Xiaobo Zhou, Ph.D.Wake Forest School of Medicine

Xiaobo Zhou, Ph.D.


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Academic: 336-716-2465 | Department: 336-716-2011


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Education & Training

  • M.S., Peking University, 1995
  • Ph.D., Peking University, 1998


  • Spie Intl Soc For Optical Engi
  • Inst of Electrical & Electroni
Xiaobo Zhou, Ph.D.

Xiaobo Zhou, Ph.D.

Professor, Radiology
Cancer Biology

Research Interests

atherosclerosis/thrombosis, biotechnology, cell growth, differentiation,d, genomics and proteomics

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Academic: 336-716-2465 | Department: 336-716-2011


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Recent Publications

Zhang X, Tang Z, Liebschner MA, Kim D, Shen S, Chang CM, Yuan P, Zhang G, Gateno J, Zhou X, Zhang SX, Xia JJ. An eFace-template method for efficiently generating patient-specific anatomically-detailed facial soft tissue FE models for craniomaxillofacial surgery simulation. Ann Biomed Eng. 2016;44(5):1656-1671.

Peng H, Tan H, Zhao W, Jin G, Sharma S, Xing F, Watabe K, Zhou X. Computational systems biology in cancer brain metastasis. Front Biosci (Schol Ed). 2016;8():169-186.

Wu K, Sharma S, Venkat S, Liu K, Zhou X, Watabe K. Non-coding RNAs in cancer brain metastasis. Front Biosci (Schol Ed). 2016;8():187-202.

Liu L, Zhao W, Zhou X. Modeling co-occupancy of transcription factors using chromatin features. Nucleic Acids Res. 2016;44(5):e49.

Zhang G, Smith BP, Plate JF, Casanova R, Hsu FC, Li J, Xia L, Li KC, Poehling GG, Zhou X. A systematic approach to predicting the risk of unicompartmental knee arthroplasty revision. Osteoarthritis Cartilage. 2016;24(6):991-999.

Clancy CE, An G, Cannon WR, Liu Y, May EE, Ortoleva P, Popel AS, Sluka JP, Su J, Vicini P, Zhou X, Eckmann DM. Multiscale modeling in the clinic: drug design and development. Ann Biomed Eng. 2016;():.

Peng H, Zhao W, Tan H, Ji Z, Li J, Li K, Zhou X. Prediction of treatment efficacy for prostate cancer using a mathematical model. Sci Rep. 2016;12(6):21599.

Zhang J, Yu H, Qian X, Liu K, Tan H, Yang T, Wang M, Li KC, Chan MD, Debinski W, Paulsson A, Wang G, Zhou X. Pseudo progression identification of glioblastoma with dictionary learning. Comput Biol Med. 2016;73():94-101.

Miller LD, Chou JA, Black MA, Print C, Chifman J, Alistar A, Putti T, Zhou X, Bedognetti D, Hendrickx W, Pullikuth A, Rennhack J, Andrechek ER, Demaria S, Wang E, Marincola FM. Immunogenic subtypes of breast cancer delineated by gene classifiers of immune responsiveness. Cancer Immunol Res. 2016;4(7):600-610.

Zhang G, Tan H, Qian X, Zhang J, Li K, David LR, Zhou X. A systematic approach to predicting spring force for sagittal craniosynostosis surgery. J Craniofac Surg. 2016;27(3):636-643.

Liu K, Chyr J, Zhao W, Zhou X. Immune signaling-based Cascade Propagation approach re-stratifies HNSCC patients. Methods. 2016;():.

Wu D, Guo X, Su J, Chen R, Berenzon D, Guthold M, Bonin K, Zhao W, Zhou X. CD138-negative myeloma cells regulate mechanical properties of bone marrow stromal cells through SDF-1/CXCR4/AKT signaling pathway. Biochim Biophys Acta. 2015;1853(2):338-347.

Choi DS, Stark DJ, Raphael RM, Wen J, Su J, Zhou X, Chang CC, Zu Y. SDF-1 alpha stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II. Int J Cancer. 2015;136(5):E219-E229.

Suresh V, Liu L, Adjeroh D, Zhou X. RPI-Pred: predicting ncRNA-protein interaction using sequence and structural information. Nucleic Acids Res. 2015;43(3):1370-1379.

Wu K, Fukuda K, Xing F, Zhang Y, Sharma S, Liu Y, Chan M, Zhou X, Qasem S, Pochampally R, Mo YY, Watabe K. Roles of the cyclooxygenase 2-matrix metalloproteinase 1 pathway in brain metastasis of breast cancer. J Biol Chem. 2015;290(15):9842-9854.

Guo D, Li KC, Peters TR, Snively BM, Poehling KA, Zhou X. Multi-scale modeling for the transmission of influenza and the evaluation of interventions toward it. Sci Rep. 2015;5():8980.

Liu L, Jin G, Zhou X. Modeling the relationship of epigenetic modifications to transcription factor binding. Nucleic Acids Res. 2015;43(8):3873-3885.

Chen X, Liu L, Mims J, Punska EC, Williams KE, Zhao W, Arcaro KF, Tsang AW, Zhou X, Furdui CM. Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors. Epigenetics. 2015;10(6):545-561.

Pu M, Cheng JW, Zhang J, Cheng P, Zhou X. Call for the development of a three-dimensional printing algorithm specific to echocardiography: an initial study with an in vitro validation [abstract]. J Am Soc Echocardiogr. 2015;28(6):B123-B124.

Liu L, Wang H, Wen J, Tseng CE, Zu Y, Chang CC, Zhou X. Mutated genes and driver pathways involved in myelodysplastic syndromes-a transcriptome sequencing based approach. Mol Biosyst. 2015;11(8):2158-2166.

Tan H, Bao J, Zhou X. Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity. Sci Rep. 2015;5():12566.

Song Q, Wang H, Bao J, Pullikuth AK, Li KC, Miller LD, Zhou X. Systems biology approach to studying proliferation-dependent prognostic subnetworks in breast cancer. Sci Rep. 2015;5():12981.

Ji Z, Wu D, Zhao W, Peng H, Zhao S, Huang D, Zhou X. Systemic modeling myeloma-osteoclast interactions under normoxic/hypoxic condition using a novel computational approach. Sci Rep. 2015;5():13291.

Qian X, Tan H, Zhang J, Zhuang X, Branch L, Sanger C, Thompson A, Zhao W, Li KC, David L, Zhou X. Objective classification system for sagittal craniosynostosis based on suture segmentation. Med Phys. 2015;42(9):5545.

Wu D, Guo XY, Su J, Chen RY, Berenzon D, Bonin K, Guthold M, Zhao WL, Zhou XB. CD138-negative myeloma cells regulate mechanical properties of bone marrow stromal cells through SDF-1/CXCR4/AKT signaling pathway [abstract]. Clin Cancer Res. 2015;21(17 Suppl):A09.

Qiao M, Wu D, Carey M, Zhou X, Zhang L. Multi-scale agent-based multiple myeloma cancer modeling and the related study of the balance between osteoclasts and osteoblasts. PLoS One. 2015;10(12):e0143206.

Jin GX, Liu L, Wang RS, Liu KQ, Mastsuo K, Wei K, Zhou XB. Computational analysis of patient-to-patient signaling heterogeneity elucidates patient-specific clinical outcomes [abstract]. Cancer Res. 2015;75(15 Suppl):LB-304.

Zhang T, Liu K, Brinkley TE, Feng X, Marsh A, Nicklas B, Zhou XB, Kritchevsky SB. MiRNAs as biomarkers of the gait speed response to aerobic exercise training in obese older adults [abstract]. Gerontologist. 2015;55(Suppl 2):338.

Su J, Zhang L, Zhang W, Choi DS, Wen J, Jiang B, Chang CC, Zhou X. Targeting the biophysical properties of the myeloma initiating cell niches: a pharmaceutical synergism analysis using multi-scale agent-based modeling. PLoS One. 2014;9(1):e85059.

Tang L, van de Ven AL, Guo D, Andasari V, Cristini V, Li KC, Zhou X. Computational modeling of 3D tumor growth and angiogenesis for chemotherapy evaluation. PLoS One. 2014;9(1):e83962.

Peng T, Peng H, Choi DS, Su J, Chang CC, Zhou X. Modeling cell-cell interactions in regulating multiple myeloma initiating cell fate. IEEE J Biomed Health Inform. 2014;18(2):484-491.

Xing J, Huang L, Lu JH, Zhou XB, Li HW, Bian JW. HMMotif: predicting sequence motifs governing constitutive exon splicing. Res J Biotechnol. 2014;9(4):56-59.

Guo DM, van de Ven AL, Zhou XB. Red blood cell tracking using optical flow methods. IEEE J Biomed Health Inform. 2014;18(3):991-998.

Zhang R, Zhao C, Xiong Z, Zhou X. Pathway bridge based multiobjective optimization approach for lurking pathway prediction. Biomed Res Int. 2014;():351095.

Ji Z, Su J, Liu C, Wang H, Huang D, Zhou X. Integrating genomics and proteomics data to predict drug effects using binary linear programming. PLoS One. 2014;9(7):e102798.

Mandl KD, Kohane IS, McFadden D, Weber GM, Natter M, Mandel J, Schneeweiss S, Weiler S, Klann JG, Bickel J, Adams WG, Ge Y, Zhou X, Perkins J, Marsolo K, Bernstam E, Showalter J, Quarshie A, Ofili E, Hripcsak G, Murphy SN. Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): architecture. J Am Med Inform Assoc. 2014;21(4):615-620.

Peng H, Peng T, Wen J, Engler DA, Matsunami RK, Su J, Zhang L, Chang CC, Zhou X. Characterization of p38 MAPK isoforms for drug resistance study using systems biology approach. Bioinformatics. 2014;30(13):1899-1907.

Zhou X. Cancer bioinformatics: detection of chromatin states, SNP-containing motifs, and functional enrichment modules [editorial]. Chin J Cancer. 2013;32(4):153-154.

Sun X, Kang Y, Bao J, Zhang Y, Yang Y, Zhou X. Modeling vascularized bone regeneration within a porous biodegradable CaP scaffold loaded with growth factors. Biomaterials. 2013;34(21):4971-4981.

Bian J, Liu C, Wang H, Xing J, Kachroo P, Zhou X. SNVHMM: predicting single nucleotide variants from next generation sequencing. BMC Bioinformatics. 2013;14():225.

Wang J, Zhang L, Jing C, Ye G, Wu H, Miao H, Wu Y, Zhou X. Multi-scale agent-based modeling on melanoma and its related angiogenesis analysis. Theor Biol Med Model. 2013;10():41.

Tan H, Wei K, Bao J, Zhou X. In silico study on multidrug resistance conferred by I223R/H275Y double mutant neuraminidase. Mol Biosyst. 2013;9(11):2764-2774.

Wang H, Wen J, Chang CC, Zhou X. Discovering transcription and splicing networks in myelodysplastic syndromes. PLoS One. 2013;8(11):e79118.

Shao H, Peng T, Ji Z, Su J, Zhou X. Systematically studying kinase inhibitor induced signaling network signatures by integrating both therapeutic and side effects. PLoS One. 2013;8(12):e80832.

Sun X, Bao J, Nelson KC, Li KC, Kulik G, Zhou X. Systems modeling of anti-apoptotic pathways in prostate cancer: psychological stress triggers a synergism pattern switch in drug combination therapy. PLoS Comput Biol. 2013;9(12):e1003358.

Liu C, Ma J, Chang CJ, Zhou X. FusionQ: a novel approach for gene fusion detection and quantification from paired-end RNA-Seq. BMC Bioinformatics. 2013;14():193.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Radiology

Xiaobo Zhou, Ph.D.

Xiaobo Zhou, Ph.D.

Professor, Radiology
Cancer Biology

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