Health Encyclopedia > Medications

acetaminophen and hydrocodone

Pronunciation: a SEET a MIN oh fen and hye droe KOE done

Brand: Anexsia, Co-Gesic, Hycet, Liquicet, Lorcet 10/650, Lorcet Plus, Lortab 10/500, Lortab 2.5/500, Lortab 5/500, Lortab 7.5/500, Lortab Elixir, Maxidone, Norco, Polygesic, Stagesic, Vicodin, Vicodin ES, Vicodin HP, Xodol, Zamicet, Zolvit, Zydone

Acetaminophen-Hydrocodone 325 mg-10 mg-QUA

oval, yellow, imprinted with LOGO, 36 01

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Acetaminophen-Hydrocodone 325 mg-10 mg-WAT

oblong, yellow, imprinted with Watson 853

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Acetaminophen-Hydrocodone 325 mg-5 mg-AMN

capsule, white, imprinted with IP 109

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Acetaminophen-Hydrocodone 325 mg-5 mg-WAT

oblong, white/orange specks, imprinted with 3202, WATSON

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Acetaminophen-Hydrocodone 325 mg-7.5 mg-WAT

oval, orange, imprinted with WATSON, 3203

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Acetaminophen-Hydrocodone 500 mg-5 mg-MAL

oval, white, imprinted with M 357

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Acetaminophen-Hydrocodone 500 mg-7.5 mg-MAL

oblong, white, imprinted with M 358

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Acetaminophen-Hydrocodone 650 mg-10 mg-MAL

oblong, blue, imprinted with M 361

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Acetaminophen-Hydrocodone 650 mg-10 mg-WAT

oblong, green, imprinted with WATSON 503

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Acetaminophen-Hydrocodone 650 mg-7.5 mg-MAL

oblong, white, imprinted with M 359

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Acetaminophen-Hydrocodone 660 mg-10 mg-AND

oblong, white, imprinted with Logo 567

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Acetaminophen-Hydrocodone 750 mg-10 mg-WAT

oval, yellow, imprinted with WATSON 3228

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Acetaminophen-Hydrocodone 750 mg-7.5 mg-MAL

oblong, white, imprinted with M 360

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Anexsia 5-500

round, white, imprinted with ANEXSIA, MPC 207

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APAP-HC 10-500 mg-WAT

oblong, blue, imprinted with WATSON 540

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APAP-HC 10-500-WAT

elliptical, white, imprinted with WATSON 540

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APAP-HC 10-650 mg-WAT

oblong, green, imprinted with WATSON 503

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APAP-HC 2.5-500 mg-WAT

oblong, white, imprinted with WATSON 388

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APAP-HC 5-500 mg-WAT

capsule, white, imprinted with WATSON 349

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APAP-HC 5-500-WAT

capsule, white, imprinted with WATSON 349

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APAP-HC 7.5-500 mg

oblong, white, imprinted with WATSON 385

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APAP-HC 7.5-500 mg-WAT

oblong, white, imprinted with WATSON 385

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APAP-HC 7.5-650 mg

oblong, pink, imprinted with WATSON 502

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APAP-HC 7.5-750 mg-WAT

oblong, white, imprinted with WATSON 387

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APAP-HC 7.5-750-WAT

oblong, white, imprinted with WATSON 387

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APAP-Hydrocodone 660 mg-10 mg-MAL

oblong, white, imprinted with M362

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Hydrocodone-APAP 5mg-325mg-MAL

oblong, white, imprinted with M365

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Lorcet Plus 7.5-650

oblong, white, imprinted with 201, UU

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Lortab 10-500 mg

oblong, pink, imprinted with 910, UCB

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Lortab 5-500

oblong, white/blue specks, imprinted with ucb, 902

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Lortab 7.5-500 mg

oblong, white, imprinted with 903, UCB

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Maxidone 10-750 mg

oval, yellow, imprinted with MAXIDONE 634

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Norco 10-325

oblong, yellow, imprinted with NORCO 539

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Norco 5-325 mg

oblong, white/orange specks, imprinted with 913, WATSON

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Norco 7.5-325 mg

oblong, orange, imprinted with NORCO 729

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Stagesic 500 mg-5 mg Cap

capsule, white, imprinted with Stagesic

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Vicodin ES

oblong, white, imprinted with VICODIN ES

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Xodol 300 mg-10 mg

oblong, white, imprinted with 10 300, TP

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Zydone 400 mg-10 mg

octagonal, red, imprinted with E, 10

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Zydone 400 mg-5 mg

octagonal, yellow, imprinted with E, 5

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Zydone 400 mg-7.5 mg

octagonal, blue, imprinted with E, 7.5

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What is the most important information I should know about acetaminophen and hydrocodone?

Multum emt

Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

Multum donot

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Multum habit

Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it.

Multum emt

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Multum dizzy

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how acetaminophen and hydrocodone will affect you.

Multum noalcohol

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

What is acetaminophen and hydrocodone?

Hydrocodone is an opioid pain medication. An opioid is sometimes called a narcotic.

Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone.

The combination of acetaminophen and hydrocodone is used to relieve moderate to severe pain.

Acetaminophen and hydrocodone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking acetaminophen and hydrocodone?

Multum donot

Do not use this medication if you are allergic to acetaminophen (Tylenol) or hydrocodone.

Multum emt

Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

To make sure you can safely take acetaminophen and hydrocodone, tell your doctor if you have any of these other conditions:

  • asthma, COPD, sleep apnea, or other breathing disorders;
  • liver or kidney disease;
  • a history of head injury or brain tumor;
  • low blood pressure;
  • a stomach or intestinal disorder;
  • underactive thyroid;
  • Addison's disease or other adrenal gland disorder;
  • curvature of the spine;
  • mental illness; or
  • a history of drug or alcohol addiction.
Multum habit

Hydrocodone may be habit forming and should be used only by the person it was prescribed for. Never share acetaminophen and hydrocodone with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Multum nopreg

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby, but it could cause breathing problems or addiction/withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

Acetaminophen and hydrocodone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take acetaminophen and hydrocodone?

Multum donot

Take exactly as prescribed. Never take acetaminophen and hydrocodone in larger amounts, or for longer than recommended by your doctor. An overdose of acetaminophen can damage your liver or cause death.

One acetaminophen and hydrocodone tablet may contain up to 750 mg of acetaminophen. Know the amount of acetaminophen in the specific product you are taking.

Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Multum water

Drink 6 to 8 full glasses of water daily to help prevent constipation while you are taking acetaminophen and hydrocodone. Ask your doctor about ways to increase the fiber in your diet. Do not use a stool softener (laxative) without first asking your doctor.

Multum donot

Do not stop using this medicine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using acetaminophen and hydrocodone.

Acetaminophen can cause false results with certain lab tests for glucose (sugar) in the urine. Talk to your doctor if you are diabetic and you notice changes in your glucose levels during treatment.

If you need surgery, tell the surgeon ahead of time that you are using acetaminophen and hydrocodone. You may need to stop using the medicine for a short time.

Multum rt

Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Always check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.

What happens if I miss a dose?

Since acetaminophen and hydrocodone is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen and hydrocodone can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include extreme drowsiness, pinpoint pupils, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing

What should I avoid while taking acetaminophen and hydrocodone?

Multum dizzy

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how acetaminophen and hydrocodone will affect you.

Multum emt

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Multum noalcohol

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

What are the possible side effects of acetaminophen and hydrocodone?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Call your doctor at once if you have any of these serious side effects:

  • shallow breathing, slow heartbeat;
  • feeling light-headed, fainting;
  • confusion, fear, unusual thoughts or behavior;
  • seizure (convulsions);
  • problems with urination; or
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • anxiety, dizziness, drowsiness;
  • mild nausea, vomiting, upset stomach, constipation;
  • headache, mood changes;
  • blurred vision;
  • ringing in your ears; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect acetaminophen and hydrocodone?

Multum dizzy

Do not take acetaminophen and hydrocodone with any other narcotic pain medications, sedatives, tranquilizers, sleeping pills, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.

Tell your doctor about all other medicines you use, especially:

  • an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan), nortriptyline (Pamelor), and others;
  • an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate);
  • atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), glycopyrrolate (Robinul), mepenzolate (Cantil), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
  • bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);
  • a bronchodilator such as ipratropium (Atrovent) or tiotropium (Spiriva); or
  • irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), or propantheline (Pro-Banthine).

This list is not complete and other drugs may interact with acetaminophen and hydrocodone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about acetaminophen and hydrocodone.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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