesenchymal stem cells in an azoospermic rat model. Int J Mol Sci. 2014;15(8):13151-65.

Huang JW, Xie MK, Zhang Y, Wei GJ, Li X, Li HB, Wang JH, Zhu WD, Li C, Xu YM, Song LJ. Reconstruction of penile urethra with the 3-dimensional porous bladder acellular matrix in a rabbit model. Urology. 2014;84(6):1499-1505.

Liu G, Li T, Zhang J, Yang X, Liang X, Zhang Y. The potential application of urine derived stem cells in male infertility [abstract]. Fertil Steril. 2014;102(3 Suppl):e192.

Orabi H, AbouShwareb T, Zhang Y, Yoo JJ, Atala A. Cell-seeded tubularized scaffolds for reconstruction of long urethral defects: a preclinical study. Eur Urol. 2013;63(3):531-538.

Lang R, Liu G, Shi Y, Bharadwaj S, Leng X, Zhou X, Liu H, Atala A, Zhang Y. Self-renewal and differentiation capacity of urine-derived stem cells after urine preservation for 24 hours. PLoS One. 2013;8(1):e53980.

Liu G, Pareta RA, Wu R, Shi Y, Zhou X, Liu H, Deng C, Sun X, Atala A, Opara EC, Zhang Y. Skeletal myogenic differentiation of urine-derived stem cells and angiogenesis using microbeads loaded with growth factors. Biomaterials. 2013;34(4):1311-1326.

Song L, Xie M, Zhang Y, Xu Y. Imaging techniques for the diagnosis of male traumatic urethral strictures. J Xray Sci Technol. 2013;21(1):111-123.

Wu R, Liu G, Bharadwaj S, Zhang Y. Isolation and myogenic differentiation of mesenchymal stem cells for urologic tissue engineering. Methods Mol Biol. 2013;1001():65-80.

Guo Y, Liu G, Yang D, Sun X, Wang H, Deng C, Zhang Y, Feng ST. Role of MRI in assessment of ejaculatory duct obstruction. J Xray Sci Technol. 2013;21(1):141-146.

Li H, Sun X, Liu G, Zhang Y, Chu J, Deng C, Zhou B, Chen W, Yang J. Endovascular stent placement for nutcracker phenomenon. J Xray Sci Technol. 2013;21(1):95-102.

Xue BX, Zang YC, Zhang YY, Yang DR, Gao J, Sun CY, Cui Y, Zhu J, Liu XL, Shan YX. GreenLight HPS 120-W laser vaporization versus transurethral resection of the prostate for treatment of benign prostatic hyperplasia: a prospective randomized trial. J Xray Sci Technol. 2013;21(1):125-132.

Dai W, Gerczuk P, Zhang Y, Smith L, Kopyov O, Kay GL, Jyrala AJ, Kloner RA. Intramyocardial injection of heart tissue-derived extracellular matrix improves postinfarction cardiac function in rats. J Cardiovasc Pharmacol Ther. 2013;18(3):270-279.

Guan X, Mack D, Shi YA, Markert C, Liu GH, Lawlor M, Moorefield E, Jones T, Furth M, Zhang YY, Childers MK. iPSC-derived cardiomyocytes from the urine of a patient with Duchenne muscular dystrophy [abstract]. Mol Ther. 2013;21(Suppl 1):S182.

Markert CD, Guo X, Skardal A, Bharadwaj S, Zhang Y, Bonin K, Guthold M. How stiff is it? Characterizing the micro-scale elastic modulus of hydrogels for use in regenerative medicine [abstract]. FASEB J. 2013;27():1217.21.

Tao W, Yang D, Shan Y, Xue B, Sun C, Zang Y, Zhang Y. Safety and efficacy of 120W high performance system greenlight laser vaporization for non-muscle-invasive bladder cancer. J Xray Sci Technol. 2013;21(2):309-316.

Tu XA, Zhuang JT, Zhao L, Zhao LY, Zhao JQ, Lu KL, Sun XZ, Qiu SP, Zhang Y, Deng CH. Transurethral bipolar plasma kinetic resection of ejaculatory duct for treatment of ejaculatory duct obstruction. J Xray Sci Technol. 2013;21(2):293-302.

Zhang Y, Tong Z, Zhang Y. X-ray computed tomography and sonography features of continuous splenogonadal fusion. J Xray Sci Technol. 2013;21(2):303-308.

Tao W, Xue B, Zang Y, Sun C, Yang D, Zhang Y, Shan Y. The application of 120-W high-performance system GreenLight laser vaporization of the prostate in high-risk patients. Lasers Med Sci. 2013;28(4):1151-1157.

Wu Y, Xu B, Yang Q, Li X, Zhang Y, Ma X, Xia Q, Zeng C, Zhang Y. A novel natural ECM-derived biphasic scaffold for intervertebral disc tissue engineering. Mater Lett. 2013;105():102-105.

Yang B, Zheng JH, Zhang YY. Myogenic differentiation of mesenchymal stem cells for muscle regeneration in urinary tract. Chin Med J (Engl). 2013;126(15):2952-2959.

Zhang Y, Atala A. Urothelial cell culture. Methods Mol Biol. 2013;1037():27-43.

Liu G, Sun X, Bian J, Wu R, Guan X, Ouyang B, Huang Y, Xiao H, Luo D, Atala A, Zhang Y, Deng C. Correction of diabetic erectile dysfunction with adipose derived stem cells modified with the vascular endothelial growth factor gene in a rodent diabetic model. PLoS One. 2013;8(8):e72790.

Shao Q, Xu J, Adams T, Tao S, Cui Y, Shen H, Cao W, Xie J, Fan Y, Zhang Y, Huang M. Comparison of aspiration-sclerotherapy versus laparoscopic decortication in management of symptomatic simple renal cysts. J Xray Sci Technol. 2013;21(3):419-428.

Ji Q, Liu G, Sun X, Liu G, Lu M, Xie X, Xu M, Zhang Y, Zheng S. Liver specific phase of perflubutane microbubbles contrast-enhanced ultrasound for potential use in the diagnosis of focal liver lesions. J Xray Sci Technol. 2013;21(3):409-418.

Luo D, Liu G, Mo J, Xiao L, Xie Q, Li M, Zhang Z, Lu J, Liang Z, Meng X, Zhang Y, Deng C, Mi Q. Suprapubic-assisted umbilical laparoendoscopic mini-dual-site surgery in the treatment of simple kidney cyst: report of 26 cases. J Xray Sci Technol. 2013;21(3):441-447.

Xu C, Zhang Z, Ye H, Wu C, Zhang C, Zhang Y, Wang Y, Cao Z, Wang H, Xu W, Pan A, Wei R, Zeng S, Sun Y. Imaging diagnosis and endoscopic treatment for ureteral fibroepithelial polyp prolapsing into the bladder. J Xray Sci Technol. 2013;21(3):393-399.

Zeng D, Liu G, Sun X, Zhuang W, Zhang Y, Guo W, Yang J, Chen W. Transarterial embolization for serious renal hemorrhage following renal biopsy. J Xray Sci Technol. 2013;21(3):401-407.

Bharadwaj S, Liu G, Shi Y, Wu R, Yang B, He T, Fan Y, Lu X, Zhou X, Liu H, Atala A, Rohozinski J, Zhang Y. Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology. Stem Cells. 2013;31(9):1840-1856.

Li W, Yang B, Che JP, Yan Y, Liu M, Li QY, Zhang YY, Zheng JH. Diagnosis and treatment of extra-adrenal pheochromocytoma of urinary bladder: case report and literature review. Int J Clin Exp Med. 2013;6(9):832-839.

Markert CD, Guo X, Skardal A, Wang Z, Bharadwaj S, Zhang Y, Bonin K, Guthold M. Characterizing the micro-scale elastic modulus of hydrogels for use in regenerative medicine. J Mech Behav Biomed Mater. 2013;27():115-127.

Gao Y, Huang YP, Tu XA, Luo DS, Wang DH, Qiu SP, Xiang P, Li WQ, Rohozinski J, Zhang YY, Sun XZ, Deng CH. Genetic characterization and protein stability analysis of a Chinese family with Von Hippel-Lindau disease. Chin Med J (Engl). 2013;126(19):3690-3693.

Lei J, Hui D, Huang W, Liao Y, Yang L, Liu L, Zhang Q, Qi G, Song W, Zhang Y, Xiang AP, Zhou Q. Heterogeneity of the biological properties and gene expression profiles of murine bone marrow stromal cells. Int J Biochem Cell Biol. 2013;45(11):2431-2443.

Chen S, Wu R, Huang Y, Zheng F, Ou Y, Tu X, Zhang Y, Gao Y, Chen X, Zheng T, Yang Q, Wan Z, Zhang Y, Sun X, Liu G, Deng C. Insulin resistance is an independent determinate of ED in young adult men. PLoS One. 2013;8(12):e83951.

Zhang Y, Atala A.Urothelial cell culture

Du F, Wang H, Zhao W, Li D, Kong D, Yang J, Zhang Y. Gradient nanofibrous chitosan/poly ?-caprolactone scaffolds as extracellular microenvironments for vascular tissue engineering. Biomaterials. 2012;33(3):762-770.

Shao Q, Ouyang J, Fan Y, Xie J, Zhou J, Wu J, Kader AK, Xu J, Liu G, Shan Y, Wen D, Zhang Y. Prostate cancer in the senior men from rural areas in east district of China: contemporary management and 5-year outcomes at multi-institutional collaboration. Cancer Lett. 2012;315(2):170-177.

Wang M, Liu F, Hsing AW, Wang X, Shao Q, Zhang Y, Jin G, Sun J, Zheng SL, Xu J, et al. Replication and cumulative effects of GWAS-identified genetic variations for prostate cancer in Asians: a case-control study in the ChinaPCa consortium. Carcinogenesis. 2012;33(2):356-360.

Gao Y, Xu M, Xu Z-F, Liu D-W, Tu X-A, Zheng Y-L, Wang D-H, Sun X-Z, Zheng F-F, Qiu S-P, Lu M-D, Zhang Y-Y, Xie X-Y, Deng C-H. Percutaneous ultrasound-guided radiofrequency ablation treatment and genetic testing for renal cell carcinoma with Von Hippel-Lindau disease. J Xray Sci Technol. 2012;20(1):121-129.

Skardal A, Smith L, Bharadwaj S, Atala A, Soker S, Zhang Y. Tissue specific synthetic ECM hydrogels for 3-D in vitro maintenance of hepatocyte function. Biomaterials. 2012;33(18):4565-4575.

Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN, Breuer C, Burnett L, Christ G, Farney A, Figliuzzi M, Holmes JH IV, Koch K, Macchiarini P, Mirmalek Sani S-H, Opara E, Remuzzi A, Rogers J, Saul JM, Seliktar D,. Regenerative medicine as applied to general surgery. Ann Surg. 2012;255(5):867-880.

Guan X, Shi Y, Markert CD, Mack DL, Jones TN, Moorefield EC, Zhang Y, Childers MK. Rapid generation of induced pluripotent stem cells (iPSCs) from the urine of a patient with Duchenne muscular dystrophy [abstract]. Mol Ther. 2012;20(Suppl 1):S111.

Fu W-J, Xu Y-D, Wang Z-X, Li G, Shi J-G, Cui F-Z, Zhang Y, Zhang X. New ureteral scaffold constructed with composite poly(L-lactic acid)-collagen and urothelial cells by new centrifugal seeding system. J Biomed Mater Res A. 2012;100(7):1725-1733.

Bharadwaj S, Liu GH, Wu S, Andersson K-E, Atala A, Zhang Y. Biological characterization of human urine-derived stem cells from the upper urinary tract for potential use in bladder regeneration in patients with end-stage bladder disease [abstract]. J Tissue Eng Regen Med. 2012;6(Suppl 1):132.

Shi YA, Liu GH, Bharadwaj S, Markert C, Atala A, Zhang Y. Urine derived stem cells with high telomerase activity: an optimized cell source for regenerative medicine in urology [abstract]. J Tissue Eng Regen Med. 2012;6(Suppl 1):132.

Zang Y, Xue B, Zhang Y, Yang D, Gao J, Sun C, Cui Y, Tao W, Chen D, Shan Y. Photoselective vaporization of the prostate with GreenLight HPS 120-W laser for benign prostatic hyperplasia: 36 months' follow-up. Urol Int. 2012;89(2):203-207.

Sun X, Su J, Bao J, Peng T, Zhang L, Zhang Y, Yang Y, Zhou X. Cytokine combination therapy prediction for bone remodeling in tissue engineering based on the intracellular signaling pathway. Biomaterials. 2012;33(33):8265-8276.

Dai WD, Gerczuk P, Zhang YY, Kay GL, Jyrala AJ, Kloner RA. Intramyocardial injection of heart tissue-derived extracellular matrix improves cardiac function in a rat myocardial infarction model [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):905.23.

Huang YP, Sun XZ, Liu GH, Yao FJ, Zheng FF, Dai YP, Tu XG, Xie XY, Deng LW, Zhang YY, et al. Glycosylated serum protein may improve our ability to predict endothelial and erectile dysfunction in nonorganic patients. J Sex Med. 2011;8(3):840-850.

Bharadwaj S, Liu G, Shi Y, Markert C, Andersson K-E, Atala A, Zhang Y. Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering. Tissue Eng Part A. 2011;17(15-16):2123-2132.

Lang R, Stern MM, Smith L, Bharadwaj S, Baptista PM, Bergman CR, Soker S, Yoo JJ, Atala A, Zhang Y, et al. Three-dimensional culture of hepatocytes on porcine liver tissue-derived extracellular matrix. Biomaterials. 2011;32(29):7042-7052.

Tu X, Zhuang J, Wang W, Zhao L, Zhao L, Zhao J, Deng C, Qiu S, Zhang Y. Screening and identification of a renal carcinoma specific peptide from a phage display peptide library. J Exp Clin Cancer Res. 2011;30():105.

Tian H, Bharadwaj S, Liu Y, Ma H, Ma PX, Atala A, Zhang Y. Myogenic differentiation of human bone marrow mesenchymal stem cells on a 3D nano fibrous scaffold for bladder tissue engineering. Biomaterials. 2010;31(5):870-877.

Markert CD, Bharadwaj S, Zhang Y, Childers MK, Furth ME. Immunofluorescence microscopy for imaging of nuclear p63 in human primary keratinocytes: a comparison of antibodies and fixation methods. J Immunol Methods. 2010;352(1-2):174-177.

Tian H, Bharadwaj S, Liu Y, Ma PX, Atala A, Zhang Y. Differentiation of human bone marrow mesenchymal stem cells into bladder cells: potential for urological tissue engineering. Tissue Eng Part A. 2010;16(5):1769-1779.

Bodin A, Bharadwaj S, Wu S, Gatenholm P, Atala A, Zhang Y. Tissue-engineered conduit using urine-derived stem cells seeded bacterial cellulose polymer in urinary reconstruction and diversion. Biomaterials. 2010;31(34):8889-8901.

Zhang Y, He Y, Bharadwaj S, Hammam N, Carnagey K, Myers R, Atala A, Van Dyke M. Tissue-specific extracellular matrix coatings for the promotion of cell proliferation and maintenance of cell phenotype. Biomaterials. 2009;30(23-24):4021-4028.

Liu Y, Bharadwaj S, Lee SJ, Atala A, Zhang Y. Optimization of a natural collagen scaffold to aid cell-matrix penetration for urologic tissue engineering. Biomaterials. 2009;30(23-24):3865-3873.

Orlando G, Mirmalek-Sani S-H, Baptista PM, Zhang Y, Atala A, Soker S. A rapid decellularization technique for organ storage and recellularization [abstract]. Transpl Int. 2009;22(Suppl 2):253.

Zhang YY, McNeill E, Soker S, Yoo JJ, Atala A. A novel cell source for urologic tissue reconstruction [abstract]. Tissue Eng Part A. 2008;14(5):697.

Zhang Y, McNeill E, Tian H, Soker S, Andersson K-E, Yoo JJ, Atala A. Urine derived cells are a potential source for urological tissue reconstruction. J Urol. 2008;180(5):2226-2233.

Egydio F, Moore P, Zhang Y, Atala A, Yoo JJ. Erythropoietin producing cells for the treatment of renal failure induced anemia [abstract]. Tissue Eng. 2007;13(7):1690.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Yuanyuan Zhang, M.D., Ph.D.

Yuanyuan Zhang, M.D., Ph.D.

Assistant Professor, Institute for Regenerative Medicine
Hypertension and Vascular Research Center

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