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Multiple System Atrophy

National Organization for Rare Disorders, Inc.

Important

It is possible that the main title of the report Multiple System Atrophy is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • MSA
  • progressive autonomic failure with multiple system atrophy
  • Shy-Drager syndrome (SDS)
  • sporadic olivopontocerebellar atrophy (sOPCA)
  • striatonigral degeneration (SND

Disorder Subdivisions

  • MSA-C (cerebellar phenotype)
  • MSA-P (parkinsonian phenotype)

General Discussion

Summary

Multiple system atrophy (MSA) is a rare sporadic progressive neurological disorder characterized by a varying combination of symptoms and signs. Onset is during adulthood (>30 years). Affected individuals may experience symptoms similar to those found in Parkinson's disease (parkinsonism); cerebellar signs such as progressive impairment of the ability to coordinate voluntary movements (cerebellar ataxia); and impaired functioning of the portion of the nervous system (autonomic nervous system) that regulates certain involuntary body functions (autonomic failure) such as heart rate, blood pressure, sweating, and bowel and bladder control. When parkinsonian symptoms predominate, the disorder may be referred to as MSA-P (parkinsonian phenotype); when the cerebellar symptoms predominate the disorder may be referred to as MSA-C (cerebellar phenotype). The exact cause of MSA is unknown.



Introduction

The term multiple system atrophy was first introduced in the medical literature in 1969. It encompasses three presentations of a single disease formerly thought to be separate disorders, specifically Shy-Drager syndrome (which emphasized autonomic dysfunction), striatonigral degeneration (which emphasized parkinsonian symptoms), and sporadic olivopontocerebellar atrophy (which emphasized cerebellar symptoms), although the cases of each of these that were originally described presented a combination of all three clinical features, and brain pathology was found in both the striatonigral and olivopontocerebellar structures. Additionally, there is a hereditary form of olivopontocerebellar atrophy that is not part of the multiple system atrophy spectrum.

Resources

WE MOVE (Worldwide Education and Awareness for Movement Disorders)

5731 Mosholu Avenue

Bronx, NY 10471

USA

Tel: (347)843-6132

Fax: (718)601-5112

Email: wemove@wemove.org

Internet: http://www.wemove.org



Parkinson's Disease Foundation, Inc.

1359 Broadway

Suite 1509

New York, NY 10018

Tel: (212)923-4700

Fax: (212)923-4778

Tel: (800)457-6676

Email: info@pdf.org

Internet: http://www.pdf.org



National Ataxia Foundation

2600 Fernbrook Lane Suite 119

Minneapolis, MN 55447

USA

Tel: (763)553-0020

Fax: (763)553-0167

Email: naf@ataxia.org

Internet: http://www.ataxia.org



CurePSP: Foundation for PSP l CBD & Related Brain Diseases

30 E. Padonia Road, Suite 201

Timonium, MD 21093

Tel: (410)785-7004

Fax: (410)785-7009

Tel: (800)457-4777

Email: info@curepsp.org

Internet: http://www.curepsp.org



NIH/National Institute of Neurological Disorders and Stroke

P.O. Box 5801

Bethesda, MD 20824

Tel: (301)496-5751

Fax: (301)402-2186

Tel: (800)352-9424

TDD: (301)468-5981

Internet: http://www.ninds.nih.gov/



Vanderbilt's Autonomic Dysfunction Center

Vanderbilt University Medical Center

1211 Medical Center Drive

Nashville, TN 37232-2195

USA

Tel: (615)322-5000

Fax: (615)343-8649

Email: david.robertson@vanderbilt.edu

Internet: http://www.mc.vanderbilt.edu/gcrc/adc



National Dysautonomia Research Foundation

PO Box 301

Red Wing, MN 55066-0102

Tel: (651)327-0367

Email: ndrf@ndrf.org

Internet: http://www.ndrf.org



Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223

Internet: http://rarediseases.info.nih.gov/GARD/



SDS/MSA Support Group

8311 Brier Creek Parkway Suite 105-434

Raleigh, NC 27617

Tel: (866)737-4999

Email: Vjames@shy-drager.org or jbiedenharn@shy-drager.org

Internet: http://www.shy-drager.org



National Parkinson Foundation, Inc.

1501 NW 9th Ave/Bob Hope Road

Miami, FL 33136-1494

Tel: (305)243-6666

Fax: (305)243-6073

Tel: (800)327-4545

Email: contact@parkinson.org

Internet: http://www.parkinson.org



Movement Disorder Society

555 E. Wells Street

Suite 1100

Milwaukee, WI 53202-3823

Tel: (414)276-2145

Fax: (414)276-3349

Email: info@movementdisorders.org

Internet: http://www.movementdisorders.org



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  1/15/2013

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