HLA/Immunogenetics Lab

Diseases Associated with Specific HLA Typings

Several diseases occur with strong HLA associations. Examples:
  • HLA-B27 and arthropathies
  • HLA-A29 and birdshot retinopathy
  • HLA-DR15 (DR2) and DQ6 with narcolepsy

HLA class I typing may be done by serological or molecular methods.

HLA class II low and high resolution typings are performed by molecular methods.

HLA typing is done on an individual basis, please contact the laboratory at hlalab@wakehealth.edu for information on specimen requirements and if necessary speak with our director to determine the correct types of testing for your needs.

DiseaseHLA-specificity/GeneApproximate Relative Risk
Autoimmune chronic hepatitis HLA-DR3 14
Addison's Disease HLA-DR3 9
Ankylosing Spondylitis HLA-B27 100
Birdshot Chorioretinopathy HLA-A29 200
Celiac Disease HLA-DQ2 30
Diabetes Mellitus, type I HLA-DQ6 10
Graves Disease HLA-DR3 4
Hemochromatosis HLA- A3 -
Multiple sclerosis HLA-DR3 10
Narcolepsy HLA-DR15/DQB1*0602 100
Postinfectious arthritides HLA-B27 10-20
Rheumatoid arthritides HLA-DR1, 4 7
Psoriasis vulgaris HLA-Cw6 5
Reiter's Syndrome HLA-B27 35

Special thanks to John McIntyre, PhD and Dawn Wagenknecht, CHS from St. Francis Hospital’s HLA laboratory in Beechgrove, Indiana for allowing us to partially reproduce information from their Web site!

Quick Reference

HLA/Immunogentics Lab

336-716-4456
336-716-2279

Hours
Monday-Friday
8 am to 5 pm
24/7 On-call
WFSM HLA/Immunogenetics Laboratory
145 Kimel Park Dr., Ste 250
Winston-Salem, NC  27103-6972
Find a Doctor Ways to Give
Last Updated: 12-16-2013
USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.