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Yuanyuan Zhang, M.D., Ph.D.Wake Forest School of Medicine

Yuanyuan Zhang, M.D., Ph.D.

Assistant Professor,


Contact Information

Academic: 336-713-1189 | Department: 336-713-1493

Email: yzhang@wakehealth.edu

Education & Training

  • M.D., China-Jiangxi Medical College, 1982
  • M.S., China-Jiangxi Medical College, 1989
  • Ph.D., Univ Lausanne Faculty of Medicine-Switzerland, 2001
  • Fellowship, Urology, Hospital-New Zealand, 1995
  • Fellowship, Pediatrics, Univ Lausanne Faculty of Medic, 1997
Yuanyuan Zhang, M.D., Ph.D.

Yuanyuan Zhang, M.D., Ph.D.

Assistant Professor, Institute for Regenerative Medicine
Hypertension and Vascular Research Center
Center on Diabetes, Obesity, and Metabolism

Research Interests

Accident Prevention; Automobile Driving; Attention; Synaptophysin; GAP-43 Protein
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Contact Information

Academic: 336-713-1189 | Department: 336-713-1493

Email: yzhang@wakehealth.edu

Recent Publications

Skeletal myogenic differentiation of human urine-derived cells as a potential source for skeletal muscle regeneration. Chen W, Xie M, Yang B, Bharadwaj S, Song L, Liu G, Yi S, Ye G, Atala A, Zhang Y.. J Tissue Eng Regen Med. 2017;11(2):334-341.

Co-expression of Piwil2/Piwil4 in nucleus indicates poor prognosis of hepatocellular carcinoma. Zeng G, Zhang D, Liu X, Kang Q, Fu Y, Tang B, Guo W, Zhang Y, Wei G, He D.. Oncotarget. 2017;8(3):4607-4617.

Characterization of sodium dodecyl sulfate decellularized cow diaphragmatic tendon extracellular matrix as sling biomaterial in stress urinary incontinence treatment. Xue L, Zhang X, Niu GG, Yang B, Zhang YY.. J Biomater Tissue Eng. 2017;7(1):83-89.

Human neural progenitors derived from integration-free iPSCs for SCI therapy. Liu Y, Zheng Y, Li S, Xue H, Schmitt K, Hergenroeder GW, Wu J, Zhang Y, Kim DH, Cao Q.. Stem Cell Res. 2017;19():55-64.

Piwil2-transfected human fibroblasts are cancer stem cell-like and genetically unstable. Zhang D, Wu X, Liu X, Cai C, Zeng G, Rohozinski J, Zhang Y, Wei G, He D.. Oncotarget. 2017;8(7):12259-71.

Bilateral duplex urinary collecting systems accompanied with horseshoe kidneys deformity and right renal ureteral calculi and hydronephrosis: diagnosis in magnetic resonance urography. Yu Y, Li J, Guo L, Gu T, Xiao R, Ye Y, Pan Q, Zhang Y, Huang H.. J Xray Sci Technol. 2017;():.

Urethral reconstruction with autologous urine-derived stem cells seeded in three-dimensional porous small intestinal submucosa in a rabbit model. Liu Y, Ma W, Liu B, Wang Y, Chu J, Xiong G, Shen L, Long C, Lin T, He D, Butnaru D, Alexey L, Zhang Y, Zhang D, Wei G.. Stem Cell Res Ther. 2017;8(1):63.

Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model. Li J, Luo H, Dong X, Liu Q, Wu C, Zhang T, Hu X, Zhang Y, Song B, Li L.. Stem Cell Res Ther. 2017;8(1):107.

Subinguinal microsurgical varicocelectomy with intraoperative microvascular Doppler ultrasound leads to the pain-free outcome after surgery. Lv KL, Zhang YD, Zhuang JT, Gao Y, Zhao L, Wan Z, Zhou MK, Yu JW, Sun XZ, Zhang YY, Tu XA.. J Xray Sci Technol. 2017;():.

Benign mixed epithelial and stromal tumor of the kidney with inferior vena cava tumor thrombus: a rare case report and review of literature. Zhang C, Li X, Mo C, Peng Z, Yang R, Tang Y, Zhang Y, Wu R.. J Xray Sci Technol. 2017;():.

Tissue-specific extracellular matrix enhances skeletal muscle precursor cell expansion and differentiation for potential application in cell therapy. Zhang D, Zhang Y, Zhang Y, Yi H, Wang Z, Wu R, He D, Wei G, Wei S, Hu Y, Deng J, Criswell T, Yoo JJ, Zhou Y, Atala A.. Tissue Eng Part A. 2017;23(15-16):784-794.

Human umbilical cord-derived mesenchymal stem cells conditioned medium attenuate interstitial fibrosis and stimulate the repair of tubular epithelial cells in an irreversible model of unilateral ureteral obstruction. Liu B, Ding FX, Liu Y, Xiong G, Lin T, He DW, Zhang YY, Zhang DY, Wei GH.. Nephrology (Carlton). 2017;():.

Circular RNAs: a novel type of biomarker and genetic tools in cancer. Han YN, Xia SQ, Zhang YY, Zheng JH, Li W.. Oncotarget. 2017;8(38):64551-563.

Minimally invasive surgery combined with regenerative biomaterials in treating intra-bony defects: a meta-analysis. Liu S, Hu B, Zhang Y, Li W, Song J.. PLoS One. 2016;11(1):e0147001.

Beneficial effects of urine-derived stem cells on fibrosis and apoptosis of myocardial, glomerular and bladder cells. Dong X, Zhang T, Liu Q, Zhu J, Zhao J, Li J, Sun B, Ding G, Hu X, Yang Z, Zhang Y, Li L.. Mol Cell Endocrinol. 2016;427():21-32.

Strategies to optimize adult stem cell therapy for tissue regeneration. Liu S, Zhou J, Zhang X, Liu Y, Chen J, Hu B, Song J, Zhang Y.. Int J Mol Sci. 2016;17(6):E982.

Diagnosis value of multi-slice spiral CT in renal trauma. Wang X, Zhang Z, Fu S, Fan J, Zhang Y.. J Xray Sci Technol. 2016;24(5):649-655.

Evaluation of a large adrenal carcinoma with 3D reconstruction of computed tomography images: a case report and literature review. Chen L, Zeng X, Li S, Gong C, Peng E, Wu B, Zhang W, Zhang Y.. J Xray Sci Technol. 2016;24(5):665-671.

3D reconstruction images of cone beam computed tomography in dental medicine application: a case study and mini-review. Li Y, Sun J, Zhang Y, Li W, Hu B, Song J.. J Xray Sci Technol. 2016;24(5):673-680.

Incidence and risk of hypertension associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors in cancer patients: a comprehensive network meta-analysis of 72 randomized controlled trials involving 30013 patients. Liu B, Ding F, Liu Y, Xiong G, Lin T, He D, Zhang Y, Zhang D, Wei G.. Oncotarget. 2016;7(41):67661-73.

Urine-derived stem cells: a novel source for tissue engineering and regenerative medicine. Liu B, Ding FX, Liu Y, Xiong G, Lin T, He DW, Zhang YY, Zhang DY, Wei GH.. J Biomater Tissue Eng. 2016;6(8):589-601.

3D reconstruction computed tomography scan in diagnosis of bilateral wilm's tumor with its embolus in right atrium. Zhang D, Zeng G, Zhang Y, Liu X, Wu S, Hua Y, Liu F, Lu P, Feng C, Qin B, Cai J, Zhang Y, He D, Lin T, Wei G.. J Xray Sci Technol. 2016;24(5):657-660.

Intraglomerular crosstalk elaborately regulates podocyte injury and repair in diabetic patients: insights from a 3D multiscale modeling study. Tan H, Yi H, Zhao W, Ma JX, Zhang Y, Zhou X.. Oncotarget. 2016;7(45):73130-46.

Transplantation of human urine-derived stem cells transfected with pigment epithelium-derived factor to protect erectile function in a rat model of cavernous nerve injury. Yang Q, Chen X, Zheng T, Han D, Zhang H, Shi Y, Bian J, Sun X, Xia K, Liang X, Liu G, Zhang Y, Deng C.. Cell Transplant. 2016;25(11):1987-2001.

Hypoxia preconditioning enhances reparative function of urine derived stem cells from patients with diabetic nephropathy [abstract]. Xiong G, Zhang Y.. Tissue Eng Part A. 2016;22(Suppl 1):S107-S108.

Improvement of penile histomorphological structure and function with stem cell in a rat model of neurovascular erectile dysfunction [abstract]. Zhong L, Zhang Y, Jackson J, Atala A.. Tissue Eng Part A. 2016;22(Suppl 1):S76.

Optimization of skeletal myocytes expansion for potential application in cell therapy for urinary incontinence [abstract]. Long T, Yi H, Zhang D, Zhang Y, Hu Y, Wang Z, Yoo J, Atala A, Zhang Y.. Tissue Eng Part A. 2016;22(Suppl 1):S92.

Progenitor cells from urine and methods for using the same. Atala A, Zhang Y, inventors; Wake Forest University Health Sciences, assignee.. Japan patent JP 5996841. 2016 Sep 2; South Korea patent SKR 1722033. 2017 Mar 27. 2016;():.

Virus integration and genome influence in approaches to stem cell based therapy for andro-urology. Li L, Zhang D, Li P, Damaser M, Zhang Y.. Adv Drug Deliv Rev. 2015;82-83():12-21.

Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in rodent models. Li M, Tang Z, Zhang D, Sun H, Liu H, Zhang Y, Zhang Y, Chen X.. Biomaterials. 2015;51():161-172.

Evaluation of transforming growth factor-beta1 suppress Pokemon/epithelial-mesenchymal transition expression in human bladder cancer cells. Li W, Kidiyoor A, Hu Y, Guo C, Liu M, Yao X, Zhang Y, Peng B, Zheng J.. Tumour Biol. 2015;36(2):1155-1162.

Biochemical hormone parameters in seminal and blood plasma samples correlate with histopathologic properties of testicular biopsy in azoospermic patients. Lei B, Lv D, Zhou X, Zhang S, Shu F, Ding Y, Zhang Y, Mao X.. Urology. 2015;85(5):1074-1078.

TrAmplification of human dental follicle cells by piggyBac transposon - mediated reversible immortalization system. Wu Y, Feng G, Song J, Zhang Y, Yu Y, Huang L, Zheng L, Deng F.. PLoS One. 2015;10(7):e0130937.

Improving the osteogenic efficacy of BMP2 with mechano growth factor by regulating the signaling events in BMP pathway. Deng MY, Liu P, Xiao HL, Zhang YY, Wang YL, Zhao JH, Xu JZ.. Cell Tissue Res. 2015;361(3):723-731.

Tailored minimally invasive management of complex calculi in horseshoe kidney. Ding J, Zhang Y, Cao Q, Huang T, Xu W, Huang K, Fang J, Bai Q, Qi J, Huang Y.. J Xray Sci Technol. 2015;23(5):601-610.

Characterization of rabbit urine-derived stem cells for potential application in urethral tissue regeneration [abstract]. Jiang Y, Chen B, Liu G, Deng C, Zhang Y.. Tissue Eng Part A. 2015;21(Suppl 1):S208.

Skeletal myogenic differentiation of urine-derived stem cells using hydrogel loaded with growth factors for potential treatment of urinary incontinence [abstract]. Jiang Y, Yi H, Liu G, Atala A, Opara EC, Zhang Y.. Tissue Eng Part A. 2015;21(Suppl 1):S248.

Mir-646 in clear cell renal carcinoma correlated with tumour metastasis by targeting the nin one binding protein [abstract]. Li W, Yi H, Zhang X, Zhang Y, Zheng J.. Tissue Eng Part A. 2015;21(Suppl 1):S174.

Paracrine effects of human urine-derived stem cells in treatment of female stress urinary incontinence in a rodent model [abstract]. Tran CN, Tangada A, Balog B, Zhang Y, Damaser M.. Tissue Eng Part A. 2015;21(Suppl 1):S385.

Restoration of penile erectile function using stem cells in a rat model of neurovascular erectile dysfunction [abstract]. Shi H, Li W, Zhang Y, Clouse C, Sink S, George S, Lue T, Yoo J, Atala A, Jackson J.. Tissue Eng Part A. 2015;21(Suppl 1):S34-S35.

Three-dimensional quantification of orthodontic root resorption with time-lapsed imaging of micro-computed tomography in a rodent model. Yang C, Zhang Y, Zhang Y, Fan Y, Deng F.. J Xray Sci Technol. 2015;23(5):617-626.

Skeletal myogenic differentiation of human urine-derived cells as a potential source of cell therapy for urethral sphincter muscle dysfunction [abstract]. Yi H, Chen W, M X, Yang B, S B, Song L, Liu G, Atala A, Zhang Y.. Tissue Eng Part A. 2015;21(Suppl 1):S76.

Bio-functionalized alginate hydrogels for improved cell-matrix interactions and growth factor sequestration kinetics [abstract]. Yi H, Forsythe S, Zhang Y, Skardal A.. Tissue Eng Part A. 2015;21(Suppl 1):S187.

Comparison of the after discharges induced by electrical stimulation of the prefrontal cortex in urethane- and ketamine-anesthetized mice. Chen XL, Kong LZ, Liu XP, Xiong CL, Zhang YY, Yan J, Jiang L.. Eur Rev Med Pharmacol Sci. 2015;19(20):3865-3872.

Challenge in preoperative diagnosis of retroperitoneal mucinous cyst in a pediatric patient. Zhang D, Zhang Y, Liu X, Zhu J, Feng C, Yang C, Wu S, Liu J, Hua Y, Liu F, Zhang N, Zhang Y, He D, Lin T, Wei G.. Int J Clin Exp Med. 2015;8(10):19540-7.

Comparison of decellularization protocols for preparing a decellularized porcine annulus fibrosus scaffold. Xu H, Xu B, Yang Q, Li X, Ma X, Xia Q, Zhang Y, Zhang C, Wu Y, Zhang Y.. PLoS One. 2014;9(1):e86723.

Role of insulin-transferrin-selenium in auricular chondrocyte proliferation and engineered cartilage formation in vitro. Liu X, Liu J, Kang N, Yan L, Wang Q, Fu X, Zhang Y, Xiao R, Cao Y.. Int J Mol Sci. 2014;15(1):1525-1537.

Comparison of ESWL and ureteroscopic holmium laser lithotripsy in management of ureteral stones. Cui Y, Cao W, Shen H, Xie J, Adams TS, Zhang Y, Shao Q.. PLoS One. 2014;9(2):e87634.

Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery of doxorubicin. Li M, Tang Z, Lv S, Song W, Hong H, Jing X, Zhang Y, Chen X.. Biomaterials. 2014;35(12):3851-3864.

Bladder acellular matrix and its application in bladder augmentation. Song L, Murphy SV, Yang B, Xu Y, Zhang Y, Atala A.. Tissue Eng Part B Rev. 2014;20(2):163-172.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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