Health Encyclopedia > Medications

hydrochlorothiazide and losartan

Pronunciation: HYE droe KLOR oh THYE a zide and loe SAR tan

Brand: Hyzaar

HCTZ-Losartan 12.5-100 mg-TEV

oval, white, imprinted with 93, 7369

Image of HCTZ-Losartan 12.5-100 mg-TEV
slide 1 of 9
    

HCTZ-Losartan 12.5-50 mg-TEV

oval, yellow, imprinted with 93, 7367

Image of HCTZ-Losartan 12.5-50 mg-TEV
slide 2 of 9
    

HCTZ-Losartan 25-100 mg-TEV

oval, yellow, imprinted with 93, 7368

Image of HCTZ-Losartan 25-100 mg-TEV
slide 3 of 9
    

Hyzaar 12.5 mg-50 mg

oval, yellow, imprinted with 717

Image of Hyzaar 12.5 mg-50 mg
slide 4 of 9
    

Hyzaar 12.5-100 mg

oval, white, imprinted with 745

Image of Hyzaar 12.5-100 mg
slide 5 of 9
    

Hyzaar 25 mg-100 mg

oval, yellow, imprinted with 747

Image of Hyzaar 25 mg-100 mg
slide 6 of 9
    

Losartan-HCTZ 100-12.5 mg-ROX

round, white, imprinted with 54, 931

Image of Losartan-HCTZ 100-12.5 mg-ROX
slide 7 of 9
    

Losartan-HCTZ 100-25 mg-ROX

round, yellow, imprinted with 54 557

Image of Losartan-HCTZ 100-25 mg-ROX
slide 8 of 9
    

Losartan-HCTZ 50-12.5 mg-ROX

round, yellow, imprinted with 54 717

Image of Losartan-HCTZ 50-12.5 mg-ROX
slide 9 of 9
    

What is the most important information I should know about hydrochlorothiazide and losartan?

Multum nopreg

Do not use hydrochlorothiazide and losartan if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant.

Multum donot

You should not use this medication if you are allergic to hydrochlorothiazide or losartan, or if you are unable to urinate.

Before using hydrochlorothiazide and losartan, tell your doctor if you have congestive heart failure, kidney or liver disease, glaucoma, asthma, low or high blood levels of potassium, gout, lupus, diabetes, or an allergy to sulfa drugs or penicillin.

Multum dizzy

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Multum noalcohol

Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and losartan.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Multum donot

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and losartan, unless your doctor has told you to.

Multum emt

In rare cases, hydrochlorothiazide and losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

What is hydrochlorothiazide and losartan?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Losartan is an angiotensin II receptor antagonists. Losartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

The combination of hydrochlorothiazide and losartan is used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease.

Hydrochlorothiazide and losartan may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking hydrochlorothiazide and losartan?

Multum donot

You should not use this medication if you are allergic to hydrochlorothiazide or losartan, or if you are unable to urinate.

To make sure you can safely take hydrochlorothiazide and losartan, tell your doctor if you have any of these other conditions:

  • kidney disease;
  • liver disease;
  • congestive heart failure;
  • glaucoma;
  • asthma;
  • low or high levels of potassium in your blood;
  • gout;
  • lupus;
  • diabetes; or
  • an allergy to sulfa drugs or penicillin.
Multum nopreg

FDA pregnancy category D. Do not use hydrochlorothiazide and losartan if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Losartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking hydrochlorothiazide and losartan.

Multum nobrfeed

It is not known whether hydrochlorothiazide and losartan passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take hydrochlorothiazide and losartan?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Multum water

Take this medication with a full glass (8 ounces) of water.

Multum emt

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance.

Your blood pressure will need to be checked often. Your kidney function may also need to be tested. Visit your doctor regularly.

Multum emt

If you need surgery or medical tests, tell the doctor ahead of time that you are taking medication that contains hydrochlorothiazide. You may need to stop using the medicine for a short time.

Multum finish

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fast or slow heartbeat, feeling light-headed, or fainting.

What should I avoid while taking hydrochlorothiazide and losartan?

Multum dizzy

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Multum noalcohol

Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and losartan.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Multum donot

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and losartan, unless your doctor has told you to.

What are the possible side effects of hydrochlorothiazide and losartan?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum emt

In rare cases, hydrochlorothiazide and losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Multum donot

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • eye pain, vision problems;
  • feeling light-headed, fainting;
  • swelling, rapid weight gain;
  • urinating less than usual, or not at all;
  • drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting;
  • fast or pounding heartbeats;
  • pale skin, easy bruising or bleeding;
  • jaundice (yellowing of the skin or eyes); or
  • high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling).

Less serious side effects may include:

  • stomach pain;
  • back pain;
  • dizziness, tired feeling;
  • skin rash;
  • runny or stuffy nose, sore throat; or
  • dry cough.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydrochlorothiazide and losartan?

Tell your doctor about all other medicines you use, especially:

  • any other blood pressure medications;
  • steroids (prednisone and others);
  • lithium (Eskalith, Lithobid);
  • celecoxib (Celebrex);
  • cholestyramine (Prevalite, Questran) or colestipol (Colestid);
  • insulin or diabetes medications you take by mouth;
  • rifampin (Rifadin, Rimactane, Rifater);
  • a barbiturate such as phenobarbital (Luminal, Solfoton) and others;
  • any other diuretics, such as amiloride (Midamor), bumetanide (Bumex), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Lopressor HCT, Vasoretic, Zestoretic), spironolactone (Aldactone), torsemide (Demadex), and others;
  • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;
  • a muscle relaxer such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), methocarbamol (Robaxin), tizanidine (Zanaflex), and others; or
  • narcotic pain medication such as codeine (Tylenol #3), hydrocodone (Lortab, Vicodin, Vicoprofen), hydromorphone (Dilaudid, Palladone), oxycodone (OxyContin, Combunox, Roxicodone, Percocet), fentanyl (Abstral, Actiq, Fentora, Duragesic, Ionsys, Lazanda, Onsolis), methadone (Methadose, Dolophine), or morphine (Kadian, MS Contin, Oramorph).

This list is not complete and other drugs may interact with hydrochlorothiazide and losartan. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about hydrochlorothiazide and losartan.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 10.02. Revision date: 3/12/2012.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.