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Cutaneous T-Cell Lymphomas

National Organization for Rare Disorders, Inc.

Important

It is possible that the main title of the report Cutaneous T-Cell Lymphomas is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • CTCL

Disorder Subdivisions

  • Mycosis Fungoides
  • Sezary Syndrome
  • Granulomatous Slack Skin
  • Primary Cutaneous Anaplastic Large Cell Lymphomas
  • Lymphomatoid Papulosis
  • Subcutaneous Panniculitic T-Cell Lymphoma
  • Pagetoid Reticulosis (Woringer-Kolopp Disease)

General Discussion

Cutaneous T-cell lymphomas (CTCLs) are a group of disorders characterized by abnormal accumulation of malignant T-cells in the skin potentially resulting in the development of rashes, plaques and tumors. CTCLs belong to a larger group of disorders known as non-Hodgkin's lymphomas (NHLs), which are related malignancies (cancers) that affect the lymphatic system (lymphomas). Functioning as part of the immune system, the lymphatic system helps to protect the body against infection and disease. It consists of a network of tubular channels (lymph vessels) that drain a thin watery fluid known as lymph from different areas of the body into the bloodstream. Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes.



There are two main types of lymphocytes: B-lymphocytes, which may produce specific antibodies to "neutralize" certain invading microorganisms, and T-lymphocytes, which may directly destroy microorganisms or assist in the activities of other lymphocytes. CTCLs result from errors in the production of T-lymphocytes or transformation of T-lymphocytes into malignant cells. In CTCLs abnormal, uncontrolled growth and multiplication (proliferation) of malignant T-lymphocytes result in accumulation of these lymphocytes in the skin. In some cases, malignant lymphocytes may spread to affect the lymph nodes and eventually to other bodily tissues and organs, potentially resulting in life-threatening complications. The specific symptoms and physical findings may vary from case to case, depending upon the extent and region(s) of involvement, the specific type of CTCL present, and various additional factors.



Non-Hodgkin's lymphomas, such as CTCLs, may also be categorized based upon certain characteristics of the cancer cells as seen under a microscope and how quickly they may tend to grow and spread. For example, CTCLs may be characterized as "low-grade" (or indolent) lymphomas, which tend to grow slowly and result in few associated symptoms, or "intermediate-grade" or "high-grade" (aggressive) lymphomas, which typically grow rapidly, requiring prompt treatment. Most cases of CTCL, especially the classic form (mycosis fungoides), are slow-growing (indolent) lymphomas.

Resources

Leukemia & Lymphoma Society

1311 Mamaroneck Avenue

Suite 310

White Plains, NY 10605

Tel: (914)949-5213

Fax: (914)949-6691

Tel: (800)955-4572

Email: infocenter@LLS.org

Internet: http://www.LLS.org



American Cancer Society, Inc.

250 Williams NW St

Ste 6000

Atlanta, GA 30303

USA

Tel: (404)320-3333

Tel: (800)227-2345

TDD: (866)228-4327

Internet: http://www.cancer.org



National Cancer Institute Physician Data Query

Office of Communications and Education

Public Inquiries Office

6116 Executive Blvd

Suite 300

Bethesda, MD 20892-8322

Tel: (800)422-6237

Email: cancergovstaff@mail.nih.gov

Internet: http://www.cancer.gov/cancertopics/pdq/cancerdatabase



National Cancer Institute

6116 Executive Blvd Suite 300

Bethesda, MD 20892-8322

USA

Tel: (301)435-3848

Tel: (800)422-6237

TDD: (800)332-8615

Email: cancergovstaff@mail.nih.gov

Internet: http://www.cancer.gov



National Coalition for Cancer Survivorship

1010 Wayne Avenue

7th Floor

Silver Spring, MD 20910

Tel: (301)650-9127

Fax: (301)565-9670

Tel: (888)650-9127

Email: info@canceradvocacy.org

Internet: http://www.canceradvocacy.org/



Cancer Hope Network

2 North Road

Suite A

Chester, NJ 07930

Tel: (908)879-4039

Fax: (908)879-6518

Tel: (800)552-4366

Email: info@cancerhopenetwork.org

Internet: http://www.cancerhopenetwork.org



OncoLink: The University of Pennsylvania Cancer Center Resource

3400 Spruce Street

2 Donner

Philadelphia, PA 19104-4283

USA

Tel: (215)349-8895

Fax: (215)349-5445

Email: hampshire@uphs.upenn.edu

Internet: http://www.oncolink.upenn.edu



Lymphoma Research Foundation

115 Broadway

Suite 1301

New York, NY 10006

USA

Tel: (212)349-2910

Fax: (212)349-2886

Tel: (800)235-6848

Email: LRF@lymphoma.org

Internet: http://www.lymphoma.org



Canadian Cancer Society

55 St. Clair Avenue West Suite 500

Toronto, M4V 2Y7

Canada

Tel: 4164885400

Fax: 4164882872

Tel: 8002688874

Email: webmaster@ontario.cancer.ca

Internet: http://www.cancer.ca/



Lymphoma Foundation Canada

16-1375 Southdown Road

Suite 236

Mississauga

Ontario, L5J 2Z1

Canada

Tel: 9058225135

Fax: 9058149152

Tel: 8666595556

Email: info@lymphoma.ca

Internet: http://www.lymphoma.ca



Lymphoma Association (UK)

PO Box 386

Aylesbury, HP20 2GA

United Kingdom

Tel: 01296619400

Email: information@lymphomas.org.uk

Internet: www.lymphomas.org.uk



International Cancer Alliance for Research and Education (ICARE)

4853 Cordell Avenue

Suite 14

Bethesda, MD 20814

Tel: (301)656-3461

Fax: (301)654-8684

Tel: (800)422-7361

Email: info@icare.org

Internet: http://www.icare.org



Rare Cancer Alliance

1649 North Pacana Way

Green Valley, AZ 85614

USA

Internet: http://www.rare-cancer.org



Cutaneous Lymphoma Foundation

PO Box 374

Birmingham, MI 48012-0374

USA

Tel: (248)644-9014

Fax: (248)644-9014

Email: info@clfoundation.org

Internet: http://www.clfoundation.org



Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223

Internet: http://rarediseases.info.nih.gov/GARD/



Friends of Cancer Research

1800 M Street NW

Suite 1050 South

Washington, DC 22202

Tel: (202)944-6700

Email: info@focr.org

Internet: http://www.focr.org



Cancer Support Community

1050 17th St NW Suite 500

Washington, DC 20036

Tel: (202)659-9709

Fax: (202)974-7999

Tel: (888)793-9355

Internet: http://www.cancersupportcommunity.org/



Lance Armstrong Foundation

2201 E. Sixth Street

Austin, TX 78702

Tel: (512)236-8820

Fax: (512)236-8482

Tel: (877)236-8820

Email: media@livestrong.org

Internet: http://www.livestrong.org



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  1/3/2007

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