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Primary Lateral Sclerosis

National Organization for Rare Disorders, Inc.

Important

It is possible that the main title of the report Primary Lateral Sclerosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Central Motor Neuron Disease
  • PLS

Disorder Subdivisions

  • None

General Discussion

Primary lateral sclerosis (PLS) is a rare, neuromuscular disorder that affects the central motor neurons and is characterized by painless but progressive weakness and stiffness of the muscles of the legs. Such weakness may progress to affect the arms and the muscles at the base of the brain (bulbar muscles). Less frequently, the muscles of the face are affected. In most cases, the disorder affects adults during midlife. The exact cause of primary lateral sclerosis is unknown.

Resources

Amyotrophic Lateral Sclerosis Association

27001 Agoura Road

Suite 250

Calabasas Hills, CA 91301-5104

USA

Tel: (818)880-9007

Fax: (818)880-9006

Tel: (800)782-4747

TDD: (818)593-3540

Email: als@alsa-national.org

Internet: http://www.alsa.org



Motor Neurone Disease Association

PO Box 246

Northampton, NN1 2BG

United Kingdom

Tel: 01604250505

Fax: 441604624726

Email: enquiries@mndassociation.org

Internet: http://www.mndassociation.org



NIH/National Institute of Neurological Disorders and Stroke

P.O. Box 5801

Bethesda, MD 20824

Tel: (301)496-5751

Fax: (301)402-2186

Tel: (800)352-9424

TDD: (301)468-5981

Internet: http://www.ninds.nih.gov/



Les Turner Amyotrophic Lateral Sclerosis Foundation, Ltd.

5550 W. Touhy Avenue,

Suite 302

Skokie, IL 60077-3254

Tel: (847)679-3311

Fax: (847)679-9109

Tel: (888)257-1107

Email: info@lesturnerals.org

Internet: http://www.lesturnerals.org



Spastic Paraplegia Foundation

5305 Miramar Ln

Colleyville, TX 76034

USA

Tel: (877)773-4483

Email: information@sp-foundation.org

Internet: http://sp-foundation.org



International Alliance of ALS/MND Associations

P.O. Box 246

Northampton, NN1 2PR

United Kingdom

Tel: 441604611821

Fax: 441604624726

Email: alliance@alsmndalliance.org

Internet: http://www.alsmndalliance.org



Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223

Internet: http://rarediseases.info.nih.gov/GARD/



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  8/17/2007

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