Profile

Xue Wei Zhu, Ph.D.Wake Forest School of Medicine

Xue Wei Zhu, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-1445 | Department: 336-716-2011

Email: xwzhu@wakehealth.edu

Education & Training

  • Ph.D., Peking Medical College-China , 2004
Xue Wei Zhu, Ph.D.

Xue Wei Zhu, Ph.D.

Assistant Professor, Molecular Medicine

Research Interests

atherosclerosis/thrombosis, immunology/allergy/inflammatio, molecular biology/molecular me, nutrition

Contact Information

Academic: 336-713-1445 | Department: 336-716-2011

Email: xwzhu@wakehealth.edu

Recent Publications

Liu M, Seo J, Allegood J, Bi X, Zhu X, Boudyguina E, Gebre AK, Avni D, Shah D, Sorci-Thomas MG, Thomas MJ, Shelness GS, Spiegel S, Parks JS. Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein. J Biol Chem. 2014;289(5):2801-2814.

Bi X, Zhu X, Gao C, Shewale S, Cao Q, Liu M, Boudyguina E, Gebre AK, Wilson MD, Brown AL, Parks JS. Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol. 2014;34(9):1888-1899.

Westerterp M, Murphy AJ, Wang M, Pagler TA, Vengrenyuk Y, Kappus MS, Gorman DJ, Nagareddy PR, Zhu X, Abramowicz S, Parks JS, Welch C, Fisher EA, Wang N, Yvan-Charvet L, Tall AR. Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice. Circ Res. 2013;112(11):1456-1465.

Zhu X, Chung S, Bi X, Chuang CC, Brown AL, Liu M, Seo J, Cuffe H, Gebre AK, Boudyguina E, Parks JS. Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models. J Lipid Res. 2013;54(10):2708-2717.

Bi X, Zhu X, Duong M, Boudyguina EY, Wilson MD, Gebre AK, Parks JS. Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis. Arterioscler Thromb Vasc Biol. 2013;33(10):2288-2296.

Liu MX, Seo JM, Allegood J, Bi X, Zhu XW, Boudyguina E, Gebre AK, Sorci-Thomas M, Thomas MS, Shelness GS, Spiegel S, Parks JS. Overexpression of apoM in liver stimulates formation of larger, apoM/S1P-enriched plasma HDL [abstract]. Circulation. 2013;128(22 Suppl):A19183.

Youm Y-H, Kanneganti T-D, Vandanmagsar B, Zhu X, Ravussin A, Adijiang A, Owen JS, Thomas MJ, Francis J, Parks JS, Dixit VD. The NLRP3 inflammasome promotes age-related thymic demise and immunosenescence. Cell Rep. 2012;1(1):56-68.

Sorci-Thomas MG, Owen JS, Fulp B, Bhat S, Zhu X, Parks JS, Shah D, Jerome WG, Gerelus M, Zabalawi M, Thomas MJ. Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers. J Lipid Res. 2012;53(9):1890-1909.

Zhu X, Parks JS. New roles of HDL in inflammation and hematopoiesis. Annu Rev Nutr. 2012;32():161-182.

Brown AL, Zhu X, Rong S, Shewale S, Seo J, Boudyguina E, Gebre AK, Alexander-Miller MA, Parks JS. Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions. Arterioscler Thromb Vasc Biol. 2012;32(9):2122-2130.

Zhu X, Westcott MM, Bi X, Liu M, Gowdy KM, Seo J, Cao Q, Gebre AK, Fessler MB, Hiltbold EM, Parks JS. Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection. Circ Res. 2012;111(11):1398-1409.

Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Zhu X, Brown AL, Shah R, Davis MA, Kelley K, Wilson MD, Parks JS, Rudell LL, et al. Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol. 2010;30(1):24-30.

Smoak KA, Aloor JJ, Madenspacher J, Merrick BA, Collins JB, Zhu X, Cavigiolio G, Oda MN, Parks JS, Fessler MB. Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation. Cell Metab. 2010;11(6):493-502.

Zhu X, Owen JS, Wilson MD, Li H, Griffiths GL, Thomas MJ, Hiltbold EM, Fessler MB, Parks JS. Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol. J Lipid Res. 2010;51(11):3196-3206.


Brown AL, Zhu X, Wilson MD, Alexander-Miller M, Parks JS. Echium oil promotes phenotypic shifting in the macrophage lineage [abstract]. Arterioscler Thromb Vasc Biol. 2009;29(7):e24.

Zhu XW, Owen JS, Wilson M, Thomas MJ, Hiltbold E, Fessler MB, Parks JS. Macrophage ABCA1 functions as an inhibitor of inflammation through modulation of cellular free cholesterol content [abstract]. Arterioscler Thromb Vasc Biol. 2009;29(7):e63.

Brown JM, Chung S, Alger HM, Sawyer JK, Degirolamo C, Nguyen T, Zhu X, Duong M-N, Wibley AL, Davis MA, Kelley K, Wilson MD, Parks JS, Rudel LL. Inhibition of stearoyl-CoA desaturase 1 (SCD1) dissociates insulin resistance and obesity from atherosclerosis [abstract]. Arterioscler Thromb Vasc Biol. 2008;28(6):e-93.

Zhu X, Lee J-Y, Hiltbold E, Maeda N, Parks JS. Macrophage ABCA1 dampens inflammation by modulation of free cholesterol distribution in membrane lipid rafts [abstract]. Arterioscler Thromb Vasc Biol. 2008;28(6):e-126.

Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Zhu X, Duong M-N, Wibley AL, Shah R, Davis MA, Kelley K, Wilson MD, Kent C, Parks JS, Rudel LL, et al. Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis. Circulation. 2008;118(14):1467-1475.

Zhu X, Lee J-Y, Timmins JM, Brown JM, Boudyguina E, Mulya A, Gebre AK, Willingham MC, Mishra N, Parks JS, et al. Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. J Biol Chem. 2008;283(34):22930-41.

Duong M, Zhu X, Boudyguina E, Maeda N, Parks JS. The effect of selective inactivation of macrophage ATP binding cassette transporter al (ABCA1) on atherosclerosis in LDL-receptor knockout (LDLrK0) mice [abstract]. Arterioscler Thromb Vasc Biol. 2007;27(6):e-64.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Molecular Medicine

Xue Wei Zhu, Ph.D.

Xue Wei Zhu, Ph.D.

Assistant Professor, Molecular Medicine

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