Health Encyclopedia > Medications

articaine and epinephrine

Pronunciation: AR ti kane and EP i NEF rin

Brand: Septocaine

What is the most important information I should know about articaine and epinephrine?

Multum donot

You should not receive articaine and epinephrine if you have ever had an allergic reaction to any type of numbing medicine.

Before receiving this medication, tell your dentist if you have high or low blood pressure, asthma or a sulfite allergy, or a history of seizures.

This medication can cause numbness for an extended period of time. Avoid eating, chewing gum, or drinking hot liquids until the feeling in your mouth has returned completely. Chewing while your mouth is numb could result in a bite injury to your tongue, lips, or inside of your cheek.

What is articaine and epinephrine?

Articaine and epinephrine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain.

Articaine and epinephrine is used as an anesthetic for dental procedures.

Articaine and epinephrine may also be used for other purposes not listed in this medication guide.

What should I discuss with my health care provider before receiving articaine and epinephrine?

Multum donot

You should not receive articaine and epinephrine if you have ever had an allergic reaction to any type of numbing medicine.

Before receiving articaine and epinephrine, tell your dentist if you are allergic to any drugs, or if you have:

  • low or high blood pressure;
  • asthma or a sulfite allergy; or
  • a history of seizures.
Multum nopreg

FDA pregnancy category C. This medication may be harmful to an unborn baby. Before you receive articaine and epinephrine, tell your dentist if you are pregnant.

Multum nobrfeed

It is not known whether articaine and epinephrine passes into breast or if it could harm a nursing baby. Before you receive articaine and epinephrine, tell your dentist if you are breast-feeding a baby.

How is articaine and epinephrine given?

Articaine and epinephrine is given as an injection that is usually placed into the gum area inside your mouth. You will receive this injection in a dentist's office or oral surgical setting.

What happens if I miss a dose?

Since articaine and epinephrine is given as needed before a dental procedure, you are not likely to be on a dosing schedule.

What happens if I overdose?

Multum emt

Tell your caregivers right away if you think you have received too much of this medicine.

Overdose symptoms may include extreme drowsiness, fainting, seizure (convulsions), shallow breathing, or slow heart rate.

What should I avoid after receiving articaine and epinephrine?

This medication can cause numbness for an extended period of time. Avoid eating, chewing gum, or drinking hot liquids until the feeling in your mouth has returned completely. Chewing while your mouth is numb could result in a bite injury to your tongue, lips, or inside of your cheek.

What are the possible side effects of articaine and epinephrine?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling or puffiness of your face, lips, tongue, or throat.

Multum emt

Tell your caregivers at once if you have a serious side effect such as:

  • weak or shallow breathing;
  • slow heart rate, weak pulse;
  • feeling like you might pass out;
  • swelling in your face;
  • swollen or bleeding gums;
  • anxiety, confusion, restless feeling, tremors or shaking;
  • blurred vision, ringing in your ears; or
  • seizure (convulsions).

Less serious side effects may include:

  • tongue pain or swelling, mouth sores;
  • nausea, vomiting, constipation, diarrhea, upset stomach;
  • increased thirst, drooling;
  • nervousness, dizziness, drowsiness;
  • ear pain, neck pain, joint or muscle pain;
  • unusual or unpleasant taste in your mouth;
  • numbness or tingly feeling;
  • mild skin rash or itching; or
  • runny nose, sore throat.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect articaine and epinephrine?

Before receiving articaine and epinephrine, tell your dentist if you are using any of the following drugs:

  • cold medicine, diet pills, stimulants, or medication to treat ADHD;
  • medicine to treat a psychiatric disorder (Haldol, Inapsine, Thorazine, Prolixin, Serentil, Mellaril, and others);
  • medication to treat nausea and vomiting, such as Compazine or Motillium; or
  • an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).

This list is not complete and there may be other drugs that can interact with articaine and epinephrine. Tell your dentist about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.

Where can I get more information?

Your dentist or pharmacist can provide more information about articaine and epinephrine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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