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Weiling ZhaoWake Forest School of Medicine

Weiling Zhao

Assistant Professor,

Contact Information

Academic: 336-713-1506 | Department: 336-716-2011


Education & Training

  • M.S., University of Iowa College of Medicine, 1998
  • Ph.D., University of Iowa College of Medicine, 2000
Weiling Zhao

Weiling Zhao

Assistant Professor, Radiology

Research Interests

Radiation Injuries; MAP Kinase Signaling System; Oxidative Stress; Cranial Irradiation; Microglia
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Contact Information

Academic: 336-713-1506 | Department: 336-716-2011


Recent Publications

Predicting the impact of combined therapies on myeloma cell growth using a hybrid multi-scale agent-based model. Ji Z, Su J, Wu D, Peng H, Zhao W, Nlong Zhao B, Zhou X.. Oncotarget. 2017;8(5):7647-7665.

Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method. Liu K, Beck D, Thoms JAI, Liu L, Zhao W, Pimanda JE, Zhou X.. Bioinformatics. 2017;():.

Computational systems biology in cancer brain metastasis. Peng H, Tan H, Zhao W, Jin G, Sharma S, Xing F, Watabe K, Zhou X.. Front Biosci (Schol Ed). 2016;8():169-186.

Modeling co-occupancy of transcription factors using chromatin features. Liu L, Zhao W, Zhou X.. Nucleic Acids Res. 2016;44(5):e49.

Prediction of treatment efficacy for prostate cancer using a mathematical model. Peng H, Zhao W, Tan H, Ji Z, Li J, Li K, Zhou X.. Sci Rep. 2016;12(6):21599.

Immune signaling-based Cascade Propagation approach re-stratifies HNSCC patients. Liu K, Chyr J, Zhao W, Zhou X.. Methods. 2016;111():72-79.

Identification of biomarkers for pseudo and true progression of GBM based on radiogenomics study. Qian X, Tan H, Zhang J, Liu K, Yang T, Wang M, Debinskie W, Zhao W, Chan MD, Zhou X.. Oncotarget. 2016;7(34):55377-94.

Integration of genomic data analysis for demonstrating potential targets in the subgroup populations of squamous cell lung cancer patients. Wang Y, Zhao W, Zhou X.. Oncotarget. 2016;():.

The role of SH3GL3 in myeloma cell migration/invasion, stemness and chemo-resistance. Chen R, Zhao H, Wu D, Zhao C, Zhao W, Zhou X.. Oncotarget. 2016;7(45):73101-13.

Intraglomerular crosstalk elaborately regulates podocyte injury and repair in diabetic patients: insights from a 3D multiscale modeling study. Tan H, Yi H, Zhao W, Ma JX, Zhang Y, Zhou X.. Oncotarget. 2016;7(45):73130-46.

Matrix factorization reveals aging-specific co-expression gene modules in the fat and muscle tissues in nonhuman primates. Wang Y, Zhao W, Zhou X.. Sci Rep. 2016;6():34335.

CD138-negative myeloma cells regulate mechanical properties of bone marrow stromal cells through SDF-1/CXCR4/AKT signaling pathway. Wu D, Guo X, Su J, Chen R, Berenzon D, Guthold M, Bonin K, Zhao W, Zhou X.. Biochim Biophys Acta. 2015;1853(2):338-347.

Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors. Chen X, Liu L, Mims J, Punska EC, Williams KE, Zhao W, Arcaro KF, Tsang AW, Zhou X, Furdui CM.. Epigenetics. 2015;10(6):545-561.

Systemic modeling myeloma-osteoclast interactions under normoxic/hypoxic condition using a novel computational approach. Ji Z, Wu D, Zhao W, Peng H, Zhao S, Huang D, Zhou X.. Sci Rep. 2015;5():13291.

Objective classification system for sagittal craniosynostosis based on suture segmentation. Qian X, Tan H, Zhang J, Zhuang X, Branch L, Sanger C, Thompson A, Zhao W, Li KC, David L, Zhou X.. Med Phys. 2015;42(9):5545.

CD138-negative myeloma cells regulate mechanical properties of bone marrow stromal cells through SDF-1/CXCR4/AKT signaling pathway [abstract]. Wu D, Guo XY, Su J, Chen RY, Berenzon D, Bonin K, Guthold M, Zhao WL, Zhou XB.. Clin Cancer Res. 2015;21(17 Suppl):A09.

Increased expression of MuRF1 is associated with radiation-induced laryngeal muscle atrophy. Han X, Pires L, Browne JD, Sullivan CA, Zhao W, Feng X.. Anticancer Res. 2015;35(11):6049-6056.

Enhanced expression of galectin-3 is associated with the alternative activation of macrophages and development oflung fibrosis following radiation [abstract]. Zhao WL, Zhang JH, Lopes IJ.. Cancer Res. 2015;75(15 Suppl):3308.

The peroxisomal proliferator-activated receptor (PPAR) alpha agonist, fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment. Greene-Schloesser D, Payne V, Peiffer AM, Hsu FC, Riddle DR, Zhao W, Chan MD, Metheny-Barlow L, Robbins ME [deceased].. Radiat Res. 2014;181(1):33-44.

The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. Files DC, Xiao K, Zhang T, Liu C, Qian J, Zhao W, Morris PE, Delbono O, Feng X.. PLoS One. 2014;9(1):e87587.

Strained cycloalkynes as new protein sulfenic acid traps. Poole TH, Reisz JA, Zhao W, Poole LB, Furdui CM, King SB.. J Am Chem Soc. 2014;136(17):6167-6170.

Effects of ionizing radiation on biological molecules-mechanisms of damage and emerging methods of detection. Reisz JA, Bansal N, Qian J, Zhao W, Furdui CM.. Antioxid Redox Signal. 2014;21(2):260-292.

Broad phenotypic changes associated with gain of radiation resistance in head and neck squamous cell cancer. Bansal N, Mims J, Kuremsky JG, Olex AL, Zhao W, Yin L, Wani R, Qian J, Center B, Marrs GS, Porosnicu M, Fetrow JS, Tsang AW, Furdui CM.. Antioxid Redox Signal. 2014;21(2):221-236.

The role of alveolar epithelium in radiation-induced lung injury. Almeida C, Nagarajan D, Tian J, Leal SW, Wheeler K, Munley M, Blackstock W, Zhao W.. PLoS One. 2013;8(1):e53628.

ERK/GSK3beta/Snail signaling mediates radiation-induced alveolar epithelial-to-mesenchymal transition. Nagarajan D, Melo T, Deng Z, Almeida C, Zhao W.. Free Radic Biol Med. 2012;52(6):983-992.

Radiation-induced c-Jun activation depends on MEK1-ERK1/2 signaling pathway in microglial cells. Deng Z, Sui G, Rosa PM, Zhao W.. PLoS ONE. 2012;7(5):e36739.

Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment. Lee TC, Greene-Schloesser D, Payne V, Diz DI, Hsu F-C, Kooshki M, Mustafa R, Riddle DR, Zhao W, Chan MD, Robbins ME.. Radiat Res. 2012;178(1):46-56.

Expression of genes involved in mouse lung cell differentiation/regulation after acute exposure to photons and protons with or without low-dose preirradiation. Tian J, Zhao W, Tian S, Slater JM, Deng Z, Gridley DS.. Radiat Res. 2011;176(5):553-564.

Role of PPARs in radiation-induced brain injury. Ramanan S, Zhao W, Riddle DR, Robbins ME.. PPAR Res. 2010;2010():art.234975.

Renin-angiotensin system blockers and modulation of radiation-induced brain injury. Robbins ME, Zhao W, Garcia-Espinosa MA Diz DI.. Curr Drug Targets. 2010;11(11):1413-1422.

A7 nicotinic receptor agonist enhances neurogenesis and reduces brain inflammation after lipopolysaccharide (LPS) or radiation treatment [abstract]. Zhao W, Toler SM, Lippiello PM, Bencherif M.. Eur Neuropsychopharmacol. 2010;20(Suppl 3):S242.

The AT1 receptor antagonist, L-158,809, prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment. Robbins ME, Payne V, Tommasi E, Diz DI, Hsu F-C, Brown WR, Wheeler KT, Olson J, Zhao W.. Int J Radiat Oncol Biol Phys. 2009;73(2):499-505.

Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications. Zhao W, Robbins ME.. Curr Med Chem. 2009;16(2):130-143.

The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation. Ramanan S, Kooshki M, Zhao W, Hsu F-C, Riddle DR, Robbins ME.. Int J Radiat Oncol Biol Phys. 2009;75(3):870-877.

NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells. Collins-Underwood JR, Zhao W, Sharpe JG, Robbins ME.. Free Radic Biol Med. 2008;45(6):929-938.

Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H2O2. Smith-Pearson PS, Kooshki M, Spitz DR, Poole LB, Zhao W, Robbins ME.. Free Radic Biol Med. 2008;45(8):1178-1189.

PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways. Ramanan S, Kooshki M, Zhao W, Hsu F-C, Robbins ME.. Free Radic Biol Med. 2008;45(12):1695-1704.

Chronic inhibition of the renin-angiotensin system prevents radiation-induced cognitive impairment in the adult male rat [abstract]. Robbins M, Payne V, Diz D, Hsu FC, Zhao WL.. Neuro Oncol. 2008;10(5):851.

Administration of the peroxisomal proliferator-activated receptor gamma agonist pioglitazone during fractionated brain irradiation prevents radiation-induced cognitive impairment. Zhao W, Payne V, Tommasi E, Diz DI, Hsu F-C, Robbins ME.. Int J Radiat Oncol Biol Phys. 2007;67(1):6-9.

Inhibiting catalase activity sensitizes 36B10 rat glioma cells to oxidative stress. Smith PS, Zhao W, Spitz DR, Robbins ME.. Free Radic Biol Med. 2007;42(6):787-797.

Knocking out peroxisome proliferator-activated receptor (PPAR) alpha inhibits radiation-induced apoptosis in the mouse kidney through activation of NF-kappaB and increased expression of IAPs. Zhao W, Iskandar S, Kooshki M, Sharpe JG, Payne V, Robbins ME.. Radiat Res. 2007;167(5):581-591.

Oxidative damage pathways in relation to normal tissue injury. Zhao W, Diz DI, Robbins ME.. Br J Radiol. 2007;80(Special Issue 1):S23-S31.

Quantitative magnetic resonance spectroscopy reveals a potential relationship between radiation-induced changes in rat brain metabolites and cognitive impairment. Atwood T, Payne VS, Zhao W, Brown WR, Wheeler KT, Zhu J-M, Robbins ME.. Radiat Res. 2007;168(5):574-581.

Fatty acid synthase: a novel target for antiglioma therapy. Zhao W, Kridel S, Thorburn A, Kooshki M, Little J, Hebbar S, Robbins M.. Br J Cancer. 2006;95(7):869-878.

Role of NADPH oxidase in radiation-induced oxidative stress and inflammation in brain endothelium [abstract]. Collins-Underwood JR, Zhao W, Kooshki M, Robbins M.. Free Radic Res. 2006;40(Suppl 1):S52.

Knocking down catalase increases sensitivity of gliomas to oxidative stress [abstract]. Smith PS, Zhao W, Robbins M.. Free Radic Res. 2006;40(Suppl 1):S70.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Radiology

Weiling Zhao

Weiling Zhao

Assistant Professor, Radiology

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