Health Encyclopedia > Medications

linaclotide

Pronunciation: LIN a KLOE tide

Brand: Linzess

What is the most important information I should know about linaclotide?

Multum donot

You should not use linaclotide if you are allergic to it, or if you have a blockage in your stomach or intestines.

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Do not give this medication to any child or teenager without the advice of a doctor.

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Take linaclotide in the morning on an empty stomach, at least 30 minutes before your first meal. Do not crush, chew, break, or open a linaclotide capsule. Swallow it whole.

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Stop using linaclotide and call your doctor at once if you have severe or ongoing diarrhea, severe stomach pain, or black, bloody, or tarry stools.

What is linaclotide?

Linaclotide works by increasing the secretion of chloride and water in the intestines, which can soften stools and stimulate bowel movements.

Linaclotide is used to treat chronic constipation, or chronic irritable bowel syndrome (IBS) in people who have had constipation as the main symptom.

Linaclotide may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking linaclotide?

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You should not use linaclotide if you are allergic to it, or if you have a blockage in your stomach or intestines.

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FDA pregnancy category C. It is not known whether linaclotide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

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It is not known whether linaclotide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

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Linaclotide should not be given to a child younger than 6 years old. Do not give this medication to any child or teenager without the advice of a doctor.

How should I take linaclotide?

Follow the directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

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Do not crush, chew, break, or open a linaclotide capsule. Swallow it whole.

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Take linaclotide in the morning on an empty stomach, at least 30 minutes before your first meal.

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It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed. Call your doctor if your symptoms do not improve, or if they get worse while using linaclotide.

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Store at room temperature away from moisture and heat.

Keep the capsules in their original container, along with the packet of moisture-absorbing preservative that comes with this medicine. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking linaclotide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of linaclotide?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Stop using linaclotide and call your doctor at once if you have a serious side effect such as:

  • severe or ongoing diarrhea;
  • severe stomach pain; or
  • black, bloody, or tarry stools.

Other common side effects may include:

  • mild diarrhea;
  • mild stomach discomfort;
  • heartburn, vomiting, gas, bloating;
  • headache; or
  • cold symptoms such as stuffy nose, sneezing, sinus pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect linaclotide?

Other drugs may interact with linaclotide, including prescription, over-the-counter, vitamin, and herbal products. Tell your doctor about all medications you use, and those you start or stop using during your treatment with linaclotide.

Where can I get more information?

Your pharmacist can provide more information about linaclotide.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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