Profile

Yuanyuan Zhang, M.D., Ph.D.

Yuanyuan Zhang, M.D., Ph.D.

Assistant Professor, Institute for Regenerative Medicine

Contact Information

Academic: 336-713-1189 | Department: 336-716-2011

Email: yzhang@wakehealth.edu

Education & Training

  • M.D., , 1982
  • Ph.D., Univ Lausanne Faculty of Medicine-Switzerland , 2001
  • M.S., , 1989
  • Fellowship, Urology, Hospital-New Zealand, 1995
  • Fellowship, Pediatrics, Univ Lausanne Faculty of Medicine-Switzerland, 1997
Yuanyuan Zhang, M.D., Ph.D.

Yuanyuan Zhang, M.D., Ph.D.

Assistant Professor, Institute for Regenerative Medicine

Research Interests

cell growth, differentiation,d, congenital defects, growth & development

Contact Information

Academic: 336-713-1189 | Department: 336-716-2011

Email: yzhang@wakehealth.edu

Recent Publications


Orabi H, AbouShwareb T, Zhang Y, Yoo JJ, Atala A. Cell-seeded tubularized scaffolds for reconstruction of long urethral defects: a preclinical study. Eur Urol. 2013;63(3):531-538.

Lang R, Liu G, Shi Y, Bharadwaj S, Leng X, Zhou X, Liu H, Atala A, Zhang Y. Self-renewal and differentiation capacity of urine-derived stem cells after urine preservation for 24 hours. PLoS One. 2013;8(1):e53980.


Liu G, Pareta RA, Wu R, Shi Y, Zhou X, Liu H, Deng C, Sun X, Atala A, Opara EC, Zhang Y. Skeletal myogenic differentiation of urine-derived stem cells and angiogenesis using microbeads loaded with growth factors. Biomaterials. 2013;34(4):1311-1326.

Song L, Xie M, Zhang Y, Xu Y. Imaging techniques for the diagnosis of male traumatic urethral strictures. J Xray Sci Technol. 2013;21(1):111-123.

Wu R, Liu G, Bharadwaj S, Zhang Y. Isolation and myogenic differentiation of mesenchymal stem cells for urologic tissue engineering. Methods Mol Biol. 2013;1001():65-80.

Du F, Wang H, Zhao W, Li D, Kong D, Yang J, Zhang Y. Gradient nanofibrous chitosan/poly ?-caprolactone scaffolds as extracellular microenvironments for vascular tissue engineering. Biomaterials. 2012;33(3):762-770.

Shao Q, Ouyang J, Fan Y, Xie J, Zhou J, Wu J, Kader AK, Xu J, Liu G, Shan Y, Wen D, Zhang Y. Prostate cancer in the senior men from rural areas in east district of China: contemporary management and 5-year outcomes at multi-institutional collaboration. Cancer Lett. 2012;315(2):170-177.

Wang M, Liu F, Hsing AW, Wang X, Shao Q, Zhang Y, Jin G, Sun J, Zheng SL, Xu J, et al. Replication and cumulative effects of GWAS-identified genetic variations for prostate cancer in Asians: a case-control study in the ChinaPCa consortium. Carcinogenesis. 2012;33(2):356-360.

Gao Y, Xu M, Xu Z-F, Liu D-W, Tu X-A, Zheng Y-L, Wang D-H, Sun X-Z, Zheng F-F, Qiu S-P, Lu M-D, Zhang Y-Y, Xie X-Y, Deng C-H. Percutaneous ultrasound-guided radiofrequency ablation treatment and genetic testing for renal cell carcinoma with Von Hippel-Lindau disease. J Xray Sci Technol. 2012;20(1):121-129.



Skardal A, Smith L, Bharadwaj S, Atala A, Soker S, Zhang Y. Tissue specific synthetic ECM hydrogels for 3-D in vitro maintenance of hepatocyte function. Biomaterials. 2012;33(18):4565-4575.

Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN, Breuer C, Burnett L, Christ G, Farney A, Figliuzzi M, Holmes JH IV, Koch K, Macchiarini P, Mirmalek Sani S-H, Opara E, Remuzzi A, Rogers J, Saul JM, Seliktar D,. Regenerative medicine as applied to general surgery. Ann Surg. 2012;255(5):867-880.

Guan X, Shi Y, Markert CD, Mack DL, Jones TN, Moorefield EC, Zhang Y, Childers MK. Rapid generation of induced pluripotent stem cells (iPSCs) from the urine of a patient with Duchenne muscular dystrophy [abstract]. Mol Ther. 2012;20(Suppl 1):S111.

Fu W-J, Xu Y-D, Wang Z-X, Li G, Shi J-G, Cui F-Z, Zhang Y, Zhang X. New ureteral scaffold constructed with composite poly(L-lactic acid)-collagen and urothelial cells by new centrifugal seeding system. J Biomed Mater Res A. 2012;100(7):1725-1733.




Bharadwaj S, Liu GH, Wu S, Andersson K-E, Atala A, Zhang Y. Biological characterization of human urine-derived stem cells from the upper urinary tract for potential use in bladder regeneration in patients with end-stage bladder disease [abstract]. J Tissue Eng Regen Med. 2012;6(Suppl 1):132.

Shi YA, Liu GH, Bharadwaj S, Markert C, Atala A, Zhang Y. Urine derived stem cells with high telomerase activity: an optimized cell source for regenerative medicine in urology [abstract]. J Tissue Eng Regen Med. 2012;6(Suppl 1):132.

Zang Y, Xue B, Zhang Y, Yang D, Gao J, Sun C, Cui Y, Tao W, Chen D, Shan Y. Photoselective vaporization of the prostate with GreenLight HPS 120-W laser for benign prostatic hyperplasia: 36 months' follow-up. Urol Int. 2012;89(2):203-207.

Sun X, Su J, Bao J, Peng T, Zhang L, Zhang Y, Yang Y, Zhou X. Cytokine combination therapy prediction for bone remodeling in tissue engineering based on the intracellular signaling pathway. Biomaterials. 2012;33(33):8265-8276.

Dai WD, Gerczuk P, Zhang YY, Kay GL, Jyrala AJ, Kloner RA. Intramyocardial injection of heart tissue-derived extracellular matrix improves cardiac function in a rat myocardial infarction model [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):905.23.



Huang YP, Sun XZ, Liu GH, Yao FJ, Zheng FF, Dai YP, Tu XG, Xie XY, Deng LW, Zhang YY, et al. Glycosylated serum protein may improve our ability to predict endothelial and erectile dysfunction in nonorganic patients. J Sex Med. 2011;8(3):840-850.


Bharadwaj S, Liu G, Shi Y, Markert C, Andersson K-E, Atala A, Zhang Y. Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering. Tissue Eng Part A. 2011;17(15-16):2123-2132.

Lang R, Stern MM, Smith L, Bharadwaj S, Baptista PM, Bergman CR, Soker S, Yoo JJ, Atala A, Zhang Y, et al. Three-dimensional culture of hepatocytes on porcine liver tissue-derived extracellular matrix. Biomaterials. 2011;32(29):7042-7052.


Tu X, Zhuang J, Wang W, Zhao L, Zhao L, Zhao J, Deng C, Qiu S, Zhang Y. Screening and identification of a renal carcinoma specific peptide from a phage display peptide library. J Exp Clin Cancer Res. 2011;30():105.

Tian H, Bharadwaj S, Liu Y, Ma H, Ma PX, Atala A, Zhang Y. Myogenic differentiation of human bone marrow mesenchymal stem cells on a 3D nano fibrous scaffold for bladder tissue engineering. Biomaterials. 2010;31(5):870-877.

Markert CD, Bharadwaj S, Zhang Y, Childers MK, Furth ME. Immunofluorescence microscopy for imaging of nuclear p63 in human primary keratinocytes: a comparison of antibodies and fixation methods. J Immunol Methods. 2010;352(1-2):174-177.

Tian H, Bharadwaj S, Liu Y, Ma PX, Atala A, Zhang Y. Differentiation of human bone marrow mesenchymal stem cells into bladder cells: potential for urological tissue engineering. Tissue Eng Part A. 2010;16(5):1769-1779.

Bodin A, Bharadwaj S, Wu S, Gatenholm P, Atala A, Zhang Y. Tissue-engineered conduit using urine-derived stem cells seeded bacterial cellulose polymer in urinary reconstruction and diversion. Biomaterials. 2010;31(34):8889-8901.

Zhang Y, He Y, Bharadwaj S, Hammam N, Carnagey K, Myers R, Atala A, Van Dyke M. Tissue-specific extracellular matrix coatings for the promotion of cell proliferation and maintenance of cell phenotype. Biomaterials. 2009;30(23-24):4021-4028.

Liu Y, Bharadwaj S, Lee SJ, Atala A, Zhang Y. Optimization of a natural collagen scaffold to aid cell-matrix penetration for urologic tissue engineering. Biomaterials. 2009;30(23-24):3865-3873.

Orlando G, Mirmalek-Sani S-H, Baptista PM, Zhang Y, Atala A, Soker S. A rapid decellularization technique for organ storage and recellularization [abstract]. Transpl Int. 2009;22(Suppl 2):253.


Zhang YY, McNeill E, Soker S, Yoo JJ, Atala A. A novel cell source for urologic tissue reconstruction [abstract]. Tissue Eng Part A. 2008;14(5):697.

Zhang Y, McNeill E, Tian H, Soker S, Andersson K-E, Yoo JJ, Atala A. Urine derived cells are a potential source for urological tissue reconstruction. J Urol. 2008;180(5):2226-2233.

Egydio F, Moore P, Zhang Y, Atala A, Yoo JJ. Erythropoietin producing cells for the treatment of renal failure induced anemia [abstract]. Tissue Eng. 2007;13(7):1690.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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