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Xiaobo Zhou, Ph.D.Wake Forest School of Medicine

Xiaobo Zhou, Ph.D.

Ctr for Vaccines at Extremes

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Academic: 336-716-2465 | Department: 336-716-2011


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Education & Training

  • M.S., Peking University, 1995
  • Ph.D., Peking University, 1998


  • Spie Intl Soc For Optical Engi
  • Inst of Electrical & Electroni
Xiaobo Zhou, Ph.D.

Xiaobo Zhou, Ph.D.

Professor, Radiology
Ctr for Vaccines at Extremes
Cancer Biology

Research Interests

Models, Biological; Multiple Myeloma; Systems Biology; Neoplasm Proteins; Signal Transduction
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Academic: 336-716-2465 | Department: 336-716-2011


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Recent Publications

Predicting the impact of combined therapies on myeloma cell growth using a hybrid multi-scale agent-based model. Ji Z, Su J, Wu D, Peng H, Zhao W, Nlong Zhao B, Zhou X.. Oncotarget. 2017;8(5):7647-7665.

Hidden Markov models in bioinformatics: SNV inference from next generation sequence. Bian J, Zhou X.. Methods Mol Biol. 2017;1552():123-133.

Circulating MiRNAs as biomarkers of gait speed responses to aerobic exercise training in obese older adults. Zhang T, Brinkley TE, Liu K, Feng X, Marsh AP, Kritchevsky S, Zhou X, Nicklas BJ.. Aging (Albany NY). 2017;9(3):900-913.

Reconstruction-based digital dental occlusion of the partially edentulous dentition. Zhang J, Xia JJ, Li J, Zhou X.. IEEE J Biomed Health Inform. 2017;21(1):201-210.

RPI-Bind: a structure-based method for accurate identification of RNA-protein binding sites. Luo J, Liu L, Venkateswaran S, Song Q, Zhou X.. Sci Rep. 2017;7(1):614.

Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method. Liu K, Beck D, Thoms JAI, Liu L, Zhao W, Pimanda JE, Zhou X.. Bioinformatics. 2017;():.

A clinically validated simulation method for facial soft tissue change prediction following double-jaw orthognathic surgery. Kim D, Ho DC, Mai H, Zhang X, Shen SGF, Shen S, Yuan P, Liu S, Zhang G, Zhou X, Gateno J, Liebschner MAK, Xia JJ.. Med Phys. 2017;():.

An eFace-template method for efficiently generating patient-specific anatomically-detailed facial soft tissue FE models for craniomaxillofacial surgery simulation. Zhang X, Tang Z, Liebschner MA, Kim D, Shen S, Chang CM, Yuan P, Zhang G, Gateno J, Zhou X, Zhang SX, Xia JJ.. Ann Biomed Eng. 2016;44(5):1656-1671.

Computational systems biology in cancer brain metastasis. Peng H, Tan H, Zhao W, Jin G, Sharma S, Xing F, Watabe K, Zhou X.. Front Biosci (Schol Ed). 2016;8():169-186.

Non-coding RNAs in cancer brain metastasis. Wu K, Sharma S, Venkat S, Liu K, Zhou X, Watabe K.. Front Biosci (Schol Ed). 2016;8():187-202.

Modeling co-occupancy of transcription factors using chromatin features. Liu L, Zhao W, Zhou X.. Nucleic Acids Res. 2016;44(5):e49.

A systematic approach to predicting the risk of unicompartmental knee arthroplasty revision. Zhang G, Smith BP, Plate JF, Casanova R, Hsu FC, Li J, Xia L, Li KC, Poehling GG, Zhou X.. Osteoarthritis Cartilage. 2016;24(6):991-999.

Multiscale modeling in the clinic: drug design and development. Clancy CE, An G, Cannon WR, Liu Y, May EE, Ortoleva P, Popel AS, Sluka JP, Su J, Vicini P, Zhou X, Eckmann DM.. Ann Biomed Eng. 2016;44(9):2591-2610.

Prediction of treatment efficacy for prostate cancer using a mathematical model. Peng H, Zhao W, Tan H, Ji Z, Li J, Li K, Zhou X.. Sci Rep. 2016;12(6):21599.

Pseudo progression identification of glioblastoma with dictionary learning. Zhang J, Yu H, Qian X, Liu K, Tan H, Yang T, Wang M, Li KC, Chan MD, Debinski W, Paulsson A, Wang G, Zhou X.. Comput Biol Med. 2016;73():94-101.

Immunogenic subtypes of breast cancer delineated by gene classifiers of immune responsiveness. Miller LD, Chou JA, Black MA, Print C, Chifman J, Alistar A, Putti T, Zhou X, Bedognetti D, Hendrickx W, Pullikuth A, Rennhack J, Andrechek ER, Demaria S, Wang E, Marincola FM.. Cancer Immunol Res. 2016;4(7):600-610.

A systematic approach to predicting spring force for sagittal craniosynostosis surgery. Zhang G, Tan H, Qian X, Zhang J, Li K, David LR, Zhou X.. J Craniofac Surg. 2016;27(3):636-643.

Immune signaling-based Cascade Propagation approach re-stratifies HNSCC patients. Liu K, Chyr J, Zhao W, Zhou X.. Methods. 2016;111():72-79.

Prediction of soft tissue deformations after CMF surgery with incremental kernel ridge regression. Pan B, Zhang G, Xia JJ, Yuan P, Ip HH, He Q, Lee PK, Chow B, Zhou X.. Comput Biol Med. 2016;75():1-9.

Identification of biomarkers for pseudo and true progression of GBM based on radiogenomics study. Qian X, Tan H, Zhang J, Liu K, Yang T, Wang M, Debinskie W, Zhao W, Chan MD, Zhou X.. Oncotarget. 2016;7(34):55377-94.

Multi-scale modeling in clinical oncology: opportunities and barriers to success. Yankeelov TE, An G, Saut O, Luebeck EG, Popel AS, Ribba B, Vicini P, Zhou X, Weis JA, Ye K, Genin GM.. Ann Biomed Eng. 2016;44(9):2626-2641.

Activation of the c-Met pathway mobilizes an inflammatory network in the brain microenvironment to promote brain metastasis of breast cancer. Xing F, Liu Y, Sharma S, Wu K, Chan MD, Lo HW, Carpenter RL, Metheny-Barlow LJ, Zhou X, Qasem SA, Pasche B, Watabe K.. Cancer Res. 2016;76(17):4970-4980.

Integration of genomic data analysis for demonstrating potential targets in the subgroup populations of squamous cell lung cancer patients. Wang Y, Zhao W, Zhou X.. Oncotarget. 2016;():.

Integrative analysis of LINCRNA expression in 922 acute myeloid leukemia patients reveals multiple prognostic gene signatures [abstract]. Beck D, Thoms J, Palu C, Herold T, Shah A, Olivier J, Boelen L, Huang Y, Chacon D, Brown A, Babic M, Hahn C, Perugini M, Zhou X, Huntly B, Lewis I, D'Andrea R, Wong J, Pimanda J.. Haematologica. 2016;101(Suppl 1):208-209.

The role of SH3GL3 in myeloma cell migration/invasion, stemness and chemo-resistance. Chen R, Zhao H, Wu D, Zhao C, Zhao W, Zhou X.. Oncotarget. 2016;7(45):73101-13.

Brain metastasis velocity: a novel prognostic metric predictive of overall survival and freedom from whole-brain radiation therapy after upfront radiosurgery alone for brain metastases [abstract]. Farris M, McTyre E, Hughes RT, Ayala-Peacock DN, Randolph DM II, Bourland JD, Tatter SB, Laxton AW, Watabe K, Ruiz J, Li W, Zhou X, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):S180.

Intraglomerular crosstalk elaborately regulates podocyte injury and repair in diabetic patients: insights from a 3D multiscale modeling study. Tan H, Yi H, Zhao W, Ma JX, Zhang Y, Zhou X.. Oncotarget. 2016;7(45):73130-46.

Matrix factorization reveals aging-specific co-expression gene modules in the fat and muscle tissues in nonhuman primates. Wang Y, Zhao W, Zhou X.. Sci Rep. 2016;6():34335.

Investigation of mechanism of bone regeneration in a porous biodegradable calcium phosphate (CaP) scaffold by a combination of a multi-scale agent-based model and experimental optimization/validation. Zhang L, Qiao M, Gao H, Hu B, Tan H, Zhou X, Li CM.. Nanoscale. 2016;8(31):14877-87.

Improved Rubin-Bodner model for the prediction of soft tissue deformations. Zhang G, Xia JJ, Liebschner M, Zhang X, Kim D, Zhou X.. Med Eng Phys. 2016;38(11):1369-1375.

Stratification of pseudoprogression and true progression of glioblastoma multiform based on longitudinal diffusion tensor imaging without segmentation. Qian X, Tan H, Zhang J, Zhao W, Chan MD, Zhou X.. Med Phys. 2016;43(11):5889.

CD138-negative myeloma cells regulate mechanical properties of bone marrow stromal cells through SDF-1/CXCR4/AKT signaling pathway. Wu D, Guo X, Su J, Chen R, Berenzon D, Guthold M, Bonin K, Zhao W, Zhou X.. Biochim Biophys Acta. 2015;1853(2):338-347.

SDF-1 alpha stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II. Choi DS, Stark DJ, Raphael RM, Wen J, Su J, Zhou X, Chang CC, Zu Y.. Int J Cancer. 2015;136(5):E219-E229.

RPI-Pred: predicting ncRNA-protein interaction using sequence and structural information. Suresh V, Liu L, Adjeroh D, Zhou X.. Nucleic Acids Res. 2015;43(3):1370-1379.

Roles of the cyclooxygenase 2-matrix metalloproteinase 1 pathway in brain metastasis of breast cancer. Wu K, Fukuda K, Xing F, Zhang Y, Sharma S, Liu Y, Chan M, Zhou X, Qasem S, Pochampally R, Mo YY, Watabe K.. J Biol Chem. 2015;290(15):9842-9854.

Multi-scale modeling for the transmission of influenza and the evaluation of interventions toward it. Guo D, Li KC, Peters TR, Snively BM, Poehling KA, Zhou X.. Sci Rep. 2015;5():8980.

Modeling the relationship of epigenetic modifications to transcription factor binding. Liu L, Jin G, Zhou X.. Nucleic Acids Res. 2015;43(8):3873-3885.

Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors. Chen X, Liu L, Mims J, Punska EC, Williams KE, Zhao W, Arcaro KF, Tsang AW, Zhou X, Furdui CM.. Epigenetics. 2015;10(6):545-561.

Call for the development of a three-dimensional printing algorithm specific to echocardiography: an initial study with an in vitro validation [abstract]. Pu M, Cheng JW, Zhang J, Cheng P, Zhou X.. J Am Soc Echocardiogr. 2015;28(6):B123-B124.

Mutated genes and driver pathways involved in myelodysplastic syndromes-a transcriptome sequencing based approach. Liu L, Wang H, Wen J, Tseng CE, Zu Y, Chang CC, Zhou X.. Mol Biosyst. 2015;11(8):2158-2166.

Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity. Tan H, Bao J, Zhou X.. Sci Rep. 2015;5():12566.

Systems biology approach to studying proliferation-dependent prognostic subnetworks in breast cancer. Song Q, Wang H, Bao J, Pullikuth AK, Li KC, Miller LD, Zhou X.. Sci Rep. 2015;5():12981.

Systemic modeling myeloma-osteoclast interactions under normoxic/hypoxic condition using a novel computational approach. Ji Z, Wu D, Zhao W, Peng H, Zhao S, Huang D, Zhou X.. Sci Rep. 2015;5():13291.

Objective classification system for sagittal craniosynostosis based on suture segmentation. Qian X, Tan H, Zhang J, Zhuang X, Branch L, Sanger C, Thompson A, Zhao W, Li KC, David L, Zhou X.. Med Phys. 2015;42(9):5545.

CD138-negative myeloma cells regulate mechanical properties of bone marrow stromal cells through SDF-1/CXCR4/AKT signaling pathway [abstract]. Wu D, Guo XY, Su J, Chen RY, Berenzon D, Bonin K, Guthold M, Zhao WL, Zhou XB.. Clin Cancer Res. 2015;21(17 Suppl):A09.

Multi-scale agent-based multiple myeloma cancer modeling and the related study of the balance between osteoclasts and osteoblasts. Qiao M, Wu D, Carey M, Zhou X, Zhang L.. PLoS One. 2015;10(12):e0143206.

Computational analysis of patient-to-patient signaling heterogeneity elucidates patient-specific clinical outcomes [abstract]. Jin GX, Liu L, Wang RS, Liu KQ, Mastsuo K, Wei K, Zhou XB.. Cancer Res. 2015;75(15 Suppl):LB-304.

MiRNAs as biomarkers of the gait speed response to aerobic exercise training in obese older adults [abstract]. Zhang T, Liu KQ, Brinkley TE, Feng X, Marsh A, Nicklas B, Zhou XB, Kritchevsky SB.. Gerontologist. 2015;55(Suppl 2):338.

Targeting the biophysical properties of the myeloma initiating cell niches: a pharmaceutical synergism analysis using multi-scale agent-based modeling. Su J, Zhang L, Zhang W, Choi DS, Wen J, Jiang B, Chang CC, Zhou X.. PLoS One. 2014;9(1):e85059.

Computational modeling of 3D tumor growth and angiogenesis for chemotherapy evaluation. Tang L, van de Ven AL, Guo D, Andasari V, Cristini V, Li KC, Zhou X.. PLoS One. 2014;9(1):e83962.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Radiology

Xiaobo Zhou, Ph.D.

Xiaobo Zhou, Ph.D.

Professor, Radiology
Ctr for Vaccines at Extremes
Cancer Biology

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