Enfuvirtide is available only as an injection. Maraviroc is also called a chemokine receptor 5 (CCR-5) inhibitor.
HIV invades your body, the virus attaches to the
outside of a CD4+ cell (a type of
white blood cell) where it joins (fuses) with the cell
and then multiplies. Entry inhibitors prevent fusion between the
virus and the cell from occurring and prevent the virus from entering the cell.
So HIV is not able to infect the cell and multiply.
Enfuvirtide and maraviroc are used in
combination with other antiretroviral medicines for the treatment of HIV to
prevent the virus from spreading in the body and to reduce the amount of virus
in your blood (viral load). Enfuvirtide and maraviroc may be
effective for people who have taken other anti-HIV drugs without
The use of three or more antiretroviral medicines (antiretroviral therapy, or ART) is the usual treatment for HIV
The combination of medicines used for ART will depend
on your health, other conditions you might have (such as
hepatitis), and results of testing. Talk to your
doctor about the best treatment plan for you.
Medical experts recommend that people begin treatment for HIV as soon as they know they are infected.1, 2 Treatment is especially important for pregnant women, people who have other infections (such as tuberculosis or hepatitis), and people who have symptoms of AIDS.
You may also want to start HIV treatment if your sex partner does not have HIV. Treatment of your HIV infection can help prevent the spread of HIV to your sex partner.3
Enfuvirtide and maraviroc strengthen
the immune system by reducing the amount of virus in the blood and increasing
CD4+ counts.4, 5
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
or other emergency services right away if you have:
Call your doctor if you have:
Common side effects of enfuvirtide include:
Common side effects of maraviroc include:
See Drug Reference for a full list of side effects.
(Drug Reference is not available in all systems.)
Maraviroc is only effective against
certain strains of HIV. Before maraviroc treatment is considered, you need to
be tested to see if maraviroc will work against the virus you are infected
with. This is called a tropism test. You should not take maraviroc unless you
have had this test and it shows that maraviroc will be effective against the
type of virus you have.
Enfuvirtide and maraviroc are used in
combination with other anti-HIV drugs.
resistant to enfuvirtide, so your viral load and CD4+
cell counts will be closely monitored while you are taking this
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
If you are pregnant, breast-feeding, or planning to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breast-feeding, or planning to get pregnant.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
U.S. Department of Health and
Human Services Panel on Antiretroviral Guidelines for Adults and Adolescents (2012). Guidelines for the Use of Antiretroviral Agents
in HIV-1-Infected Adults and Adolescents. Available online: http://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf.
Thompson MA, et al. (2012). Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society—USA Panel. JAMA, 308(4): 387–402.
U.S. Department of Health and Human Services Panel on Antiretroviral Guidelines for Adults and Adolescents (2011). Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Available online: http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf.
Lalezari JP, et al. (2003). Enfuvirtide, an HIV-1
fusion inhibitor, for drug-resistant HIV infection in North and South America.
New England Journal of Medicine, 348(22):
Hanson K, Hicks C (2006). New antiretroviral drugs.
Current HIV/AIDS Reports, 3(2): 93–101.
November 7, 2012
E. Gregory Thompson, MD - Internal Medicine
& Peter Shalit, MD, PhD - Internal Medicine
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