Thyroid Cancer
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Definition
Thyroid cancer is a cancer that starts in the thyroid gland. The thyroid gland is located inside the front of your lower neck.
Alternative Names
Tumor - thyroid; Cancer - thyroid
Causes, incidence, and risk factors
Thyroid cancer can occur in all age groups.
Radiation increases the risk of developing thyroid cancer. Exposure may occur from:
- Radiation therapy to the neck (especially in childhood)
- Radiation exposure from nuclear plant disasters
Other risk factors are a family history of thyroid cancer and chronic goiter.
There are several types of thyroid cancer:
Anaplastic carcinoma (also called giant and spindle cell cancer) is the most dangerous form of thyroid cancer. It is rare, and spreads quickly.
Follicular carcinoma is more likely to come back and spread.
Medullary carcinoma is a cancer of non-thyroid cells that are normally present in the thyroid gland. This form of thyroid cancer tends to occur in families.
- Papillary carcinoma is the most common type, and it usually affects women of childbearing age. It spreads slowly and is the least dangerous type of thyroid cancer.
References
Ladenson P, Kim M. Thyroid. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 244.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Thyroid Cancer. Version 1.2011
Review Date: 3/22/2012
Reviewed By: Shehzad Topiwala, MD, Chief Consultant Endocrinologist, Premier Medical Associates, The Villages, FL. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2004 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
Alternative Names
Tumor - thyroid; Cancer - thyroid
Symptoms
Symptoms vary depending on the type of thyroid cancer, but may include:
- Cough
- Difficulty swallowing
- Enlargement of the thyroid gland
- Hoarseness or changing voice
- Neck swelling
- Thyroid lump (nodule)
Signs and tests
Your health care provider will perform a physical exam. This may reveal a lump in the thyroid, or swollen lymph nodes in the neck.
The following tests may be done:
- Calcitonin blood test to check for medullary cancer
- Laryngoscopy
- Thyroid biopsy
- Thyroid scan
- TSH, free T4
- Ultrasound of the thyroid
References
Ladenson P, Kim M. Thyroid. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 244.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Thyroid Cancer. Version 1.2011
Review Date: 3/22/2012
Reviewed By: Shehzad Topiwala, MD, Chief Consultant Endocrinologist, Premier Medical Associates, The Villages, FL. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2004 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
Alternative Names
Tumor - thyroid; Cancer - thyroid
Treatment
Treatment depends on the type of thyroid cancer.
Surgery is most often done. The entire thyroid gland is usually removed. If the doctor suspects that the cancer has spread to lymph nodes in the neck, these will also be removed.
Radiation therapy may be done with or without surgery. It may be performed by:
- Aiming external beam (x-ray) radiation at the thyroid
- Taking radioactive iodine by mouth
Patients who are treated for thyroid cancer must take thyroid hormone pills for the rest of their lives. The dose is usually a little higher than what your body needs. This can keep the cancer from coming back.
If the cancer does not respond to surgery or radiation and has spread to other parts of the body, chemotherapy may be used. This is only effective for a small number of patients.
Complications
Complications of thyroid cancer may include:
- Injury to the voice box and hoarseness after thyroid surgery
- Low calcium levels from accidental removal of the parathyroid glands during surgery
- Spread of the cancer to the lungs, bones, or other parts of the body
Calling your health care provider
Call your health care provider if you notice a lump in your neck.
References
Ladenson P, Kim M. Thyroid. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 244.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Thyroid Cancer. Version 1.2011
Review Date: 3/22/2012
Reviewed By: Shehzad Topiwala, MD, Chief Consultant Endocrinologist, Premier Medical Associates, The Villages, FL. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2004 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
Alternative Names
Tumor - thyroid; Cancer - thyroid
Prevention
There is no known prevention. Awareness of risk (such as previous radiation therapy to the neck) can allow earlier diagnosis and treatment.
Sometimes, people with strong family histories and genetic mutations related to thyroid cancer will have their thyroid gland removed for preventive purposes.
References
Ladenson P, Kim M. Thyroid. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 244.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Thyroid Cancer. Version 1.2011
Review Date: 3/22/2012
Reviewed By: Shehzad Topiwala, MD, Chief Consultant Endocrinologist, Premier Medical Associates, The Villages, FL. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2004 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
Review Date: 3/22/2012
Reviewed By: Shehzad Topiwala, MD, Chief Consultant Endocrinologist, Premier Medical Associates, The Villages, FL. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2004 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.