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Xuewei Zhu, Ph.D.Wake Forest School of Medicine

Xuewei Zhu, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-1445 | Department: 336-713-4259


Education & Training

Xuewei Zhu, Ph.D.

Xuewei Zhu, Ph.D.

Assistant Professor, Molecular Medicine
Center on Diabetes, Obesity, and Metabolism
Office of Women in Medicine and Science

Research Interests

Cholesterol; Macrophages; ATP-Binding Cassette Transporters; Membrane Microdomains; Lipoproteins, HDL
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Contact Information

Academic: 336-713-1445 | Department: 336-713-4259


Recent Publications

Hepatocyte ABCA1 deletion impairs liver insulin signaling and lipogenesis. Key CC, Liu M, Kurtz CL, Chung S, Boudyguina E, Dinh TA, Bashore A, Phelan PE, Freedman BI, Osborne TF, Zhu X, Ma L, Sethupathy P, Biddinger SB, Parks JS.. Cell Rep. 2017;19(10):2116-2129.

Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy. Shen L, Yang Y, Ou T, Key CC, Tong SH, Sequeira RC, Nelson JM, Nie Y, Wang Z, Boudyguina E, Shewale SV, Zhu X.. J Lipid Res. 2017;58(9):1808-1821.

Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles. Liu M, Allegood J, Zhu X, Seo J, Gebre AK, Boudyguina E, Cheng D, Chuang CC, Shelness GS, Spiegel S, Parks JS.. J Biol Chem. 2015;290(12):7861-7870.

Proteomic analysis of ABCA1-null macrophages reveals a role for stomatin like protein-2 in raft composition and Toll-like receptor signaling. Chowdhury SM, Zhu X, Aloor JJ, Azzam KM, Gabor KA, Ge W, Addo KA, Tomer KB, Parks JS, Fessler MB.. Mol Cell Proteomics. 2015;14(7):1859-1870.

Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver. Shewale SV, Boudyguina E, Zhu X, Shen L, Hutchins PM, Barkley RM, Murphy RC, Parks JS.. J Lipid Res. 2015;56(6):1191-1205.

Procollagen C-endopeptidase enhancer protein 2 (PCPE2) reduces atherosclerosis in mice by enhancing scavenger receptor class B1 (SR-BI)-mediated high-density lipoprotein (HDL)-cholesteryl ester uptake. Pollard RD, Blesso CN, Zabalawi M, Fulp B, Gerelus M, Zhu X, Lyons EW, Nuradin N, Francone OL, Li XA, Sahoo D, Thomas MJ, Sorci-Thomas MG.. J Biol Chem. 2015;290(25):15496-511.

Biogenesis and cytotoxicity of APOL1 renal-risk variant proteins in hepatocytes and hepatoma cells. Cheng D, Weckerle A, Yu Y, Ma L, Zhu X, Murea M, Freedman BI, Parks JS, Shelness GS.. J Lipid Res. 2015;56(8):1583-1593.

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P.. Elife. 2015;4():e08009.

Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein. Liu M, Seo J, Allegood J, Bi X, Zhu X, Boudyguina E, Gebre AK, Avni D, Shah D, Sorci-Thomas MG, Thomas MJ, Shelness GS, Spiegel S, Parks JS.. J Biol Chem. 2014;289(5):2801-2814.

Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice. Bi X, Zhu X, Gao C, Shewale S, Cao Q, Liu M, Boudyguina E, Gebre AK, Wilson MD, Brown AL, Parks JS.. Arterioscler Thromb Vasc Biol. 2014;34(9):1888-1899.

Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice. Westerterp M, Murphy AJ, Wang M, Pagler TA, Vengrenyuk Y, Kappus MS, Gorman DJ, Nagareddy PR, Zhu X, Abramowicz S, Parks JS, Welch C, Fisher EA, Wang N, Yvan-Charvet L, Tall AR.. Circ Res. 2013;112(11):1456-1465.

Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models. Zhu X, Chung S, Bi X, Chuang CC, Brown AL, Liu M, Seo J, Cuffe H, Gebre AK, Boudyguina E, Parks JS.. J Lipid Res. 2013;54(10):2708-2717.

Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis. Bi X, Zhu X, Duong M, Boudyguina EY, Wilson MD, Gebre AK, Parks JS.. Arterioscler Thromb Vasc Biol. 2013;33(10):2288-2296.

Overexpression of apoM in liver stimulates formation of larger, apoM/S1P-enriched plasma HDL [abstract]. Liu MX, Seo JM, Allegood J, Bi X, Zhu XW, Boudyguina E, Gebre AK, Sorci-Thomas M, Thomas MS, Shelness GS, Spiegel S, Parks JS.. Circulation. 2013;128(22 Suppl):A19183.

The NLRP3 inflammasome promotes age-related thymic demise and immunosenescence. Youm Y-H, Kanneganti T-D, Vandanmagsar B, Zhu X, Ravussin A, Adijiang A, Owen JS, Thomas MJ, Francis J, Parks JS, Dixit VD.. Cell Rep. 2012;1(1):56-68.

Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers. Sorci-Thomas MG, Owen JS, Fulp B, Bhat S, Zhu X, Parks JS, Shah D, Jerome WG, Gerelus M, Zabalawi M, Thomas MJ.. J Lipid Res. 2012;53(9):1890-1909.

New roles of HDL in inflammation and hematopoiesis. Zhu X, Parks JS.. Annu Rev Nutr. 2012;32():161-182.

Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions. Brown AL, Zhu X, Rong S, Shewale S, Seo J, Boudyguina E, Gebre AK, Alexander-Miller MA, Parks JS.. Arterioscler Thromb Vasc Biol. 2012;32(9):2122-2130.

Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection. Zhu X, Westcott MM, Bi X, Liu M, Gowdy KM, Seo J, Cao Q, Gebre AK, Fessler MB, Hiltbold EM, Parks JS.. Circ Res. 2012;111(11):1398-1409.

Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis. Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Zhu X, Brown AL, Shah R, Davis MA, Kelley K, Wilson MD, Parks JS, Rudell LL, et al.. Arterioscler Thromb Vasc Biol. 2010;30(1):24-30.

Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation. Smoak KA, Aloor JJ, Madenspacher J, Merrick BA, Collins JB, Zhu X, Cavigiolio G, Oda MN, Parks JS, Fessler MB.. Cell Metab. 2010;11(6):493-502.

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol. Zhu X, Owen JS, Wilson MD, Li H, Griffiths GL, Thomas MJ, Hiltbold EM, Fessler MB, Parks JS.. J Lipid Res. 2010;51(11):3196-3206.

Inhibition of collar-induced carotid atherosclerosis by recombinant apoA-I cysteine mutants in apoE-deficient mice. Zhang X, Zhu X, Chen B.. J Lipid Res. 2010;51(12):3434-3442.

Echium oil promotes phenotypic shifting in the macrophage lineage [abstract]. Brown AL, Zhu X, Wilson MD, Alexander-Miller M, Parks JS.. Arterioscler Thromb Vasc Biol. 2009;29(7):e24.

Macrophage ABCA1 functions as an inhibitor of inflammation through modulation of cellular free cholesterol content [abstract]. Zhu XW, Owen JS, Wilson M, Thomas MJ, Hiltbold E, Fessler MB, Parks JS.. Arterioscler Thromb Vasc Biol. 2009;29(7):e63.

Inhibition of stearoyl-CoA desaturase 1 (SCD1) dissociates insulin resistance and obesity from atherosclerosis [abstract]. Brown JM, Chung S, Alger HM, Sawyer JK, Degirolamo C, Nguyen T, Zhu X, Duong M-N, Wibley AL, Davis MA, Kelley K, Wilson MD, Parks JS, Rudel LL.. Arterioscler Thromb Vasc Biol. 2008;28(6):e-93.

Macrophage ABCA1 dampens inflammation by modulation of free cholesterol distribution in membrane lipid rafts [abstract]. Zhu X, Lee J-Y, Hiltbold E, Maeda N, Parks JS.. Arterioscler Thromb Vasc Biol. 2008;28(6):e-126.

Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis. Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Zhu X, Duong M-N, Wibley AL, Shah R, Davis MA, Kelley K, Wilson MD, Kent C, Parks JS, Rudel LL, et al.. Circulation. 2008;118(14):1467-1475.

Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. Zhu X, Lee J-Y, Timmins JM, Brown JM, Boudyguina E, Mulya A, Gebre AK, Willingham MC, Mishra N, Parks JS, et al.. J Biol Chem. 2008;283(34):22930-41.

The effect of selective inactivation of macrophage ATP binding cassette transporter al (ABCA1) on atherosclerosis in LDL-receptor knockout (LDLrK0) mice [abstract]. Duong M, Zhu X, Boudyguina E, Maeda N, Parks JS.. Arterioscler Thromb Vasc Biol. 2007;27(6):e-64.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Molecular Medicine

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