Health Encyclopedia > Medications

hydrocortisone (oral)

Pronunciation: hye droe KOR ti sone

Brand: Cortef, Hydrocortone

Cortef 10 mg

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Cortef 5 mg

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Hydrocortisone 20 mg-MAJ

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What is the most important information I should know about hydrocortisone?

Multum donot

You should not use this medication if you are allergic to hydrocortisone, or if you have a fungal infection anywhere in your body.

Before taking hydrocortisone, tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.

Your steroid medication needs may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you during treatment.

Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Do not receive a "live" vaccine while you are taking hydrocortisone. Vaccines may not work as well while you are taking a steroid.

Multum donot

Do not stop using hydrocortisone suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

Multum emt

Carry an ID card or wear a medical alert bracelet stating that you are taking a steroid, in case of emergency.

What is hydrocortisone?

Hydrocortisone is in a class of drugs called steroids. Hydrocortisone prevents the release of substances in the body that cause inflammation.

Hydrocortisone is used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.

Hydrocortisone may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking hydrocortisone?

Multum donot

You should not use this medication if you are allergic to hydrocortisone, or if you have a fungal infection anywhere in your body.

Steroid medication can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Before taking this medication, tell your doctor about any illness or infection you have had within the past several weeks.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take hydrocortisone:

  • liver disease (such as cirrhosis);
  • kidney disease;
  • a thyroid disorder;
  • diabetes;
  • a history of malaria;
  • tuberculosis;
  • osteoporosis;
  • a muscle disorder such as myasthenia gravis;
  • glaucoma or cataracts;
  • herpes infection of the eyes;
  • stomach ulcers, ulcerative colitis, or diverticulitis;
  • depression or mental illness;
  • congestive heart failure; or
  • high blood pressure
Multum nopreg

FDA pregnancy category C. It is not known whether hydrocortisone is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

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Hydrocortisone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Steroids can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using this medication.

How should I take hydrocortisone?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Your steroid medication needs may change if you have unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using hydrocortisone.

Multum donot

Do not stop using hydrocortisone suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

Multum emt

Carry an ID card or wear a medical alert bracelet stating that you are taking a steroid, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking steroid medication.

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Store hydrocortisone at room temperature away from moisture and heat.

What happens if I miss a dose?

If you miss a dose or forget to take your medicine, contact your doctor or pharmacist for instructions.

What happens if I overdose?

Multum emt

Seek emergency medical attention if you think you have received too much of this medicine.

A single large dose of hydrocortisone is not expected to produce life-threatening symptoms. However, high doses taken over a long period of time may cause weight gain, roundness of the face, increased facial hair growth, bruising, swelling, and muscle pain or weakness.

What should I avoid while taking hydrocortisone?

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Do not receive a "live" vaccine while you are being treated with hydrocortisone. Vaccines may not work as well while you are taking a steroid.

Multum noalcohol

Avoid drinking alcohol while you are taking hydrocortisone.

What are the possible side effects of hydrocortisone?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum emt

Call your doctor at once if you have any of these serious side effects:

  • problems with your vision;
  • swelling, rapid weight gain, feeling short of breath;
  • severe depression, unusual thoughts or behavior, seizure (convulsions);
  • bloody or tarry stools, coughing up blood;
  • pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate);
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

  • sleep problems (insomnia), mood changes;
  • acne, dry skin, thinning skin, bruising or discoloration;
  • slow wound healing;
  • increased sweating;
  • headache, dizziness, spinning sensation;
  • nausea, stomach pain, bloating; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydrocortisone?

There are many other medicines that can interact with steroids. Below is only a partial list of these medicines:

  • aspirin (taken on a daily basis or at high doses);
  • a diuretic (water pill);
  • a blood thinner such as warfarin (Coumadin);
  • cyclosporine (Gengraf, Neoral, Sandimmune);
  • insulin or diabetes medications you take by mouth;
  • ketoconazole (Nizoral);
  • rifampin (Rifadin, Rifater, Rifamate, Rimactane); or
  • seizure medications such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton).

This list is not complete and there may be other drugs that can interact with hydrocortisone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about hydrocortisone.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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