Health Encyclopedia > Medications

alendronate

Pronunciation: a LEN dro nate

Brand: Binosto, Fosamax

Alendronate 10 mg-APO

round, white, imprinted with APO, A10

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Alendronate 10 mg-MYL

round, white, imprinted with A7, M

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Alendronate 10 mg-TEV

round, white, imprinted with 93, 5141

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Alendronate 35 mg-APO

oval, white, imprinted with APO, ALE 35

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Alendronate 35 mg-MYL

oblong, white, imprinted with M A11

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Alendronate 35 mg-TEV

square, white, imprinted with 93, 5172

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Alendronate 35mg-WAT16252

oval, white, imprinted with AN35, LOGO

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Alendronate 40 mg-TEV

oval, white, imprinted with 93, 5142

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Alendronate 5 mg-APO

round, white, imprinted with A, 5

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Alendronate 5 mg-MYL

round, white, imprinted with AG, M

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Alendronate 5 mg-TEV

round, white, imprinted with 93, 5140

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Alendronate 70 mg-APO

oval, white, imprinted with APO, ALE 70

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Alendronate 70 mg-MYL

oblong, white, imprinted with M A12

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Alendronate 70 mg-TEV

square, white, imprinted with 93, 5171

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Alendronate 70mg-BAR

oval, white, imprinted with b 70, 720

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Fosamax 10 mg

oblong, white, imprinted with MRK, 936

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Fosamax 35 mg

oval, white, imprinted with LOGO BONE, 77

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Fosamax 40 mg

triangular, white, imprinted with FOSAMAX, MRK 212

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Fosamax 5 mg

round, white, imprinted with LOGO BONE, MRK 925

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Fosamax 70 mg

oval, white, imprinted with LOGO BONE, 31

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What is the most important information I should know about alendronate?

Multum donot

Do not take an alendronate tablet if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious problems in the stomach or esophagus (the tube that connects your mouth and stomach). You will need to stay upright for at least 30 minutes after taking this medication.

Take the alendronate tablet first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine.

Multum water

Take each dose with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water, coffee, tea, or juice) when taking an alendronate tablet.

For at least the first 30 minutes after taking an alendronate tablet, do not lie down or recline; do not eat or drink anything other than plain water; and do not take any other medicines including vitamins, calcium, or antacids.

Some people using medicines similar to alendronate have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem.

Multum emt

If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using alendronate. You may need to stop using the medicine for a short time.

Talk with your doctor about the risks and benefits of using this medication.

What is alendronate?

Alendronate is in the group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body. Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures.

Alendronate is used in men and women to treat or prevent osteoporosis that is caused by menopause or by taking steroids. Alendronate is also used to increase bone mass in men who have osteoporosis, and to treat Paget's disease of bone in men and women.

Alendronate may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking alendronate?

Multum donot

Do not take an alendronate tablet if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious problems in the stomach or esophagus (the tube that connects your mouth and stomach). You will need to stay upright for at least 30 minutes after taking this medication.

Multum donot

You should not take alendronate if you are allergic to it, or if you have low levels of calcium in your blood (hypocalcemia), or a problem with the movement of muscles in your esophagus.

To make sure you can safely take alendronate, tell your doctor if you have any of these other conditions:

  • trouble swallowing;
  • a vitamin D deficiency;
  • a dental problem;
  • kidney disease; or
  • an ulcer or other problem in your stomach or esophagus.

Some people using medicines similar to alendronate have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums.

You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and dental surgery or pre-existing dental problems.

Talk with your doctor about the risks and benefits of using this medication.

Multum nopreg

FDA pregnancy category C. It is not known whether alendronate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

It is not known whether alendronate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take alendronate?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Alendronate tablets are taken either once each day or once each week.

To use the Binosto effervescent tablet, dissolve the tablet in at least 4 ounces of water. Stir this mixture and drink all of it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

Take the Fosamax tablet first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. If you take an alendronate tablet only once a week, take it on the same day each week and always first thing in the morning.

Multum water

Take Fosamax with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking the tablet.

Multum nocrush

Do not crush, chew, or suck the Fosamax tablet. Swallow the pill whole.

Multum donot

After taking alendronate, carefully follow these instructions:

  • Do not lie down or recline for at least 30 minutes after taking alendronate.
  • Do not eat or drink anything other than plain water.
  • Do not take any other medicines including vitamins, calcium, or antacids for at least 30 minutes after taking alendronate. It may be best to take your other medicines at a different time of the day. Talk with your doctor about the best dosing schedule for your other medicines.

To be sure this medication is helping your condition, your bone mineral density will need to be tested on a regular basis. You may not need to take alendronate for longer than 3 to 5 years if you take it for osteoporosis. Visit your doctor regularly.

Multum emt

If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using alendronate. You may need to stop using the medicine for a short time.

Alendronate is only part of a complete program of treatment that may also include diet changes, exercise, and taking calcium and vitamin supplements. Follow your diet, medication, and exercise routines very closely.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

If you take alendronate once daily: If you forget to take this medicine first thing in the morning, do not take it later in the day. Wait until the following morning to take the medicine and skip the missed dose. Do not take two (2) tablets in one day.

If you take alendronate once a week: If you forget to take alendronate on your scheduled day, take it first thing in the morning on the day after you remember the missed dose. Then return to your regular weekly schedule on your chosen dose day. Do not take two (2) tablets in one day.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Drink a full glass of milk and call your local poison control center or emergency room right away. Do not make yourself vomit and do not lie down.

Overdose symptoms may include nausea, heartburn, stomach pain, diarrhea, muscle cramps, numbness or tingling, tight muscles in your face, seizure (convulsions), irritability, and unusual thoughts or behavior.

What should I avoid while taking alendronate?

Multum emt

Avoid taking any other medicines including vitamins, calcium, or antacids for at least 30 minutes after taking alendronate. Some medicines can make it harder for your body to absorb alendronate.

Multum donot

Do not lie down for at least 30 minutes after you take an alendronate tablet.

What are the possible side effects of alendronate?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using alendronate and call your doctor at once if you have a serious side effect such as:

  • chest pain;
  • difficulty or pain when swallowing;
  • pain or burning under the ribs or in the back;
  • severe heartburn, burning pain in your upper stomach, or coughing up blood;
  • new or worsening heartburn;
  • fever, body aches, flu symptoms;
  • severe joint, bone, or muscle pain;
  • new or unusual pain in your thigh or hip;
  • jaw pain, numbness, or swelling.

Less serious side effects may include:

  • mild heartburn, bloating;
  • mild nausea, vomiting, or stomach pain;
  • diarrhea, gas, or constipation;
  • mild joint pain or swelling;
  • swelling in your hands or feet; or
  • dizziness, eye pain, headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect alendronate?

Tell your doctor about all other medicines you use, especially aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as:

  • celecoxib (Celebrex);
  • diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze);
  • diflunisal (Dolobid);
  • ibuprofen (Motrin, Advil);
  • indomethacin (Indocin);
  • ketoprofen (Orudis)
  • ketorolac (Toradol);
  • meloxicam (Mobic);
  • naproxen (Aleve, Naprosyn, Naprelan, Treximet); or
  • piroxicam (Feldene).

This list is not complete and other drugs may interact with alendronate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about alendronate.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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