Diseases Associated with Specific HLA Typings
Several diseases occur with strong HLA associations. Examples:
- HLA-B27 and arthropathies
- HLA-A29 and birdshot retinopathy
- HLA-DR15 (DR2) and DQ6 with narcolepsy
HLA class I typing may be done by serological or molecular methods.
HLA class II low and high resolution typings are performed by molecular methods.
HLA typing is done on an individual basis, please contact the laboratory at firstname.lastname@example.org for information on specimen requirements and if necessary speak with our director to determine the correct types of testing for your needs.
|Disease||HLA-specificity/Gene||Approximate Relative Risk|
|Autoimmune chronic hepatitis ||HLA-DR3 ||14 |
|Addison's Disease ||HLA-DR3 ||9 |
|Ankylosing Spondylitis ||HLA-B27 ||100 |
|Birdshot Chorioretinopathy ||HLA-A29 ||200 |
|Celiac Disease ||HLA-DQ2 ||30 |
|Diabetes Mellitus, type I ||HLA-DQ6 ||10 |
|Graves Disease ||HLA-DR3 ||4 |
|Hemochromatosis ||HLA- A3 ||- |
|Multiple sclerosis ||HLA-DR3 ||10 |
|Narcolepsy ||HLA-DR15/DQB1*0602 ||100 |
|Postinfectious arthritides ||HLA-B27 ||10-20 |
|Rheumatoid arthritides ||HLA-DR1, 4 ||7 |
|Psoriasis vulgaris ||HLA-Cw6 ||5 |
|Reiter's Syndrome ||HLA-B27 ||35 |
Special thanks to John McIntyre, PhD and Dawn Wagenknecht, CHS from St. Francis Hospital’s HLA laboratory in Beechgrove, Indiana for allowing us to partially reproduce information from their Web site!